Nod1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nod1
Entrez Gene ID	500133
Full Name	nucleotide-binding oligomerization domain containing 1
Synonyms	RGD1562269
General protein information	Preferred Names nucleotide-binding oligomerization domain containing 1 Names nucleotide-binding oligomerization domain-containing protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q24

mRNA and Protein(s)

mRNA	Protein	Name
XM_008762910.2	XP_008761132.1	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
NM_001109236.1	NP_001102706.1	nucleotide-binding oligomerization domain-containing protein 1

Pathways from BioSystems

Homologies

	NOD1	XP_001085719.1
Canis lupus familiaris (dog)	NOD1	XP_539499.3
Gallus gallus (chicken)	NOD1	XP_418777.2
Homo sapiens (human)	NOD1	NP_006083.1
Bos taurus (cattle)	NOD1	NP_001243492.1
Danio rerio (zebrafish)	nod1	XP_002665106.3
Rattus norvegicus (Norway rat)	Nod1	NP_001102706.1
Mus musculus (house mouse)	Nod1	NP_001164478.1
Xenopus tropicalis (tropical clawed frog)	nod1	XP_002937900.2
Pan troglodytes (chimpanzee)	NOD1	XP_001165528.1

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of Nucleotide-Binding and Oligomerization Domain-Like Receptors in the Intestinal Injury of Severe Acute Pancreatitis in Rats.
Xu S, Wei S, Guo Y, Cui D, Yao J
Pancreas47(2)245-251(2018 Feb)

High Glucose and Lipopolysaccharide Activate NOD1- RICK-NF-?B Inflammatory Signaling in Mesangial Cells.
Huang W, Gou F, Long Y, Li Y, Feng H, Zhang Q, Gao C, Chen G, Xu Y
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association124(8)512-517(2016 Sep)

Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity.
Hosokawa Y, Hirao K, Yumoto H, Washio A, Nakanishi T, Takegawa D, Kitamura C, Matsuo T
BioMed research international20169325436(2016)

NOD1 and NOD2 Interact with the Phagosome Cargo in Mast Cells: A Detailed Morphological Evidence.
Zabucchi G, Trevisan E, Vita F, Soranzo MR, Borelli V
Inflammation38(3)1113-25(2015)

Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators.
Parkhouse R, Boyle JP, Monie TP
FEBS letters588(18)3382-9(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

combined results support the hypothesis that high glucose and LPS can activate the NOD1-RICK-NF-kappaB inflammatory signaling pathway via the NOD1 receptor, and may participate in the development of diabetic nephropathy.
Title: High Glucose and Lipopolysaccharide Activate NOD1- RICK-NF-?B Inflammatory Signaling in Mesangial Cells.

These findings indicated that NOD1 expressed in odontoblasts functions to upregulate the chemokines expression via p38-AP-1 signaling pathway and suggested that NOD1 may play important roles in the initiation and progression of pulpitis.
Title: Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity.

in rat peritoneal mast cells the ingested cargo can, through interruptions of the phagosome membrane, interact directly with NOD1 and NOD2 proteins, which act as switches in the process of cytokine production.
Title: NOD1 and NOD2 Interact with the Phagosome Cargo in Mast Cells: A Detailed Morphological Evidence.

A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses.
Title: A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses.

Experiments performed with the synthetic Nod1 ligand L-Ala-D-gamma-Glu-meso-diaminopimelic acid confirmed that IKKalpha is involved in NF-kappaB activation triggered downstream of Nod1-mediated peptidoglycan recognition
Title: IKK? contributes to canonical NF-?B activation downstream of Nod1-mediated peptidoglycan recognition.

The following Nod1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nod1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09392	NM_001109236.1 Latest version!	Rattus norvegicus nucleotide-binding oligomerization domain containing 1 (Nod1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa49315	XM_008762910.2 Latest version!	Rattus norvegicus nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nod1 ( NM_001109236.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102706.1 Rattus norvegicus nucleotide-binding oligomerization domain containing 1 (Nod1), mRNA.

