Havcr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Havcr2
Entrez Gene ID	363578
Full Name	hepatitis A virus cellular receptor 2
Synonyms	tim3
General protein information	Preferred Names hepatitis A virus cellular receptor 2 Names hepatitis A virus cellular receptor 2 homolog HAVcr-2 T cell immunoglobulin mucin-3 T-cell immunoglobulin and mucin domain-containing protein 3 T-cell immunoglobulin mucin receptor 3 T-cell membrane protein 3 TIM-3 TIMD-3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q21

mRNA and Protein(s)

mRNA	Protein	Name
XM_006246171.3	XP_006246233.1	hepatitis A virus cellular receptor 2 homolog isoform X1
NM_001100762.1	NP_001094232.1	hepatitis A virus cellular receptor 2 homolog precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Havcr2	NP_001094232.1
Pan troglodytes (chimpanzee)	HAVCR2	XP_518059.3
Homo sapiens (human)	HAVCR2	NP_116171.3
Canis lupus familiaris (dog)	HAVCR2	NP_001241644.1
Bos taurus (cattle)	HAVCR2	NP_001070573.1
Mus musculus (house mouse)	Havcr2	NP_599011.2

Gene Ontology
Bibliography

Related articles in PubMed

The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.
Li YH, Zhou WH, Tao Y, Wang SC, Jiang YL, Zhang D, Piao HL, Fu Q, Li DJ, Du MR
Cellular & molecular immunology13(1)73-81(2016 Jan)

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS
Nature517(7534)386-90(2015 01)

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.
Tomkowicz B, Walsh E, Cotty A, Verona R, Sabins N, Kaplan F, Santulli-Marotto S, Chin CN, Mooney J, Lingham RB, Naso M, McCabe T
PloS one10(10)e0140694(2015)

Regulation of osteoclastogenesis through Tim-3: possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction.
Moriyama K, Kukita A, Li YJ, Uehara N, Zhang JQ, Takahashi I, Kukita T
Laboratory investigation; a journal of technical methods and pathology94(11)1200-11(2014 Nov)

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
Hou H, Liu W, Wu S, Lu Y, Peng J, Zhu Y, Lu Y, Wang F, Sun Z
PloS one9(10)e110585(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we show that the galectin-9/Tim-3 cell signaling pathway is involved in inflammation induced by stroke
Title: Tim-3 cell signaling and iNOS are involved in the protective effects of ischemic postconditioning against focal ischemia in rats.

Osteoclasts and osteoclast precursors express Tim-3, and osteoclast differentiation is negatively regulated by its ligand galectin-9.
Title: Regulation of osteoclastogenesis through Tim-3: possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction.

The study described that enhanced Tim-3 and its ligand Galectin-9 in allografts might play an important role in the pathogenesis of rat lung transplant rejection.
Title: Increased expression of Tim-3 and its ligand Galectin-9 in rat allografts during acute rejection episodes.

Tim3(+) cells might include a distinct macrophage population, which may be involved in anti-inflammatory effect and recovery from experimental autoimmune neuritis
Title: Distinct expression of Tim-3 during different stages of rat experimental autoimmune neuritis.

The following Havcr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Havcr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13375	NM_001100762.1 Latest version!	Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa32987	XM_006246171.3 Latest version!	Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Havcr2 ( NM_001100762.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001094232.1 Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), mRNA.

