Cxcr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcr1
Entrez Gene ID	54258
Full Name	C-X-C motif chemokine receptor 1
Synonyms	Il8ra
General protein information	Preferred Names C-X-C motif chemokine receptor 1 Names C-X-C chemokine receptor type 1 CXC-R1 CXCR-1 IL-8R A chemokine (C-X-C motif) receptor 1 high affinity interleukin-8 receptor A interleukin 8 receptor, alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33
Summary	G-protein coupled receptor for interleukin 8 [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006245273.3	XP_006245335.2	C-X-C chemokine receptor type 1 isoform X1
NM_019310.1	NP_062183.1	C-X-C chemokine receptor type 1

Pathways from BioSystems

Homologies

	CXCR1	NP_001035510.1
Homo sapiens (human)	CXCR1	NP_000625.1
Rattus norvegicus (Norway rat)	Cxcr1	NP_062183.1
Gallus gallus (chicken)	CXCR2	NP_001026762.1
Pan troglodytes (chimpanzee)	CXCR1	NP_001035537.1
Mus musculus (house mouse)	Cxcr1	NP_839972.1

Gene Ontology
Bibliography

Related articles in PubMed

The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs.
Feng C, Zhang Y, Yang M, Lan M, Liu H, Wang J, Zhou Y, Huang B
Biochimica et biophysica acta1863(1)220-230(2017 Jan)

Effect of acupuncture on CXCL8 receptors in rats suffering from embryo implantation failure.
Gao WN, Yang W, Liu YF, Tang X, Guo Y, Wang LJ, Zhang MM, Huang GY
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban34(1)91-8(2014 Feb)

Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.
Ozaltin F, Besbas N, Iskit AB, Cil O, Akcoren Z, Kale G, Bakkaloglu A
Renal failure35(3)380-5(2013)

Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children.
Javor J, Bucova M, Cervenova O, Kralinsky K, Sadova E, Suchankova M, Liptakova A
International journal of immunogenetics39(4)338-45(2012 Aug)

Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury.
Xing D, Li P, Gong K, Yang Z, Yu H, Hage FG, Oparil S, Chen YF
Circulation125(12)1533-41(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate that acupuncture can increase the number of implanted embryos in embryo implantation failure, which may be relevant with up-regulation the expression of CXCL8 receptors CXCR1 and CXCR2 in endometrium.
Title: Effect of acupuncture on CXCL8 receptors in rats suffering from embryo implantation failure.

may contribute to inflammation in experimental mesangioproliferative glomerulonephritis
Title: Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.

IL8RA-endothelial cells (EC), IL8RB-EC, and IL8RA/IL8RB-EC treatment reduces neointima formation dramatically in carotid artery endothelial cells at 28 days after injury.
Title: Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury.

Inhibition of CXCR1 and CXCR2 chemokine receptors improves motor and autonomic neurological outcomes after spinal cord injury.
Title: Inhibition of CXCR1 and CXCR2 chemokine receptors attenuates acute inflammation, preserves gray matter and diminishes autonomic dysreflexia after spinal cord injury.

The following Cxcr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42464	NM_019310.1 Latest version!	Rattus norvegicus C-X-C motif chemokine receptor 1 (Cxcr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa42464	XM_006245273.3 Latest version!	Rattus norvegicus C-X-C motif chemokine receptor 1 (Cxcr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcr1 ( NM_019310.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062183.1 Rattus norvegicus C-X-C motif chemokine receptor 1 (Cxcr1), mRNA.

