Slk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slk
Entrez Gene ID	54308
Full Name	STE20-like kinase
Synonyms	Stk2
General protein information	Preferred Names STE20-like kinase Names STE20-like serine/threonine-protein kinase STE20-related kinase STE20-related serine/threonine-protein kinase serine/threonine kinase 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54
Summary	putative serine/threonine protein kinase [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006231558.3	XP_006231620.1	STE20-like serine/threonine-protein kinase isoform X1
NM_019349.2	NP_062222.2	STE20-like serine/threonine-protein kinase
XM_008760447.2	XP_008758669.1	STE20-like serine/threonine-protein kinase isoform X2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Slk	NP_033315.2
Canis lupus familiaris (dog)	SLK	XP_544006.2
Pan troglodytes (chimpanzee)	SLK	XP_508017.2
Rattus norvegicus (Norway rat)	Slk	NP_062222.2
Gallus gallus (chicken)	SLK	XP_004942322.1
	SLK	XP_001114162.1
Danio rerio (zebrafish)	slka	NP_001139073.1
Homo sapiens (human)	SLK	NP_055535.2
Bos taurus (cattle)	SLK	NP_001193006.1

Gene Ontology
Bibliography

Related articles in PubMed

Deletion ofMst1 attenuates neuronal loss andimproves neurological impairment inarat model oftraumatic brain injury.
Li D, Ni H, Rui Q, Gao R, Chen G
Brain research(2017 Oct)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.
Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S
The EMBO journal27(4)704-14(2008 Feb)

Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.
Hao W, Takano T, Guillemette J, Papillon J, Ren G, Cybulsky AV
The Journal of biological chemistry281(6)3075-84(2006 Feb)

Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54.
Vitt U, Gietzen D, Stevens K, Wingrove J, Becha S, Bulloch S, Burrill J, Chawla N, Chien J, Crawford M, Ison C, Kearney L, Kwong M, Park J, Policky J, Weiler M, White R, Xu Y, Daniels S, Jacob H, Jensen-Seaman MI, Lazar J, Stuve L, Schmidt J
Genome research14(4)640-50(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Activation of the cascade involving Src homology 2 domain-containing protein-tyrosine phosphatase 1, casein kinase II and SLK is responsible for RhoA phosphorylation and inhibition of RhoA-mediated arterial contraction induced by AT(2)R activation
Title: Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.

SLK is an anoxia/recovery-dependent kinase that is activated via homodimerization and that signals via ASK1 and p38 to promote apoptosis
Title: Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.

Stk2 is a renal epithelial protein kinase whose expression and activity are increased during development and recovery from acute renal failure (germinal center kinase SK2)
Title: Renal expression and activity of the germinal center kinase SK2.

The following Slk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04513	NM_019349.2 Latest version!	Rattus norvegicus STE20-like kinase (Slk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
ORa24209	XM_006231558.3 Latest version!	Rattus norvegicus STE20-like kinase (Slk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00
ORa43433	XM_008760447.2 Latest version!	Rattus norvegicus STE20-like kinase (Slk), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slk ( NM_019349.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062222.2 Rattus norvegicus STE20-like kinase (Slk), mRNA.

