Hsp90b1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hsp90b1
Entrez Gene ID	362862
Full Name	heat shock protein 90 beta family member 1
Synonyms	Grp94,Tra1
General protein information	Preferred Names heat shock protein 90 beta family member 1 Names endoplasmin 94 kDa glucose-regulated protein GRP-94 heat shock protein 90 kDa beta member 1 heat shock protein 90, beta, member 1 heat shock protein 90kDa beta (Grp94), member 1 tumor rejection antigen gp96
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q13
Summary	molecular chaperone protein localized to the endoplasmic reticulum; may be involved in heme protein assembly [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012197.2	NP_001012197.2	endoplasmin precursor

Pathways from BioSystems

Homologies

	HSP90B1	XP_001095189.1
Mus musculus (house mouse)	Hsp90b1	NP_035761.1
Rattus norvegicus (Norway rat)	Hsp90b1	NP_001012197.2
Homo sapiens (human)	HSP90B1	NP_003290.1
Canis lupus familiaris (dog)	HSP90B1	NP_001003327.1
Bos taurus (cattle)	HSP90B1	NP_777125.1
Oryza sativa (rice)	Os06g0716700	NP_001058590.1
Gallus gallus (chicken)	HSP90B1	NP_989620.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001424	XP_321706.5
Caenorhabditis elegans (roundworm)	CELE_T05E11.3	NP_001255536.1
Danio rerio (zebrafish)	hsp90b1	NP_937853.1
Drosophila melanogaster (fruit fly)	Gp93	NP_651601.1
Arabidopsis thaliana (thale cress)	SHD	NP_974606.1
Xenopus tropicalis (tropical clawed frog)	hsp90b1	NP_001039228.1
Pan troglodytes (chimpanzee)	HSP90B1	NP_001233416.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of ERAD components essential for dislocation of the null Hong Kong variant of ?-1-antitrypsin (NHK).
Zhong Y, Shen H, Wang Y, Yang Y, Yang P, Fang S
Biochemical and biophysical research communications458(2)424-8(2015 Mar)

Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- ? in rat strains with different susceptibilities to experimental autoimmune encephalomyelitis.
Grubi?-Kezele T, Blagojevi? Zagorac G, Jakovac H, Domitrovi? R, Milin C, Rado?evi?-Sta?i? B
Clinical & developmental immunology2013750406(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The maintenance of Grp94 expression is sufficient to counter unloading atrophy and oxidative stress by mechanistically stabilizing nNOS-multiprotein complex at the myofiber sarcolemma.
Title: The stress protein/chaperone Grp94 counteracts muscle disuse atrophy by stabilizing subsarcolemmal neuronal nitric oxide synthase.

gp96 might be involved in proteostasis and immune-related pathways linked with the reparative processes in the central nervous system
Title: Expression pattern of the endoplasmic reticulum stress protein gp96 in monophasic and chronic relapsing form of experimental autoimmune encephalomyelitis in rats.

Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- beta in rat strains contributed to different susceptibilities to experimental autoimmune encephalomyelitis.
Title: Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- ? in rat strains with different susceptibilities to experimental autoimmune encephalomyelitis.

GRP94 immunoactivity is expressed at low levels in gray matter and white matter in normal condition and increased after spinal cord injury.
Title: Overexpression of glucose-regulated protein 94 after spinal cord injury in rats.

Results indicate that Grp94 can activate the humoral response by a cytokine-like, cell-mediated mechanism that leads to an accelerated process of B cell maturation and differentiation.
Title: Effects of glucose-regulated protein94 (Grp94) on Ig secretion from human blood mononuclear cells.

The following Hsp90b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsp90b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02663	NM_001012197.2 Latest version!	Rattus norvegicus heat shock protein 90 beta family member 1 (Hsp90b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hsp90b1 ( NM_001012197.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012197.2 Rattus norvegicus heat shock protein 90 beta family member 1 (Hsp90b1), mRNA.

Price & Availability↑

CloneID	ORa02663
Clone ID Related Accession (Same CDS sequence)	NM_001012197.2
Accession Version	NM_001012197.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2415bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	endoplasmin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC081917.1, EV771986.1 and BP471985.1. On Oct 29, 2008 this sequence version replaced NM_001012197.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGTCC TGTGGGTGCT GGGCCTCTGC TGCGTCCTGC TGACCTTCGG GTTTGTGAGA 
GCTGACGATG AAGTCGATGT GGATGGCACG GTAGAAGAGG ACCTGGGTAA AAGTAGAGAA 
GGCTCACGGA CAGACGATGA AGTTGTGCAG AGAGAGGAAG AAGCTATTCA GTTGGATGGT 
TTAAATGCAT CACAAATAAG GGAACTTAGA GAAAAATCGG AAAAGTTCGC CTTCCAAGCT 
GAAGTTAACA GGATGATGAA ACTTATCATC AATTCTTTGT ATAAAAATAA AGAGATTTTC 
CTGAGAGAAC TGATTTCAAA TGCTTCTGAT GCTTTAGACA AGATAAGGCT CATCTCACTA 
ACTGATGAAA ATGCACTTGC TGGAAATGAG GAGTTGACGG TCAAGATTAA GTGTGACAGA 
GAGAAAAACC TGCTGCATGT CACAGACACG GGTGTAGGAA TGACCAGAGA GGAGCTGGTT 
AAAAACCTGG GCACCATAGC CAAATCTGGA ACCAGCGAGT TTCTAAACAA AATGACAGAA 
GCACAAGAAG ACGGTCAGTC AACTTCCGAA CTGATCGGCC AGTTTGGTGT CGGTTTTTAT 
TCTGCCTTCC TTGTAGCAGA TAAGGTCATT GTCACGTCGA AACACAACAA TGATACCCAG 
CACATCTGGG AATCCGACTC TAATGAATTC TCTGTGATTG CTGACCCAAG AGGAAACACA 
CTAGGTCGTG GAACAACGAT TACTCTTGTC TTAAAAGAAG AAGCATCTGA TTACCTTGAA 
TTGGATACAA TTAAAAATCT CGTCAGAAAG TATTCTCAGT TCATCAACTT TCCCATCTAT 
GTGTGGAGTA GCAAGACTGA GACTGTGGAG GAGCCCTTGG AAGAAGACGA AACAGCACAA 
GAAGAGAAGG AGGAAGCTGA TGATGAAGCC GCAGTAGAAG AGGAGGAGGA AGAGAAGAAG 
CCAAAGACGA AGAAAGTTGA AAAGACTGTG TGGGACTGGG AACTTATGAA TGACATCAAA 
CCAATATGGC AGAGGCCGTC CAAAGAAGTA GAAGAAGACG AGTACAAAGC TTTCTACAAG 
TCGTTTTCAA AGGAAAGTGA TGACCCCATG GCTTATATCC ACTTTACTGC AGAAGGGGAA 
GTCACCTTCA AGTCAATTTT GTTTGTGCCT ACATCTGCGC CTCGAGGTCT GTTTGACGAG 
TATGGATCTA AGAAGAGCGA TTATATTAAG CTCTATGTGC GCCGAGTGTT CATCACAGAC 
GACTTCCATG ACATGATGCC CAAGTACCTG AATTTTGTCA AAGGTGTTGT GGATTCCGAT 
GATCTCCCCC TCAATGTTTC CCGTGAGACT CTTCAGCAAC ATAAATTGCT CAAGGTGATT 
AGGAAGAAGC TTGTCCGCAA AACTCTGGAC ATGATCAAGA AGATCGCTGA TGAGAAATAT 
AATGACACTT TCTGGAAAGA ATTTGGCACC AATATCAAGC TTGGTGTGAT TGAAGATCAC 
TCAAATCGAA CACGGCTTGC TAAACTTCTT AGGTTCCAGT CTTCTCACCA TTCAACTGAC 
ATTACTAGTT TAGACCAGTA TGTGGAAAGA ATGAAGGAAA AACAGGACAA AATCTACTTC 
ATGGCTGGGT CAAGCAGAAA AGAGGCTGAA TCTTCTCCGT TTGTTGAGAG GCTTCTGAAG 
AAGGGCTATG AAGTTATTTA CCTCACAGAG CCCGTGGATG AATACTGCAT TCAGGCTCTT 
CCTGAGTTTG ATGGGAAACG GTTCCAGAAT GTTGCCAAAG AAGGAGTGAA GTTTGATGAG 
AGTGAGAAAA GTAAAGAAAG TCGGGAAGCA ACAGAGAAGG AGTTTGAGCC TCTGCTCAAC 
TGGATGAAAG ATAAGGCCCT CAAGGACAAG ATCGAAAAGG CTGTGGTGTC CCAGCGCCTC 
ACAGAGTCTC CCTGTGCCCT TGTGGCCAGC CAGTATGGAT GGTCTGGAAA CATGGAGAGG 
ATCATGAAGG CACAAGCATA CCAGACGGGC AAGGACATCT CTACAAATTA CTATGCCAGT 
CAGAAGAAAA CGTTTGAAAT TAATCCTAGA CACCCACTGA TCAGGGACAT GCTGCGGAGG 
GTTAAGGAAG ATGAAGATGA CAAGACTGTC ATGGATCTTG CTGTAGTTTT GTTTGAAACG 
GCAACTCTTC GGTCAGGATA CCTTCTACCC GACACCAAGG CATATGGAGA CAGGATAGAA 
AGGATGCTCC GCCTCAGCTT AAACATTGAC CCTGAAGCAC AGGTAGAGGA AGAGCCAGAG 
GAGGAGCCTG AAGACACCAC AGAAGACACC ACAGATGACT CCGAGCAGGA TGAAGAAGAG 
ACAGACGCAG GGGCAGAAGA AGAAGAAGAA GAACAGGAAA CAGAAAAGGA ACCTACAGAG 
AAGGATGAAT TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012197.2
CDS	125..2539
Translation	MRVLWVLGLCCVLLTFGFVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVKIKCDREKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVRKYSQFINFPIYVWSSKTETVEEPLEEDETAQEEKEEADDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKSKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTTEDTTDDSEQDEEETDAGAEEEEEEQETEKEPTEKDEL

Target ORF information:

RefSeq Version	NM_001012197.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heat shock protein 90 beta family member 1 (Hsp90b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012197.2

ORF Insert Sequence:

ATGAGGGTCC TGTGGGTGCT GGGCCTCTGC TGCGTCCTGC TGACCTTCGG GTTTGTGAGA 
GCTGACGATG AAGTCGATGT GGATGGCACG GTAGAAGAGG ACCTGGGTAA AAGTAGAGAA 
GGCTCACGGA CAGACGATGA AGTTGTGCAG AGAGAGGAAG AAGCTATTCA GTTGGATGGT 
TTAAATGCAT CACAAATAAG GGAACTTAGA GAAAAATCGG AAAAGTTCGC CTTCCAAGCT 
GAAGTTAACA GGATGATGAA ACTTATCATC AATTCTTTGT ATAAAAATAA AGAGATTTTC 
CTGAGAGAAC TGATTTCAAA TGCTTCTGAT GCTTTAGACA AGATAAGGCT CATCTCACTA 
ACTGATGAAA ATGCACTTGC TGGAAATGAG GAGTTGACGG TCAAGATTAA GTGTGACAGA 
GAGAAAAACC TGCTGCATGT CACAGACACG GGTGTAGGAA TGACCAGAGA GGAGCTGGTT 
AAAAACCTGG GCACCATAGC CAAATCTGGA ACCAGCGAGT TTCTAAACAA AATGACAGAA 
GCACAAGAAG ACGGTCAGTC AACTTCCGAA CTGATCGGCC AGTTTGGTGT CGGTTTTTAT 
TCTGCCTTCC TTGTAGCAGA TAAGGTCATT GTCACGTCGA AACACAACAA TGATACCCAG 
CACATCTGGG AATCCGACTC TAATGAATTC TCTGTGATTG CTGACCCAAG AGGAAACACA 
CTAGGTCGTG GAACAACGAT TACTCTTGTC TTAAAAGAAG AAGCATCTGA TTACCTTGAA 
TTGGATACAA TTAAAAATCT CGTCAGAAAG TATTCTCAGT TCATCAACTT TCCCATCTAT 
GTGTGGAGTA GCAAGACTGA GACTGTGGAG GAGCCCTTGG AAGAAGACGA AACAGCACAA 
GAAGAGAAGG AGGAAGCTGA TGATGAAGCC GCAGTAGAAG AGGAGGAGGA AGAGAAGAAG 
CCAAAGACGA AGAAAGTTGA AAAGACTGTG TGGGACTGGG AACTTATGAA TGACATCAAA 
CCAATATGGC AGAGGCCGTC CAAAGAAGTA GAAGAAGACG AGTACAAAGC TTTCTACAAG 
TCGTTTTCAA AGGAAAGTGA TGACCCCATG GCTTATATCC ACTTTACTGC AGAAGGGGAA 
GTCACCTTCA AGTCAATTTT GTTTGTGCCT ACATCTGCGC CTCGAGGTCT GTTTGACGAG 
TATGGATCTA AGAAGAGCGA TTATATTAAG CTCTATGTGC GCCGAGTGTT CATCACAGAC 
GACTTCCATG ACATGATGCC CAAGTACCTG AATTTTGTCA AAGGTGTTGT GGATTCCGAT 
GATCTCCCCC TCAATGTTTC CCGTGAGACT CTTCAGCAAC ATAAATTGCT CAAGGTGATT 
AGGAAGAAGC TTGTCCGCAA AACTCTGGAC ATGATCAAGA AGATCGCTGA TGAGAAATAT 
AATGACACTT TCTGGAAAGA ATTTGGCACC AATATCAAGC TTGGTGTGAT TGAAGATCAC 
TCAAATCGAA CACGGCTTGC TAAACTTCTT AGGTTCCAGT CTTCTCACCA TTCAACTGAC 
ATTACTAGTT TAGACCAGTA TGTGGAAAGA ATGAAGGAAA AACAGGACAA AATCTACTTC 
ATGGCTGGGT CAAGCAGAAA AGAGGCTGAA TCTTCTCCGT TTGTTGAGAG GCTTCTGAAG 
AAGGGCTATG AAGTTATTTA CCTCACAGAG CCCGTGGATG AATACTGCAT TCAGGCTCTT 
CCTGAGTTTG ATGGGAAACG GTTCCAGAAT GTTGCCAAAG AAGGAGTGAA GTTTGATGAG 
AGTGAGAAAA GTAAAGAAAG TCGGGAAGCA ACAGAGAAGG AGTTTGAGCC TCTGCTCAAC 
TGGATGAAAG ATAAGGCCCT CAAGGACAAG ATCGAAAAGG CTGTGGTGTC CCAGCGCCTC 
ACAGAGTCTC CCTGTGCCCT TGTGGCCAGC CAGTATGGAT GGTCTGGAAA CATGGAGAGG 
ATCATGAAGG CACAAGCATA CCAGACGGGC AAGGACATCT CTACAAATTA CTATGCCAGT 
CAGAAGAAAA CGTTTGAAAT TAATCCTAGA CACCCACTGA TCAGGGACAT GCTGCGGAGG 
GTTAAGGAAG ATGAAGATGA CAAGACTGTC ATGGATCTTG CTGTAGTTTT GTTTGAAACG 
GCAACTCTTC GGTCAGGATA CCTTCTACCC GACACCAAGG CATATGGAGA CAGGATAGAA 
AGGATGCTCC GCCTCAGCTT AAACATTGAC CCTGAAGCAC AGGTAGAGGA AGAGCCAGAG 
GAGGAGCCTG AAGACACCAC AGAAGACACC ACAGATGACT CCGAGCAGGA TGAAGAAGAG 
ACAGACGCAG GGGCAGAAGA AGAAGAAGAA GAACAGGAAA CAGAAAAGGA ACCTACAGAG 
AAGGATGAAT TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of ERAD components essential for dislocation of the null Hong Kong variant of ?-1-antitrypsin (NHK).
Biochemical and biophysical research communications458(2)424-8(2015 Mar)
Zhong Y,Shen H,Wang Y,Yang Y,Yang P,Fang S

Hepatic expression of metallothionein I/II, glycoprotein 96, IL-6, and TGF- ? in rat strains with different susceptibilities to experimental autoimmune encephalomyelitis.
Clinical & developmental immunology2013750406(2013)
Grubi?-Kezele T,Blagojevi? Zagorac G,Jakovac H,Domitrovi? R,Milin C,Rado?evi?-Sta?i? B

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Hsp90b1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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