Price & Availability↑

CloneID	ORa42464
Clone ID Related Accession (Same CDS sequence)	XM_006245273.3 , NM_019310.1
Accession Version	NM_019310.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C chemokine receptor type 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U71089.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGCCGAGG CTGAGTATTT CATCTGGATT GCTCCTGAGG GTGACTTTGA GGAAGAATTT 
GGAAATATCA CCCGAATGCT GCCCACTGGA GAGTATTTCA GCCCCTGTAA GAGGGTTCCA 
ATGACCAACA GGCAGGCTGT AGTTGTCTTC TATGCACTGG TGTTCCTTCT TAGCTTGCTG 
GGAAACTCGC TGGTGATGCT GGTCATCTTA TACAGGCGAA GGACCCGATC CGTCACCGAT 
GTCTACGTGC TGAACCTAGC CATTGCTGAT CTACTCTTTT CATTGACTCT GCCCTTCTTG 
GCTGTCTCCA AATGGAAGGG CTGGATTTTT GGCACACCCC TGTGCAAGAT GGTCTCACTC 
CTGAAGGAAG TCAACTTCTT CAGTGGTATC TTGCTGCTGG CCTGCATCAG TGTGGATCGA 
TACCTGGCCA TCGTCCATGC CACCCGCACA CTGACCCGAA AGCGCTACTT GGTTAAATTC 
GTATGCATGG GCACCTGGGG TCTATCCTTG GTTCTGTCTC TGCCTTTTGC CATCTTCCGC 
CAGGCATATA AACCATACCG TTCTGGAACA GTCTGCTATG AGGTCCTGGG TGAAGCCACA 
GCAGATCTTA GGATAACATT GCGTGGTCTG TCCCACATAT TTGGCTTCCT CTTGCCGCTG 
TTCATCATGC TGGTCTGCTA CGGGCTCACA CTGCGCACGC TCTTTAAGGC CCACATGAGA 
CAGAAACGCC GGGCCATGTG GGTGATCTTT GCTGTTGTGT TGGTCTTCCT GCTCTGTTGT 
CTGCCCTACA ATCTGGTTCT GCTCTCGGAC ACTCTCTTAG GAGCCCACTT GATTCAAGAT 
ACTTGCGAGC GCCGCAATAA CATTGACCAG GCCTTGTATA TTACCGAGAT CCTGGGCTTT 
TCTCACAGTT GTCTTAACCC CGTCATCTAT GCCTTTGTTG GCCAAAGTTT TCGCCATGAA 
TTCCTCAAGA TCCTTGCTAA CCTGGTTCAC AAGGAGGTTT TGACACACCA CTCTGCTTCC 
TTTCGCACGT CTCTCACCAC TATCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062183.1
CDS	1..1050
Translation	MAEAEYFIWIAPEGDFEEEFGNITRMLPTGEYFSPCKRVPMTNRQAVVVFYALVFLLSLLGNSLVMLVILYRRRTRSVTDVYVLNLAIADLLFSLTLPFLAVSKWKGWIFGTPLCKMVSLLKEVNFFSGILLLACISVDRYLAIVHATRTLTRKRYLVKFVCMGTWGLSLVLSLPFAIFRQAYKPYRSGTVCYEVLGEATADLRITLRGLSHIFGFLLPLFIMLVCYGLTLRTLFKAHMRQKRRAMWVIFAVVLVFLLCCLPYNLVLLSDTLLGAHLIQDTCERRNNIDQALYITEILGFSHSCLNPVIYAFVGQSFRHEFLKILANLVHKEVLTHHSASFRTSLTTIY

Target ORF information:

RefSeq Version	NM_019310.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine receptor 1 (Cxcr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019310.1

ORF Insert Sequence:

