Clec7a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clec7a
Entrez Gene ID	502902
Full Name	C-type lectin domain containing 7A
Synonyms	Clec7b,RGD1565140
General protein information	Preferred Names C-type lectin domain containing 7A Names C-type lectin domain family 7 member A C-type lectin domain family 7, member A dectin-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42

mRNA and Protein(s)

mRNA	Protein	Name
NM_001173386.1	NP_001166857.1	C-type lectin domain family 7 member A
XM_006237100.3	XP_006237162.1	C-type lectin domain family 7 member A isoform X1

Pathways from BioSystems

Homologies

	CLEC7A	NP_001028115.1
Homo sapiens (human)	CLEC7A	NP_922938.1
Mus musculus (house mouse)	Clec7a	NP_064392.2
Pan troglodytes (chimpanzee)	CLEC7A	XP_528732.2
Canis lupus familiaris (dog)	CLEC7A	XP_854143.1
Rattus norvegicus (Norway rat)	Clec7a	NP_001166857.1
Bos taurus (cattle)	CLEC7A	NP_001027022.1

Gene Ontology
Bibliography

Related articles in PubMed

Human intestinal epithelial cells respond to ?-glucans via Dectin-1 and Syk.
Cohen-Kedar S, Baram L, Elad H, Brazowski E, Guzner-Gur H, Dotan I
European journal of immunology44(12)3729-40(2014 Dec)

Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.
Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H, Fujieda S, Sada K
The Journal of biological chemistry289(45)31565-75(2014 Nov)

Dectin-1 activation induces proliferation and migration of human keratinocytes enhancing wound re-epithelialization.
van den Berg LM, Zijlstra-Willems EM, Richters CD, Ulrich MM, Geijtenbeek TB
Cellular immunology289(1-2)49-54(2014 May-Jun)

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome.
Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TB
Nature immunology13(3)246-54(2012 Jan)

Taenia taeniaeformis in rat favors protracted skin lesions caused by Sporothrix schenckii infection: Dectin-1 and IL-17 are dispensable for clearance of this fungus.
Zhang X, Zhang J, Huang H, Xue R, Hu X, Li M, Zhong Y, Yuan L
PloS one7(12)e52514(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Syk is critical for Dectin-1-mediated activation of mast cells, although the signaling differs from that triggered by FcRI activation
Title: Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.

Dectin-1 and IL-17, which were believed to be the major anti-fungus mechanisms, are Th2 independent and dispensable for clearance of S. schenckii infection.
Title: Taenia taeniaeformis in rat favors protracted skin lesions caused by Sporothrix schenckii infection: Dectin-1 and IL-17 are dispensable for clearance of this fungus.

Dectin1 activation of beta-(1-3)/(1-6)-D-glucan produces an anti-mastitis effect in rats
Title: Dectin1 activation of ?-(1-3)/(1-6)-D-glucan produces an anti-mastitis effect in rats.

Dectin-1 binds fungal beta-glucan and activates innate immune signaling and also plays essential roles in immune responses against fungi.
Title: Characterization of rat beta-glucan receptor dectin-1.

The following Clec7a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clec7a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06514	NM_001173386.1 Latest version!	Rattus norvegicus C-type lectin domain containing 7A (Clec7a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa27608	XM_006237100.3 Latest version!	Rattus norvegicus C-type lectin domain family 7, member A (Clec7a), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clec7a ( NM_001173386.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001166857.1 Rattus norvegicus C-type lectin domain containing 7A (Clec7a), mRNA.