Price & Availability↑

CloneID	ORa09392
Clone ID Related Accession (Same CDS sequence)	NM_001109236.1
Accession Version	NM_001109236.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2862bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	nucleotide-binding oligomerization domain-containing protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474011.2. On or before Oct 4, 2007 this sequence version replaced XM_575485.2, XM_001058165.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGAAGC GCGGCCAACA TGAGATGGAA GGCGTCCCAG CCGGTTGTCA CTCCCACATT 
AAACTGTTGA GGATCAACAG GGAACACCTG GTCACCAACA TTCGGAACAC TCAGTGCCTG 
GTGGACAACT TGCTGGAGAA CGGTTACTTC TCAGCCGAGG ATGCAGAGAT CGTGTGTGCT 
TGTCCTACCC AGCCTGACAA GGTCCGAAAG ATCCTTGACC TGGTGCAGAG CAAAGGTGAG 
GAGGTGTCTG AGTTCTTCCT CTACGTGCTA CAGCAGCTGG AGGATGCTTA CGTGGACCTC 
AGGCTGTGGC TATCAGAGAT TGGCTTCTCC CCTTCCCAGC TCATCCGGAC CAAAACTATC 
GTCAATACTG ACCCAGTAAG CAGGTATACC CAGCAGCTGC GACACCAACT GGGCCGCGAT 
TCCAAGTTCA TGCTGTGCTA CGCTCAGAAG GAGGACCTGC TGCTGGAGGA GACCTATATG 
GACACACTCA TGGAGCTGGT AGGCTTCAAC AATGAAAACC TGGGCAGCCT AGGAGGCCTG 
GATTGCCTGC TGGACCACAG CACAGGTGTC CTCAACGAGC ATGGCGAGAC TGTCTTCGTG 
TTCGGGGACG CGGGAGTTGG CAAGTCCATG TTGCTACAGA GGTTGCAGAG CCTCTGGGCG 
TCTGGCAGGC TGGCCTCAAA AGCCAAATTC TTCTTCCACT TTCGCTGCCG TATGTTCAGC 
TGCTTCAAGG AGAGCGACAC ATTGACTCTG CAAGACCTGC TCTTCAAGCA TTTCTGCTAC 
CCGGAGCAGG ACCCCGAGGA GGTGTTCTCC TTCTTGCTGC GCTTTCCCCA CACAGCGCTC 
TTCACTTTTG ACGGCCTGGA TGAGCTGCAC TCAGACTTCG ACATGAGCCG CGTGCCGGAC 
AGCTGCTGCC CCTGGGAGCC GGCGCACCCT CTGGTCCTGC TAGCTAACCT CCTAAGCGGG 
AGGTTGCTCA AGGGTGCGGG CAAACTGCTC ACTGCTCGCA CAGGCGTGGA GGTCCCCCGC 
CAGCTCCTGC GCAAAAAGGT GCTGCTCCGG GGTTTTTCCC CCAGCCACCT GAGAGCCTAT 
GCCCGCCGGA TGTTCCCCGA GCGCACCGCG CAGGAACATC TGCTGCAGCA GCTGGATGCC 
AACCCCAACC TCTGCAGCCT GTGCGGGGTG CCGCTCTTCT GCTGGATCAT CTTCCGATGT 
TTCCAGCATT TCCACACGGC CTTCGAGGGC TCCTCGCAGC TGCCGGACTG CGCTGTGACC 
CTGACCGATG TCTTTCTGCT GGTCACCGAG GTGCATCTGA ACAGGACGCA GCCCATCAGC 
CTGATGCAGC GAAACACGCG CAGCCCGGCG GAAACCCTAC GTGCAGGCTG GCGCACGCTG 
CAGGCGCTGG GAGAGGTGGC TCACCGAGGC ACGGACAGGA GTCTCTTTGT GTTTGGCCAG 
GAGGAGGTGC AGGCGTCGAA ACTGCAGGAA GGGGATCTGC AGCTGGGTTT CCTGCGGGCT 
TTGCCCGATG TGGGCCCTGA ACAAAGTCAG CAGTCTTATG AATTTTTCCA CCTTACGCTC 
CAGGCTTTCT TCACTGCCTT CTTCCTGGTA GCAGATGACA AAGTGAGCAC CCAGGAATTG 
CTAAGGTTCT TTCGAGAATG GACGTCTCCC GGGGAGGCAA CAAGCAGGTC CTGCTATCCT 