Price & Availability↑

CloneID	ORa04513
Clone ID Related Accession (Same CDS sequence)	NM_019349.2
Accession Version	NM_019349.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Rattus norvegicus(Norway rat)
Product	STE20-like serine/threonine-protein kinase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI136919.1, AB003357.1 and CK227996.1. On Mar 15, 2007 this sequence version replaced NM_019349.1. Sequence Note: The sequence AB003357.1 is chimeric. Only the Slk sequence region was propagated into this RefSeq record. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAACAG 
TACGAACACG TGAAGAGAGA CCTGAACCCC GAGGAGTTTT GGGAGATTAT CGGAGAGCTG 
GGCGACGGAG CCTTTGGGAA AGTGTATAAG GCCCAGAATA AGGAGACCAA TGTTTTAGCT 
GCTGCAAAGG TGATTGACAC CAAATCTGAA GAAGAACTTG AAGATTATAT GGTTGAGATT 
GACATATTAG CATCTTGTGA TCACCCAAAC ATAGTCAAGC TTCTAGATGC CTTCTATTAT 
GAGAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGGG GAGCAGTAGA TGCCGTGATG 
CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATTCAAG TAGTTTGCAA GCAGACATTA 
GAGGCGTTGA ATTACCTACA TGACAATAAA ATCATCCACA GAGATCTAAA AGCTGGCAAT 
ATTCTCTTTA CCTTAGATGG AGACATTAAA TTAGCGGATT TTGGAGTGTC AGCTAAGAAT 
ACCAGGACAA TTCAAAGGAG GGATTCATTT ATTGGCACAC CGTATTGGAT GGCTCCTGAA 
GTCGTCATGT GTGAGACATC GAAGGACAGA CCCTATGACT ACAAAGCGGA CGTTTGGTCC 
CTGGGAATCA CTTTAATAGA AATGGCTGAG ATAGAGCCGC CTCATCATGA GCTAAACCCA 
ATGCGAGTGC TGCTGAAAAT AGCAAAGTCG GAGCCCCCCA CACTAGCACA GCCATCCAGA 
TGGTCTTCAA ATTTTAAGGA CTTTCTAAAG AAATGCTTGG AAAAGAATGT GGATGCGCGG 
TGGACCACAT CCCAGCTGTT ACAGCATCCC TTTGTTACCG TTGATTCCAA CAAACCAGTC 
CGAGAATTGA TTGCTGAGGC GAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 
GAAGATGACG ATGATGAGAC AGAGAGTGCT CTGCCAATAC CTGCGAATAA ACGCGCCTCC 
TCTGACCTCA GCATTGCCAG CTCTGAGGAA GATAAGCTTT CACAAAATGC TTGTATTTTG 
GAATCTGTGT CAGAAAGAAC AGAACACAAT ACTTCTGGGG ATAAATTTAG CAACAAAGTT 
CTTAGTGAGA AGCCTACTCC TGAGGGACCT GAGAAGACTG TGGATGTGGA TGGGCCTGCA 
AATGATGTTA ACTTAGAAAC TGTGGCTGAA CCAAATGACC AAGCGGTAGG ATTCCATGAG 
AATGGGAGAG AGAAGAAAAG ACCCCAACTG GAAAGTCAAC CAGATACAGA AGACCAACAA 
ACTGTGGATG TTAATTTAGT CGGTGAAGGA AATGACAGCA ATATAGTAAT TTTAGAAACA 
AACACTGATT GTCTGAAACC AGAGGAAGAC AGAAATGAAG AAAACCAAGA GATAATTGAG 
AATAAACTTA CACAATCTGA AGAAATTAAA GATATACATA TTCAAACAAT GGACTTAGTT 
TCTCAAGAAA CTGGAGAAAA AGAGGCAGAT TTTCAGGCAA TTGACAATGA AGTTGGGTTT 
ACAAAGGAAG AAACCCAAGA GAAATTGGGA AAAGATGATA AAACTCACAA AGTTGTGATC 
AGTGATATAA CCAGTGAGGT GGGAACAGAC GAGCCTCCAG GTGATACCCA GAAGTCTGCT 
GAGCAGAGCC AGGATGCAGA GGGTGGGGCT GGGGAAGAAG CCCCGGAGCC TGCCCAGACA 
CTAACAGAGA AGGCCACTGA GGGCCCTGAG GCTCATGGTG CTGAGGAAGA GCCTCGTAGT 
GGAGAGAGAG TAGAGGATAA GCAGCTAGAG CAGCAGTCTG CAGTGTGTGA AGGTGAGGGA 
CAGGTAACCA GCACTTCAGA GAGCACACGG GCAACCACGG AGGAACCAGA GACTGACGAA 
GTTGACCAAG TCAGCGAGTC AAATAGCATT GAGGAACTAG AGAGACTTGG AGTTACTGGT 
GCTGAGGAAC AGGCTCTAGG GAGCAAAGGG GAGGCTGCTA CGGAGCTAGA TTTGGAGAGA 
GAAGAAAATG CACAGGAACT GCCAGTTAAA GCAGAGCCCC AAGCTCCTGC AGCATCGCAG 
GCCAGCGAAC CTCCCCCTGT CTTAATACCC AGTATTAATA TTCATTCGGA AAACACAGAA 
AATAAAGGAG AAATGGGTGC TTTGCCAAAA CCTGAAACCA TACTGCCACC AGAGCCTGAA 
AATGGAAAGG GAAATGACAC GGACTCAGGG ACTGGGTCCA CTGTGGAGAA CAGCAGCAGT 
GACCTGAACT TGTCCATCTC TAGCTTCCTG AGCAAAACCA AGGACAGTGG CTCGGTGTCT 
CTGCAGGAGA CAAGAAGACA GAAGAAAACA TTGAAGAAAA CACGTAAATT TATTGTTGAT 
GGAGTAGAAG TGAGTGTGAC AACATCAAAG ATAGTTACAG ACAGCGACTC TAAAACCGAG 
GAATTGAGGT TTCTCAGGCG TCAGGAACTT CGAGAGCTAA GGCTTCTCCA GAAGGAAGAG 
CAGAAAGCCC AGCAGCAGCT CAACGGGAAA TTGCAGCAGC AGCGCGAGCA GATCTTCAGG 
CGCTTTGAGC AGGAGATGCT GAGTAAGAAG CGACAATATG ACCAAGAAAT TGAGAATCTA 
GAGAAGCAGC AGAAACAGAC AATTGAACGA CTAGAACAAG AACACACAAA CCGCCTGAGA 
GACGAAGCTA AGCGCATCAA AGGAGAGCAG GAGAAGGAGC TGTCCAAATT CCAGAATATG 
CTAAGAAACC GAAAGAAGGA GGAACAAGAA TTTGTTCAGA AGCAACAGCA AGAGTTAGAC 
GGCGCTCTGA AAAAGATCAT CCAGCAGCAG AAGGCAGAGT TGGCCAATAT TGAGAGAGAG 
TGCTTGAATA ACAAGCAGCA GCTCCTGAGA GCCCGAGAAG CTGCAATTTG GGAGCTTGAA 
GAACGACATT TACAAGAAAA GCACCAGCTG CTTAAACAGC AACTTAAAGA TCAGTATTTC 
ATACAGAGAC ATCAGCTGCT TAAACGCCAT GAGAAGGAAA CAGAACAAAT GCAGCGTTAC 
AATCAACGAC TTATTGAAGA ATTGAAGAAC AGACAGACTC AGGAACGAGC TAGACTGCCC 
AAGATTCAGA GAAGTGAAGC CAAGACACGA ATGGCCATGT TTAAAAAAAG TTTGAGGATT 
AACTCAACAG CTACACCAGA CCAGGACCGT GAAAAAATTA AACAGTTTGC TGCACAGGAA 
GAAAAGAGAC AGAAAAATGA GAGAATGGCT CAGCATCAAA AACATGAGAG TCAGATGCGG 
GACCTTCAGT TGCAGTGTGA AGCCAACGTC CGAGAGCTGC ACCAGCTGCA GAATGAAAAA 
TGCCACCTGT TGGTTGAACA TGAGACTCAG AAACTGAAGG AGTTAGATGA GGAGCACAGC 
CAAGAGCTCA AGGAGTGGAG AGAGAAGCTG AGGCCCAGGA AGAAGACACT GGAGGAAGAG 
TTTGCCAGGA AACTTCAGGA ACAGGAAGTG TTCTTTAAAA TGACCGGGGA GTCCGAATGC 
CTCAACCCCT CAGCGCAGAG CCGGATCTCC AAATTCTACC CTATTCCCAC CTTACATTCC 
ACTGGGTCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062222.2
CDS	169..3780
Translation	MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKEEDDDDETESALPIPANKRASSDLSIASSEEDKLSQNACILESVSERTEHNTSGDKFSNKVLSEKPTPEGPEKTVDVDGPANDVNLETVAEPNDQAVGFHENGREKKRPQLESQPDTEDQQTVDVNLVGEGNDSNIVILETNTDCLKPEEDRNEENQEIIENKLTQSEEIKDIHIQTMDLVSQETGEKEADFQAIDNEVGFTKEETQEKLGKDDKTHKVVISDITSEVGTDEPPGDTQKSAEQSQDAEGGAGEEAPEPAQTLTEKATEGPEAHGAEEEPRSGERVEDKQLEQQSAVCEGEGQVTSTSESTRATTEEPETDEVDQVSESNSIEELERLGVTGAEEQALGSKGEAATELDLEREENAQELPVKAEPQAPAASQASEPPPVLIPSINIHSENTENKGEMGALPKPETILPPEPENGKGNDTDSGTGSTVENSSSDLNLSISSFLSKTKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRLLQKEEQKAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLRNRKKEEQEFVQKQQQELDGALKKIIQQQKAELANIERECLNNKQQLLRAREAAIWELEERHLQEKHQLLKQQLKDQYFIQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNERMAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS

Target ORF information:

RefSeq Version	NM_019349.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus STE20-like kinase (Slk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019349.2

ORF Insert Sequence:

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAACAG 
TACGAACACG TGAAGAGAGA CCTGAACCCC GAGGAGTTTT GGGAGATTAT CGGAGAGCTG 
GGCGACGGAG CCTTTGGGAA AGTGTATAAG GCCCAGAATA AGGAGACCAA TGTTTTAGCT 
GCTGCAAAGG TGATTGACAC CAAATCTGAA GAAGAACTTG AAGATTATAT GGTTGAGATT 
GACATATTAG CATCTTGTGA TCACCCAAAC ATAGTCAAGC TTCTAGATGC CTTCTATTAT 
GAGAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGGG GAGCAGTAGA TGCCGTGATG 
CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATTCAAG TAGTTTGCAA GCAGACATTA 
GAGGCGTTGA ATTACCTACA TGACAATAAA ATCATCCACA GAGATCTAAA AGCTGGCAAT 
ATTCTCTTTA CCTTAGATGG AGACATTAAA TTAGCGGATT TTGGAGTGTC AGCTAAGAAT 
ACCAGGACAA TTCAAAGGAG GGATTCATTT ATTGGCACAC CGTATTGGAT GGCTCCTGAA 
GTCGTCATGT GTGAGACATC GAAGGACAGA CCCTATGACT ACAAAGCGGA CGTTTGGTCC 
CTGGGAATCA CTTTAATAGA AATGGCTGAG ATAGAGCCGC CTCATCATGA GCTAAACCCA 
ATGCGAGTGC TGCTGAAAAT AGCAAAGTCG GAGCCCCCCA CACTAGCACA GCCATCCAGA 
TGGTCTTCAA ATTTTAAGGA CTTTCTAAAG AAATGCTTGG AAAAGAATGT GGATGCGCGG 
TGGACCACAT CCCAGCTGTT ACAGCATCCC TTTGTTACCG TTGATTCCAA CAAACCAGTC 
CGAGAATTGA TTGCTGAGGC GAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 
GAAGATGACG ATGATGAGAC AGAGAGTGCT CTGCCAATAC CTGCGAATAA ACGCGCCTCC 
TCTGACCTCA GCATTGCCAG CTCTGAGGAA GATAAGCTTT CACAAAATGC TTGTATTTTG 
GAATCTGTGT CAGAAAGAAC AGAACACAAT ACTTCTGGGG ATAAATTTAG CAACAAAGTT 
CTTAGTGAGA AGCCTACTCC TGAGGGACCT GAGAAGACTG TGGATGTGGA TGGGCCTGCA 
AATGATGTTA ACTTAGAAAC TGTGGCTGAA CCAAATGACC AAGCGGTAGG ATTCCATGAG 
AATGGGAGAG AGAAGAAAAG ACCCCAACTG GAAAGTCAAC CAGATACAGA AGACCAACAA 
ACTGTGGATG TTAATTTAGT CGGTGAAGGA AATGACAGCA ATATAGTAAT TTTAGAAACA 
AACACTGATT GTCTGAAACC AGAGGAAGAC AGAAATGAAG AAAACCAAGA GATAATTGAG 
AATAAACTTA CACAATCTGA AGAAATTAAA GATATACATA TTCAAACAAT GGACTTAGTT 
TCTCAAGAAA CTGGAGAAAA AGAGGCAGAT TTTCAGGCAA TTGACAATGA AGTTGGGTTT 
ACAAAGGAAG AAACCCAAGA GAAATTGGGA AAAGATGATA AAACTCACAA AGTTGTGATC 
AGTGATATAA CCAGTGAGGT GGGAACAGAC GAGCCTCCAG GTGATACCCA GAAGTCTGCT 
GAGCAGAGCC AGGATGCAGA GGGTGGGGCT GGGGAAGAAG CCCCGGAGCC TGCCCAGACA 
CTAACAGAGA AGGCCACTGA GGGCCCTGAG GCTCATGGTG CTGAGGAAGA GCCTCGTAGT 
GGAGAGAGAG TAGAGGATAA GCAGCTAGAG CAGCAGTCTG CAGTGTGTGA AGGTGAGGGA 
CAGGTAACCA GCACTTCAGA GAGCACACGG GCAACCACGG AGGAACCAGA GACTGACGAA 
GTTGACCAAG TCAGCGAGTC AAATAGCATT GAGGAACTAG AGAGACTTGG AGTTACTGGT 
GCTGAGGAAC AGGCTCTAGG GAGCAAAGGG GAGGCTGCTA CGGAGCTAGA TTTGGAGAGA 
GAAGAAAATG CACAGGAACT GCCAGTTAAA GCAGAGCCCC AAGCTCCTGC AGCATCGCAG 
GCCAGCGAAC CTCCCCCTGT CTTAATACCC AGTATTAATA TTCATTCGGA AAACACAGAA 
AATAAAGGAG AAATGGGTGC TTTGCCAAAA CCTGAAACCA TACTGCCACC AGAGCCTGAA 
AATGGAAAGG GAAATGACAC GGACTCAGGG ACTGGGTCCA CTGTGGAGAA CAGCAGCAGT 
GACCTGAACT TGTCCATCTC TAGCTTCCTG AGCAAAACCA AGGACAGTGG CTCGGTGTCT 
CTGCAGGAGA CAAGAAGACA GAAGAAAACA TTGAAGAAAA CACGTAAATT TATTGTTGAT 
GGAGTAGAAG TGAGTGTGAC AACATCAAAG ATAGTTACAG ACAGCGACTC TAAAACCGAG 
GAATTGAGGT TTCTCAGGCG TCAGGAACTT CGAGAGCTAA GGCTTCTCCA GAAGGAAGAG 
CAGAAAGCCC AGCAGCAGCT CAACGGGAAA TTGCAGCAGC AGCGCGAGCA GATCTTCAGG 
CGCTTTGAGC AGGAGATGCT GAGTAAGAAG CGACAATATG ACCAAGAAAT TGAGAATCTA 
GAGAAGCAGC AGAAACAGAC AATTGAACGA CTAGAACAAG AACACACAAA CCGCCTGAGA 
GACGAAGCTA AGCGCATCAA AGGAGAGCAG GAGAAGGAGC TGTCCAAATT CCAGAATATG 
CTAAGAAACC GAAAGAAGGA GGAACAAGAA TTTGTTCAGA AGCAACAGCA AGAGTTAGAC 
GGCGCTCTGA AAAAGATCAT CCAGCAGCAG AAGGCAGAGT TGGCCAATAT TGAGAGAGAG 