Price & Availability↑

CloneID	ORa06514
Clone ID Related Accession (Same CDS sequence)	NM_001173386.1
Accession Version	NM_001173386.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	C-type lectin domain family 7 member A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC166774.1. On or before May 13, 2010 this sequence version replaced XM_001067977.2, XM_578404.4. ##Evidence-Data-START## Transcript exon combination :: BC166774.1, AB455106.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGACGAAG ATGGATATAC TCAATTAGAC TTCGGCACTC GAAACATCCA CAAAAGACCT 
GTAAAATCAG AGAAAGGAAG CCCAGCTCCA TCTTCTCGTT GGCGGTCCAT TGCGGTAGCT 
TTAGGAATCC TGTGCTTGCT CACAGTAGTG GTCGCAGCAG TGCTGGGTGC CCTAGCATTT 
CGGAGATTCA ATTCAGGGAG ATATCCAGAG GAGAAAGACA ACTTCCCATC AAGAAATAAG 
GAGAACCACA AACCCACAGA ACCATCTTTA GATGAGAAGG TGGCTCCCTC CAAGGCATCC 
CAAACTACAG GCGTCTTTTC TGGACCTTGC CTTCCCAATT GGATCATGCA TGCCAAGAGC 
TGTTATCTAT TTAGCTTCTC AGAAAATTCC TGGTATGGAA GTAGGAGACA CTGTTCCCAG 
CTAGGAGCTC ATCTATTGAA GATAGACAAT GCAAAAGAAT TTGAGTTCAT TGAAAGCCAA 
ACATCTTCTC ACCGTGTTAA CTCATTCTGG ATAGGTCTAT CTCGCAATCA GAGTGAAGGG 
CCGTGGTTCT GGGAGGATGG ATCAGCATTT ACCCCCAACT CGTTTCAAGT CAGAAATACA 
GCTCCCCAAG AAAGCTTACC CCACAATTGT GTTTGGATCC ATGGGTCAGA GGTCTACAAC 
CAAATGTGCA TTGCTTCCTC ATTCACTATC TGTGAGAAGG AACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166857.1
CDS	69..776
Translation	MDEDGYTQLDFGTRNIHKRPVKSEKGSPAPSSRWRSIAVALGILCLLTVVVAAVLGALAFRRFNSGRYPEEKDNFPSRNKENHKPTEPSLDEKVAPSKASQTTGVFSGPCLPNWIMHAKSCYLFSFSENSWYGSRRHCSQLGAHLLKIDNAKEFEFIESQTSSHRVNSFWIGLSRNQSEGPWFWEDGSAFTPNSFQVRNTAPQESLPHNCVWIHGSEVYNQMCIASSFTICEKEL

Target ORF information:

RefSeq Version	NM_001173386.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-type lectin domain containing 7A (Clec7a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173386.1

ORF Insert Sequence:

ATGGACGAAG ATGGATATAC TCAATTAGAC TTCGGCACTC GAAACATCCA CAAAAGACCT 
GTAAAATCAG AGAAAGGAAG CCCAGCTCCA TCTTCTCGTT GGCGGTCCAT TGCGGTAGCT 
TTAGGAATCC TGTGCTTGCT CACAGTAGTG GTCGCAGCAG TGCTGGGTGC CCTAGCATTT 
CGGAGATTCA ATTCAGGGAG ATATCCAGAG GAGAAAGACA ACTTCCCATC AAGAAATAAG 
GAGAACCACA AACCCACAGA ACCATCTTTA GATGAGAAGG TGGCTCCCTC CAAGGCATCC 
CAAACTACAG GCGTCTTTTC TGGACCTTGC CTTCCCAATT GGATCATGCA TGCCAAGAGC 
TGTTATCTAT TTAGCTTCTC AGAAAATTCC TGGTATGGAA GTAGGAGACA CTGTTCCCAG 
CTAGGAGCTC ATCTATTGAA GATAGACAAT GCAAAAGAAT TTGAGTTCAT TGAAAGCCAA 
ACATCTTCTC ACCGTGTTAA CTCATTCTGG ATAGGTCTAT CTCGCAATCA GAGTGAAGGG 
CCGTGGTTCT GGGAGGATGG ATCAGCATTT ACCCCCAACT CGTTTCAAGT CAGAAATACA 
GCTCCCCAAG AAAGCTTACC CCACAATTGT GTTTGGATCC ATGGGTCAGA GGTCTACAAC 
CAAATGTGCA TTGCTTCCTC ATTCACTATC TGTGAGAAGG AACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Clec7a ( XM_006237100.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237162.1 Rattus norvegicus C-type lectin domain family 7, member A (Clec7a), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa27608
Clone ID Related Accession (Same CDS sequence)	XM_006237100.3
Accession Version	XM_006237100.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	C-type lectin domain family 7 member A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237100.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACGAAG ATGGATATAC TCAATTAGAC TTCGGCACTC GAAACATCCA CAAAAGACCT 
GTAAAATCAG AGAAAGGAAG CCCAGCTCCA TCTTCTCGTT GGCGGTCCAT TGCGGTAGCT 
TTAGGAATCC TGTGCTTGCT CACAGTAGTG GTCGCAGCAG TGCTGGGTGC CCTAGGCGTC 
TTTTCTGGAC CTTGCCTTCC CAATTGGATC ATGCATGCCA AGAGCTGTTA TCTATTTAGC 
TTCTCAGAAA ATTCCTGGTA TGGAAGTAGG AGACACTGTT CCCAGCTAGG AGCTCATCTA 
TTGAAGATAG ACAATGCAAA AGAATTTGAG TTCATTGAAA GCCAAACATC TTCTCACCGT 
GTTAACTCAT TCTGGATAGG TCTATCTCGC AATCAGAGTG AAGGGCCGTG GTTCTGGGAG 
GATGGATCAG CATTTACCCC CAACTCGTTT CAAGTCAGAA ATACAGCTCC CCAAGAAAGC 
TTACCCCACA ATTGTGTTTG GATCCATGGG TCAGAGGTCT ACAACCAAAT GTGCATTGCT 
TCCTCATTCA CTATCTGTGA GAAGGAACTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237162.1
CDS	192..764
Translation	MDEDGYTQLDFGTRNIHKRPVKSEKGSPAPSSRWRSIAVALGILCLLTVVVAAVLGALGVFSGPCLPNWIMHAKSCYLFSFSENSWYGSRRHCSQLGAHLLKIDNAKEFEFIESQTSSHRVNSFWIGLSRNQSEGPWFWEDGSAFTPNSFQVRNTAPQESLPHNCVWIHGSEVYNQMCIASSFTICEKEL

