Cd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd2
Entrez Gene ID	497761
Full Name	Cd2 molecule
Synonyms	CD2R,LFA-2,LFA2,OX-34,OX34
General protein information	Preferred Names Cd2 molecule Names T-cell surface antigen CD2 CD2 antigen LFA-3 receptor OX-34 antigen OX-45 surface antigen homolog to human T lymphocyte CD2 antigen T-cell surface antigen T11/Leu-5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	cell surface antigen involved in T lymphocyte activation and proliferation; interacts with CD5 [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012830.1	NP_036962.1	T-cell surface antigen CD2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cd2	NP_036962.1
Mus musculus (house mouse)	Cd2	NP_038514.1
Homo sapiens (human)	CD2	NP_001758.2
Pan troglodytes (chimpanzee)	CD2	NP_001180592.1
	CD2	XP_001112881.1
Bos taurus (cattle)	CD2	NP_001011676.2
Gallus gallus (chicken)	CD2	XP_001232013.2
Canis lupus familiaris (dog)	CD2	XP_849219.1
Xenopus tropicalis (tropical clawed frog)	LOC100487379	XP_002943736.1

Gene Ontology
Bibliography

Related articles in PubMed

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M
Nature immunology12(5)450-9(2011 May)

Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction.
Ebert EC, Panja A, Praveen R
American journal of physiology. Gastrointestinal and liver physiology296(3)G671-7(2009 Mar)

In vivo proliferation of rat lamina propria T lymphocytes: general hyporesponsiveness but increased importance of the CD2 and CD28 pathways.
Hoffmann JC, Peters K, Pawlowski NN, Grollich K, Henschke S, Herrmann B, Zeitz M, Westermann J
Immunological investigations38(6)466-82(2009)

Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2.
Nunes RJ, Castro MA, Gon?alves CM, Bamberger M, Pereira CF, Bismuth G, Carmo AM
Journal of immunology (Baltimore, Md. : 1950)180(2)988-97(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD2/CD28 costimulation is the strongest T cell stimulus in vivo in rat lamina propria.
Title: In vivo proliferation of rat lamina propria T lymphocytes: general hyporesponsiveness but increased importance of the CD2 and CD28 pathways.

CD48 is a CD2 and CD244 (2B4)-binding protein
Title: Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.

Data show that designed cyclic peptides with beta-turn structure have the ability to modulate the CD2-CD58 interaction, which is critical for an immune response.
Title: Design, structure and biological activity of beta-turn peptides of CD2 protein for inhibition of T-cell adhesion.

The fact that both the extracellular and the cytoplasmic domains of CD2 interact with CD5 suggests a specific and tight association between the two molecules, possibly relevant for the fine-tuning of signal transduction in T lymphocytes.
Title: CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains.

Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Review.
Title: Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation.

The following Cd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01063	NM_012830.1 Latest version!	Rattus norvegicus Cd2 molecule (Cd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd2 ( NM_012830.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036962.1 Rattus norvegicus Cd2 molecule (Cd2), mRNA.

Price & Availability↑

CloneID	ORa01063
Clone ID Related Accession (Same CDS sequence)	NM_012830.1
Accession Version	NM_012830.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	T-cell surface antigen CD2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X05111.1. On Jan 12, 2005 this sequence version replaced XM_346638.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X05111.1, BC088164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGAGATGTA AATTCCTAGG GAGTTTCTTT CTGCTCTTCA GCCTGTCCAG CAAAGGAGCA 
GACTGCAGAG ACAGTGGGAC CGTCTGGGGT GCCCTGGGTC ATGGCATCAA CCTGAACATC 
CCTAACTTTC AAATGACTGA TGATATTGAT GAGGTGCGAT GGGAGAGGGG GAGCACCCTG 
GTTGCCGAGT TTAAAAGGAA GATGAAGCCT TTTTTGAAAT CGGGAGCATT TGAGATCTTA 
GCAAATGGAG ACTTGAAGAT AAAGAATCTG ACAAGAGATG ACAGTGGCAC CTATAATGTA 
ACGGTATACA GCACAAATGG GACACGTATC CTGGACAAGG CACTGGACTT GAGGATTCTA 
GAGATGGTCT CAAAGCCGAT GATCTACTGG GAGTGCAGCA ACGCAACCCT GACCTGTGAG 
GTCTTGGAAG GAACAGATGT TGAACTAAAG CTGTACCAAG GAAAGGAGCA TCTCAGGAGC 
CTCCGTCAGA AGACCATGAG TTACCAGTGG ACCAACCTGA GAGCACCGTT TAAGTGCAAG 
GCGGTAAACA GGGTCAGCCA GGAGTCTGAG ATGGAAGTTG TCAACTGTCC AGAGAAAGGT 
CTGCCCCTCT ATCTCATAGT GGGGGTCAGT GCAGGAGGAC TCCTCTTGGT GTTCTTTGGG 
GCGCTGTTTA TTTTCTGTAT CTGCAAGAGG AAAAAACGGA ACAGGAGGAG AAAAGGTGAA 
GAGCTGGAGA TAAAAGCTTC CAGAATGAGC ACTGTGGAAA GGGGACCCAA GCCACACTCA 
ACCCAGGCCT CAGCACCAGC ATCACAGAAT CCAGTGGCTT CCCAAGCTCC TCCTCCACCT 
GGCCATCATC TCCAGACACC TGGCCATCGT CCCCTGCCTC CAAGCCACCG TAACCGTGAG 
CACCAGCCGA AGAAGAGACC TCCTCCATCA GGCACACAGG TTCACCAGCA GAAAGGCCCT 
CCTTTGCCCA GACCCCGAGT TCAGCCAAAG CCTCCCTGTG GGAGTGGAGA TGTTTCGTTG 
CCACCCCCTA ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036962.1
CDS	91..1125
Translation	MRCKFLGSFFLLFSLSSKGADCRDSGTVWGALGHGINLNIPNFQMTDDIDEVRWERGSTLVAEFKRKMKPFLKSGAFEILANGDLKIKNLTRDDSGTYNVTVYSTNGTRILDKALDLRILEMVSKPMIYWECSNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLRAPFKCKAVNRVSQESEMEVVNCPEKGLPLYLIVGVSAGGLLLVFFGALFIFCICKRKKRNRRRKGEELEIKASRMSTVERGPKPHSTQASAPASQNPVASQAPPPPGHHLQTPGHRPLPPSHRNREHQPKKRPPPSGTQVHQQKGPPLPRPRVQPKPPCGSGDVSLPPPN