TGCTTGAATA ACAAGCAGCA GCTCCTGAGA GCCCGAGAAG CTGCAATTTG GGAGCTTGAA 
GAACGACATT TACAAGAAAA GCACCAGCTG CTTAAACAGC AACTTAAAGA TCAGTATTTC 
ATACAGAGAC ATCAGCTGCT TAAACGCCAT GAGAAGGAAA CAGAACAAAT GCAGCGTTAC 
AATCAACGAC TTATTGAAGA ATTGAAGAAC AGACAGACTC AGGAACGAGC TAGACTGCCC 
AAGATTCAGA GAAGTGAAGC CAAGACACGA ATGGCCATGT TTAAAAAAAG TTTGAGGATT 
AACTCAACAG CTACACCAGA CCAGGACCGT GAAAAAATTA AACAGTTTGC TGCACAGGAA 
GAAAAGAGAC AGAAAAATGA GAGAATGGCT CAGCATCAAA AACATGAGAG TCAGATGCGG 
GACCTTCAGT TGCAGTGTGA AGCCAACGTC CGAGAGCTGC ACCAGCTGCA GAATGAAAAA 
TGCCACCTGT TGGTTGAACA TGAGACTCAG AAACTGAAGG AGTTAGATGA GGAGCACAGC 
CAAGAGCTCA AGGAGTGGAG AGAGAAGCTG AGGCCCAGGA AGAAGACACT GGAGGAAGAG 
TTTGCCAGGA AACTTCAGGA ACAGGAAGTG TTCTTTAAAA TGACCGGGGA GTCCGAATGC 
CTCAACCCCT CAGCGCAGAG CCGGATCTCC AAATTCTACC CTATTCCCAC CTTACATTCC 
ACTGGGTCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slk ( XM_006231558.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006231620.1 Rattus norvegicus STE20-like kinase (Slk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa24209
Clone ID Related Accession (Same CDS sequence)	XM_006231558.3
Accession Version	XM_006231558.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	STE20-like serine/threonine-protein kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006231558.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAACAG 
TACGAACACG TGAAGAGAGA CCTGAACCCC GAGGAGTTTT GGGAGATTAT CGGAGAGCTG 
GGCGACGGAG CCTTTGGGAA AGTGTATAAG GCCCAGAATA AGGAGACCAA TGTTTTAGCT 
GCTGCAAAGG TGATTGACAC CAAATCTGAA GAAGAACTTG AAGATTATAT GGTTGAGATT 
GACATATTAG CATCTTGTGA TCACCCAAAC ATAGTCAAGC TTCTAGATGC CTTCTATTAT 
GAGAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGGG GAGCAGTAGA TGCCGTGATG 
CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATTCAAG TAGTTTGCAA GCAGACATTA 
GAGGCGTTGA ATTACCTACA TGACAATAAA ATCATCCACA GAGATCTAAA AGCTGGCAAT 
ATTCTCTTTA CCTTAGATGG AGACATTAAA TTAGCGGATT TTGGAGTGTC AGCTAAGAAT 
ACCAGGACAA TTCAAAGGAG GGATTCATTT ATTGGCACAC CGTATTGGAT GGCTCCTGAA 
GTCGTCATGT GTGAGACATC GAAGGACAGA CCCTATGACT ACAAAGCGGA CGTTTGGTCC 
CTGGGAATCA CTTTAATAGA AATGGCTGAG ATAGAGCCGC CTCATCATGA GCTAAACCCA 
ATGCGAGTGC TGCTGAAAAT AGCAAAGTCG GAGCCCCCCA CACTAGCACA GCCATCCAGA 
TGGTCTTCAA ATTTTAAGGA CTTTCTAAAG AAATGCTTGG AAAAGAATGT GGATGCGCGG 
TGGACCACAT CCCAGCTGTT ACAGCATCCC TTTGTTACCG TTGATTCCAA CAAACCAGTC 
CGAGAATTGA TTGCTGAGGC GAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 
GAAGATGACG ATGATGAGAC AGAGAGTGCT CTGCCAATAC CTGCGAATAA ACGCGCCTCC 
TCTGACCTCA GCATTGCCAG CTCTGAGGAA GATAAGCTTT CACAAAATGC TTGTATTTTG 
GAATCTGTGT CAGAAAGAAC AGAACACAAT ACTTCTGGGG ATAAATTTAG CAACAAAGTT 
CTTAGTGAGA AGCCTACTCC TGAGGGACCT GAGAAGGCTG TGGATGTGGA TGGGCCTGCA 
AATGATGTTA ACTTAGAAAC TGTGGCTGAA CCAAATGACC AAGCGGTAGG ATTCCATGAG 
AATGGGAGAG AGAAGAAAAG ACCCAAACTG GAAAGTCAAC CAGATACAGA AGACCAACAA 
ACTGTGGATG TTAATTTAGT CGGTGAAGGA AATGACAGCA ATATAGTAAT TTTAGAAACA 
AACACTGATT GTCTGAAACC AGAGGAAGAC AGAAATGAAG AAAACCAAGA GATAATTGAG 
AATAAACTTA CACAATCTGA AGAAATTAAA GATATACATA TTCAAACAAT GGACTTAGTT 
TCTCAAGAAA CTGGAGAAAA AGAGGCAGAT TTTCAGGCAA TTGACAATGA AGTTGGGTTT 
ACAAAGGAAG AAACCCAAGA GAAATTGGGA AAAGATGATA AAACTCAAAA AGTTGTGATC 
AGTGATATAA GCAGTGAGGT GGGAACAGAC GAGGCTCCAG GTGATACCCA GAAGGCTGCT 
