Aadac cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aadac
Entrez Gene ID	57300
Full Name	arylacetamide deacetylase
Synonyms	Aada
General protein information	Preferred Names arylacetamide deacetylase Names arylacetamide deacetylase arylacetamide deacetylase (esterase)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_020538.1	NP_065413.1	arylacetamide deacetylase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	AADAC	XP_534309.2
Bos taurus (cattle)	AADAC	NP_001069259.1
	AADAC	XP_001106694.1
Schizosaccharomyces pombe (fission yeast)	SPAC1039.03	NP_594994.1
Magnaporthe oryzae (rice blast fungus)	MGG_04867	XP_003712347.1
Xenopus tropicalis (tropical clawed frog)	aadac	NP_001004960.1
Homo sapiens (human)	AADAC	NP_001077.2
Pan troglodytes (chimpanzee)	AADAC	XP_001145851.1
Rattus norvegicus (Norway rat)	Aadac	NP_065413.1
Gallus gallus (chicken)	AADACL2	XP_422836.2
Danio rerio (zebrafish)	LOC100148912	XP_001923714.2
Mus musculus (house mouse)	Aadac	NP_075872.1
Magnaporthe oryzae (rice blast fungus)	MGG_10441	XP_003713341.1

Gene Ontology
Bibliography

Related articles in PubMed

Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells.
Lo V, Erickson B, Thomason-Hughes M, Ko KW, Dolinsky VW, Nelson R, Lehner R
Journal of lipid research51(2)368-77(2010 Feb)

Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis.
Watanabe A, Fukami T, Nakajima M, Takamiya M, Aoki Y, Yokoi T
Drug metabolism and disposition: the biological fate of chemicals37(7)1513-20(2009 Jul)

Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.
Frick C, Atanasov AG, Arnold P, Ozols J, Odermatt A
The Journal of biological chemistry279(30)31131-8(2004 Jul)

Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.
Trickett JI, Patel DD, Knight BL, Saggerson ED, Gibbons GF, Pease RJ
The Journal of biological chemistry276(43)39522-32(2001 Oct)

Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase.
Mziaut H, Korza G, Hand AR, Gerard C, Ozols J
The Journal of biological chemistry274(20)14122-9(1999 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Aadac gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aadac cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04802	NM_020538.1 Latest version!	Rattus norvegicus arylacetamide deacetylase (Aadac), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aadac ( NM_020538.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_065413.1 Rattus norvegicus arylacetamide deacetylase (Aadac), mRNA.

Price & Availability↑

CloneID	ORa04802
Clone ID Related Accession (Same CDS sequence)	NM_020538.1
Accession Version	NM_020538.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	arylacetamide deacetylase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF182426.1. ##Evidence-Data-START## Transcript exon combination :: AF182426.1, BC088143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGGGAAGAA CTATTTTTCT TCTCATCTCT GTGGTGCTTG TAGCTTATTA TATTTATATA 
CCTCTCCCAG ATGATATTGA AGAGCCTTGG AAAATAATAT TGGGAAATAC ACTTCTAAAA 
CTTGGAGGAG ATTTGGCTTC TTTTGGTGAA CTTTTGGGAC TCAATCATTT CATGGACACG 
GTACAGTTAT TTATGAGATT TCAAGTTGTC CCACCCACTT CTGATGAGAA TGTCACTGTG 
ATGGAGACAG ATTTCAACAG TGTTCCTGTT CGCATATATA TACCCAAAAG GAAGTCAACG 
ACGCTCAGGA GGGGCTTGTT TTTTATTCAT GGTGGTGGCT GGTGTCTGGG GAGTGCTGCT 
TACTTCATGT ATGACACTCT GTCAAGACGG ACTGCCCATA GACTTGATGC CGTTGTTGTG 
TCAACTGACT ATGGCTTAGC CCCAAAATAC CATTTTCCAA AACAGTTTGA AGATGTATAT 
CATAGTTTAC GATGGTTCTT ACAAGAGGAC ATTCTTGAAA AATATGGTGT AGATCCTAGA 
AGAGTTGGTG TGTCTGGGGA CAGTGCTGGT GGAAACTTAA CTGCAGCTGT GACACAACAG 
ATTCTACAGG ATCCAGATGT CAAGATCAAA CTCAAGGTCC AAGCTTTAAT ATATCCTGCC 
CTTCAGGCTC TTGATATGAA TGTACCATCA CAACAAGAAA ATTCACAATA CCCACTTTTA 
ACCAGGTCAT TATTGATCCG TTTCTGGAGT GAATACTTTA CTACAGACCG AGACCTTGAG 
AAAGCCATGC TTCTCAACCA ACATGTACCT GTGGAATTCA GCCATTTGTT ACAATTTGTG 
AATTGGAGTT CCTTGCTCCC TCAGAGATAT AAGAAAGGTT ACTTTTATAA AACTCCCACT 
CCTGGTAGTT TGGAGCTGGC TCAAAAGTAC CCAGGGTTCA CAGATGTAAA GGCATGCCCT 
CTGTTGGCCA ATGACAGTAT ATTACATCAT TTACCTATGA CCTATATTAT CACTTGTCAG 
TATGATGTTC TAAGAGATGA CGGACTCATG TATGTCAAGC GGCTTCAGAA TACTGGAGTT 
CATGTGACTC ATCACCATAT TGAAGATGGA TTCCATGGAG CACTTACCTT ACCTGGTTTG 
AAAATTACAT ACAGGATGCA AAATCAGTAC TTGAATTGGC TTCACAAAAA TCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065413.1
CDS	26..1222
Translation	MGRTIFLLISVVLVAYYIYIPLPDDIEEPWKIILGNTLLKLGGDLASFGELLGLNHFMDTVQLFMRFQVVPPTSDENVTVMETDFNSVPVRIYIPKRKSTTLRRGLFFIHGGGWCLGSAAYFMYDTLSRRTAHRLDAVVVSTDYGLAPKYHFPKQFEDVYHSLRWFLQEDILEKYGVDPRRVGVSGDSAGGNLTAAVTQQILQDPDVKIKLKVQALIYPALQALDMNVPSQQENSQYPLLTRSLLIRFWSEYFTTDRDLEKAMLLNQHVPVEFSHLLQFVNWSSLLPQRYKKGYFYKTPTPGSLELAQKYPGFTDVKACPLLANDSILHHLPMTYIITCQYDVLRDDGLMYVKRLQNTGVHVTHHHIEDGFHGALTLPGLKITYRMQNQYLNWLHKNL

