Slc30a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc30a1
Entrez Gene ID	58976
Full Name	solute carrier family 30 member 1
General protein information	Preferred Names solute carrier family 30 member 1 Names zinc transporter 1 solute carrier family 30 (zinc transporter), member 1 znT-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q27
Summary	zinc-binding carrier molecule; may function to transport zinc out of the cell [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022853.2	NP_074044.1	zinc transporter 1

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0F08723g	XP_455476.1
Magnaporthe oryzae (rice blast fungus)	MGG_03634	XP_003716256.1
Rattus norvegicus (Norway rat)	Slc30a1	NP_074044.1
Drosophila melanogaster (fruit fly)	ZnT63C	NP_728857.1
Saccharomyces cerevisiae (baker's yeast)	ZRC1	NP_013970.1
Homo sapiens (human)	SLC30A1	NP_067017.2
	LOC711624	XP_001108878.1
Mus musculus (house mouse)	Slc30a1	NP_033605.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005918	XP_315949.4
Eremothecium gossypii	AGOS_ABR129C	NP_983076.2
Schizosaccharomyces pombe (fission yeast)	zhf1	NP_593645.1
Neurospora crassa	NCU03145	XP_964194.1
Pan troglodytes (chimpanzee)	SLC30A1	XP_001170094.1
Canis lupus familiaris (dog)	SLC30A1	XP_003434978.2
Bos taurus (cattle)	SLC30A1	NP_001192822.1
Gallus gallus (chicken)	SLC30A1	XP_419437.4
Danio rerio (zebrafish)	slc30a1a	NP_957173.1
Xenopus tropicalis (tropical clawed frog)	slc30a1	NP_001007940.1

Gene Ontology
Bibliography

Related articles in PubMed

ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in Astrocytes After Ischemic Stroke.
Pan R, Liu KJ
Acta neurochirurgica. Supplement121257-61(2016)

Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density.
Mellone M, Pelucchi S, Alberti L, Genazzani AA, Di Luca M, Gardoni F
Journal of neurochemistry132(2)159-68(2015 Jan)

Suppression of placental metallothionein 1 and zinc transporter 1 mRNA expressions contributes to fetal heart malformations caused by maternal zinc deficiency.
Liu C, He X, Hong X, Kang F, Chen S, Wang Q, Chen X, Hu D, Sun Q
Cardiovascular toxicology14(4)329-38(2014 Dec)

Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses.
Sindreu C, Bay?s ?, Altafaj X, P?rez-Clausell J
Molecular brain716(2014 Mar)

The effects of transformation and ZnT-1 silencing on zinc homeostasis in cultured cells.
Sankavaram K, Freake HC
The Journal of nutritional biochemistry23(6)629-34(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hypoxia/reoxygenation dramatically decreased ZnT-1 expression in rat astrocytes.
Title: ZNT-1 Expression Reduction Enhances Free Zinc Accumulation in Astrocytes After Ischemic Stroke.

ZNT-1 interacts with GluN2A-containing NMDA receptors at the glutamatergic synapse. This complex is regulated by synaptic plasticity induction. ZNT-1 expression modulation in hippocampal neurons shrank dendritic spines and reduced GluN2A surface levels.
Title: Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density.

These data indicate that maternal zinc deficiency resulted in an elevated incidence of fetal heart malformations, which was associated with significant decreases in placental MT-1 and ZnT-1 mRNA expressions
Title: Suppression of placental metallothionein 1 and zinc transporter 1 mRNA expressions contributes to fetal heart malformations caused by maternal zinc deficiency.

ZnT-1 expression is crucial for maintaining zinc homeostasis, in particular, for the enhanced retention of zinc in transformed cells when subjected to zinc deprivation.
Title: The effects of transformation and ZnT-1 silencing on zinc homeostasis in cultured cells.

The mRNA levels of ZnT-1 and BDNF were significantly increased in spinal cord injury model group.
Title: The correlation among the dynamic change of Zn2+, ZnT-1, and brain-derived neurotrophic factor after acute spinal cord injury in rats.

The following Slc30a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc30a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06366	NM_022853.2 Latest version!	Rattus norvegicus solute carrier family 30 member 1 (Slc30a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc30a1 ( NM_022853.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_074044.1 Rattus norvegicus solute carrier family 30 member 1 (Slc30a1), mRNA.

