Ywhab cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ywhab
Entrez Gene ID	56011
Full Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
General protein information	Preferred Names tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta Names 14-3-3 protein beta/alpha 14-3-3 protein beta-subtype 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide KCIP-1 prepronerve growth factor RNH-1 protein kinase C inhibitor protein 1 tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42
Summary	member of the 14-3-3 protein family; may mediate signal transduction by binding to phosphoserine-containing proteins; may play a role in cell cycle regulation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019377.1	NP_062250.1	14-3-3 protein beta/alpha

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	YWHAB	XP_003317000.1
Canis lupus familiaris (dog)	YWHAB	XP_852754.1
Gallus gallus (chicken)	YWHAB	NP_001006289.1
Mus musculus (house mouse)	Ywhab	NP_061223.2
Homo sapiens (human)	YWHAB	NP_003395.1
Danio rerio (zebrafish)	ywhaba	NP_001076267.1
	YWHAB	XP_001109676.2
Bos taurus (cattle)	YWHAB	NP_777219.2
Rattus norvegicus (Norway rat)	Ywhab	NP_062250.1
Danio rerio (zebrafish)	ywhabb	NP_998310.1
Xenopus tropicalis (tropical clawed frog)	ywhab	NP_001011116.1

Gene Ontology
Bibliography

Related articles in PubMed

Up-regulation of 14-3-3? plays a role in intimal hyperplasia following carotid artery injury in diabetic Sprague Dawley rats by promoting endothelial cell migration and proliferation.
Feng L, Ma X, Wang J, Tian Q
Biochemical and biophysical research communications490(4)1237-1243(2017 09)

Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Lee DH, Steinacker P, Seubert S, Turnescu T, Melms A, Manzel A, Otto M, Linker RA
Journal of neuroinflammation12187(2015 Oct)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
Riou P, Kj?r S, Garg R, Purkiss A, George R, Cain RJ, Bineva G, Reymond N, McColl B, Thompson AJ, O'Reilly N, McDonald NQ, Parker PJ, Ridley AJ
Cell153(3)640-53(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results indicate that hyperglycemia-induced up-regulation of YWHAB in endothelial cell plays a significant role in intimal hyperplasia following carotid artery injury by enhancing endothelial cell proliferation and migration.
Title: Up-regulation of 14-3-3? plays a role in intimal hyperplasia following carotid artery injury in diabetic Sprague Dawley rats by promoting endothelial cell migration and proliferation.

This study reveals that 14-3-3 gamma protein is present in oligodendroglial cells and that 14-3-3 gamma deficiency leads to more severe chronic EAE with enhanced demyelination.
Title: Role of glial 14-3-3 gamma protein in autoimmune demyelination.

PKC-mediated KCNK3 internalization required the presence of both 14-3-3beta and a novel potassium channel endocytic motif
Title: The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3?-dependent, protein kinase C (PKC)-mediated endocytic trafficking.

Results showed that sepsis alters the expression of 14-3-3 beta isoform in a time-, cell-, and topography-dependent manner, with the choroid plexus showed constantly increased beta isoform expression.
Title: Alternations of 14-3-3 ? and ? protein levels in brain during experimental sepsis.

Results indicate that the phosphorylation-dependent interaction between 14-3-3beta and alphaII spectrin acts as a switch between positive and negative regulation of neurite outgrowth stimulated by NCAM.
Title: Binding of alphaII spectrin to 14-3-3beta is involved in NCAM-dependent neurite outgrowth.

The following Ywhab gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ywhab cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04604	NM_019377.1 Latest version!	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta (Ywhab), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ywhab ( NM_019377.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062250.1 Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta (Ywhab), mRNA.

