Lancl2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lancl2
Entrez Gene ID	362375
Full Name	LanC like 2
General protein information	Preferred Names LanC like 2 Names lanC-like protein 2 LanC (bacterial lantibiotic synthetase component C)-like 2 LanC lantibiotic synthetase component C-like 2 testis-specific adriamycin sensitivity protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q24

mRNA and Protein(s)

mRNA	Protein	Name
XM_006236581.3	XP_006236643.1	lanC-like protein 2 isoform X1
NM_001014187.1	NP_001014209.1	lanC-like protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	LANCL2	NP_061167.1
Danio rerio (zebrafish)	lancl2	NP_001076472.1
Neurospora crassa	NCU08190	XP_959280.1
Arabidopsis thaliana (thale cress)	GPCR	NP_175700.2
Xenopus tropicalis (tropical clawed frog)	lancl2	NP_001039268.1
Canis lupus familiaris (dog)	LANCL2	XP_005631064.1
Bos taurus (cattle)	LANCL2	NP_001095726.1
Mus musculus (house mouse)	Lancl2	NP_598498.1
Gallus gallus (chicken)	LANCL2	XP_418874.2
Pan troglodytes (chimpanzee)	LANCL2	XP_003318497.1
Rattus norvegicus (Norway rat)	Lancl2	NP_001014209.1
Arabidopsis thaliana (thale cress)	GCL2	NP_850003.1
Oryza sativa (rice)	Os10g0497900	NP_001064963.1
	LANCL2	XP_001090911.1
Oryza sativa (rice)	Os04g0529600	NP_001174024.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.
Sturla L, Fresia C, Guida L, Bruzzone S, Scarf? S, Usai C, Fruscione F, Magnone M, Millo E, Basile G, Grozio A, Jacchetti E, Allegretti M, De Flora A, Zocchi E
The Journal of biological chemistry284(41)28045-57(2009 Oct)

Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin.
Landlinger C, Salzer U, Prohaska R
Biochimica et biophysica acta1758(11)1759-67(2006 Nov)

Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism.
Park S, James CD
Cancer research63(3)723-7(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that lanthionine synthetase C-like protein (LANCL2) is required for abscisic acid binding on human granulocyte membranes and that LANCL2 is necessary for transduction of the ABA signal into granulocytes and rat insulinoma cells.
Title: LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.

The following Lancl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lancl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05344	NM_001014187.1 Latest version!	Rattus norvegicus LanC like 2 (Lancl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$265.30 $379.00
ORa27301	XM_006236581.3 Latest version!	Rattus norvegicus LanC like 2 (Lancl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lancl2 ( NM_001014187.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001014209.1 Rattus norvegicus LanC like 2 (Lancl2), mRNA.

