Mcl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mcl1
Entrez Gene ID	60430
Full Name	MCL1, BCL2 family apoptosis regulator
General protein information	Preferred Names MCL1, BCL2 family apoptosis regulator Names induced myeloid leukemia cell differentiation protein Mcl-1 homolog BCL2 family apoptosis regulator myeloid cell leukemia 1 myeloid cell leukemia sequence 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	ovarian BAD-interacting protein; may inhibit apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021846.2	NP_068618.2	induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MCL1	NP_001003016.1
Mus musculus (house mouse)	Mcl1	NP_032588.1
Rattus norvegicus (Norway rat)	Mcl1	NP_068618.2
Gallus gallus (chicken)	MCL1	NP_001244212.1
Danio rerio (zebrafish)	mcl1b	NP_919375.2
	MCL1	XP_001102283.1
Danio rerio (zebrafish)	mcl1a	NP_571674.1
Pan troglodytes (chimpanzee)	MCL1	XP_001169313.2
Bos taurus (cattle)	MCL1	NP_001092676.1
Homo sapiens (human)	MCL1	NP_068779.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of miR-302 Suppresses Hypoxia-Reoxygenation-Induced H9c2 Cardiomyocyte Death by Regulating Mcl-1 Expression.
Fang YC, Yeh CH
Oxidative medicine and cellular longevity20177968905(2017)

miR-153 regulates apoptosis and autophagy of cardiomyocytes by targeting Mcl-1.
Zou Y, Liu W, Zhang J, Xiang D
Molecular medicine reports14(1)1033-9(2016 Jul)

Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.
Chang SH, Hwang CS, Yin JH, Chen SD, Yang DI
Biochimica et biophysica acta1853(10 Pt A)2306-25(2015 Oct)

Placental autophagy regulation by the BOK-MCL1 rheostat.
Kalkat M, Garcia J, Ebrahimi J, Melland-Smith M, Todros T, Post M, Caniggia I
Autophagy9(12)2140-53(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the results of the present study elucidated a novel mechanism by which miR153 regulates the survival of cardimyocytes during oxidative stress through the modulation of apoptosis and autophagy. These effects may be mediated directly by targeting Mcl1.
Title: miR-153 regulates apoptosis and autophagy of cardiomyocytes by targeting Mcl-1.

findings indicated that OSM induces Mcl-1 expression via activation of ERK1/2, JAK1/2, STAT1/3, and CREB; furthermore, OSM-mediated Mcl-1 induction contributes to bioenergetic improvements
Title: Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.

our data show that CK2 induces the expression of the antiapoptotic gene Mcl-1 through activation of the SRF-mediated pathway in hippocampal CA1 neurons
Title: Protein kinase CK2 enhances Mcl-1 gene expression through the serum response factor-mediated pathway in the rat hippocampus.

This study demonstrated that the expression of Mcl1 is involved in the survival of neuronal cells.
Title: Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1-dependent autophagy in ischemic stroke in rats.

Mcl-1L is an anti-apoptotic protein induced during liver regeneration after partial hepatectomy
Title: IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt/CREB signaling pathway in hepatocytes: implication of an anti-apoptotic role during liver regeneration.

The following Mcl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mcl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42828	NM_021846.2 Latest version!	Rattus norvegicus MCL1 apoptosis regulator, BCL2 family member (Mcl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mcl1 ( NM_021846.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068618.2 Rattus norvegicus MCL1 apoptosis regulator, BCL2 family member (Mcl1), mRNA.

Price & Availability↑

CloneID	ORa42828
Clone ID Related Accession (Same CDS sequence)	NM_021846.2
Accession Version	NM_021846.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Rattus norvegicus(Norway rat)
Product	induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078835.1. On Aug 8, 2004 this sequence version replaced NM_021846.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078835.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTTTGGCC TTCGGAGAAA CGCGGTAATC GGCTTGAACC TGTACTGCGG CGGCGCTAGC 
CTCGGCGCGG GCGGCGGCTC TCCGGCCGGG ACGCGCCTGG CGGCCGAGGA GGCCAAGGCG 
CGGCGCGAGG GGGGAGGGGA GGCCGCTCTG CTGCCCGGCG CGCGGGTGGT CGCCCGGCCG 
CCTCCGGTGG GCGCCGAGGA CCCCGACGTC ACCGCGTCGG CAGAGAGGCG GCTGCTCAAG 
TCGCCCGGCC TCCTCGCCGT GCCGCCTGAG GAGATGGCCG CGTCGGCCGC CGCCATCATG 
TCTCCCGAGG AGGAGCTGGA CGGCTGCGAG CCGGAGGTGC TCAGCAAACG CCCGGCGGTG 
CTGCCCCTAC TGGAGCGCGT GAGCGAGGCG GCTAAGAGCT CCGGAGCTGA CGGCTCGCTG 
CCCTCCACGC CGCCGCCGCC TGAGGAGGAA GACGACGAGC TGTACCGCCA GTCGCTGGAG 
ATCATCTCCC GCTACCTGCG GGAGCAGGCG ACGGGCTCCA AGGACGCGAA GCCTCTGGGC 
GAGGCCGGCG CAGCGGGCCG GAGGGCGCTG GAGACCCTGC GGCGCGTGGG CGACGGCGTG 
CAGCGCAACC ACGAGACGGC CTTCCAGGGC ATGCTTCGGA AACTGGACAT TAAAAACGAG 
GACGATGTTA AATCTTTTTC TCGAGTGATG ACCCATGTTT TCAAAGATGG CGTAACAAAC 
TGGGGCAGGA TTGTGACTCT TATTTCTTTT GGTGCCTTTG TGGCCAAACA CTTAAAGAGC 
ATAAACCAAG AAAGCTGCAT CGAACCTTTA GCAGAAAGTA TCACAGACGT TCTTGTAAGG 
ACGAAGCGGG ACTGGCTTGT GAAACAAAGA GGCTGGGATG GGTTTGTGGA GTTCTTCCAC 
GTACAGGACC TAGAAGGCGG CATCAGAAAT GTGCTGCTGG CTTTTGCGGG TGTTGCTGGA 
GTAGGGGCTG GTCTGGCATA TCTAATAAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068618.2
CDS	69..1061
Translation	MFGLRRNAVIGLNLYCGGASLGAGGGSPAGTRLAAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLLKSPGLLAVPPEEMAASAAAIMSPEEELDGCEPEVLSKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEDDELYRQSLEIISRYLREQATGSKDAKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSFSRVMTHVFKDGVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR

Target ORF information:

RefSeq Version	NM_021846.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MCL1 apoptosis regulator, BCL2 family member (Mcl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021846.2

ORF Insert Sequence:

ATGTTTGGCC TTCGGAGAAA CGCGGTAATC GGCTTGAACC TGTACTGCGG CGGCGCTAGC 
CTCGGCGCGG GCGGCGGCTC TCCGGCCGGG ACGCGCCTGG CGGCCGAGGA GGCCAAGGCG 
CGGCGCGAGG GGGGAGGGGA GGCCGCTCTG CTGCCCGGCG CGCGGGTGGT CGCCCGGCCG 
CCTCCGGTGG GCGCCGAGGA CCCCGACGTC ACCGCGTCGG CAGAGAGGCG GCTGCTCAAG 
TCGCCCGGCC TCCTCGCCGT GCCGCCTGAG GAGATGGCCG CGTCGGCCGC CGCCATCATG 
TCTCCCGAGG AGGAGCTGGA CGGCTGCGAG CCGGAGGTGC TCAGCAAACG CCCGGCGGTG 
CTGCCCCTAC TGGAGCGCGT GAGCGAGGCG GCTAAGAGCT CCGGAGCTGA CGGCTCGCTG 
CCCTCCACGC CGCCGCCGCC TGAGGAGGAA GACGACGAGC TGTACCGCCA GTCGCTGGAG 
ATCATCTCCC GCTACCTGCG GGAGCAGGCG ACGGGCTCCA AGGACGCGAA GCCTCTGGGC 
GAGGCCGGCG CAGCGGGCCG GAGGGCGCTG GAGACCCTGC GGCGCGTGGG CGACGGCGTG 
CAGCGCAACC ACGAGACGGC CTTCCAGGGC ATGCTTCGGA AACTGGACAT TAAAAACGAG 
GACGATGTTA AATCTTTTTC TCGAGTGATG ACCCATGTTT TCAAAGATGG CGTAACAAAC 
TGGGGCAGGA TTGTGACTCT TATTTCTTTT GGTGCCTTTG TGGCCAAACA CTTAAAGAGC 
ATAAACCAAG AAAGCTGCAT CGAACCTTTA GCAGAAAGTA TCACAGACGT TCTTGTAAGG 
ACGAAGCGGG ACTGGCTTGT GAAACAAAGA GGCTGGGATG GGTTTGTGGA GTTCTTCCAC 
GTACAGGACC TAGAAGGCGG CATCAGAAAT GTGCTGCTGG CTTTTGCGGG TGTTGCTGGA 
GTAGGGGCTG GTCTGGCATA TCTAATAAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of miR-302 Suppresses Hypoxia-Reoxygenation-Induced H9c2 Cardiomyocyte Death by Regulating Mcl-1 Expression.
Oxidative medicine and cellular longevity20177968905(2017)
Fang YC,Yeh CH

miR-153 regulates apoptosis and autophagy of cardiomyocytes by targeting Mcl-1.
Molecular medicine reports14(1)1033-9(2016 Jul)
Zou Y,Liu W,Zhang J,Xiang D

Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons.
Biochimica et biophysica acta1853(10 Pt A)2306-25(2015 Oct)
Chang SH,Hwang CS,Yin JH,Chen SD,Yang DI

Placental autophagy regulation by the BOK-MCL1 rheostat.
Autophagy9(12)2140-53(2013 Dec)
Kalkat M,Garcia J,Ebrahimi J,Melland-Smith M,Todros T,Post M,Caniggia I

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Mcl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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