Price & Availability↑

CloneID	ORa04604
Clone ID Related Accession (Same CDS sequence)	NM_019377.1
Accession Version	NM_019377.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	14-3-3 protein beta/alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S83440.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC076502.1, D17446.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACCATGG ACAAAAGTGA GCTGGTACAG AAAGCCAAAC TTGCTGAGCA AGCTGAGCGT 
TATGATGATA TGGCCGCAGC TATGAAGGCT GTAACAGAGC AGGGACATGA ACTCTCCAAT 
GAAGAGAGGA ATCTACTCTC TGTTGCCTAC AAGAATGTGG TAGGTGCCCG CCGTTCTTCC 
TGGCGAGTCA TCTCCAGCAT CGAACAGAAA ACAGAGAGGA ATGAGAAGAA GCAGCAGATG 
GGCAAGGAGT ACCGTGAGAA GATAGAGGCC GAGCTGCAGG ACATCTGCAG TGACGTTCTG 
GAGCTGTTGG ACAAATATCT CATTCTCAAT GCTACCCATG CAGAAAGCAA AGTGTTCTAC 
TTAAAAATGA AAGGAGACTA TTTTAGGTAT CTTTCTGAAG TTGCATCTGG AGATAATAAA 
CAAACCACTG TGTCAAACTC CCAGCAGGCG TACCAAGAAG CATTTGAAAT CAGCAAGAAA 
GAAATGCAGC CTACACACCC GATTCGCCTT GGCCTGGCTC TGAATTTCTC AGTCTTTTAC 
TATGAGATTC TAAACTCTCC TGAAAAGGCC TGTAGCCTGG CCAAAACGGC GTTTGATGAA 
GCCATTGCTG AGTTGGACAC CCTGAATGAA GAGTCTTACA AAGACAGCAC CCTGATCATG 
CAGCTGCTAA GGGACAATCT CACCCTGTGG ACGTCAGAAA ACCAGGGGGA TGAAGGAGAT 
GCTGGAGAGG GAGAGAACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062250.1
CDS	162..902
Translation	MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICSDVLELLDKYLILNATHAESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN

Target ORF information:

RefSeq Version	NM_019377.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta (Ywhab), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019377.1

ORF Insert Sequence:

ATGACCATGG ACAAAAGTGA GCTGGTACAG AAAGCCAAAC TTGCTGAGCA AGCTGAGCGT 
TATGATGATA TGGCCGCAGC TATGAAGGCT GTAACAGAGC AGGGACATGA ACTCTCCAAT 
GAAGAGAGGA ATCTACTCTC TGTTGCCTAC AAGAATGTGG TAGGTGCCCG CCGTTCTTCC 
TGGCGAGTCA TCTCCAGCAT CGAACAGAAA ACAGAGAGGA ATGAGAAGAA GCAGCAGATG 
GGCAAGGAGT ACCGTGAGAA GATAGAGGCC GAGCTGCAGG ACATCTGCAG TGACGTTCTG 
GAGCTGTTGG ACAAATATCT CATTCTCAAT GCTACCCATG CAGAAAGCAA AGTGTTCTAC 
TTAAAAATGA AAGGAGACTA TTTTAGGTAT CTTTCTGAAG TTGCATCTGG AGATAATAAA 
CAAACCACTG TGTCAAACTC CCAGCAGGCG TACCAAGAAG CATTTGAAAT CAGCAAGAAA 
GAAATGCAGC CTACACACCC GATTCGCCTT GGCCTGGCTC TGAATTTCTC AGTCTTTTAC 
TATGAGATTC TAAACTCTCC TGAAAAGGCC TGTAGCCTGG CCAAAACGGC GTTTGATGAA 
GCCATTGCTG AGTTGGACAC CCTGAATGAA GAGTCTTACA AAGACAGCAC CCTGATCATG 
CAGCTGCTAA GGGACAATCT CACCCTGTGG ACGTCAGAAA ACCAGGGGGA TGAAGGAGAT 
GCTGGAGAGG GAGAGAACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Up-regulation of 14-3-3? plays a role in intimal hyperplasia following carotid artery injury in diabetic Sprague Dawley rats by promoting endothelial cell migration and proliferation.
Biochemical and biophysical research communications490(4)1237-1243(2017 09)
Feng L,Ma X,Wang J,Tian Q

Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Journal of neuroinflammation12187(2015 Oct)
Lee DH,Steinacker P,Seubert S,Turnescu T,Melms A,Manzel A,Otto M,Linker RA

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
Cell153(3)640-53(2013 Apr)
Riou P,Kj?r S,Garg R,Purkiss A,George R,Cain RJ,Bineva G,Reymond N,McColl B,Thompson AJ,O'Reilly N,McDonald NQ,Parker PJ,Ridley AJ

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Ywhab cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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