Ap1m2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ap1m2
Entrez Gene ID	367038
Full Name	adaptor-related protein complex 1, mu 2 subunit
Synonyms	RGD1561490
General protein information	Preferred Names adaptor-related protein complex 1, mu 2 subunit Names AP-1 complex subunit mu-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108996.2	NP_001102466.1	AP-1 complex subunit mu-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	AP1M2	XP_001165482.2
Rattus norvegicus (Norway rat)	Ap1m2	NP_001102466.1
Caenorhabditis elegans (roundworm)	apm-1	NP_491572.2
Xenopus tropicalis (tropical clawed frog)	ap1m2	NP_001006851.1
Homo sapiens (human)	AP1M2	NP_005489.2
Canis lupus familiaris (dog)	AP1M2	XP_853941.2
Bos taurus (cattle)	AP1M2	NP_001029683.1
Mus musculus (house mouse)	Ap1m2	NP_001103770.1
Danio rerio (zebrafish)	ap1m2	NP_991277.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium.
Efendiev R, Krmar RT, Ogimoto G, Zwiller J, Tripodi G, Katz AI, Bianchi G, Pedemonte CH, Bertorello AM
Circulation research95(11)1100-8(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression of the hypertensive rat or human variant of adducin into normal renal epithelial cells recreates the hypertensive phenotype with higher Na+,K+-ATPase activity, adaptin-2 mu2-subunit hyperphosphorylation, and impaired Na+,K+-ATPase endocytosis.
Title: Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium.

The following Ap1m2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ap1m2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08799	NM_001108996.2 Latest version!	Rattus norvegicus adaptor related protein complex 1 subunit mu 2 (Ap1m2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ap1m2 ( NM_001108996.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102466.1 Rattus norvegicus adaptor related protein complex 1 subunit mu 2 (Ap1m2), mRNA.

Price & Availability↑

CloneID	ORa08799
Clone ID Related Accession (Same CDS sequence)	NM_001108996.2
Accession Version	NM_001108996.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-08
Organism	Rattus norvegicus(Norway rat)
Product	AP-1 complex subunit mu-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC167082.1. On May 11, 2008 this sequence version replaced NM_001108996.1. ##Evidence-Data-START## Transcript exon combination :: BC167082.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689597, SAMEA2689599 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGCCT CGGCAGTCTT CATTCTGGAC GTCAAGGGCA AGCCTCTGAT TAGCCGAAAC 
TACAAAGGCG ATGTGCCCAT GACGGAGATT GACCACTTCA TGCCTCTGCT TATGCAACGG 
GAGGAGGAGG GTATGCTGGC CCCGCTGCTG AGCCACGGCC GAGTGCACTT CTTGTGGATC 
AAACACAGCA ATCTCTACTT GGTGGCCACC ACACTGAAGA ACGCCAACGC CTCTCTGGTG 
TACTCCTTTC TGTACAAGAC TGTGGAGGTC TTCTGCGAGT ACTTTAAGGA GCTGGAGGAG 
GAGAGCATCC GAGACAACTT TGTCATTGTG TACGAGCTGC TGGACGAGCT GATGGACTTC 
GGCTTTCCGC AGACCACGGA CAGCAAGATC CTGCAGGAGT ACATCACACA GCAGGGCAAC 
AAGCTGGAGA CCGGCAAGTC TCGAGTGCCA CCGACAGTCA CCAATGCTGT GTCCTGGCGC 
TCCGAGGGCA TCAAGTACAA AAAGAACGAG GTCTTCATTG ATGTCATCGA GTCTGTTAAC 
CTTCTGGTGA ATGCTAATGG GAGTGTCTTG CTCAGCGAGA TTGTGGGCAC CATCAAGCTG 
AAGGTGTTTC TGTCTGGGAT GCCAGAGCTG CGGCTGGGCC TCAATGACCG AGTGCTCTTT 
GAGCTTACTG GCCGCAGCAA GAACAAGTCT GTGGAGCTGG AAGATGTGAA ATTCCACCAG 
TGTGTGAGGC TTTCACGCTT CGACAACGAC CGCACCATCT CCTTCATACC CCCGGATGGG 
GACTTCGAAC TCATGTCCTA CCGTCTCAGC ACCCAGGTCA AACCTCTGAT CTGGATCGAG 
TCAGTCATTG AGAAATTCTC CCACAGCCGA GTGGAGATCA TGGTGAAGGC CAAGGGTCAG 
TTTAAGAAGC AGTCGGTGGC CAACGGCGTG GAAATCTCTG TGCCTGTACC TAGCGATGCA 
GATTCTCCAC GCTTCAAGAC CAGTGTGGGC AGTGCCAAGT ATGTGCCTGA GAAGAATGTC 
GTCATTTGGA GCATCAAGTC TTTCCCTGGG GGCAAGGAGT ACTTGATGCG TGCCCATTTT 
GGCCTCCCCA GCGTGGAAAC TGAGGAGGTA GAGGGCCGGC CACCCATCGG TGTCAAGTTT 
GAGATTCCAT ACTTTACTGT TTCCGGCATC CAGGTCCGTT ACATGAAGAT CATCGAGAAA 
AGCGGGTACC AGGCCCTGCC CTGGGTCCGC TACATCACCC AGAGTGGTGA TTATCAACTT 
CGGACCAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102466.1
CDS	34..1305
Translation	MSASAVFILDVKGKPLISRNYKGDVPMTEIDHFMPLLMQREEEGMLAPLLSHGRVHFLWIKHSNLYLVATTLKNANASLVYSFLYKTVEVFCEYFKELEEESIRDNFVIVYELLDELMDFGFPQTTDSKILQEYITQQGNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGRSKNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPEKNVVIWSIKSFPGGKEYLMRAHFGLPSVETEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDYQLRTS

Target ORF information:

RefSeq Version	NM_001108996.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adaptor related protein complex 1 subunit mu 2 (Ap1m2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108996.2

ORF Insert Sequence:

ATGTCGGCCT CGGCAGTCTT CATTCTGGAC GTCAAGGGCA AGCCTCTGAT TAGCCGAAAC 
TACAAAGGCG ATGTGCCCAT GACGGAGATT GACCACTTCA TGCCTCTGCT TATGCAACGG 
GAGGAGGAGG GTATGCTGGC CCCGCTGCTG AGCCACGGCC GAGTGCACTT CTTGTGGATC 
AAACACAGCA ATCTCTACTT GGTGGCCACC ACACTGAAGA ACGCCAACGC CTCTCTGGTG 
TACTCCTTTC TGTACAAGAC TGTGGAGGTC TTCTGCGAGT ACTTTAAGGA GCTGGAGGAG 
GAGAGCATCC GAGACAACTT TGTCATTGTG TACGAGCTGC TGGACGAGCT GATGGACTTC 
GGCTTTCCGC AGACCACGGA CAGCAAGATC CTGCAGGAGT ACATCACACA GCAGGGCAAC 
AAGCTGGAGA CCGGCAAGTC TCGAGTGCCA CCGACAGTCA CCAATGCTGT GTCCTGGCGC 
TCCGAGGGCA TCAAGTACAA AAAGAACGAG GTCTTCATTG ATGTCATCGA GTCTGTTAAC 
CTTCTGGTGA ATGCTAATGG GAGTGTCTTG CTCAGCGAGA TTGTGGGCAC CATCAAGCTG 
AAGGTGTTTC TGTCTGGGAT GCCAGAGCTG CGGCTGGGCC TCAATGACCG AGTGCTCTTT 
GAGCTTACTG GCCGCAGCAA GAACAAGTCT GTGGAGCTGG AAGATGTGAA ATTCCACCAG 
TGTGTGAGGC TTTCACGCTT CGACAACGAC CGCACCATCT CCTTCATACC CCCGGATGGG 
GACTTCGAAC TCATGTCCTA CCGTCTCAGC ACCCAGGTCA AACCTCTGAT CTGGATCGAG 
TCAGTCATTG AGAAATTCTC CCACAGCCGA GTGGAGATCA TGGTGAAGGC CAAGGGTCAG 
TTTAAGAAGC AGTCGGTGGC CAACGGCGTG GAAATCTCTG TGCCTGTACC TAGCGATGCA 
GATTCTCCAC GCTTCAAGAC CAGTGTGGGC AGTGCCAAGT ATGTGCCTGA GAAGAATGTC 
GTCATTTGGA GCATCAAGTC TTTCCCTGGG GGCAAGGAGT ACTTGATGCG TGCCCATTTT 
GGCCTCCCCA GCGTGGAAAC TGAGGAGGTA GAGGGCCGGC CACCCATCGG TGTCAAGTTT 
GAGATTCCAT ACTTTACTGT TTCCGGCATC CAGGTCCGTT ACATGAAGAT CATCGAGAAA 
AGCGGGTACC AGGCCCTGCC CTGGGTCCGC TACATCACCC AGAGTGGTGA TTATCAACTT 
CGGACCAGCT AG