Price & Availability↑

CloneID	ORa05344
Clone ID Related Accession (Same CDS sequence)	NM_001014187.1
Accession Version	NM_001014187.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1353bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	lanC-like protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079412.1. On Apr 1, 2005 this sequence version replaced XM_342699.1. ##Evidence-Data-START## Transcript exon combination :: BC079412.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCGAGA CCATGTCAAA GAGACTCAAG TTCCACCTAG GAGAGGCGGA GATGGAGGAG 
CGGTCGTTTC CTAATCCCTT CCTAGACTAT GAGGTCGCTG CCTCCGCCAC GGGGTTCGCC 
TCTGGAACTG CGGAGGAAAC AGGCCGTGTT TGCCCTCTTC CCACCACAGA AGACCCGGGC 
CTCCCTTTCC ACCCCAACGG GAAGATTGTT CCTAACTTGA TAAAGCGTAT CCAGACCAAA 
ATTAAAGATC TTCTGCAGCA AATGGAAGAA GGGCTGAAGA CAGCTGATCC CCATGATTGC 
TCTGCATACA CTGGTTGGAC AGGCATAGCA CTTTTGTACC TGCAGCTGTA CCGGGTCACT 
GGTGACCAGA CCTACCTGCT CCGATCCCTG GATTATGTGA AGAGAACACT CCGAAATTTG 
AGTGGACGCA GAGTCACTTT CCTTTGTGGA GATGCTGGGC CCCTTGCTGT GGGAGCTGTG 
ATATATCATA AACTCAAAAG TGAATGTGAG TCCCAGGAAT GCATCACAAA ACTTCTACAG 
ATGCATAGAA CTATTGTCTG CCAAGAATCA GAGCTTCCTG ACGAGCTGCT GTTCGGACGG 
GCAGGATACC TGTATGCCTT ACTGTACCTG AACACAGAAA TCGGCCCTGG CACTGTTGGT 
GAGACAGCTA TTAAAGAGGT AGTCACTGCT ATTATTGAGT CAGGAAAGAG GCTATCTCGG 
GAAGAGAGGA AAAGTGAGCG CTGCCCTCTG TTGTATCAGT GGCACAGGAA GCAATATGTT 
GGAGCAGCCC ATGGTATGGC TGGCATCTAC TACATGTTAA TGCAGCCAGA AGCAAAAGTG 
GACCAAGAAA CCTTGACAGA AATGGTGAAA CCCAGCATCG ATTATGTGCG CCACAAAAAA 
TTCAGATCTG GAAATTATCC ATCTTCATTA AGCAATGAAA CAGATCGATT GGTCCACTGG 
TGCCACGGTG CTCCAGGAGT CATCCACATG CTCTTACGGG CATACCAGGT TTTTAAGGAG 
GAAAAATACT TGAAAGAGGC CATGGAGTGC AGTGATGTGA TTTGGCAGCG AGGTCTGCTC 
CGGAAAGGCT ATGGAATCTG CCATGGAACT GCTGGAAATG GTTATTCCTT TTTGTCCCTT 
TATCAACTGA CACAGGATAA GAAGTATCTC TATCGAGCTT GTAAGTTTGC AGAGTGGTGT 
CTAGATTATG GAGCTCACGG ATGCCGCATT CCTGACAGGC CTTATTCCCT CTTTGAAGGT 
ATGGCTGGTG CTGTTCACTT TCTTTCTGAC ATGTTGGTAC CAGAGACAGC ACGGTTTCCG 
GCATTTGAAC TTGGCTTTGT GCAGAAGGAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014209.1
CDS	10..1362
Translation	MGETMSKRLKFHLGEAEMEERSFPNPFLDYEVAASATGFASGTAEETGRVCPLPTTEDPGLPFHPNGKIVPNLIKRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTGDQTYLLRSLDYVKRTLRNLSGRRVTFLCGDAGPLAVGAVIYHKLKSECESQECITKLLQMHRTIVCQESELPDELLFGRAGYLYALLYLNTEIGPGTVGETAIKEVVTAIIESGKRLSREERKSERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPEAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLLRAYQVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYQLTQDKKYLYRACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAVHFLSDMLVPETARFPAFELGFVQKD

Target ORF information:

RefSeq Version	NM_001014187.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus LanC like 2 (Lancl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014187.1

ORF Insert Sequence:

ATGGGCGAGA CCATGTCAAA GAGACTCAAG TTCCACCTAG GAGAGGCGGA GATGGAGGAG 
CGGTCGTTTC CTAATCCCTT CCTAGACTAT GAGGTCGCTG CCTCCGCCAC GGGGTTCGCC 
TCTGGAACTG CGGAGGAAAC AGGCCGTGTT TGCCCTCTTC CCACCACAGA AGACCCGGGC 
CTCCCTTTCC ACCCCAACGG GAAGATTGTT CCTAACTTGA TAAAGCGTAT CCAGACCAAA 
ATTAAAGATC TTCTGCAGCA AATGGAAGAA GGGCTGAAGA CAGCTGATCC CCATGATTGC 
TCTGCATACA CTGGTTGGAC AGGCATAGCA CTTTTGTACC TGCAGCTGTA CCGGGTCACT 
GGTGACCAGA CCTACCTGCT CCGATCCCTG GATTATGTGA AGAGAACACT CCGAAATTTG 
AGTGGACGCA GAGTCACTTT CCTTTGTGGA GATGCTGGGC CCCTTGCTGT GGGAGCTGTG 
ATATATCATA AACTCAAAAG TGAATGTGAG TCCCAGGAAT GCATCACAAA ACTTCTACAG 
ATGCATAGAA CTATTGTCTG CCAAGAATCA GAGCTTCCTG ACGAGCTGCT GTTCGGACGG 
GCAGGATACC TGTATGCCTT ACTGTACCTG AACACAGAAA TCGGCCCTGG CACTGTTGGT 
GAGACAGCTA TTAAAGAGGT AGTCACTGCT ATTATTGAGT CAGGAAAGAG GCTATCTCGG 
GAAGAGAGGA AAAGTGAGCG CTGCCCTCTG TTGTATCAGT GGCACAGGAA GCAATATGTT 
GGAGCAGCCC ATGGTATGGC TGGCATCTAC TACATGTTAA TGCAGCCAGA AGCAAAAGTG 
GACCAAGAAA CCTTGACAGA AATGGTGAAA CCCAGCATCG ATTATGTGCG CCACAAAAAA 
TTCAGATCTG GAAATTATCC ATCTTCATTA AGCAATGAAA CAGATCGATT GGTCCACTGG 
TGCCACGGTG CTCCAGGAGT CATCCACATG CTCTTACGGG CATACCAGGT TTTTAAGGAG 
GAAAAATACT TGAAAGAGGC CATGGAGTGC AGTGATGTGA TTTGGCAGCG AGGTCTGCTC 
CGGAAAGGCT ATGGAATCTG CCATGGAACT GCTGGAAATG GTTATTCCTT TTTGTCCCTT 
TATCAACTGA CACAGGATAA GAAGTATCTC TATCGAGCTT GTAAGTTTGC AGAGTGGTGT 
CTAGATTATG GAGCTCACGG ATGCCGCATT CCTGACAGGC CTTATTCCCT CTTTGAAGGT 
ATGGCTGGTG CTGTTCACTT TCTTTCTGAC ATGTTGGTAC CAGAGACAGC ACGGTTTCCG 
GCATTTGAAC TTGGCTTTGT GCAGAAGGAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lancl2 ( XM_006236581.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006236643.1 Rattus norvegicus LanC like 2 (Lancl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa27301
Clone ID Related Accession (Same CDS sequence)	XM_006236581.3
Accession Version	XM_006236581.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1092bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	lanC-like protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236581.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGAAG GGCTGAAGAC AGCTGATCCC CATGATTGCT CTGCATACAC TGGTTGGACA 
GGCATAGCAC TTTTGTACCT GCAGCTGTAC CGGGTCACTG GTGACCAGAC CTACCTGCTC 
CGATCCCTGG ATTATGTGAA GAGAACACTC CGAAATTTGA GTGGACGCAG AGTCACTTTC 
CTTTGTGGAG ATGCTGGGCC CCTTGCTGTG GGAGCTGTGA TATATCATAA ACTCAAAAGT 
GAATGTGAGT CCCAGGAATG CATCACAAAA CTTCTACAGA TGCATAGAAC TATTGTCTGC 
CAAGAATCAG AGCTTCCTGA CGAGCTGCTG TTCGGACGGG CAGGATACCT GTATGCCTTA 
CTGTACCTGA ACACAGAAAT CGGCCCTGGC ACTGTTGGTG AGACAGCTAT TAAAGAGGTA 
GTCACTGCTA TTATTGAGTC AGGAAAGAGG CTATCTCGGG AAGAGAGGAA AAGTGAGCGC 
TGCCCTCTGT TGTATCAGTG GCACAGGAAG CAATATGTTG GAGCAGCCCA TGGTATGGCT 
GGCATCTACT ACATGTTAAT GCAGCCAGAA GCAAAAGTGG ACCAAGAAAC CTTGACAGAA 
ATGGTGAAAC CCAGCATCGA TTATGTGCGC CACAAAAAAT TCAGATCTGG AAATTATCCA 
TCTTCATTAA GCAATGAAAC AGATCGATTG GTCCACTGGT GCCACGGTGC TCCAGGAGTC 
ATCCACATGC TCTTACGGGC ATACCAGGTT TTTAAGGAGG AAAAATACTT GAAAGAGGCC 
ATGGAGTGCA GTGATGTGAT TTGGCAGCGA GGTCTGCTCC GGAAAGGCTA TGGAATCTGC 
CATGGAACTG CTGGAAATGG TTATTCCTTT TTGTCCCTTT ATCAACTGAC ACAGGATAAG 
AAGTATCTCT ATCGAGCTTG TAAGTTTGCA GAGTGGTGTC TAGATTATGG AGCTCACGGA 
TGCCGCATTC CTGACAGGCC TTATTCCCTC TTTGAAGGTA TGGCTGGTGC TGTTCACTTT 
CTTTCTGACA TGTTGGTACC AGAGACAGCA CGGTTTCCGG CATTTGAACT TGGCTTTGTG 
CAGAAGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006236643.1
CDS	271..1362
Translation	MEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTGDQTYLLRSLDYVKRTLRNLSGRRVTFLCGDAGPLAVGAVIYHKLKSECESQECITKLLQMHRTIVCQESELPDELLFGRAGYLYALLYLNTEIGPGTVGETAIKEVVTAIIESGKRLSREERKSERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPEAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLLRAYQVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYQLTQDKKYLYRACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAVHFLSDMLVPETARFPAFELGFVQKD

Target ORF information:

RefSeq Version	XM_006236581.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus LanC like 2 (Lancl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006236581.3

ORF Insert Sequence:

ATGGAAGAAG GGCTGAAGAC AGCTGATCCC CATGATTGCT CTGCATACAC TGGTTGGACA 
GGCATAGCAC TTTTGTACCT GCAGCTGTAC CGGGTCACTG GTGACCAGAC CTACCTGCTC 
CGATCCCTGG ATTATGTGAA GAGAACACTC CGAAATTTGA GTGGACGCAG AGTCACTTTC 
CTTTGTGGAG ATGCTGGGCC CCTTGCTGTG GGAGCTGTGA TATATCATAA ACTCAAAAGT 
GAATGTGAGT CCCAGGAATG CATCACAAAA CTTCTACAGA TGCATAGAAC TATTGTCTGC 
CAAGAATCAG AGCTTCCTGA CGAGCTGCTG TTCGGACGGG CAGGATACCT GTATGCCTTA 
CTGTACCTGA ACACAGAAAT CGGCCCTGGC ACTGTTGGTG AGACAGCTAT TAAAGAGGTA 
GTCACTGCTA TTATTGAGTC AGGAAAGAGG CTATCTCGGG AAGAGAGGAA AAGTGAGCGC 
TGCCCTCTGT TGTATCAGTG GCACAGGAAG CAATATGTTG GAGCAGCCCA TGGTATGGCT 
GGCATCTACT ACATGTTAAT GCAGCCAGAA GCAAAAGTGG ACCAAGAAAC CTTGACAGAA 
ATGGTGAAAC CCAGCATCGA TTATGTGCGC CACAAAAAAT TCAGATCTGG AAATTATCCA 
TCTTCATTAA GCAATGAAAC AGATCGATTG GTCCACTGGT GCCACGGTGC TCCAGGAGTC 
ATCCACATGC TCTTACGGGC ATACCAGGTT TTTAAGGAGG AAAAATACTT GAAAGAGGCC 
ATGGAGTGCA GTGATGTGAT TTGGCAGCGA GGTCTGCTCC GGAAAGGCTA TGGAATCTGC 
CATGGAACTG CTGGAAATGG TTATTCCTTT TTGTCCCTTT ATCAACTGAC ACAGGATAAG 
AAGTATCTCT ATCGAGCTTG TAAGTTTGCA GAGTGGTGTC TAGATTATGG AGCTCACGGA 
TGCCGCATTC CTGACAGGCC TTATTCCCTC TTTGAAGGTA TGGCTGGTGC TGTTCACTTT 
CTTTCTGACA TGTTGGTACC AGAGACAGCA CGGTTTCCGG CATTTGAACT TGGCTTTGTG 
CAGAAGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.
The Journal of biological chemistry284(41)28045-57(2009 Oct)
Sturla L,Fresia C,Guida L,Bruzzone S,Scarf? S,Usai C,Fruscione F,Magnone M,Millo E,Basile G,Grozio A,Jacchetti E,Allegretti M,De Flora A,Zocchi E

Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin.
Biochimica et biophysica acta1758(11)1759-67(2006 Nov)
Landlinger C,Salzer U,Prohaska R

Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism.
Cancer research63(3)723-7(2003 Feb)
Park S,James CD