TCCTTCTTCT CCTTCCAGTG CCTGGGTAGC GGTAGCCGGT TGGGCCCTGA TCCTTTCAAG 
AACAAAGATC ACTTCCAGTT CACCAACCTC TTCTTGTGCG GGCTGCTGGC CAAAGCCCGA 
CAGAAACTCC TTCAGCAGCT GGTGCCCAAG GCTATCCTAA GGAAGAAGCG CAAGGCCCTG 
TGGGCTCACC TGTTTGCCAG CCTGCGCTCC TACTTGAAGA GCCTACCCCG GGTCCAGTCT 
GATGGGTTTA ACCAGGTACA TGCCATGCCC ACATTCCTGT GGATGCTGCG CTGCATCTAT 
GAGACACAGA GTCAGAAGGT GGGGCGCTTA GCCGCCAGGG GCATCAGTGC GGACTACCTC 
AAGCTAGCCT TCTGCAATGC TTGTTCTGCC GACTGTAGTG CCTTGTCCTT CGTCCTGCAT 
CACTTCCACA GACAGCTGGC CCTAGACCTG GACAACAACA ACCTCAATGA CTATGGAGTT 
CGAGAGCTGC AGCCTTGCTT TAGCCGTCTC ACGGTTATCA GACTCAGTGT CAACCAGATC 
ACCGACATGG GGGTGAAGGT GCTGTGTGAG GAACTGACCA AGTACAAAAT CGTGACATTC 
TTGGGTTTAT ACAACAACCA GATCACTGAT ATCGGAGCCA GGTATGTGGC CCAAATCCTG 
GATGAATGCA GAGGCCTCAC GCACCTTAAA CTGGGGAAAA ACAGAATAAC AAGTGAGGGC 
GGCAGGTGTG TGGCCCAGGC TGTGAAGAAC AGCACCTCCA TTGTTGAGGT TGGGATGTGG 
GGCAATCAGA TTGGAGACGA GGGAGCAAAA GCCTTCGCAG AGGCGCTGAG GGACCACCCC 
AGCCTGACCA CTCTTAGTCT TGCATTCAAT GGCATCTCCC CGGAGGGAGG GAAGAGCCTT 
GCACAGGCCC TGAAGCAGAA CACCACTCTG ACAATAATCT GGCTGACCAA AAATGAACTT 
AATGATGAGG CCGCAGAGTG CTTCGCCGAG ATGCTGAGGG TGAACCAGAC ACTGAAGCAT 
TTATGGCTAA TCCAGAATCA TATCACAGCT GAGGGGACAG CCCAGCTGGC CAGGGCACTG 
CAGAAGAATA CCACCATCAC AGAGATTTGC CTCAATGGAA ACTTAATTAA GCCCGAGGAG 
GCCAAAGTCT TTGAAAATGA GAAGCGGATC ATCTGTTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102706.1
CDS	229..3090
Translation	MEKRGQHEMEGVPAGCHSHIKLLRINREHLVTNIRNTQCLVDNLLENGYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLWLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYMDTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLASKAKFFFHFRCRMFSCFKESDTLTLQDLLFKHFCYPEQDPEEVFSFLLRFPHTALFTFDGLDELHSDFDMSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTARTGVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFHTAFEGSSQLPDCAVTLTDVFLLVTEVHLNRTQPISLMQRNTRSPAETLRAGWRTLQALGEVAHRGTDRSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQSQQSYEFFHLTLQAFFTAFFLVADDKVSTQELLRFFREWTSPGEATSRSCYPSFFSFQCLGSGSRLGPDPFKNKDHFQFTNLFLCGLLAKARQKLLQQLVPKAILRKKRKALWAHLFASLRSYLKSLPRVQSDGFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVRELQPCFSRLTVIRLSVNQITDMGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLTHLKLGKNRITSEGGRCVAQAVKNSTSIVEVGMWGNQIGDEGAKAFAEALRDHPSLTTLSLAFNGISPEGGKSLAQALKQNTTLTIIWLTKNELNDEAAECFAEMLRVNQTLKHLWLIQNHITAEGTAQLARALQKNTTITEICLNGNLIKPEEAKVFENEKRIICF