Price & Availability↑

CloneID	ORa13375
Clone ID Related Accession (Same CDS sequence)	NM_001100762.1
Accession Version	NM_001100762.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	hepatitis A virus cellular receptor 2 homolog precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07029515.1. On or before Oct 20, 2007 this sequence version replaced XM_343881.3, XM_001069084.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTTTTCAT GGCTTCCCTT CAGCTGTGCC CTGCTGCTGC TGCAACCACT ACCTGCAAGG 
TCCTTGGAAA ATGCTTACAC AGCTGAGGTC GGGAAGAATG CCTATCTGCC CTGCAGCTAC 
ACTGTACCTG CCCCTGGGAC GCTCGTGCCT ATCTGCTGGG GCAAGGGATC CTGTCCTTTG 
TTACAGTGTG CCAGTGTGGT GCTCAGAACG GATGAAACGA ATGTGACATA TCGGAAATCC 
AGAAGATACC AGCTAAAGGG GAATTTCTAC AAAGGAGACA TGTCGCTGAC CATAAAGAAT 
GTGACTCTAG CTGACTCTGG GACCTACTGC TGCAGGATAC AATTCCCTGG CCCAATGAAT 
GATGAAAAAT TAGAGCTGAA ATTAAGCATC ACTGAACCAG CCAAAGTCAT CCCAGCTGGG 
ACTGCTCATG GGGATTCTAC AACAGCTTCT CCCAGAACCC TAACCACTGA GGGAAGTGGC 
TCAGAGACAC AGACCCTGGT GACCCTCCAT GATAACAATG GAACAAAAAT TTCCACATGG 
GCCGATGAAA TTAAGGACTC TGGAGAAACT ATCAGAACTG CTGTCCACAT TGGAGTAGGC 
GTCTCTGCTG GGCTGGCCCT GGCACTTATT CTTGGTGTTT TAATCCTTAA ATGGTATTCC 
TCTAAGAAAA AGAAGTTGCA GGATTTGAGT CTTATTACAC TGGCCAACTC CCCACCAGGA 
GGGTTGGTGA ATGCAGGAGC AGGCAGGATT CGGTCTGAGG AAAACATCTA CACTATAGAG 
GAGAACATAT ATGAAATGGA GAATTCAAAT GAGTACTACT GCTATGTCAG CAGCCAGCAG 
CCATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094232.1
CDS	71..919
Translation	MFSWLPFSCALLLLQPLPARSLENAYTAEVGKNAYLPCSYTVPAPGTLVPICWGKGSCPLLQCASVVLRTDETNVTYRKSRRYQLKGNFYKGDMSLTIKNVTLADSGTYCCRIQFPGPMNDEKLELKLSITEPAKVIPAGTAHGDSTTASPRTLTTEGSGSETQTLVTLHDNNGTKISTWADEIKDSGETIRTAVHIGVGVSAGLALALILGVLILKWYSSKKKKLQDLSLITLANSPPGGLVNAGAGRIRSEENIYTIEENIYEMENSNEYYCYVSSQQPS

Target ORF information:

RefSeq Version	NM_001100762.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100762.1

ORF Insert Sequence:

ATGTTTTCAT GGCTTCCCTT CAGCTGTGCC CTGCTGCTGC TGCAACCACT ACCTGCAAGG 
TCCTTGGAAA ATGCTTACAC AGCTGAGGTC GGGAAGAATG CCTATCTGCC CTGCAGCTAC 
ACTGTACCTG CCCCTGGGAC GCTCGTGCCT ATCTGCTGGG GCAAGGGATC CTGTCCTTTG 
TTACAGTGTG CCAGTGTGGT GCTCAGAACG GATGAAACGA ATGTGACATA TCGGAAATCC 
AGAAGATACC AGCTAAAGGG GAATTTCTAC AAAGGAGACA TGTCGCTGAC CATAAAGAAT 
GTGACTCTAG CTGACTCTGG GACCTACTGC TGCAGGATAC AATTCCCTGG CCCAATGAAT 
GATGAAAAAT TAGAGCTGAA ATTAAGCATC ACTGAACCAG CCAAAGTCAT CCCAGCTGGG 
ACTGCTCATG GGGATTCTAC AACAGCTTCT CCCAGAACCC TAACCACTGA GGGAAGTGGC 
TCAGAGACAC AGACCCTGGT GACCCTCCAT GATAACAATG GAACAAAAAT TTCCACATGG 
GCCGATGAAA TTAAGGACTC TGGAGAAACT ATCAGAACTG CTGTCCACAT TGGAGTAGGC 
GTCTCTGCTG GGCTGGCCCT GGCACTTATT CTTGGTGTTT TAATCCTTAA ATGGTATTCC 
TCTAAGAAAA AGAAGTTGCA GGATTTGAGT CTTATTACAC TGGCCAACTC CCCACCAGGA 
GGGTTGGTGA ATGCAGGAGC AGGCAGGATT CGGTCTGAGG AAAACATCTA CACTATAGAG 
GAGAACATAT ATGAAATGGA GAATTCAAAT GAGTACTACT GCTATGTCAG CAGCCAGCAG 
CCATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Havcr2 ( XM_006246171.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246233.1 Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa32987
Clone ID Related Accession (Same CDS sequence)	XM_006246171.3
Accession Version	XM_006246171.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	hepatitis A virus cellular receptor 2 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006246171.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTTCAT GGCTTCCCTT CAGCTGTGCC CTGCTGCTGC TGCAACCACT ACCTGCAAGG 
TCCTTGGAAA ATGCTTACAC AGCTGAGGTC GGGAAGAATG CCTATCTGCC CTGCAGCTAC 
ACTGTACCTG CCCCTGGGAC GCTCGTGCCT ATCTGCTGGG GCAAGGGATC CTGTCCTTTG 
TTACAGTGTG CCAGTGTGGT GCTCAGAACG GATGAAACGA ATGTGACATA TCGGAAATCC 
AGAAGATACC AGCTAAAGGG GAATTTCTAC AAAGGAGACA TGTCGCTGAC CATAAAGAAT 
GTGACTCTAG CTGACTCTGG GACCTACTGC TGCAGGATAC AATTCCCTGG CCCAATGAAT 
GATGAAAAAT TAGAGCTGAA ATTAAGCATC ACTGAACCAG AGACACAGAC CCTGGTGACC 
CTCCATGATA ACAATGGAAC AAAAATTTCC ACATGGGCCG ATGAAATTAA GGACTCTGGA 
GAAACTATCA GAACTGCTGT CCACATTGGA GTAGGCGTCT CTGCTGGGCT GGCCCTGGCA 
CTTATTCTTG GTGTTTTAAT CCTTAAATGG TATTCCTCTA AGAAAAAGAA GTTGCAGGAT 
TTGAGTCTTA TTACACTGGC CAACTCCCCA CCAGGAGGGT TGGTGAATGC AGGAGCAGGC 
AGGATTCGGT CTGAGGAAAA CATCTACACT ATAGAGGAGA ACATATATGA AATGGAGAAT 
TCAAATGAGT ACTACTGCTA TGTCAGCAGC CAGCAGCCAT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246233.1
CDS	128..892
Translation	MFSWLPFSCALLLLQPLPARSLENAYTAEVGKNAYLPCSYTVPAPGTLVPICWGKGSCPLLQCASVVLRTDETNVTYRKSRRYQLKGNFYKGDMSLTIKNVTLADSGTYCCRIQFPGPMNDEKLELKLSITEPETQTLVTLHDNNGTKISTWADEIKDSGETIRTAVHIGVGVSAGLALALILGVLILKWYSSKKKKLQDLSLITLANSPPGGLVNAGAGRIRSEENIYTIEENIYEMENSNEYYCYVSSQQPS