Price & Availability↑

CloneID	ORa06366
Clone ID Related Accession (Same CDS sequence)	NM_022853.2
Accession Version	NM_022853.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U17133.1. On Aug 31, 2012 this sequence version replaced NM_022853.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U17133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTGCT GGGGCCGCAA CCGCGGCCGG CTGCTGTGCA TGCTGCTGCT GACCTTCATG 
TTCATGGTGC TGGAGGTGGT GGTGAGCCGG GTGACCGCGT CGCTCGCCAT GCTGTCCGAC 
TCCTTCCACA TGCTGTCGGA CGTGCTGGCG CTCGTGGTGG CGCTGGTGGC CGAGCGCTTC 
GCCCGGAGGA CTCACGCCAC GCAGAAGAAC ACATTCGGCT GGATCCGCGC TGAGGTGATG 
GGCGCGCTGG TGAACGCCAT CTTCCTCACG GGGCTGTGCT TCGCCATCCT GCTGGAAGCC 
GTCGAGCGCT TCATCGAGCC GCATGAGATG CAGCAGCCGC TCGTGGTGCT TAGCGTCGGC 
GTGGCGGGGC TGCTAGTCAA CGTGCTGGGG CTCTGCCTGT TCCACCACCA CAGCGGCGAG 
GGCCAGGGCG CAGGCCACGG CCACTCGCAC GGCCACGGCC ACGGCCACCT CGCCAAGGGC 
GCGCGCAAGG CGGGCCGCGC GGGGGGCGAA GCGGGCGCGC CGCCGGGCCG GGCGCCGGAC 
CAGGAGCCGG ACCAGGAGGA GACCAACACG CTAGTGGCTA ACACCAGCAA TTCCAACGGG 
CTGAAGGCGG ACCAGGCAGA GCCAGAGAAG TTGAGAAGTG ATGATCCAGT GGATGTACAG 
GTAAATGGGA ATCTCATCCA GGAGTCAGAC AGTCTGGAAT CAGAAGACAA CAGGGCTGGA 
CAGCTGAACA TGCGAGGAGT GTTTCTGCAC GTCCTTGGAG ATGCCCTGGG CTCTGTGATC 
GTTGTTGTGA ATGCCTTGGT CTTCTACTTT TCCTGGAAGG GTTGTACTGA AGACGACTTT 
TGTGTGAACC CGTGTTTTCC TGATCCCTGC AAATCGTCTG TAGAGCTGAT GAACAGCACC 
CAGGCCCCCA TGCACGAGGC TGGTCCGTGC TGGGTCCTCT ACCTAGATCC AACCCTGTGC 
ATTATAATGG TTTGTATACT TCTTTACACG ACGTACCCAC TGCTCAAGGA GTCCGCTCTC 
ATTCTTCTAC AGACTGTTCC TAAGCAAATT GATATCAAAC ATTTGGTAAA AGAGCTACGA 
GATGTTGAAG GAGTGGAGGA AGTCCATGAG TTACACGTCT GGCAGCTCGC CGGAAGCAGG 
ATCATCGCCA CTGCTCATAT AAAATGTGAA GACCCAGCTT CATACATGCA GGTGGCCAAA 
ACCATTAAAG ATGTTTTTCA CAATCATGGA ATTCACGCCA CCACCATCCA GCCTGAATTC 
GCTAGCGTAG GCTCTAAATC AAGTGTCGTC CCGTGTGAGC TCGCCTGCAG AACTCAGTGT 
GCTTTGAAGC AGTGCTGTGG GACACGGCCA CAGGTCCATT CTGGAAAGGA GGCAGAGAAG 
GCTCCAACAG TTAGCATTTC TTGTTTAGAA CTCAGTGAAA ACCTAGAGAA GAAGCCCAGG 
AGGACTAAAG CTGAAGGCAG TGTCCCCGCT GTGGTGATAG AGATTAAAAA TGTGCCAAAC 
AAACAGCCCG AATCATCTTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_074044.1
CDS	173..1696
Translation	MGCWGRNRGRLLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAVERFIEPHEMQQPLVVLSVGVAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKGARKAGRAGGEAGAPPGRAPDQEPDQEETNTLVANTSNSNGLKADQAEPEKLRSDDPVDVQVNGNLIQESDSLESEDNRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGCTEDDFCVNPCFPDPCKSSVELMNSTQAPMHEAGPCWVLYLDPTLCIIMVCILLYTTYPLLKESALILLQTVPKQIDIKHLVKELRDVEGVEEVHELHVWQLAGSRIIATAHIKCEDPASYMQVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVVPCELACRTQCALKQCCGTRPQVHSGKEAEKAPTVSISCLELSENLEKKPRRTKAEGSVPAVVIEIKNVPNKQPESSL

