Kcnk18 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnk18
Entrez Gene ID	445371
Full Name	potassium two pore domain channel subfamily K member 18
Synonyms	Tresk-2
General protein information	Preferred Names potassium two pore domain channel subfamily K member 18 Names potassium channel subfamily K member 18 potassium channel, subfamily K, member 18 potassium channel, two pore domain subfamily K, member 18 tandem-pore K+ (K(2P)) channel two-pore-domain potassium channel TRESK
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q55
Summary	mouse homolog induces a time-independent, noninactivating K+ current [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134912.1	NP_001128384.1	potassium channel subfamily K member 18 isoform 2
NM_001003820.1	NP_001003820.1	potassium channel subfamily K member 18 isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcnk18	NP_001003820.1
Danio rerio (zebrafish)	kcnk18	NP_001177236.2
Homo sapiens (human)	KCNK18	NP_862823.1
Pan troglodytes (chimpanzee)	KCNK18	XP_521614.2
Mus musculus (house mouse)	Kcnk18	NP_997144.1
Gallus gallus (chicken)	KCNK18	XP_001234729.2
Xenopus tropicalis (tropical clawed frog)	LOC100486306	XP_002943434.2
	KCNK18	XP_001095493.1
Canis lupus familiaris (dog)	KCNK18	XP_003640047.1
Bos taurus (cattle)	KCNK18	XP_002698581.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased Activation of the TRESK K
Grabauskas G, Wu X, Song I, Zhou SY, Lanigan T, Owyang C
Gastroenterology151(5)910-922.e7(2016 Nov)

Functional analysis of a migraine-associated TRESK K+ channel mutation.
Liu P, Xiao Z, Ren F, Guo Z, Chen Z, Zhao H, Cao YQ
The Journal of neuroscience : the official journal of the Society for Neuroscience33(31)12810-24(2013 Jul)

N-linked glycosylation determines cell surface expression of two-pore-domain K+ channel TRESK.
Egenberger B, Polleichtner G, Wischmeyer E, D?ring F
Biochemical and biophysical research communications391(2)1262-7(2010 Jan)

Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system.
Yoo S, Liu J, Sabbadini M, Au P, Xie GX, Yost CS
Neuroscience letters465(1)79-84(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In 2 rat models of diabetes, activation of the TRESK K(+) channel reduced nodose ganglia excitability and disrupted gastrointestinal functions.
Title: Increased Activation of the TRESK K

The endogenous TRESK currents control the onset and the frequency of action potential in small-diameter TG neurons and the frameshift mutation results in hyperexcitability of these neurons.
Title: Functional analysis of a migraine-associated TRESK K+ channel mutation.

These results provide an anatomic basis for identifying functional roles of TRESK in the rat nervous system.
Title: Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system.

TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells.
Title: Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family.