Target ORF information:

RefSeq Version	NM_012830.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Cd2 molecule (Cd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012830.1

ORF Insert Sequence:

ATGAGATGTA AATTCCTAGG GAGTTTCTTT CTGCTCTTCA GCCTGTCCAG CAAAGGAGCA 
GACTGCAGAG ACAGTGGGAC CGTCTGGGGT GCCCTGGGTC ATGGCATCAA CCTGAACATC 
CCTAACTTTC AAATGACTGA TGATATTGAT GAGGTGCGAT GGGAGAGGGG GAGCACCCTG 
GTTGCCGAGT TTAAAAGGAA GATGAAGCCT TTTTTGAAAT CGGGAGCATT TGAGATCTTA 
GCAAATGGAG ACTTGAAGAT AAAGAATCTG ACAAGAGATG ACAGTGGCAC CTATAATGTA 
ACGGTATACA GCACAAATGG GACACGTATC CTGGACAAGG CACTGGACTT GAGGATTCTA 
GAGATGGTCT CAAAGCCGAT GATCTACTGG GAGTGCAGCA ACGCAACCCT GACCTGTGAG 
GTCTTGGAAG GAACAGATGT TGAACTAAAG CTGTACCAAG GAAAGGAGCA TCTCAGGAGC 
CTCCGTCAGA AGACCATGAG TTACCAGTGG ACCAACCTGA GAGCACCGTT TAAGTGCAAG 
GCGGTAAACA GGGTCAGCCA GGAGTCTGAG ATGGAAGTTG TCAACTGTCC AGAGAAAGGT 
CTGCCCCTCT ATCTCATAGT GGGGGTCAGT GCAGGAGGAC TCCTCTTGGT GTTCTTTGGG 
GCGCTGTTTA TTTTCTGTAT CTGCAAGAGG AAAAAACGGA ACAGGAGGAG AAAAGGTGAA 
GAGCTGGAGA TAAAAGCTTC CAGAATGAGC ACTGTGGAAA GGGGACCCAA GCCACACTCA 
ACCCAGGCCT CAGCACCAGC ATCACAGAAT CCAGTGGCTT CCCAAGCTCC TCCTCCACCT 
GGCCATCATC TCCAGACACC TGGCCATCGT CCCCTGCCTC CAAGCCACCG TAACCGTGAG 
CACCAGCCGA AGAAGAGACC TCCTCCATCA GGCACACAGG TTCACCAGCA GAAAGGCCCT 
CCTTTGCCCA GACCCCGAGT TCAGCCAAAG CCTCCCTGTG GGAGTGGAGA TGTTTCGTTG 
CCACCCCCTA ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Nature immunology14(8)858-66(2013 Aug)
Liang Y,Cucchetti M,Roncagalli R,Yokosuka T,Malzac A,Bertosio E,Imbert J,Nijman IJ,Suchanek M,Saito T,W?lfing C,Malissen B,Malissen M

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Nature immunology12(5)450-9(2011 May)
Motomura Y,Kitamura H,Hijikata A,Matsunaga Y,Matsumoto K,Inoue H,Atarashi K,Hori S,Watarai H,Zhu J,Taniguchi M,Kubo M

Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction.
American journal of physiology. Gastrointestinal and liver physiology296(3)G671-7(2009 Mar)
Ebert EC,Panja A,Praveen R

In vivo proliferation of rat lamina propria T lymphocytes: general hyporesponsiveness but increased importance of the CD2 and CD28 pathways.
Immunological investigations38(6)466-82(2009)
Hoffmann JC,Peters K,Pawlowski NN,Grollich K,Henschke S,Herrmann B,Zeitz M,Westermann J

Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2.
Journal of immunology (Baltimore, Md. : 1950)180(2)988-97(2008 Jan)
Nunes RJ,Castro MA,Gon?alves CM,Bamberger M,Pereira CF,Bismuth G,Carmo AM

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

[email protected]

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Cd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム