Xrcc5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xrcc5
Entrez Gene ID	363247
Full Name	X-ray repair cross complementing 5
Synonyms	Ku80,Kup80
General protein information	Preferred Names X-ray repair cross complementing 5 Names X-ray repair cross-complementing protein 5 Ku autoantigen, 80kD) X-ray repair complementing defective repair in Chinese hamster cells 5 X-ray repair cross complementation (double-strand-break rejoining X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33

mRNA and Protein(s)

mRNA	Protein	Name
NM_177419.2	NP_803154.1	X-ray repair cross-complementing protein 5

Pathways from BioSystems

Homologies

	XRCC5	XP_001084586.2
Bos taurus (cattle)	LOC531945	NP_001095611.1
Danio rerio (zebrafish)	LOC100331090	XP_002665537.3
Neurospora crassa	NCU00077	XP_956387.2
Canis lupus familiaris (dog)	XRCC5	XP_536061.4
Rattus norvegicus (Norway rat)	Xrcc5	NP_803154.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009910	XP_319031.4
Mus musculus (house mouse)	Xrcc5	NP_033559.2
Gallus gallus (chicken)	XRCC5	XP_422072.4
Schizosaccharomyces pombe (fission yeast)	pku80	NP_596791.1
Magnaporthe oryzae (rice blast fungus)	MGG_10157	XP_003713796.1
Homo sapiens (human)	XRCC5	NP_066964.1
Pan troglodytes (chimpanzee)	XRCC5	XP_001151873.2
Danio rerio (zebrafish)	xrcc5	NP_001017360.1
Arabidopsis thaliana (thale cress)	KU80	NP_564520.1
Xenopus tropicalis (tropical clawed frog)	xrcc5	XP_002942054.2

Gene Ontology
Bibliography

Related articles in PubMed

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D, Dubois E, Schwartz O, Bennasser Y, Benkirane M
Molecular cell67(3)387-399.e5(2017 Aug)

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.
Gilmore JM, Sardiu ME, Groppe BD, Thornton JL, Liu X, Dayebgadoh G, Banks CA, Slaughter BD, Unruh JR, Workman JL, Florens L, Washburn MP
PloS one11(6)e0155492(2016)

Heat shock factor 1, an inhibitor of non-homologous end joining repair.
Kang GY, Kim EH, Lee HJ, Gil NY, Cha HJ, Lee YS
Oncotarget6(30)29712-24(2015 Oct)

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Craxton A, Somers J, Munnur D, Jukes-Jones R, Cain K, Malewicz M
Cell death and differentiation22(6)890-7(2015 Jun)

Blockage of Autophagy in C6 Glioma Cells Enhanced Radiosensitivity Possibly by Attenuating DNA-PK-Dependent DSB Due to Limited Ku Nuclear Translocation and DNA Binding.
Liu C, He W, Jin M, Li H, Xu H, Liu H, Yang K, Zhang T, Wu G, Ren J
Current molecular medicine15(7)663-73(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The radiosensitizing effect of beclin-1 knockdown may result from the disruption of nuclear translocation and DNA binding activity of Ku proteins and consequent attenuation of double strand break repair.
Title: Blockage of Autophagy in C6 Glioma Cells Enhanced Radiosensitivity Possibly by Attenuating DNA-PK-Dependent DSB Due to Limited Ku Nuclear Translocation and DNA Binding.

Sp1, Sp2 and Sp4 transcription factors play a role in activating cholesterol desmolase gene transcription in the nervous system, and Ku antigen may further augment this activation
Title: Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.

The following Xrcc5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xrcc5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04016	NM_177419.2 Latest version!	Rattus norvegicus X-ray repair cross complementing 5 (Xrcc5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xrcc5 ( NM_177419.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_803154.1 Rattus norvegicus X-ray repair cross complementing 5 (Xrcc5), mRNA.