Target ORF information:

RefSeq Version	NM_001109236.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nucleotide-binding oligomerization domain containing 1 (Nod1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109236.1

ORF Insert Sequence:

ATGGAGAAGC GCGGCCAACA TGAGATGGAA GGCGTCCCAG CCGGTTGTCA CTCCCACATT 
AAACTGTTGA GGATCAACAG GGAACACCTG GTCACCAACA TTCGGAACAC TCAGTGCCTG 
GTGGACAACT TGCTGGAGAA CGGTTACTTC TCAGCCGAGG ATGCAGAGAT CGTGTGTGCT 
TGTCCTACCC AGCCTGACAA GGTCCGAAAG ATCCTTGACC TGGTGCAGAG CAAAGGTGAG 
GAGGTGTCTG AGTTCTTCCT CTACGTGCTA CAGCAGCTGG AGGATGCTTA CGTGGACCTC 
AGGCTGTGGC TATCAGAGAT TGGCTTCTCC CCTTCCCAGC TCATCCGGAC CAAAACTATC 
GTCAATACTG ACCCAGTAAG CAGGTATACC CAGCAGCTGC GACACCAACT GGGCCGCGAT 
TCCAAGTTCA TGCTGTGCTA CGCTCAGAAG GAGGACCTGC TGCTGGAGGA GACCTATATG 
GACACACTCA TGGAGCTGGT AGGCTTCAAC AATGAAAACC TGGGCAGCCT AGGAGGCCTG 
GATTGCCTGC TGGACCACAG CACAGGTGTC CTCAACGAGC ATGGCGAGAC TGTCTTCGTG 
TTCGGGGACG CGGGAGTTGG CAAGTCCATG TTGCTACAGA GGTTGCAGAG CCTCTGGGCG 
TCTGGCAGGC TGGCCTCAAA AGCCAAATTC TTCTTCCACT TTCGCTGCCG TATGTTCAGC 
TGCTTCAAGG AGAGCGACAC ATTGACTCTG CAAGACCTGC TCTTCAAGCA TTTCTGCTAC 
CCGGAGCAGG ACCCCGAGGA GGTGTTCTCC TTCTTGCTGC GCTTTCCCCA CACAGCGCTC 
TTCACTTTTG ACGGCCTGGA TGAGCTGCAC TCAGACTTCG ACATGAGCCG CGTGCCGGAC 
AGCTGCTGCC CCTGGGAGCC GGCGCACCCT CTGGTCCTGC TAGCTAACCT CCTAAGCGGG 
AGGTTGCTCA AGGGTGCGGG CAAACTGCTC ACTGCTCGCA CAGGCGTGGA GGTCCCCCGC 
CAGCTCCTGC GCAAAAAGGT GCTGCTCCGG GGTTTTTCCC CCAGCCACCT GAGAGCCTAT 
GCCCGCCGGA TGTTCCCCGA GCGCACCGCG CAGGAACATC TGCTGCAGCA GCTGGATGCC 
AACCCCAACC TCTGCAGCCT GTGCGGGGTG CCGCTCTTCT GCTGGATCAT CTTCCGATGT 
TTCCAGCATT TCCACACGGC CTTCGAGGGC TCCTCGCAGC TGCCGGACTG CGCTGTGACC 
CTGACCGATG TCTTTCTGCT GGTCACCGAG GTGCATCTGA ACAGGACGCA GCCCATCAGC 
CTGATGCAGC GAAACACGCG CAGCCCGGCG GAAACCCTAC GTGCAGGCTG GCGCACGCTG 
CAGGCGCTGG GAGAGGTGGC TCACCGAGGC ACGGACAGGA GTCTCTTTGT GTTTGGCCAG 
GAGGAGGTGC AGGCGTCGAA ACTGCAGGAA GGGGATCTGC AGCTGGGTTT CCTGCGGGCT 
TTGCCCGATG TGGGCCCTGA ACAAAGTCAG CAGTCTTATG AATTTTTCCA CCTTACGCTC 
CAGGCTTTCT TCACTGCCTT CTTCCTGGTA GCAGATGACA AAGTGAGCAC CCAGGAATTG 
CTAAGGTTCT TTCGAGAATG GACGTCTCCC GGGGAGGCAA CAAGCAGGTC CTGCTATCCT 
TCCTTCTTCT CCTTCCAGTG CCTGGGTAGC GGTAGCCGGT TGGGCCCTGA TCCTTTCAAG 
AACAAAGATC ACTTCCAGTT CACCAACCTC TTCTTGTGCG GGCTGCTGGC CAAAGCCCGA 
CAGAAACTCC TTCAGCAGCT GGTGCCCAAG GCTATCCTAA GGAAGAAGCG CAAGGCCCTG 
TGGGCTCACC TGTTTGCCAG CCTGCGCTCC TACTTGAAGA GCCTACCCCG GGTCCAGTCT 
GATGGGTTTA ACCAGGTACA TGCCATGCCC ACATTCCTGT GGATGCTGCG CTGCATCTAT 
GAGACACAGA GTCAGAAGGT GGGGCGCTTA GCCGCCAGGG GCATCAGTGC GGACTACCTC 