ATGGCCGAGG CTGAGTATTT CATCTGGATT GCTCCTGAGG GTGACTTTGA GGAAGAATTT 
GGAAATATCA CCCGAATGCT GCCCACTGGA GAGTATTTCA GCCCCTGTAA GAGGGTTCCA 
ATGACCAACA GGCAGGCTGT AGTTGTCTTC TATGCACTGG TGTTCCTTCT TAGCTTGCTG 
GGAAACTCGC TGGTGATGCT GGTCATCTTA TACAGGCGAA GGACCCGATC CGTCACCGAT 
GTCTACGTGC TGAACCTAGC CATTGCTGAT CTACTCTTTT CATTGACTCT GCCCTTCTTG 
GCTGTCTCCA AATGGAAGGG CTGGATTTTT GGCACACCCC TGTGCAAGAT GGTCTCACTC 
CTGAAGGAAG TCAACTTCTT CAGTGGTATC TTGCTGCTGG CCTGCATCAG TGTGGATCGA 
TACCTGGCCA TCGTCCATGC CACCCGCACA CTGACCCGAA AGCGCTACTT GGTTAAATTC 
GTATGCATGG GCACCTGGGG TCTATCCTTG GTTCTGTCTC TGCCTTTTGC CATCTTCCGC 
CAGGCATATA AACCATACCG TTCTGGAACA GTCTGCTATG AGGTCCTGGG TGAAGCCACA 
GCAGATCTTA GGATAACATT GCGTGGTCTG TCCCACATAT TTGGCTTCCT CTTGCCGCTG 
TTCATCATGC TGGTCTGCTA CGGGCTCACA CTGCGCACGC TCTTTAAGGC CCACATGAGA 
CAGAAACGCC GGGCCATGTG GGTGATCTTT GCTGTTGTGT TGGTCTTCCT GCTCTGTTGT 
CTGCCCTACA ATCTGGTTCT GCTCTCGGAC ACTCTCTTAG GAGCCCACTT GATTCAAGAT 
ACTTGCGAGC GCCGCAATAA CATTGACCAG GCCTTGTATA TTACCGAGAT CCTGGGCTTT 
TCTCACAGTT GTCTTAACCC CGTCATCTAT GCCTTTGTTG GCCAAAGTTT TCGCCATGAA 
TTCCTCAAGA TCCTTGCTAA CCTGGTTCAC AAGGAGGTTT TGACACACCA CTCTGCTTCC 
TTTCGCACGT CTCTCACCAC TATCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cxcr1 ( XM_006245273.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006245335.2 Rattus norvegicus C-X-C motif chemokine receptor 1 (Cxcr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa42464
Clone ID Related Accession (Same CDS sequence)	XM_006245273.3 , NM_019310.1
Accession Version	XM_006245273.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C chemokine receptor type 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006245273.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGAGG CTGAGTATTT CATCTGGATT GCTCCTGAGG GTGACTTTGA GGAAGAATTT 
GGAAATATCA CCCGAATGCT GCCCACTGGA GAGTATTTCA GCCCCTGTAA GAGGGTTCCA 
ATGACCAACA GGCAGGCTGT AGTTGTCTTC TATGCACTGG TGTTCCTTCT TAGCTTGCTG 
GGAAACTCGC TGGTGATGCT GGTCATCTTA TACAGGCGAA GGACCCGATC CGTCACCGAT 
GTCTACGTGC TGAACCTAGC CATTGCTGAT CTACTCTTTT CATTGACTCT GCCCTTCTTG 
GCTGTCTCCA AATGGAAGGG CTGGATTTTT GGCACACCCC TGTGCAAGAT GGTCTCACTC 
CTGAAGGAAG TCAACTTCTT CAGTGGTATC TTGCTGCTGG CCTGCATCAG TGTGGATCGA 
TACCTGGCCA TCGTCCATGC CACCCGCACA CTGACCCGAA AGCGCTACTT GGTTAAATTC 
GTATGCATGG GCACCTGGGG TCTATCCTTG GTTCTGTCTC TGCCTTTTGC CATCTTCCGC 
CAGGCATATA AACCATACCG TTCTGGAACA GTCTGCTATG AGGTCCTGGG TGAAGCCACA 
GCAGATCTTA GGATAACATT GCGTGGTCTG TCCCACATAT TTGGCTTCCT CTTGCCGCTG 
TTCATCATGC TGGTCTGCTA CGGGCTCACA CTGCGCACGC TCTTTAAGGC CCACATGAGA 
CAGAAACGCC GGGCCATGTG GGTGATCTTT GCTGTTGTGT TGGTCTTCCT GCTCTGTTGT 
CTGCCCTACA ATCTGGTTCT GCTCTCGGAC ACTCTCTTAG GAGCCCACTT GATTCAAGAT 
ACTTGCGAGC GCCGCAATAA CATTGACCAG GCCTTGTATA TTACCGAGAT CCTGGGCTTT 
TCTCACAGTT GTCTTAACCC CGTCATCTAT GCCTTTGTTG GCCAAAGTTT TCGCCATGAA 
TTCCTCAAGA TCCTTGCTAA CCTGGTTCAC AAGGAGGTTT TGACACACCA CTCTGCTTCC 
TTTCGCACGT CTCTCACCAC TATCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006245335.2
CDS	78..1127
Translation	MAEAEYFIWIAPEGDFEEEFGNITRMLPTGEYFSPCKRVPMTNRQAVVVFYALVFLLSLLGNSLVMLVILYRRRTRSVTDVYVLNLAIADLLFSLTLPFLAVSKWKGWIFGTPLCKMVSLLKEVNFFSGILLLACISVDRYLAIVHATRTLTRKRYLVKFVCMGTWGLSLVLSLPFAIFRQAYKPYRSGTVCYEVLGEATADLRITLRGLSHIFGFLLPLFIMLVCYGLTLRTLFKAHMRQKRRAMWVIFAVVLVFLLCCLPYNLVLLSDTLLGAHLIQDTCERRNNIDQALYITEILGFSHSCLNPVIYAFVGQSFRHEFLKILANLVHKEVLTHHSASFRTSLTTIY