Target ORF information:

RefSeq Version	NM_020538.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus arylacetamide deacetylase (Aadac), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020538.1

ORF Insert Sequence:

ATGGGAAGAA CTATTTTTCT TCTCATCTCT GTGGTGCTTG TAGCTTATTA TATTTATATA 
CCTCTCCCAG ATGATATTGA AGAGCCTTGG AAAATAATAT TGGGAAATAC ACTTCTAAAA 
CTTGGAGGAG ATTTGGCTTC TTTTGGTGAA CTTTTGGGAC TCAATCATTT CATGGACACG 
GTACAGTTAT TTATGAGATT TCAAGTTGTC CCACCCACTT CTGATGAGAA TGTCACTGTG 
ATGGAGACAG ATTTCAACAG TGTTCCTGTT CGCATATATA TACCCAAAAG GAAGTCAACG 
ACGCTCAGGA GGGGCTTGTT TTTTATTCAT GGTGGTGGCT GGTGTCTGGG GAGTGCTGCT 
TACTTCATGT ATGACACTCT GTCAAGACGG ACTGCCCATA GACTTGATGC CGTTGTTGTG 
TCAACTGACT ATGGCTTAGC CCCAAAATAC CATTTTCCAA AACAGTTTGA AGATGTATAT 
CATAGTTTAC GATGGTTCTT ACAAGAGGAC ATTCTTGAAA AATATGGTGT AGATCCTAGA 
AGAGTTGGTG TGTCTGGGGA CAGTGCTGGT GGAAACTTAA CTGCAGCTGT GACACAACAG 
ATTCTACAGG ATCCAGATGT CAAGATCAAA CTCAAGGTCC AAGCTTTAAT ATATCCTGCC 
CTTCAGGCTC TTGATATGAA TGTACCATCA CAACAAGAAA ATTCACAATA CCCACTTTTA 
ACCAGGTCAT TATTGATCCG TTTCTGGAGT GAATACTTTA CTACAGACCG AGACCTTGAG 
AAAGCCATGC TTCTCAACCA ACATGTACCT GTGGAATTCA GCCATTTGTT ACAATTTGTG 
AATTGGAGTT CCTTGCTCCC TCAGAGATAT AAGAAAGGTT ACTTTTATAA AACTCCCACT 
CCTGGTAGTT TGGAGCTGGC TCAAAAGTAC CCAGGGTTCA CAGATGTAAA GGCATGCCCT 
CTGTTGGCCA ATGACAGTAT ATTACATCAT TTACCTATGA CCTATATTAT CACTTGTCAG 
TATGATGTTC TAAGAGATGA CGGACTCATG TATGTCAAGC GGCTTCAGAA TACTGGAGTT 
CATGTGACTC ATCACCATAT TGAAGATGGA TTCCATGGAG CACTTACCTT ACCTGGTTTG 
AAAATTACAT ACAGGATGCA AAATCAGTAC TTGAATTGGC TTCACAAAAA TCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells.
Journal of lipid research51(2)368-77(2010 Feb)
Lo V,Erickson B,Thomason-Hughes M,Ko KW,Dolinsky VW,Nelson R,Lehner R

Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis.
Drug metabolism and disposition: the biological fate of chemicals37(7)1513-20(2009 Jul)
Watanabe A,Fukami T,Nakajima M,Takamiya M,Aoki Y,Yokoi T

Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.
The Journal of biological chemistry279(30)31131-8(2004 Jul)
Frick C,Atanasov AG,Arnold P,Ozols J,Odermatt A

Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.
The Journal of biological chemistry276(43)39522-32(2001 Oct)
Trickett JI,Patel DD,Knight BL,Saggerson ED,Gibbons GF,Pease RJ

Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase.
The Journal of biological chemistry274(20)14122-9(1999 May)
Mziaut H,Korza G,Hand AR,Gerard C,Ozols J