GAGCAGAGCC AGGATGCAGA GGGTGGGGCT GGGGAAGAAG CCCCGGAGCC TGCCCAGACA 
CTAACAGAGA AGGCCACTGA GGGCCCTGAG GCTCATGGTG CTGAGGAAGA GCCTCGTAGT 
GGAGAGAGAG TAGAGGATAA GCAGCTAGAG CAGCAGTCTG CAGTGTGTGA AGGTGAGGGA 
CAGGTAACCA GCACTTCAGA GAGCACACGG GCAACCACGG AGGAACCAGA GACTGACGAA 
GTTGACCAAG TCAGCGAGTC AAATAGCATT GAGGAACTAG AGAGACTTGG AGTTACTGGT 
GCTGAGGAAC AGGCTCTAGG GAGCAAAGGG GAGGCTGCTA CGGAGGTAGA TTTGGAGAGA 
GAAGAAAATG CACAGGAACT GCCAATTAAA GCAGAGCCCC AAGCTCCTGC AGCATCGCAG 
CCCAGTGAAC CTCCCCCTGT CTTAATACCC AGTATTAATA TTCATTCGGA AAACACAGAA 
AATAAAGGAG AAATGGGTGC TTTGCCAAAA CCTGAAACCA TACTGCCACC AGAGCCTGAA 
AATGGAAAGG GAAATGACAC GGACTCAGGG ACTGGGTCCA CTGTGGAGAA CAGCAGCAGT 
GACCTGAACT TGTCCATCTC TAGCTTCCTG AGCAAAACCA AGGACAGTGG CTCGGTGTCT 
CTGCAGGAGA CAAGAAGACA GAAGAAAACA TTGAAGAAAA CACGTAAATT TATTGTTGAT 
GGAGTAGAAG TGAGTGTGAC AACATCAAAG ATAGTTACAG ACAGCGACTC TAAAACCGAG 
GAATTGCGGT TTCTCAGGCG TCAGGAACTT CGAGAGCTAA GGCTTCTCCA GAAGGAAGAG 
CAGAAAGCCC AGCAGCAGCT CAACGGGAAA TTGCAGCAGC AGCGCGAGCA GATCTTCAGG 
CGCTTTGAGC AGGAGATGCT GAGTAAGAAG CGACAATATG ACCAAGAAAT TGAGAATCTA 
GAGAAGCAGC AGAAACAGAC AATTGAACGA CTAGAACAAG AACACACAAA CCGCCTGAGA 
GACGAAGCTA AGCGCATCAA AGGAGAGCAG GAGAAGGAGC TGTCCAAGTT CCAGAATATG 
CTAAGAAACC GAAAGAAGGA GGTTATAAAT GAAGTGGAGA AAGCACCCAA AGAGCTGAGA 
AAAGAGCTCA TGAAGCGCAG GAAAGAGGAG CTTGCACAGA GCCAGCATGC TCAGGAACAA 
GAATTTGTTC AGAAGCAACA GCAAGAGTTA GACGGCGCTC TGAAAAAGAT CATCCAGCAG 
CAGAAGGCAG AGTTGGCCAA TATTGAGAGA GAGTGCTTGA ATAACAAGCA GCAGCTCCTG 
AGAGCCCGAG AAGCTGCAAT TTGGGAGCTT GAAGAACGAC ATTTACAAGA AAAGCACCAG 
CTGCTTAAAC AGCAACTTAA AGATCAGTAT TTCATACAGA GACATCAGCT GCTTAAACGC 
CACGAGAAGG AAACAGAACA AATGCAGCGT TACAATCAAC GACTTATTGA AGAATTGAAG 
AACAGACAGA CTCAGGAACG AGCTAGACTG CCCAAGATTC AGAGAAGTGA AGCCAAGACA 
CGAATGGCCA TGTTTAAAAA AAGTTTGAGG ATTAACTCAA CAGCTACACC AGACCAGGAC 
CGTGAAAAAA TTAAACAGTT TGCTGCACAG GAAGAAAAGA GACAGAAAAA TGAGAGAATG 
GCTCAGCATC AAAAACACGA GAGTCAGATG CGGGACCTTC AGTTGCAGTG TGAAGCCAAC 
GTCCGAGAGC TGCACCAGCT GCAGAATGAA AAATGCCACC TGTTGGTTGA ACATGAGACT 
CAGAAACTGA AGGAGTTAGA TGAGGAGCAC AGCCAAGAGC TCAAGGAGTG GAGAGAGAAG 
CTGAGGCCCA GGAAGAAGAC ACTGGAGGAA GAGTTTGCCA GGAAACTTCA GGAACAGGAA 
GTGTTCTTTA AAATGACCGG GGAGTCCGAA TGCCTCAACC CCTCAGCGCA GAGCCGGATC 
TCCAAATTCT ACCCTATTCC CACCTTACAT TCCACTGGGT CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006231620.1
CDS	215..3919
Translation	MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEEFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKEEDDDDETESALPIPANKRASSDLSIASSEEDKLSQNACILESVSERTEHNTSGDKFSNKVLSEKPTPEGPEKAVDVDGPANDVNLETVAEPNDQAVGFHENGREKKRPKLESQPDTEDQQTVDVNLVGEGNDSNIVILETNTDCLKPEEDRNEENQEIIENKLTQSEEIKDIHIQTMDLVSQETGEKEADFQAIDNEVGFTKEETQEKLGKDDKTQKVVISDISSEVGTDEAPGDTQKAAEQSQDAEGGAGEEAPEPAQTLTEKATEGPEAHGAEEEPRSGERVEDKQLEQQSAVCEGEGQVTSTSESTRATTEEPETDEVDQVSESNSIEELERLGVTGAEEQALGSKGEAATEVDLEREENAQELPIKAEPQAPAASQPSEPPPVLIPSINIHSENTENKGEMGALPKPETILPPEPENGKGNDTDSGTGSTVENSSSDLNLSISSFLSKTKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRLLQKEEQKAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLRNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGALKKIIQQQKAELANIERECLNNKQQLLRAREAAIWELEERHLQEKHQLLKQQLKDQYFIQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNERMAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS

Target ORF information:

RefSeq Version	XM_006231558.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus STE20-like kinase (Slk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006231558.3

ORF Insert Sequence:

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAACAG 
TACGAACACG TGAAGAGAGA CCTGAACCCC GAGGAGTTTT GGGAGATTAT CGGAGAGCTG 
GGCGACGGAG CCTTTGGGAA AGTGTATAAG GCCCAGAATA AGGAGACCAA TGTTTTAGCT 
GCTGCAAAGG TGATTGACAC CAAATCTGAA GAAGAACTTG AAGATTATAT GGTTGAGATT 
GACATATTAG CATCTTGTGA TCACCCAAAC ATAGTCAAGC TTCTAGATGC CTTCTATTAT 
GAGAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGGG GAGCAGTAGA TGCCGTGATG 
CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATTCAAG TAGTTTGCAA GCAGACATTA 
GAGGCGTTGA ATTACCTACA TGACAATAAA ATCATCCACA GAGATCTAAA AGCTGGCAAT 
ATTCTCTTTA CCTTAGATGG AGACATTAAA TTAGCGGATT TTGGAGTGTC AGCTAAGAAT 
ACCAGGACAA TTCAAAGGAG GGATTCATTT ATTGGCACAC CGTATTGGAT GGCTCCTGAA 
GTCGTCATGT GTGAGACATC GAAGGACAGA CCCTATGACT ACAAAGCGGA CGTTTGGTCC 
CTGGGAATCA CTTTAATAGA AATGGCTGAG ATAGAGCCGC CTCATCATGA GCTAAACCCA 
ATGCGAGTGC TGCTGAAAAT AGCAAAGTCG GAGCCCCCCA CACTAGCACA GCCATCCAGA 
TGGTCTTCAA ATTTTAAGGA CTTTCTAAAG AAATGCTTGG AAAAGAATGT GGATGCGCGG 
TGGACCACAT CCCAGCTGTT ACAGCATCCC TTTGTTACCG TTGATTCCAA CAAACCAGTC 
CGAGAATTGA TTGCTGAGGC GAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 
GAAGATGACG ATGATGAGAC AGAGAGTGCT CTGCCAATAC CTGCGAATAA ACGCGCCTCC 
TCTGACCTCA GCATTGCCAG CTCTGAGGAA GATAAGCTTT CACAAAATGC TTGTATTTTG 
GAATCTGTGT CAGAAAGAAC AGAACACAAT ACTTCTGGGG ATAAATTTAG CAACAAAGTT 
CTTAGTGAGA AGCCTACTCC TGAGGGACCT GAGAAGGCTG TGGATGTGGA TGGGCCTGCA 
AATGATGTTA ACTTAGAAAC TGTGGCTGAA CCAAATGACC AAGCGGTAGG ATTCCATGAG 
AATGGGAGAG AGAAGAAAAG ACCCAAACTG GAAAGTCAAC CAGATACAGA AGACCAACAA 
ACTGTGGATG TTAATTTAGT CGGTGAAGGA AATGACAGCA ATATAGTAAT TTTAGAAACA 
AACACTGATT GTCTGAAACC AGAGGAAGAC AGAAATGAAG AAAACCAAGA GATAATTGAG 
AATAAACTTA CACAATCTGA AGAAATTAAA GATATACATA TTCAAACAAT GGACTTAGTT 
TCTCAAGAAA CTGGAGAAAA AGAGGCAGAT TTTCAGGCAA TTGACAATGA AGTTGGGTTT 
ACAAAGGAAG AAACCCAAGA GAAATTGGGA AAAGATGATA AAACTCAAAA AGTTGTGATC 
AGTGATATAA GCAGTGAGGT GGGAACAGAC GAGGCTCCAG GTGATACCCA GAAGGCTGCT 
GAGCAGAGCC AGGATGCAGA GGGTGGGGCT GGGGAAGAAG CCCCGGAGCC TGCCCAGACA 
CTAACAGAGA AGGCCACTGA GGGCCCTGAG GCTCATGGTG CTGAGGAAGA GCCTCGTAGT 
GGAGAGAGAG TAGAGGATAA GCAGCTAGAG CAGCAGTCTG CAGTGTGTGA AGGTGAGGGA 
CAGGTAACCA GCACTTCAGA GAGCACACGG GCAACCACGG AGGAACCAGA GACTGACGAA 
GTTGACCAAG TCAGCGAGTC AAATAGCATT GAGGAACTAG AGAGACTTGG AGTTACTGGT 
GCTGAGGAAC AGGCTCTAGG GAGCAAAGGG GAGGCTGCTA CGGAGGTAGA TTTGGAGAGA 
GAAGAAAATG CACAGGAACT GCCAATTAAA GCAGAGCCCC AAGCTCCTGC AGCATCGCAG 
CCCAGTGAAC CTCCCCCTGT CTTAATACCC AGTATTAATA TTCATTCGGA AAACACAGAA 
AATAAAGGAG AAATGGGTGC TTTGCCAAAA CCTGAAACCA TACTGCCACC AGAGCCTGAA 
AATGGAAAGG GAAATGACAC GGACTCAGGG ACTGGGTCCA CTGTGGAGAA CAGCAGCAGT 
GACCTGAACT TGTCCATCTC TAGCTTCCTG AGCAAAACCA AGGACAGTGG CTCGGTGTCT 
CTGCAGGAGA CAAGAAGACA GAAGAAAACA TTGAAGAAAA CACGTAAATT TATTGTTGAT 
GGAGTAGAAG TGAGTGTGAC AACATCAAAG ATAGTTACAG ACAGCGACTC TAAAACCGAG 
GAATTGCGGT TTCTCAGGCG TCAGGAACTT CGAGAGCTAA GGCTTCTCCA GAAGGAAGAG 
CAGAAAGCCC AGCAGCAGCT CAACGGGAAA TTGCAGCAGC AGCGCGAGCA GATCTTCAGG 
CGCTTTGAGC AGGAGATGCT GAGTAAGAAG CGACAATATG ACCAAGAAAT TGAGAATCTA 
GAGAAGCAGC AGAAACAGAC AATTGAACGA CTAGAACAAG AACACACAAA CCGCCTGAGA 
GACGAAGCTA AGCGCATCAA AGGAGAGCAG GAGAAGGAGC TGTCCAAGTT CCAGAATATG 
CTAAGAAACC GAAAGAAGGA GGTTATAAAT GAAGTGGAGA AAGCACCCAA AGAGCTGAGA 
AAAGAGCTCA TGAAGCGCAG GAAAGAGGAG CTTGCACAGA GCCAGCATGC TCAGGAACAA 
GAATTTGTTC AGAAGCAACA GCAAGAGTTA GACGGCGCTC TGAAAAAGAT CATCCAGCAG 
CAGAAGGCAG AGTTGGCCAA TATTGAGAGA GAGTGCTTGA ATAACAAGCA GCAGCTCCTG 
AGAGCCCGAG AAGCTGCAAT TTGGGAGCTT GAAGAACGAC ATTTACAAGA AAAGCACCAG 
CTGCTTAAAC AGCAACTTAA AGATCAGTAT TTCATACAGA GACATCAGCT GCTTAAACGC 
CACGAGAAGG AAACAGAACA AATGCAGCGT TACAATCAAC GACTTATTGA AGAATTGAAG 
AACAGACAGA CTCAGGAACG AGCTAGACTG CCCAAGATTC AGAGAAGTGA AGCCAAGACA 
CGAATGGCCA TGTTTAAAAA AAGTTTGAGG ATTAACTCAA CAGCTACACC AGACCAGGAC 
CGTGAAAAAA TTAAACAGTT TGCTGCACAG GAAGAAAAGA GACAGAAAAA TGAGAGAATG 
GCTCAGCATC AAAAACACGA GAGTCAGATG CGGGACCTTC AGTTGCAGTG TGAAGCCAAC 
GTCCGAGAGC TGCACCAGCT GCAGAATGAA AAATGCCACC TGTTGGTTGA ACATGAGACT 
CAGAAACTGA AGGAGTTAGA TGAGGAGCAC AGCCAAGAGC TCAAGGAGTG GAGAGAGAAG 
CTGAGGCCCA GGAAGAAGAC ACTGGAGGAA GAGTTTGCCA GGAAACTTCA GGAACAGGAA 
GTGTTCTTTA AAATGACCGG GGAGTCCGAA TGCCTCAACC CCTCAGCGCA GAGCCGGATC 
TCCAAATTCT ACCCTATTCC CACCTTACAT TCCACTGGGT CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slk ( XM_008760447.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758669.1 Rattus norvegicus STE20-like kinase (Slk), transcript variant X2, mRNA.