Target ORF information:

RefSeq Version	XM_006245273.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine receptor 1 (Cxcr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006245273.3

ORF Insert Sequence:

ATGGCCGAGG CTGAGTATTT CATCTGGATT GCTCCTGAGG GTGACTTTGA GGAAGAATTT 
GGAAATATCA CCCGAATGCT GCCCACTGGA GAGTATTTCA GCCCCTGTAA GAGGGTTCCA 
ATGACCAACA GGCAGGCTGT AGTTGTCTTC TATGCACTGG TGTTCCTTCT TAGCTTGCTG 
GGAAACTCGC TGGTGATGCT GGTCATCTTA TACAGGCGAA GGACCCGATC CGTCACCGAT 
GTCTACGTGC TGAACCTAGC CATTGCTGAT CTACTCTTTT CATTGACTCT GCCCTTCTTG 
GCTGTCTCCA AATGGAAGGG CTGGATTTTT GGCACACCCC TGTGCAAGAT GGTCTCACTC 
CTGAAGGAAG TCAACTTCTT CAGTGGTATC TTGCTGCTGG CCTGCATCAG TGTGGATCGA 
TACCTGGCCA TCGTCCATGC CACCCGCACA CTGACCCGAA AGCGCTACTT GGTTAAATTC 
GTATGCATGG GCACCTGGGG TCTATCCTTG GTTCTGTCTC TGCCTTTTGC CATCTTCCGC 
CAGGCATATA AACCATACCG TTCTGGAACA GTCTGCTATG AGGTCCTGGG TGAAGCCACA 
GCAGATCTTA GGATAACATT GCGTGGTCTG TCCCACATAT TTGGCTTCCT CTTGCCGCTG 
TTCATCATGC TGGTCTGCTA CGGGCTCACA CTGCGCACGC TCTTTAAGGC CCACATGAGA 
CAGAAACGCC GGGCCATGTG GGTGATCTTT GCTGTTGTGT TGGTCTTCCT GCTCTGTTGT 
CTGCCCTACA ATCTGGTTCT GCTCTCGGAC ACTCTCTTAG GAGCCCACTT GATTCAAGAT 
ACTTGCGAGC GCCGCAATAA CATTGACCAG GCCTTGTATA TTACCGAGAT CCTGGGCTTT 
TCTCACAGTT GTCTTAACCC CGTCATCTAT GCCTTTGTTG GCCAAAGTTT TCGCCATGAA 
TTCCTCAAGA TCCTTGCTAA CCTGGTTCAC AAGGAGGTTT TGACACACCA CTCTGCTTCC 
TTTCGCACGT CTCTCACCAC TATCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs.
Biochimica et biophysica acta1863(1)220-230(2017 Jan)
Feng C,Zhang Y,Yang M,Lan M,Liu H,Wang J,Zhou Y,Huang B

Effect of acupuncture on CXCL8 receptors in rats suffering from embryo implantation failure.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban34(1)91-8(2014 Feb)
Gao WN,Yang W,Liu YF,Tang X,Guo Y,Wang LJ,Zhang MM,Huang GY

Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis.
Renal failure35(3)380-5(2013)
Ozaltin F,Besbas N,Iskit AB,Cil O,Akcoren Z,Kale G,Bakkaloglu A

Genetic variations of interleukin-8, CXCR1 and CXCR2 genes and risk of acute pyelonephritis in children.
International journal of immunogenetics39(4)338-45(2012 Aug)
Javor J,Bucova M,Cervenova O,Kralinsky K,Sadova E,Suchankova M,Liptakova A

Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury.
Circulation125(12)1533-41(2012 Mar)
Xing D,Li P,Gong K,Yang Z,Yu H,Hage FG,Oparil S,Chen YF