Price & Availability↑

CloneID	ORa04016
Clone ID Related Accession (Same CDS sequence)	NM_177419.2
Accession Version	NM_177419.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2199bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	X-ray repair cross-complementing protein 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061576.1. On Aug 31, 2012 this sequence version replaced NM_177419.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTGGT CCGGTAATAA GGCAGCTGTT GTGCTGTGTA TGGATGTGGG GGTTGCCATG 
GGTAACTCCT TTCCTGGTGA AGAATCCCCA CTTGAACAGG CCAAGAAAGT GATGACTATG 
TTTGTCCAAC GACAGGTGTT TTCGGAGAGC AAGGATGAGA TCGCCTTAGT CCTCTATGGT 
ACAGAGAGCA CTGATAACGC CCTTGCTGGC AAGGACCAGT ATCAGAACAT CACAGTGCAC 
AGGCACCTGA TGCTACCAGA TTTTGATTTG CTGGAAGACA TCGGAAACAA AATCCAACCA 
AGTTCTCAAC AAGCCGACTT CCTGGACGCC CTGATTGTGT GCATGGATTT GATTCAGCGT 
GAAACCATAG GAAAGAAGTT TGGGAAGAAG CATATTGAAG TGTTCACTGA TCTCAGCAGC 
CCATTCAGCC AAGACCAACT GGACATTATA ATTTGTAACC TGAAGAAGTC CGGCATCTCC 
CTGCAGTTCT TTCTGCCTTT TCCAATCGAC AAGAATGGTG AGCCTGGGGA GACAGAAGAC 
CACGACTCCA GCTTCGACCA CTGTGCACCC TCCTTCCCTC AAAAAGGACT TACTGAGCAG 
CAAAAGGAAG GCATCCACAT GGTGACGAGG GTGATGCTGT CTTTAGAAGG CAAAGATGGT 
CTGGATGAAA TTTATTCCTT CAGCGAGAGT CTTCAGCAAC TGTGCATCTT TAAGAAGATT 
GAGAGGCGGT CCTTGCCCTG GCCCTGCCAA CTGACCATCG GCCCCAACTT GTCTATAAGG 
ATCGTAGCCT ATAAATCGAT TGTACAGGAG AAATTTAAAA AGAGTTGGGT AGTTGTGGAC 
GCAAGAACTC TAAAGAAGGA AGATATACAA AAAGAGACTG TTTATTGCCT AAATGACGAT 
GATGAAACTG AAGTTTCCAA AGAGGACACT ATTCAAGGGT TCCGCTATGG AAGCGACATC 
ATTCCTTTTT CTAAAGTGGA TGAGGAACAA ATGAAATATA AATCGGAGGG GAAGTGCTTC 
TCTGTTCTGG GGTTCTGTAA ATCTTCTCAG GTTCATAGAA GATTCTTCAT GGGACATCAA 
GTTCTGAAGG TCTTCGCAGC GAAGGATGAT GAGGCAGCAG CTGTTGCACT TTCTTCCCTA 
GTTCACGCTT TGGATGAGTT AAACATGGTC GCTATCGTCC GCTACGCCTA TGACAAAAGA 
GCTAATCCTC AAGTTGGTGT AGCCTTCCCT TTCATTAAGG ATGCCTATGA GTGTTTAGTT 
TATGTGCAGC TGCCTTTCAT GGAAGACTTG CGGCAATACA TGTTTTCCTC ACTGAAAAAC 
AATAAGAAGT GCACCCCCAC AGAGGCACAG CTGAGTGCGA TCGATGATCT GATTGATTCC 
ATGAGCTTGG TAAAGAAAAA CGAGGAAGAA GACATCATCG AAGACTTGTT TCCAACCTCC 
AAAATTCCAA ATCCTGAATT TCAGCGGTTG TACCAGTGTC TGCTGCACAG AGCCTTACAT 
CTCCAGGAGC GGCTGCCCCC AATTCAGCAG CACATTTTGA ATATGCTGGA TCCCCCCACT 
GAGATGAAAG CAAAATGTGA GATTCCACTC TCTAAAGTAA AGACCCTTTT CCCTCTGACG 
GAAGTCGTTA AGAAAAAGGA CCAAGTGACT GCTCAGGACG TTTTCCAAGA CAATATTGAA 
GAGGGGCCCG CTGCTAAAAA ATACAAGACT GAGAAAGAAG AAGGTCACAT CAGCATCTCC 
AGCCTGGCAG AAGGGAATGT CACCAAGGTT GGAAGTGTGA ATCCTGTTGA AAACTTCCGT 
GTCCTAGTAA GACAGAAGAT TGCCAGCTTT GAGGAAGCGA GTCTCCAGCT AATGAGTCAC 
ATTGAACAGT TTTTGGATAC CAATGAAACA CTGTATTTTA TGAAAAGTAT GGACCGCATC 
AAAGCTCTCC GGGAGGAAGC CATTCAGTTT TCAGAGGAGC AGCGTTTCAA CAGTTTCCTG 
GAAGGCCTTC GAGAGAAAGT GGAAATTAAA CAATTAAATC ATTTCTGGGA AATTGTCGTG 
CAGGATGGAA TTACTCTGAT CACCAAAGAC GAAAGCCCAG GAAGCTCTGT CACAGCTGAG 
GAGGCCACGA AGTTCCTGAC CCCCAAAGAC AAAGCAAAAG AAGACACAAC AGGACTTGAA 
GAAGGTGGTG ATGTGGATGA TTTACTGGAC ATGATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803154.1
CDS	99..2297
Translation	MAWSGNKAAVVLCMDVGVAMGNSFPGEESPLEQAKKVMTMFVQRQVFSESKDEIALVLYGTESTDNALAGKDQYQNITVHRHLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKKFGKKHIEVFTDLSSPFSQDQLDIIICNLKKSGISLQFFLPFPIDKNGEPGETEDHDSSFDHCAPSFPQKGLTEQQKEGIHMVTRVMLSLEGKDGLDEIYSFSESLQQLCIFKKIERRSLPWPCQLTIGPNLSIRIVAYKSIVQEKFKKSWVVVDARTLKKEDIQKETVYCLNDDDETEVSKEDTIQGFRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVHRRFFMGHQVLKVFAAKDDEAAAVALSSLVHALDELNMVAIVRYAYDKRANPQVGVAFPFIKDAYECLVYVQLPFMEDLRQYMFSSLKNNKKCTPTEAQLSAIDDLIDSMSLVKKNEEEDIIEDLFPTSKIPNPEFQRLYQCLLHRALHLQERLPPIQQHILNMLDPPTEMKAKCEIPLSKVKTLFPLTEVVKKKDQVTAQDVFQDNIEEGPAAKKYKTEKEEGHISISSLAEGNVTKVGSVNPVENFRVLVRQKIASFEEASLQLMSHIEQFLDTNETLYFMKSMDRIKALREEAIQFSEEQRFNSFLEGLREKVEIKQLNHFWEIVVQDGITLITKDESPGSSVTAEEATKFLTPKDKAKEDTTGLEEGGDVDDLLDMI