AAGCTAGCCT TCTGCAATGC TTGTTCTGCC GACTGTAGTG CCTTGTCCTT CGTCCTGCAT 
CACTTCCACA GACAGCTGGC CCTAGACCTG GACAACAACA ACCTCAATGA CTATGGAGTT 
CGAGAGCTGC AGCCTTGCTT TAGCCGTCTC ACGGTTATCA GACTCAGTGT CAACCAGATC 
ACCGACATGG GGGTGAAGGT GCTGTGTGAG GAACTGACCA AGTACAAAAT CGTGACATTC 
TTGGGTTTAT ACAACAACCA GATCACTGAT ATCGGAGCCA GGTATGTGGC CCAAATCCTG 
GATGAATGCA GAGGCCTCAC GCACCTTAAA CTGGGGAAAA ACAGAATAAC AAGTGAGGGC 
GGCAGGTGTG TGGCCCAGGC TGTGAAGAAC AGCACCTCCA TTGTTGAGGT TGGGATGTGG 
GGCAATCAGA TTGGAGACGA GGGAGCAAAA GCCTTCGCAG AGGCGCTGAG GGACCACCCC 
AGCCTGACCA CTCTTAGTCT TGCATTCAAT GGCATCTCCC CGGAGGGAGG GAAGAGCCTT 
GCACAGGCCC TGAAGCAGAA CACCACTCTG ACAATAATCT GGCTGACCAA AAATGAACTT 
AATGATGAGG CCGCAGAGTG CTTCGCCGAG ATGCTGAGGG TGAACCAGAC ACTGAAGCAT 
TTATGGCTAA TCCAGAATCA TATCACAGCT GAGGGGACAG CCCAGCTGGC CAGGGCACTG 
CAGAAGAATA CCACCATCAC AGAGATTTGC CTCAATGGAA ACTTAATTAA GCCCGAGGAG 
GCCAAAGTCT TTGAAAATGA GAAGCGGATC ATCTGTTTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nod1 ( XM_008762910.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008761132.1 Rattus norvegicus nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa49315
Clone ID Related Accession (Same CDS sequence)	XM_008762910.2
Accession Version	XM_008762910.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2373bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	nucleotide-binding oligomerization domain-containing protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008762910.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAAGC GCGGCCAACA TGAGATGGAA GGCGTCCCAG CCGGTTGTCA CTCCCACATT 
AAACTGTTGA GGATCAACAG GGAACACCTG GTCACCAACA TTCGGAACAC TCAGTGCCTG 
GTGGACAACT TGCTGGAGAA CGGTTACTTC TCAGCCGAGG ATGCAGAGAT CGTGTGTGCT 
TGTCCTACCC AGCCTGACAA GGTCCGAAAG ATCCTTGACC TGGTGCAGAG CAAAGGTGAG 
GAGGTGTCTG AGTTCTTCCT CTACGTGCTA CAGCAGCTGG AGGATGCTTA CGTGGACCTC 
AGGCTGTGGC TATCAGAGAT TGGCTTCTCC CCTTCCCAGC TCATCCGGAC CAAAACTATC 
GTCAATACTG ACCCAGTAAG CAGGTATACC CAGCAGCTGC GACACCAACT GGGCCGCGAT 
TCCAAGTTCA TGCTGTGCTA CGCTCAGAAG GAGGACCTGC TGCTGGAGGA GACCTATATG 
GACACACTCA TGGAGCTGGT AGGCTTCAAC AATGAAAACC TGGGCAGCCT AGGAGGCCTG 
GATTGCCTGC TGGACCACAG CACAGGTGTC CTCAACGAGC ATGGCGAGAC TGTCTTCGTG 
TTCGGGGACG CGGGAGTTGG CAAGTCCATG TTGCTACAGA GGTTGCAGAG CCTCTGGGCG 
TCTGGCAGGC TGGCCTCAAA AGCCAAATTC TTCTTCCACT TTCGCTGCCG TATGTTCAGC 
TGCTTCAAGG AGAGCGACAC ATTGACTCTG CAAGACCTGC TCTTCAAGCA TTTCTGCTAC 
CCGGAGCAGG ACCCCGAGGA GGTGTTCTCC TTCTTGCTGC GCTTTCCCCA CACAGCGCTC 
TTCACTTTTG ACGGCCTGGA TGAGCTGCAC TCAGACTTCG ACATGAGCCG CGTGCCGGAC 