Target ORF information:

RefSeq Version	NM_022853.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 30 member 1 (Slc30a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022853.2

ORF Insert Sequence:

ATGGGCTGCT GGGGCCGCAA CCGCGGCCGG CTGCTGTGCA TGCTGCTGCT GACCTTCATG 
TTCATGGTGC TGGAGGTGGT GGTGAGCCGG GTGACCGCGT CGCTCGCCAT GCTGTCCGAC 
TCCTTCCACA TGCTGTCGGA CGTGCTGGCG CTCGTGGTGG CGCTGGTGGC CGAGCGCTTC 
GCCCGGAGGA CTCACGCCAC GCAGAAGAAC ACATTCGGCT GGATCCGCGC TGAGGTGATG 
GGCGCGCTGG TGAACGCCAT CTTCCTCACG GGGCTGTGCT TCGCCATCCT GCTGGAAGCC 
GTCGAGCGCT TCATCGAGCC GCATGAGATG CAGCAGCCGC TCGTGGTGCT TAGCGTCGGC 
GTGGCGGGGC TGCTAGTCAA CGTGCTGGGG CTCTGCCTGT TCCACCACCA CAGCGGCGAG 
GGCCAGGGCG CAGGCCACGG CCACTCGCAC GGCCACGGCC ACGGCCACCT CGCCAAGGGC 
GCGCGCAAGG CGGGCCGCGC GGGGGGCGAA GCGGGCGCGC CGCCGGGCCG GGCGCCGGAC 
CAGGAGCCGG ACCAGGAGGA GACCAACACG CTAGTGGCTA ACACCAGCAA TTCCAACGGG 
CTGAAGGCGG ACCAGGCAGA GCCAGAGAAG TTGAGAAGTG ATGATCCAGT GGATGTACAG 
GTAAATGGGA ATCTCATCCA GGAGTCAGAC AGTCTGGAAT CAGAAGACAA CAGGGCTGGA 
CAGCTGAACA TGCGAGGAGT GTTTCTGCAC GTCCTTGGAG ATGCCCTGGG CTCTGTGATC 
GTTGTTGTGA ATGCCTTGGT CTTCTACTTT TCCTGGAAGG GTTGTACTGA AGACGACTTT 
TGTGTGAACC CGTGTTTTCC TGATCCCTGC AAATCGTCTG TAGAGCTGAT GAACAGCACC 
CAGGCCCCCA TGCACGAGGC TGGTCCGTGC TGGGTCCTCT ACCTAGATCC AACCCTGTGC 
ATTATAATGG TTTGTATACT TCTTTACACG ACGTACCCAC TGCTCAAGGA GTCCGCTCTC 
ATTCTTCTAC AGACTGTTCC TAAGCAAATT GATATCAAAC ATTTGGTAAA AGAGCTACGA 
GATGTTGAAG GAGTGGAGGA AGTCCATGAG TTACACGTCT GGCAGCTCGC CGGAAGCAGG 
ATCATCGCCA CTGCTCATAT AAAATGTGAA GACCCAGCTT CATACATGCA GGTGGCCAAA 
ACCATTAAAG ATGTTTTTCA CAATCATGGA ATTCACGCCA CCACCATCCA GCCTGAATTC 
GCTAGCGTAG GCTCTAAATC AAGTGTCGTC CCGTGTGAGC TCGCCTGCAG AACTCAGTGT 
GCTTTGAAGC AGTGCTGTGG GACACGGCCA CAGGTCCATT CTGGAAAGGA GGCAGAGAAG 
GCTCCAACAG TTAGCATTTC TTGTTTAGAA CTCAGTGAAA ACCTAGAGAA GAAGCCCAGG 
AGGACTAAAG CTGAAGGCAG TGTCCCCGCT GTGGTGATAG AGATTAAAAA TGTGCCAAAC 
AAACAGCCCG AATCATCTTT GTGA