Target ORF information:

RefSeq Version	XM_006237100.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-type lectin domain family 7, member A (Clec7a), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237100.3

ORF Insert Sequence:

ATGGACGAAG ATGGATATAC TCAATTAGAC TTCGGCACTC GAAACATCCA CAAAAGACCT 
GTAAAATCAG AGAAAGGAAG CCCAGCTCCA TCTTCTCGTT GGCGGTCCAT TGCGGTAGCT 
TTAGGAATCC TGTGCTTGCT CACAGTAGTG GTCGCAGCAG TGCTGGGTGC CCTAGGCGTC 
TTTTCTGGAC CTTGCCTTCC CAATTGGATC ATGCATGCCA AGAGCTGTTA TCTATTTAGC 
TTCTCAGAAA ATTCCTGGTA TGGAAGTAGG AGACACTGTT CCCAGCTAGG AGCTCATCTA 
TTGAAGATAG ACAATGCAAA AGAATTTGAG TTCATTGAAA GCCAAACATC TTCTCACCGT 
GTTAACTCAT TCTGGATAGG TCTATCTCGC AATCAGAGTG AAGGGCCGTG GTTCTGGGAG 
GATGGATCAG CATTTACCCC CAACTCGTTT CAAGTCAGAA ATACAGCTCC CCAAGAAAGC 
TTACCCCACA ATTGTGTTTG GATCCATGGG TCAGAGGTCT ACAACCAAAT GTGCATTGCT 
TCCTCATTCA CTATCTGTGA GAAGGAACTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human intestinal epithelial cells respond to ?-glucans via Dectin-1 and Syk.
European journal of immunology44(12)3729-40(2014 Dec)
Cohen-Kedar S,Baram L,Elad H,Brazowski E,Guzner-Gur H,Dotan I

Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.
The Journal of biological chemistry289(45)31565-75(2014 Nov)
Kimura Y,Chihara K,Honjoh C,Takeuchi K,Yamauchi S,Yoshiki H,Fujieda S,Sada K

Dectin-1 activation induces proliferation and migration of human keratinocytes enhancing wound re-epithelialization.
Cellular immunology289(1-2)49-54(2014 May-Jun)
van den Berg LM,Zijlstra-Willems EM,Richters CD,Ulrich MM,Geijtenbeek TB

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome.
Nature immunology13(3)246-54(2012 Jan)
Gringhuis SI,Kaptein TM,Wevers BA,Theelen B,van der Vlist M,Boekhout T,Geijtenbeek TB

Taenia taeniaeformis in rat favors protracted skin lesions caused by Sporothrix schenckii infection: Dectin-1 and IL-17 are dispensable for clearance of this fungus.
PloS one7(12)e52514(2012)
Zhang X,Zhang J,Huang H,Xue R,Hu X,Li M,Zhong Y,Yuan L