AGCTGCTGCC CCTGGGAGCC GGCGCACCCT CTGGTCCTGC TAGCTAACCT CCTAAGCGGG 
AGGTTGCTCA AGGGTGCGGG CAAACTGCTC ACTGCTCGCA CAGGCGTGGA GGTCCCCCGC 
CAGCTCCTGC GCAAAAAGGT GCTGCTCCGG GGTTTTTCCC CCAGCCACCT GAGAGCCTAT 
GCCCGCCGGA TGTTCCCCGA GCGCACCGCG CAGGAACATC TGCTGCAGCA GCTGGATGCC 
AACCCCAACC TCTGCAGCCT GTGCGGGGTG CCGCTCTTCT GCTGGATCAT CTTCCGATGT 
TTCCAGCATT TCCACACGGC CTTCGAGGGC TCCTCGCAGC TGCCGGACTG CGCTGTGACC 
CTGACCGATG TCTTTCTGCT GGTCACCGAG GTGCATCTGA ACAGGACGCA GCCCATCAGC 
CTGATGCAGC GAAACACGCG CAGCCCGGCG GAAACCCTAC GTGCAGGCTG GCGCACGCTG 
CAGGCGCTGG GAGAGGTGGC TCACCGAGGC ACGGACAGGA GTCTCTTTGT GTTTGGCCAG 
GAGGAGGTGC AGGCGTCGAA ACTGCAGGAA GGGGATCTGC AGCTGGGTTT CCTGCGGGCT 
TTGCCCGATG TGGGCCCTGA ACAAAGTCAG CAGTCTTATG AATTTTTCCA CCTTACGCTC 
CAGGCTTTCT TCACTGCCTT CTTCCTGGTA GCAGATGACA AAGTGAGCAC CCAGGAATTG 
CTAAGGTTCT TTCGAGAATG GACGTCTCCC GGGGAGGCAA CAAGCAGGTC CTGCTATCCT 
TCCTTCTTCT CCTTCCAGTG CCTGGGTAGC GGTAGCCGGT TGGGCCCTGA TCCTTTCAAG 
AACAAAGATC ACTTCCAGTT CACCAACCTC TTCTTGTGCG GGCTGCTGGC CAAAGCCCGA 
CAGAAACTCC TTCAGCAGCT GGTGCCCAAG GCTATCCTAA GGAAGAAGCG CAAGGCCCTG 
TGGGCTCACC TGTTTGCCAG CCTGCGCTCC TACTTGAAGA GCCTACCCCG GGTCCAGTCT 
GATGGGTTTA ACCAGGTACA TGCCATGCCC ACATTCCTGT GGATGCTGCG CTGCATCTAT 
GAGACACAGA GTCAGAAGGT GGGGCGCTTA GCCGCCAGGG GCATCAGTGC GGACTACCTC 
AAGCTAGCCT TCTGCAATGC TTGTTCTGCC GACTGTAGTG CCTTGTCCTT CGTCCTGCAT 
CACTTCCACA GACAGCTGGC CCTAGACCTG GACAACAACA ACCTCAATGA CTATGGAGTT 
CGAGAGCTGC AGCCTTGCTT TAGCCGTCTC ACGGTTATCA GACTCAGTGT CAACCAGATC 
ACCGACATGG GGGTGAAGGT GCTGTGTGAG GAACTGACCA AGTACAAAAT CGTGACATTC 
TTGGGTTTAT ACAACAACCA GATCACTGAT ATCGGAGCCA GGTATGTGGC CCAAATCCTG 
GATGAATGCA GAGGCCTCAC GCACCTTAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008761132.1
CDS	504..2876
Translation	MEKRGQHEMEGVPAGCHSHIKLLRINREHLVTNIRNTQCLVDNLLENGYFSAEDAEIVCACPTQPDKVRKILDLVQSKGEEVSEFFLYVLQQLEDAYVDLRLWLSEIGFSPSQLIRTKTIVNTDPVSRYTQQLRHQLGRDSKFMLCYAQKEDLLLEETYMDTLMELVGFNNENLGSLGGLDCLLDHSTGVLNEHGETVFVFGDAGVGKSMLLQRLQSLWASGRLASKAKFFFHFRCRMFSCFKESDTLTLQDLLFKHFCYPEQDPEEVFSFLLRFPHTALFTFDGLDELHSDFDMSRVPDSCCPWEPAHPLVLLANLLSGRLLKGAGKLLTARTGVEVPRQLLRKKVLLRGFSPSHLRAYARRMFPERTAQEHLLQQLDANPNLCSLCGVPLFCWIIFRCFQHFHTAFEGSSQLPDCAVTLTDVFLLVTEVHLNRTQPISLMQRNTRSPAETLRAGWRTLQALGEVAHRGTDRSLFVFGQEEVQASKLQEGDLQLGFLRALPDVGPEQSQQSYEFFHLTLQAFFTAFFLVADDKVSTQELLRFFREWTSPGEATSRSCYPSFFSFQCLGSGSRLGPDPFKNKDHFQFTNLFLCGLLAKARQKLLQQLVPKAILRKKRKALWAHLFASLRSYLKSLPRVQSDGFNQVHAMPTFLWMLRCIYETQSQKVGRLAARGISADYLKLAFCNACSADCSALSFVLHHFHRQLALDLDNNNLNDYGVRELQPCFSRLTVIRLSVNQITDMGVKVLCEELTKYKIVTFLGLYNNQITDIGARYVAQILDECRGLTHLK