Target ORF information:

RefSeq Version	NM_177419.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus X-ray repair cross complementing 5 (Xrcc5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177419.2

ORF Insert Sequence:

ATGGCGTGGT CCGGTAATAA GGCAGCTGTT GTGCTGTGTA TGGATGTGGG GGTTGCCATG 
GGTAACTCCT TTCCTGGTGA AGAATCCCCA CTTGAACAGG CCAAGAAAGT GATGACTATG 
TTTGTCCAAC GACAGGTGTT TTCGGAGAGC AAGGATGAGA TCGCCTTAGT CCTCTATGGT 
ACAGAGAGCA CTGATAACGC CCTTGCTGGC AAGGACCAGT ATCAGAACAT CACAGTGCAC 
AGGCACCTGA TGCTACCAGA TTTTGATTTG CTGGAAGACA TCGGAAACAA AATCCAACCA 
AGTTCTCAAC AAGCCGACTT CCTGGACGCC CTGATTGTGT GCATGGATTT GATTCAGCGT 
GAAACCATAG GAAAGAAGTT TGGGAAGAAG CATATTGAAG TGTTCACTGA TCTCAGCAGC 
CCATTCAGCC AAGACCAACT GGACATTATA ATTTGTAACC TGAAGAAGTC CGGCATCTCC 
CTGCAGTTCT TTCTGCCTTT TCCAATCGAC AAGAATGGTG AGCCTGGGGA GACAGAAGAC 
CACGACTCCA GCTTCGACCA CTGTGCACCC TCCTTCCCTC AAAAAGGACT TACTGAGCAG 
CAAAAGGAAG GCATCCACAT GGTGACGAGG GTGATGCTGT CTTTAGAAGG CAAAGATGGT 
CTGGATGAAA TTTATTCCTT CAGCGAGAGT CTTCAGCAAC TGTGCATCTT TAAGAAGATT 
GAGAGGCGGT CCTTGCCCTG GCCCTGCCAA CTGACCATCG GCCCCAACTT GTCTATAAGG 
ATCGTAGCCT ATAAATCGAT TGTACAGGAG AAATTTAAAA AGAGTTGGGT AGTTGTGGAC 
GCAAGAACTC TAAAGAAGGA AGATATACAA AAAGAGACTG TTTATTGCCT AAATGACGAT 
GATGAAACTG AAGTTTCCAA AGAGGACACT ATTCAAGGGT TCCGCTATGG AAGCGACATC 
ATTCCTTTTT CTAAAGTGGA TGAGGAACAA ATGAAATATA AATCGGAGGG GAAGTGCTTC 
TCTGTTCTGG GGTTCTGTAA ATCTTCTCAG GTTCATAGAA GATTCTTCAT GGGACATCAA 
GTTCTGAAGG TCTTCGCAGC GAAGGATGAT GAGGCAGCAG CTGTTGCACT TTCTTCCCTA 
GTTCACGCTT TGGATGAGTT AAACATGGTC GCTATCGTCC GCTACGCCTA TGACAAAAGA 
GCTAATCCTC AAGTTGGTGT AGCCTTCCCT TTCATTAAGG ATGCCTATGA GTGTTTAGTT 
TATGTGCAGC TGCCTTTCAT GGAAGACTTG CGGCAATACA TGTTTTCCTC ACTGAAAAAC 
AATAAGAAGT GCACCCCCAC AGAGGCACAG CTGAGTGCGA TCGATGATCT GATTGATTCC 
ATGAGCTTGG TAAAGAAAAA CGAGGAAGAA GACATCATCG AAGACTTGTT TCCAACCTCC 
AAAATTCCAA ATCCTGAATT TCAGCGGTTG TACCAGTGTC TGCTGCACAG AGCCTTACAT 
CTCCAGGAGC GGCTGCCCCC AATTCAGCAG CACATTTTGA ATATGCTGGA TCCCCCCACT 
GAGATGAAAG CAAAATGTGA GATTCCACTC TCTAAAGTAA AGACCCTTTT CCCTCTGACG 
GAAGTCGTTA AGAAAAAGGA CCAAGTGACT GCTCAGGACG TTTTCCAAGA CAATATTGAA 
GAGGGGCCCG CTGCTAAAAA ATACAAGACT GAGAAAGAAG AAGGTCACAT CAGCATCTCC 
AGCCTGGCAG AAGGGAATGT CACCAAGGTT GGAAGTGTGA ATCCTGTTGA AAACTTCCGT 
GTCCTAGTAA GACAGAAGAT TGCCAGCTTT GAGGAAGCGA GTCTCCAGCT AATGAGTCAC 
ATTGAACAGT TTTTGGATAC CAATGAAACA CTGTATTTTA TGAAAAGTAT GGACCGCATC 
AAAGCTCTCC GGGAGGAAGC CATTCAGTTT TCAGAGGAGC AGCGTTTCAA CAGTTTCCTG 
GAAGGCCTTC GAGAGAAAGT GGAAATTAAA CAATTAAATC ATTTCTGGGA AATTGTCGTG 
CAGGATGGAA TTACTCTGAT CACCAAAGAC GAAAGCCCAG GAAGCTCTGT CACAGCTGAG 
GAGGCCACGA AGTTCCTGAC CCCCAAAGAC AAAGCAAAAG AAGACACAAC AGGACTTGAA 
GAAGGTGGTG ATGTGGATGA TTTACTGGAC ATGATATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Molecular cell67(3)387-399.e5(2017 Aug)
Morchikh M,Cribier A,Raffel R,Amraoui S,Cau J,Severac D,Dubois E,Schwartz O,Bennasser Y,Benkirane M

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.
PloS one11(6)e0155492(2016)
Gilmore JM,Sardiu ME,Groppe BD,Thornton JL,Liu X,Dayebgadoh G,Banks CA,Slaughter BD,Unruh JR,Workman JL,Florens L,Washburn MP

Heat shock factor 1, an inhibitor of non-homologous end joining repair.
Oncotarget6(30)29712-24(2015 Oct)
Kang GY,Kim EH,Lee HJ,Gil NY,Cha HJ,Lee YS

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Cell death and differentiation22(6)890-7(2015 Jun)
Craxton A,Somers J,Munnur D,Jukes-Jones R,Cain K,Malewicz M

Blockage of Autophagy in C6 Glioma Cells Enhanced Radiosensitivity Possibly by Attenuating DNA-PK-Dependent DSB Due to Limited Ku Nuclear Translocation and DNA Binding.
Current molecular medicine15(7)663-73(2015)
Liu C,He W,Jin M,Li H,Xu H,Liu H,Yang K,Zhang T,Wu G,Ren J