The following Kcnk18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnk18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09894	NM_001003820.1 Latest version!	Rattus norvegicus potassium two pore domain channel subfamily K member 18 (Kcnk18), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa42764	NM_001134912.1 Latest version!	Rattus norvegicus potassium two pore domain channel subfamily K member 18 (Kcnk18), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnk18 ( NM_001003820.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001003820.1 Rattus norvegicus potassium two pore domain channel subfamily K member 18 (Kcnk18), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa09894
Clone ID Related Accession (Same CDS sequence)	NM_001003820.1
Accession Version	NM_001003820.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	potassium channel subfamily K member 18 isoform 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY567970.1. On Apr 19, 2005 this sequence version replaced XM_579106.1. ##Evidence-Data-START## Transcript exon combination :: AY567970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04563757, SAMN04563758 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCTG AGGAGCCACC TGAAGCCAGA AGACGCTGTC CCGAGGCCCT GGGGAAGGCC 
AGCGGATGCT GCCCTGAGGC CCCGGGGAAG GCCAGAGGAT GCTGTCCTGA GGCCCTGGGC 
AAGCTTCTGC CCGGCCTCTG CTTCCTTTGC TGCCTGGTAA CCTATGCGCT GGTGGGTGCT 
GCTCTCTTCT CCGCTGTCGA GGGCCGCCCT GACCCAGAAG CAGAGGAGAA CCCTGAGTTG 
AAGAAGTTCC TGGACAAGCT GTGCAACATC CTGAAATGCA ACCTGACAGT GGTTGAAGGT 
AGCAGGAAAG ACCTGTGTGA GCATCTACAG CAGCTCAAGC CCCAGTGGTT CAAGGCGCCT 
GAGGACTGGT CCTTCTTGAG TGCTCTTTTC TTCTGCTGCA CAGTGTTCAG CACAGTGGGT 
TATGGCCACA TGTACCCCGT CACCAGGCTG GGTAAGTTCC TGTGCATGCT ATATGCACTC 
TTTGGAATCC CTTTAATGTT CCTGGTCCTC ACAGACATCG GGGACATCCT GGCCGCCATC 
TTATCTAGGG CTTACAGCCG GTTCCAGGCT CTCCTTTGCC TCCCCCGAGA TATCTCCAAG 
TGGCGCCCCC TTCTGCTATG CCGGAAGCAG ACTGACAGCA AACCCGCAGA TGAAGCCATC 
CCTCAGATTG TCATTGATGC TGGTGCAGAC GAGCTCCTAG ACCCACAGCC CAGCAGGGAG 
CCTGCATCTC CTAGCTGCAA TGTGGAGCTG TTTGAGAGAT TGGTTGCTCG AGAGAAACAG 
AACGAGCTAC AACCACCCAT GCGGCCGGTC GAGAGGAGCA ACTCGTGTCC CGAGCTGGTG 
CTGGGGCGGC TGTCCTGTTC TATTCTTAGC AATCTGGATG AAGTGGGCCA GCAAGTGGAG 
AGGCTGGACA TCCCTCTCCC CGTCATCGCG CTGGTCATCT TCGCGTACAT CTCCTGTGCA 
GCTGCTATCC TGCCCTTCTG GGAGACCGAC CTAGGCTTCG AGGATGCCTT CTACTTCTGC 
TTTGTGACAC TGACCACCAT TGGGTTCGGG GACATCGTGT TAGTGCACCC TCACTTCTTC 
CTCTTCTTCT CCATCTACAT CATCGTGGGC ATGGAGATCC TGTTCATCGC CTTCAAACTG 
ATGCAGAACC GGCTCCTGCA CACCTACAAA ACCCTCATGC TGTTTGTTTG CCAAAGAGAG 
GTTTCGCTAC CTTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003820.1
CDS	1..1218
Translation	MEAEEPPEARRRCPEALGKASGCCPEAPGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFSAVEGRPDPEAEENPELKKFLDKLCNILKCNLTVVEGSRKDLCEHLQQLKPQWFKAPEDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILAAILSRAYSRFQALLCLPRDISKWRPLLLCRKQTDSKPADEAIPQIVIDAGADELLDPQPSREPASPSCNVELFERLVAREKQNELQPPMRPVERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVIFAYISCAAAILPFWETDLGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYKTLMLFVCQREVSLPC

Target ORF information:

RefSeq Version	NM_001003820.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium two pore domain channel subfamily K member 18 (Kcnk18), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003820.1

ORF Insert Sequence:

ATGGAGGCTG AGGAGCCACC TGAAGCCAGA AGACGCTGTC CCGAGGCCCT GGGGAAGGCC 
AGCGGATGCT GCCCTGAGGC CCCGGGGAAG GCCAGAGGAT GCTGTCCTGA GGCCCTGGGC 
AAGCTTCTGC CCGGCCTCTG CTTCCTTTGC TGCCTGGTAA CCTATGCGCT GGTGGGTGCT 
GCTCTCTTCT CCGCTGTCGA GGGCCGCCCT GACCCAGAAG CAGAGGAGAA CCCTGAGTTG 
AAGAAGTTCC TGGACAAGCT GTGCAACATC CTGAAATGCA ACCTGACAGT GGTTGAAGGT 
AGCAGGAAAG ACCTGTGTGA GCATCTACAG CAGCTCAAGC CCCAGTGGTT CAAGGCGCCT 
GAGGACTGGT CCTTCTTGAG TGCTCTTTTC TTCTGCTGCA CAGTGTTCAG CACAGTGGGT 
TATGGCCACA TGTACCCCGT CACCAGGCTG GGTAAGTTCC TGTGCATGCT ATATGCACTC 
TTTGGAATCC CTTTAATGTT CCTGGTCCTC ACAGACATCG GGGACATCCT GGCCGCCATC 
TTATCTAGGG CTTACAGCCG GTTCCAGGCT CTCCTTTGCC TCCCCCGAGA TATCTCCAAG 
TGGCGCCCCC TTCTGCTATG CCGGAAGCAG ACTGACAGCA AACCCGCAGA TGAAGCCATC 
CCTCAGATTG TCATTGATGC TGGTGCAGAC GAGCTCCTAG ACCCACAGCC CAGCAGGGAG 
CCTGCATCTC CTAGCTGCAA TGTGGAGCTG TTTGAGAGAT TGGTTGCTCG AGAGAAACAG 
AACGAGCTAC AACCACCCAT GCGGCCGGTC GAGAGGAGCA ACTCGTGTCC CGAGCTGGTG 
CTGGGGCGGC TGTCCTGTTC TATTCTTAGC AATCTGGATG AAGTGGGCCA GCAAGTGGAG 
AGGCTGGACA TCCCTCTCCC CGTCATCGCG CTGGTCATCT TCGCGTACAT CTCCTGTGCA 
GCTGCTATCC TGCCCTTCTG GGAGACCGAC CTAGGCTTCG AGGATGCCTT CTACTTCTGC 
TTTGTGACAC TGACCACCAT TGGGTTCGGG GACATCGTGT TAGTGCACCC TCACTTCTTC 
CTCTTCTTCT CCATCTACAT CATCGTGGGC ATGGAGATCC TGTTCATCGC CTTCAAACTG 
ATGCAGAACC GGCTCCTGCA CACCTACAAA ACCCTCATGC TGTTTGTTTG CCAAAGAGAG 
GTTTCGCTAC CTTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnk18 ( NM_001134912.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001128384.1 Rattus norvegicus potassium two pore domain channel subfamily K member 18 (Kcnk18), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa42764
Clone ID Related Accession (Same CDS sequence)	NM_001134912.1
Accession Version	NM_001134912.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	potassium channel subfamily K member 18 isoform 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EU152989.1. ##Evidence-Data-START## Transcript exon combination :: EU152989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04563759 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCTG AGGAGCCACC TGAAGCCAGA AGACGCTGTC CCGAGGCCCT GGGGAAGGCC 
AGCGGATGCT GCCCTGAGGC CCCGGGGAAG GCCAGAGGAT GCTGTCCTGA GGCCCTGGGC 
AAGCTTCTGC CCGGCCTCTG CTTCCTTTGC TGCCTGGTAA CCTATGCGCT GGTGGGTGCT 
GCTCTCTTCT CCGCTGTCGA GGGCCGCCCT GACCCAGAAG CAGAGGAGAA CCCTGAGTTG 
AAGAAGTTCC TGGACAAGCT GTGCAACATC CTGAAATGCA ACCTGACAGG TTATGGCCAC 
ATGTACCCCG TCACCAGGCT GGGTAAGTTC CTGTGCATGC TATATGCACT CTTTGGAATC 
CCTTTAATGT TCCTGGTCCT CACAGACATC GGGGACATCC TGGCCGCCAT CTTATCTAGG 
GCTTACAGCC GGTTCCAGGC TCTCCTTTGC CTCCCCCGAG ATATCTCCAA GTGGCGCCCC 
CTTCTGCTAT GCCGGAAGCA GACTGACAGC AAACCCGCAG ATGAAGCCAT CCCTCAGATT 
GTCATTGATG CTGGTGCAGA CGAGCTCCTA GACCCACAGC CCAGCAGGGA GCCTGCATCT 
CCTAGCTGCA ATGTGGAGCT GTTTGAGAGA TTGGTTGCTC GAGAGAAACA GAACGAGCTA 
CAACCACCCA TGCGGCCGGT CGAGAGGAGC AACTCGTGTC CCGAGCTGGT GCTGGGGCGG 
CTGTCCTGTT CTATTCTTAG CAATCTGGAT GAAGTGGGCC AGCAAGTGGA GAGGCTGGAC 
ATCCCTCTCC CCGTCATCGC GCTGGTCATC TTCGCGTACA TCTCCTGTGC AGCTGCTATC 
CTGCCCTTCT GGGAGACCGA CCTAGGCTTC GAGGATGCCT TCTACTTCTG CTTTGTGACA 
CTGACCACCA TTGGGTTCGG GGACATCGTG TTAGTGCACC CTCACTTCTT CCTCTTCTTC 
TCCATCTACA TCATCGTGGG CATGGAGATC CTGTTCATCG CCTTCAAACT GATGCAGAAC 
CGGCTCCTGC ACACCTACAA AACCCTCATG CTGTTTGTTT GCCAAAGAGA GGTTTCGCTA 
CCTTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128384.1
CDS	35..1123
Translation	MEAEEPPEARRRCPEALGKASGCCPEAPGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFSAVEGRPDPEAEENPELKKFLDKLCNILKCNLTGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILAAILSRAYSRFQALLCLPRDISKWRPLLLCRKQTDSKPADEAIPQIVIDAGADELLDPQPSREPASPSCNVELFERLVAREKQNELQPPMRPVERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVIFAYISCAAAILPFWETDLGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYKTLMLFVCQREVSLPC

Target ORF information:

RefSeq Version	NM_001134912.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium two pore domain channel subfamily K member 18 (Kcnk18), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134912.1

ORF Insert Sequence:

ATGGAGGCTG AGGAGCCACC TGAAGCCAGA AGACGCTGTC CCGAGGCCCT GGGGAAGGCC 
AGCGGATGCT GCCCTGAGGC CCCGGGGAAG GCCAGAGGAT GCTGTCCTGA GGCCCTGGGC 
AAGCTTCTGC CCGGCCTCTG CTTCCTTTGC TGCCTGGTAA CCTATGCGCT GGTGGGTGCT 
GCTCTCTTCT CCGCTGTCGA GGGCCGCCCT GACCCAGAAG CAGAGGAGAA CCCTGAGTTG 
AAGAAGTTCC TGGACAAGCT GTGCAACATC CTGAAATGCA ACCTGACAGG TTATGGCCAC 
ATGTACCCCG TCACCAGGCT GGGTAAGTTC CTGTGCATGC TATATGCACT CTTTGGAATC 
CCTTTAATGT TCCTGGTCCT CACAGACATC GGGGACATCC TGGCCGCCAT CTTATCTAGG 
GCTTACAGCC GGTTCCAGGC TCTCCTTTGC CTCCCCCGAG ATATCTCCAA GTGGCGCCCC 
CTTCTGCTAT GCCGGAAGCA GACTGACAGC AAACCCGCAG ATGAAGCCAT CCCTCAGATT 
GTCATTGATG CTGGTGCAGA CGAGCTCCTA GACCCACAGC CCAGCAGGGA GCCTGCATCT 
CCTAGCTGCA ATGTGGAGCT GTTTGAGAGA TTGGTTGCTC GAGAGAAACA GAACGAGCTA 
CAACCACCCA TGCGGCCGGT CGAGAGGAGC AACTCGTGTC CCGAGCTGGT GCTGGGGCGG 
CTGTCCTGTT CTATTCTTAG CAATCTGGAT GAAGTGGGCC AGCAAGTGGA GAGGCTGGAC 
ATCCCTCTCC CCGTCATCGC GCTGGTCATC TTCGCGTACA TCTCCTGTGC AGCTGCTATC 
CTGCCCTTCT GGGAGACCGA CCTAGGCTTC GAGGATGCCT TCTACTTCTG CTTTGTGACA 
CTGACCACCA TTGGGTTCGG GGACATCGTG TTAGTGCACC CTCACTTCTT CCTCTTCTTC 
TCCATCTACA TCATCGTGGG CATGGAGATC CTGTTCATCG CCTTCAAACT GATGCAGAAC 
CGGCTCCTGC ACACCTACAA AACCCTCATG CTGTTTGTTT GCCAAAGAGA GGTTTCGCTA 
CCTTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased Activation of the TRESK K
Gastroenterology151(5)910-922.e7(2016 Nov)
Grabauskas G,Wu X,Song I,Zhou SY,Lanigan T,Owyang C

Functional analysis of a migraine-associated TRESK K+ channel mutation.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(31)12810-24(2013 Jul)
Liu P,Xiao Z,Ren F,Guo Z,Chen Z,Zhao H,Cao YQ

N-linked glycosylation determines cell surface expression of two-pore-domain K+ channel TRESK.
Biochemical and biophysical research communications391(2)1262-7(2010 Jan)
Egenberger B,Polleichtner G,Wischmeyer E,D?ring F

Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system.
Neuroscience letters465(1)79-84(2009 Nov)
Yoo S,Liu J,Sabbadini M,Au P,Xie GX,Yost CS

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Kcnk18 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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