Target ORF information:

RefSeq Version	XM_008762910.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008762910.2

ORF Insert Sequence:

ATGGAGAAGC GCGGCCAACA TGAGATGGAA GGCGTCCCAG CCGGTTGTCA CTCCCACATT 
AAACTGTTGA GGATCAACAG GGAACACCTG GTCACCAACA TTCGGAACAC TCAGTGCCTG 
GTGGACAACT TGCTGGAGAA CGGTTACTTC TCAGCCGAGG ATGCAGAGAT CGTGTGTGCT 
TGTCCTACCC AGCCTGACAA GGTCCGAAAG ATCCTTGACC TGGTGCAGAG CAAAGGTGAG 
GAGGTGTCTG AGTTCTTCCT CTACGTGCTA CAGCAGCTGG AGGATGCTTA CGTGGACCTC 
AGGCTGTGGC TATCAGAGAT TGGCTTCTCC CCTTCCCAGC TCATCCGGAC CAAAACTATC 
GTCAATACTG ACCCAGTAAG CAGGTATACC CAGCAGCTGC GACACCAACT GGGCCGCGAT 
TCCAAGTTCA TGCTGTGCTA CGCTCAGAAG GAGGACCTGC TGCTGGAGGA GACCTATATG 
GACACACTCA TGGAGCTGGT AGGCTTCAAC AATGAAAACC TGGGCAGCCT AGGAGGCCTG 
GATTGCCTGC TGGACCACAG CACAGGTGTC CTCAACGAGC ATGGCGAGAC TGTCTTCGTG 
TTCGGGGACG CGGGAGTTGG CAAGTCCATG TTGCTACAGA GGTTGCAGAG CCTCTGGGCG 
TCTGGCAGGC TGGCCTCAAA AGCCAAATTC TTCTTCCACT TTCGCTGCCG TATGTTCAGC 
TGCTTCAAGG AGAGCGACAC ATTGACTCTG CAAGACCTGC TCTTCAAGCA TTTCTGCTAC 
CCGGAGCAGG ACCCCGAGGA GGTGTTCTCC TTCTTGCTGC GCTTTCCCCA CACAGCGCTC 
TTCACTTTTG ACGGCCTGGA TGAGCTGCAC TCAGACTTCG ACATGAGCCG CGTGCCGGAC 
AGCTGCTGCC CCTGGGAGCC GGCGCACCCT CTGGTCCTGC TAGCTAACCT CCTAAGCGGG 
AGGTTGCTCA AGGGTGCGGG CAAACTGCTC ACTGCTCGCA CAGGCGTGGA GGTCCCCCGC 
CAGCTCCTGC GCAAAAAGGT GCTGCTCCGG GGTTTTTCCC CCAGCCACCT GAGAGCCTAT 
GCCCGCCGGA TGTTCCCCGA GCGCACCGCG CAGGAACATC TGCTGCAGCA GCTGGATGCC 
AACCCCAACC TCTGCAGCCT GTGCGGGGTG CCGCTCTTCT GCTGGATCAT CTTCCGATGT 
TTCCAGCATT TCCACACGGC CTTCGAGGGC TCCTCGCAGC TGCCGGACTG CGCTGTGACC 
CTGACCGATG TCTTTCTGCT GGTCACCGAG GTGCATCTGA ACAGGACGCA GCCCATCAGC 
CTGATGCAGC GAAACACGCG CAGCCCGGCG GAAACCCTAC GTGCAGGCTG GCGCACGCTG 
CAGGCGCTGG GAGAGGTGGC TCACCGAGGC ACGGACAGGA GTCTCTTTGT GTTTGGCCAG 
GAGGAGGTGC AGGCGTCGAA ACTGCAGGAA GGGGATCTGC AGCTGGGTTT CCTGCGGGCT 
TTGCCCGATG TGGGCCCTGA ACAAAGTCAG CAGTCTTATG AATTTTTCCA CCTTACGCTC 