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CloneID	ORa43433
Clone ID Related Accession (Same CDS sequence)	XM_008760447.2
Accession Version	XM_008760447.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	STE20-like serine/threonine-protein kinase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760447.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTGAGA TTGACATATT AGCATCTTGT GATCACCCAA ACATAGTCAA GCTTCTAGAT 
GCCTTCTATT ATGAGAACAA TCTTTGGATC CTCATTGAAT TTTGTGCAGG GGGAGCAGTA 
GATGCCGTGA TGCTTGAACT TGAGAGACCA TTAACTGAGT CCCAAATTCA AGTAGTTTGC 
AAGCAGACAT TAGAGGCGTT GAATTACCTA CATGACAATA AAATCATCCA CAGAGATCTA 
AAAGCTGGCA ATATTCTCTT TACCTTAGAT GGAGACATTA AATTAGCGGA TTTTGGAGTG 
TCAGCTAAGA ATACCAGGAC AATTCAAAGG AGGGATTCAT TTATTGGCAC ACCGTATTGG 
ATGGCTCCTG AAGTCGTCAT GTGTGAGACA TCGAAGGACA GACCCTATGA CTACAAAGCG 
GACGTTTGGT CCCTGGGAAT CACTTTAATA GAAATGGCTG AGATAGAGCC GCCTCATCAT 
GAGCTAAACC CAATGCGAGT GCTGCTGAAA ATAGCAAAGT CGGAGCCCCC CACACTAGCA 
CAGCCATCCA GATGGTCTTC AAATTTTAAG GACTTTCTAA AGAAATGCTT GGAAAAGAAT 
GTGGATGCGC GGTGGACCAC ATCCCAGCTG TTACAGCATC CCTTTGTTAC CGTTGATTCC 
AACAAACCAG TCCGAGAATT GATTGCTGAG GCGAAGGCTG AAGTAACAGA AGAAGTTGAA 
GATGGCAAAG AGGAAGATGA CGATGATGAG ACAGAGAGTG CTCTGCCAAT ACCTGCGAAT 
AAACGCGCCT CCTCTGACCT CAGCATTGCC AGCTCTGAGG AAGATAAGCT TTCACAAAAT 
GCTTGTATTT TGGAATCTGT GTCAGAAAGA ACAGAACACA ATACTTCTGG GGATAAATTT 
AGCAACAAAG TTCTTAGTGA GAAGCCTACT CCTGAGGGAC CTGAGAAGGC TGTGGATGTG 
GATGGGCCTG CAAATGATGT TAACTTAGAA ACTGTGGCTG AACCAAATGA CCAAGCGGTA 
GGATTCCATG AGAATGGGAG AGAGAAGAAA AGACCCAAAC TGGAAAGTCA ACCAGATACA 
GAAGACCAAC AAACTGTGGA TGTTAATTTA GTCGGTGAAG GAAATGACAG CAATATAGTA 
ATTTTAGAAA CAAACACTGA TTGTCTGAAA CCAGAGGAAG ACAGAAATGA AGAAAACCAA 
GAGATAATTG AGAATAAACT TACACAATCT GAAGAAATTA AAGATATACA TATTCAAACA 
ATGGACTTAG TTTCTCAAGA AACTGGAGAA AAAGAGGCAG ATTTTCAGGC AATTGACAAT 
GAAGTTGGGT TTACAAAGGA AGAAACCCAA GAGAAATTGG GAAAAGATGA TAAAACTCAA 
AAAGTTGTGA TCAGTGATAT AAGCAGTGAG GTGGGAACAG ACGAGGCTCC AGGTGATACC 
CAGAAGGCTG CTGAGCAGAG CCAGGATGCA GAGGGTGGGG CTGGGGAAGA AGCCCCGGAG 
CCTGCCCAGA CACTAACAGA GAAGGCCACT GAGGGCCCTG AGGCTCATGG TGCTGAGGAA 
GAGCCTCGTA GTGGAGAGAG AGTAGAGGAT AAGCAGCTAG AGCAGCAGTC TGCAGTGTGT 
GAAGGTGAGG GACAGGTAAC CAGCACTTCA GAGAGCACAC GGGCAACCAC GGAGGAACCA 
GAGACTGACG AAGTTGACCA AGTCAGCGAG TCAAATAGCA TTGAGGAACT AGAGAGACTT 
GGAGTTACTG GTGCTGAGGA ACAGGCTCTA GGGAGCAAAG GGGAGGCTGC TACGGAGGTA 
GATTTGGAGA GAGAAGAAAA TGCACAGGAA CTGCCAATTA AAGCAGAGCC CCAAGCTCCT 
GCAGCATCGC AGCCCAGTGA ACCTCCCCCT GTCTTAATAC CCAGTATTAA TATTCATTCG 
GAAAACACAG AAAATAAAGG AGAAATGGGT GCTTTGCCAA AACCTGAAAC CATACTGCCA 
CCAGAGCCTG AAAATGGAAA GGGAAATGAC ACGGACTCAG GGACTGGGTC CACTGTGGAG 
AACAGCAGCA GTGACCTGAA CTTGTCCATC TCTAGCTTCC TGAGCAAAAC CAAGGACAGT 
GGCTCGGTGT CTCTGCAGGA GACAAGAAGA CAGAAGAAAA CATTGAAGAA AACACGTAAA 
TTTATTGTTG ATGGAGTAGA AGTGAGTGTG ACAACATCAA AGATAGTTAC AGACAGCGAC 
TCTAAAACCG AGGAATTGCG GTTTCTCAGG CGTCAGGAAC TTCGAGAGCT AAGGCTTCTC 
CAGAAGGAAG AGCAGAAAGC CCAGCAGCAG CTCAACGGGA AATTGCAGCA GCAGCGCGAG 
CAGATCTTCA GGCGCTTTGA GCAGGAGATG CTGAGTAAGA AGCGACAATA TGACCAAGAA 
ATTGAGAATC TAGAGAAGCA GCAGAAACAG ACAATTGAAC GACTAGAACA AGAACACACA 
AACCGCCTGA GAGACGAAGC TAAGCGCATC AAAGGAGAGC AGGAGAAGGA GCTGTCCAAG 
TTCCAGAATA TGCTAAGAAA CCGAAAGAAG GAGGTTATAA ATGAAGTGGA GAAAGCACCC 
AAAGAGCTGA GAAAAGAGCT CATGAAGCGC AGGAAAGAGG AGCTTGCACA GAGCCAGCAT 
GCTCAGGAAC AAGAATTTGT TCAGAAGCAA CAGCAAGAGT TAGACGGCGC TCTGAAAAAG 
ATCATCCAGC AGCAGAAGGC AGAGTTGGCC AATATTGAGA GAGAGTGCTT GAATAACAAG 
CAGCAGCTCC TGAGAGCCCG AGAAGCTGCA ATTTGGGAGC TTGAAGAACG ACATTTACAA 
GAAAAGCACC AGCTGCTTAA ACAGCAACTT AAAGATCAGT ATTTCATACA GAGACATCAG 
CTGCTTAAAC GCCACGAGAA GGAAACAGAA CAAATGCAGC GTTACAATCA ACGACTTATT 
GAAGAATTGA AGAACAGACA GACTCAGGAA CGAGCTAGAC TGCCCAAGAT TCAGAGAAGT 
GAAGCCAAGA CACGAATGGC CATGTTTAAA AAAAGTTTGA GGATTAACTC AACAGCTACA 
CCAGACCAGG ACCGTGAAAA AATTAAACAG TTTGCTGCAC AGGAAGAAAA GAGACAGAAA 
AATGAGAGAA TGGCTCAGCA TCAAAAACAC GAGAGTCAGA TGCGGGACCT TCAGTTGCAG 
TGTGAAGCCA ACGTCCGAGA GCTGCACCAG CTGCAGAATG AAAAATGCCA CCTGTTGGTT 
GAACATGAGA CTCAGAAACT GAAGGAGTTA GATGAGGAGC ACAGCCAAGA GCTCAAGGAG 
TGGAGAGAGA AGCTGAGGCC CAGGAAGAAG ACACTGGAGG AAGAGTTTGC CAGGAAACTT 
CAGGAACAGG AAGTGTTCTT TAAAATGACC GGGGAGTCCG AATGCCTCAA CCCCTCAGCG 
CAGAGCCGGA TCTCCAAATT CTACCCTATT CCCACCTTAC ATTCCACTGG GTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758669.1
CDS	1730..5206
Translation	MVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLEALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPVRELIAEAKAEVTEEVEDGKEEDDDDETESALPIPANKRASSDLSIASSEEDKLSQNACILESVSERTEHNTSGDKFSNKVLSEKPTPEGPEKAVDVDGPANDVNLETVAEPNDQAVGFHENGREKKRPKLESQPDTEDQQTVDVNLVGEGNDSNIVILETNTDCLKPEEDRNEENQEIIENKLTQSEEIKDIHIQTMDLVSQETGEKEADFQAIDNEVGFTKEETQEKLGKDDKTQKVVISDISSEVGTDEAPGDTQKAAEQSQDAEGGAGEEAPEPAQTLTEKATEGPEAHGAEEEPRSGERVEDKQLEQQSAVCEGEGQVTSTSESTRATTEEPETDEVDQVSESNSIEELERLGVTGAEEQALGSKGEAATEVDLEREENAQELPIKAEPQAPAASQPSEPPPVLIPSINIHSENTENKGEMGALPKPETILPPEPENGKGNDTDSGTGSTVENSSSDLNLSISSFLSKTKDSGSVSLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRLLQKEEQKAQQQLNGKLQQQREQIFRRFEQEMLSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLRNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGALKKIIQQQKAELANIERECLNNKQQLLRAREAAIWELEERHLQEKHQLLKQQLKDQYFIQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDREKIKQFAAQEEKRQKNERMAQHQKHESQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSAQSRISKFYPIPTLHSTGS

Target ORF information:

RefSeq Version	XM_008760447.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus STE20-like kinase (Slk), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760447.2

ORF Insert Sequence:

ATGGTTGAGA TTGACATATT AGCATCTTGT GATCACCCAA ACATAGTCAA GCTTCTAGAT 
GCCTTCTATT ATGAGAACAA TCTTTGGATC CTCATTGAAT TTTGTGCAGG GGGAGCAGTA 
GATGCCGTGA TGCTTGAACT TGAGAGACCA TTAACTGAGT CCCAAATTCA AGTAGTTTGC 
AAGCAGACAT TAGAGGCGTT GAATTACCTA CATGACAATA AAATCATCCA CAGAGATCTA 
AAAGCTGGCA ATATTCTCTT TACCTTAGAT GGAGACATTA AATTAGCGGA TTTTGGAGTG 
TCAGCTAAGA ATACCAGGAC AATTCAAAGG AGGGATTCAT TTATTGGCAC ACCGTATTGG 
ATGGCTCCTG AAGTCGTCAT GTGTGAGACA TCGAAGGACA GACCCTATGA CTACAAAGCG 
GACGTTTGGT CCCTGGGAAT CACTTTAATA GAAATGGCTG AGATAGAGCC GCCTCATCAT 
GAGCTAAACC CAATGCGAGT GCTGCTGAAA ATAGCAAAGT CGGAGCCCCC CACACTAGCA 
CAGCCATCCA GATGGTCTTC AAATTTTAAG GACTTTCTAA AGAAATGCTT GGAAAAGAAT 
GTGGATGCGC GGTGGACCAC ATCCCAGCTG TTACAGCATC CCTTTGTTAC CGTTGATTCC 
AACAAACCAG TCCGAGAATT GATTGCTGAG GCGAAGGCTG AAGTAACAGA AGAAGTTGAA 
GATGGCAAAG AGGAAGATGA CGATGATGAG ACAGAGAGTG CTCTGCCAAT ACCTGCGAAT 
AAACGCGCCT CCTCTGACCT CAGCATTGCC AGCTCTGAGG AAGATAAGCT TTCACAAAAT 
GCTTGTATTT TGGAATCTGT GTCAGAAAGA ACAGAACACA ATACTTCTGG GGATAAATTT 
AGCAACAAAG TTCTTAGTGA GAAGCCTACT CCTGAGGGAC CTGAGAAGGC TGTGGATGTG 
GATGGGCCTG CAAATGATGT TAACTTAGAA ACTGTGGCTG AACCAAATGA CCAAGCGGTA 
GGATTCCATG AGAATGGGAG AGAGAAGAAA AGACCCAAAC TGGAAAGTCA ACCAGATACA 
GAAGACCAAC AAACTGTGGA TGTTAATTTA GTCGGTGAAG GAAATGACAG CAATATAGTA 
ATTTTAGAAA CAAACACTGA TTGTCTGAAA CCAGAGGAAG ACAGAAATGA AGAAAACCAA 
GAGATAATTG AGAATAAACT TACACAATCT GAAGAAATTA AAGATATACA TATTCAAACA 
ATGGACTTAG TTTCTCAAGA AACTGGAGAA AAAGAGGCAG ATTTTCAGGC AATTGACAAT 
GAAGTTGGGT TTACAAAGGA AGAAACCCAA GAGAAATTGG GAAAAGATGA TAAAACTCAA 
AAAGTTGTGA TCAGTGATAT AAGCAGTGAG GTGGGAACAG ACGAGGCTCC AGGTGATACC 
CAGAAGGCTG CTGAGCAGAG CCAGGATGCA GAGGGTGGGG CTGGGGAAGA AGCCCCGGAG 
CCTGCCCAGA CACTAACAGA GAAGGCCACT GAGGGCCCTG AGGCTCATGG TGCTGAGGAA 
GAGCCTCGTA GTGGAGAGAG AGTAGAGGAT AAGCAGCTAG AGCAGCAGTC TGCAGTGTGT 
GAAGGTGAGG GACAGGTAAC CAGCACTTCA GAGAGCACAC GGGCAACCAC GGAGGAACCA 
GAGACTGACG AAGTTGACCA AGTCAGCGAG TCAAATAGCA TTGAGGAACT AGAGAGACTT 
GGAGTTACTG GTGCTGAGGA ACAGGCTCTA GGGAGCAAAG GGGAGGCTGC TACGGAGGTA 
GATTTGGAGA GAGAAGAAAA TGCACAGGAA CTGCCAATTA AAGCAGAGCC CCAAGCTCCT 
GCAGCATCGC AGCCCAGTGA ACCTCCCCCT GTCTTAATAC CCAGTATTAA TATTCATTCG 
GAAAACACAG AAAATAAAGG AGAAATGGGT GCTTTGCCAA AACCTGAAAC CATACTGCCA 
CCAGAGCCTG AAAATGGAAA GGGAAATGAC ACGGACTCAG GGACTGGGTC CACTGTGGAG 
AACAGCAGCA GTGACCTGAA CTTGTCCATC TCTAGCTTCC TGAGCAAAAC CAAGGACAGT 
GGCTCGGTGT CTCTGCAGGA GACAAGAAGA CAGAAGAAAA CATTGAAGAA AACACGTAAA 
TTTATTGTTG ATGGAGTAGA AGTGAGTGTG ACAACATCAA AGATAGTTAC AGACAGCGAC 
TCTAAAACCG AGGAATTGCG GTTTCTCAGG CGTCAGGAAC TTCGAGAGCT AAGGCTTCTC 
CAGAAGGAAG AGCAGAAAGC CCAGCAGCAG CTCAACGGGA AATTGCAGCA GCAGCGCGAG 
CAGATCTTCA GGCGCTTTGA GCAGGAGATG CTGAGTAAGA AGCGACAATA TGACCAAGAA 
ATTGAGAATC TAGAGAAGCA GCAGAAACAG ACAATTGAAC GACTAGAACA AGAACACACA 
AACCGCCTGA GAGACGAAGC TAAGCGCATC AAAGGAGAGC AGGAGAAGGA GCTGTCCAAG 
TTCCAGAATA TGCTAAGAAA CCGAAAGAAG GAGGTTATAA ATGAAGTGGA GAAAGCACCC 
AAAGAGCTGA GAAAAGAGCT CATGAAGCGC AGGAAAGAGG AGCTTGCACA GAGCCAGCAT 
GCTCAGGAAC AAGAATTTGT TCAGAAGCAA CAGCAAGAGT TAGACGGCGC TCTGAAAAAG 
ATCATCCAGC AGCAGAAGGC AGAGTTGGCC AATATTGAGA GAGAGTGCTT GAATAACAAG 
CAGCAGCTCC TGAGAGCCCG AGAAGCTGCA ATTTGGGAGC TTGAAGAACG ACATTTACAA 
GAAAAGCACC AGCTGCTTAA ACAGCAACTT AAAGATCAGT ATTTCATACA GAGACATCAG 
CTGCTTAAAC GCCACGAGAA GGAAACAGAA CAAATGCAGC GTTACAATCA ACGACTTATT 
GAAGAATTGA AGAACAGACA GACTCAGGAA CGAGCTAGAC TGCCCAAGAT TCAGAGAAGT 
GAAGCCAAGA CACGAATGGC CATGTTTAAA AAAAGTTTGA GGATTAACTC AACAGCTACA 
CCAGACCAGG ACCGTGAAAA AATTAAACAG TTTGCTGCAC AGGAAGAAAA GAGACAGAAA 
AATGAGAGAA TGGCTCAGCA TCAAAAACAC GAGAGTCAGA TGCGGGACCT TCAGTTGCAG 
TGTGAAGCCA ACGTCCGAGA GCTGCACCAG CTGCAGAATG AAAAATGCCA CCTGTTGGTT 
GAACATGAGA CTCAGAAACT GAAGGAGTTA GATGAGGAGC ACAGCCAAGA GCTCAAGGAG 
TGGAGAGAGA AGCTGAGGCC CAGGAAGAAG ACACTGGAGG AAGAGTTTGC CAGGAAACTT 
CAGGAACAGG AAGTGTTCTT TAAAATGACC GGGGAGTCCG AATGCCTCAA CCCCTCAGCG 
CAGAGCCGGA TCTCCAAATT CTACCCTATT CCCACCTTAC ATTCCACTGG GTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deletion ofMst1 attenuates neuronal loss andimproves neurological impairment inarat model oftraumatic brain injury.
Brain research(2017 Oct)
Li D,Ni H,Rui Q,Gao R,Chen G

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.
The EMBO journal27(4)704-14(2008 Feb)
Pike AC,Rellos P,Niesen FH,Turnbull A,Oliver AW,Parker SA,Turk BE,Pearl LH,Knapp S

Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.
The Journal of biological chemistry281(6)3075-84(2006 Feb)
Hao W,Takano T,Guillemette J,Papillon J,Ren G,Cybulsky AV

Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54.
Genome research14(4)640-50(2004 Apr)
Vitt U,Gietzen D,Stevens K,Wingrove J,Becha S,Bulloch S,Burrill J,Chawla N,Chien J,Crawford M,Ison C,Kearney L,Kwong M,Park J,Policky J,Weiler M,White R,Xu Y,Daniels S,Jacob H,Jensen-Seaman MI,Lazar J,Stuve L,Schmidt J

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Slk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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