Target ORF information:

RefSeq Version	XM_006246171.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hepatitis A virus cellular receptor 2 (Havcr2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246171.3

ORF Insert Sequence:

ATGTTTTCAT GGCTTCCCTT CAGCTGTGCC CTGCTGCTGC TGCAACCACT ACCTGCAAGG 
TCCTTGGAAA ATGCTTACAC AGCTGAGGTC GGGAAGAATG CCTATCTGCC CTGCAGCTAC 
ACTGTACCTG CCCCTGGGAC GCTCGTGCCT ATCTGCTGGG GCAAGGGATC CTGTCCTTTG 
TTACAGTGTG CCAGTGTGGT GCTCAGAACG GATGAAACGA ATGTGACATA TCGGAAATCC 
AGAAGATACC AGCTAAAGGG GAATTTCTAC AAAGGAGACA TGTCGCTGAC CATAAAGAAT 
GTGACTCTAG CTGACTCTGG GACCTACTGC TGCAGGATAC AATTCCCTGG CCCAATGAAT 
GATGAAAAAT TAGAGCTGAA ATTAAGCATC ACTGAACCAG AGACACAGAC CCTGGTGACC 
CTCCATGATA ACAATGGAAC AAAAATTTCC ACATGGGCCG ATGAAATTAA GGACTCTGGA 
GAAACTATCA GAACTGCTGT CCACATTGGA GTAGGCGTCT CTGCTGGGCT GGCCCTGGCA 
CTTATTCTTG GTGTTTTAAT CCTTAAATGG TATTCCTCTA AGAAAAAGAA GTTGCAGGAT 
TTGAGTCTTA TTACACTGGC CAACTCCCCA CCAGGAGGGT TGGTGAATGC AGGAGCAGGC 
AGGATTCGGT CTGAGGAAAA CATCTACACT ATAGAGGAGA ACATATATGA AATGGAGAAT 
TCAAATGAGT ACTACTGCTA TGTCAGCAGC CAGCAGCCAT CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.
Cellular & molecular immunology13(1)73-81(2016 Jan)
Li YH,Zhou WH,Tao Y,Wang SC,Jiang YL,Zhang D,Piao HL,Fu Q,Li DJ,Du MR

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature517(7534)386-90(2015 01)
Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.
PloS one10(10)e0140694(2015)
Tomkowicz B,Walsh E,Cotty A,Verona R,Sabins N,Kaplan F,Santulli-Marotto S,Chin CN,Mooney J,Lingham RB,Naso M,McCabe T

Regulation of osteoclastogenesis through Tim-3: possible involvement of the Tim-3/galectin-9 system in the modulation of inflammatory bone destruction.
Laboratory investigation; a journal of technical methods and pathology94(11)1200-11(2014 Nov)
Moriyama K,Kukita A,Li YJ,Uehara N,Zhang JQ,Takahashi I,Kukita T

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one9(10)e110585(2014)
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z

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Havcr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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