CAGGCTTTCT TCACTGCCTT CTTCCTGGTA GCAGATGACA AAGTGAGCAC CCAGGAATTG 
CTAAGGTTCT TTCGAGAATG GACGTCTCCC GGGGAGGCAA CAAGCAGGTC CTGCTATCCT 
TCCTTCTTCT CCTTCCAGTG CCTGGGTAGC GGTAGCCGGT TGGGCCCTGA TCCTTTCAAG 
AACAAAGATC ACTTCCAGTT CACCAACCTC TTCTTGTGCG GGCTGCTGGC CAAAGCCCGA 
CAGAAACTCC TTCAGCAGCT GGTGCCCAAG GCTATCCTAA GGAAGAAGCG CAAGGCCCTG 
TGGGCTCACC TGTTTGCCAG CCTGCGCTCC TACTTGAAGA GCCTACCCCG GGTCCAGTCT 
GATGGGTTTA ACCAGGTACA TGCCATGCCC ACATTCCTGT GGATGCTGCG CTGCATCTAT 
GAGACACAGA GTCAGAAGGT GGGGCGCTTA GCCGCCAGGG GCATCAGTGC GGACTACCTC 
AAGCTAGCCT TCTGCAATGC TTGTTCTGCC GACTGTAGTG CCTTGTCCTT CGTCCTGCAT 
CACTTCCACA GACAGCTGGC CCTAGACCTG GACAACAACA ACCTCAATGA CTATGGAGTT 
CGAGAGCTGC AGCCTTGCTT TAGCCGTCTC ACGGTTATCA GACTCAGTGT CAACCAGATC 
ACCGACATGG GGGTGAAGGT GCTGTGTGAG GAACTGACCA AGTACAAAAT CGTGACATTC 
TTGGGTTTAT ACAACAACCA GATCACTGAT ATCGGAGCCA GGTATGTGGC CCAAATCCTG 
GATGAATGCA GAGGCCTCAC GCACCTTAAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of Nucleotide-Binding and Oligomerization Domain-Like Receptors in the Intestinal Injury of Severe Acute Pancreatitis in Rats.
Pancreas47(2)245-251(2018 Feb)
Xu S,Wei S,Guo Y,Cui D,Yao J

High Glucose and Lipopolysaccharide Activate NOD1- RICK-NF-?B Inflammatory Signaling in Mesangial Cells.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association124(8)512-517(2016 Sep)
Huang W,Gou F,Long Y,Li Y,Feng H,Zhang Q,Gao C,Chen G,Xu Y

Functional Roles of NOD1 in Odontoblasts on Dental Pulp Innate Immunity.
BioMed research international20169325436(2016)
Hosokawa Y,Hirao K,Yumoto H,Washio A,Nakanishi T,Takegawa D,Kitamura C,Matsuo T

NOD1 and NOD2 Interact with the Phagosome Cargo in Mast Cells: A Detailed Morphological Evidence.
Inflammation38(3)1113-25(2015)
Zabucchi G,Trevisan E,Vita F,Soranzo MR,Borelli V

Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators.
FEBS letters588(18)3382-9(2014 Sep)
Parkhouse R,Boyle JP,Monie TP