Fgfrl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgfrl1
Entrez Gene ID	360903
Full Name	fibroblast growth factor receptor-like 1
Synonyms	Fgfr5
General protein information	Preferred Names fibroblast growth factor receptor-like 1 Names fibroblast growth factor receptor-like 1 FGF receptor-like protein 1 alpha-L-iduronidase fibroblast growth factor receptor 5 fibroblast growth factor receptor-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p22
Summary	transmembrane receptor; has a negative effect on cell proliferation and may act as a decoy receptor for FGF ligands [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_199114.1	NP_954545.1	fibroblast growth factor receptor-like 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fgfrl1	NP_954545.1
Caenorhabditis elegans (roundworm)	igcm-4	NP_508377.1
Homo sapiens (human)	FGFRL1	NP_068742.2
Bos taurus (cattle)	FGFRL1	NP_001192925.1
Danio rerio (zebrafish)	fgfrl1a	NP_956670.1
Xenopus tropicalis (tropical clawed frog)	fgfrl1	NP_001011189.1
	FGFRL1	XP_001092871.1
Gallus gallus (chicken)	FGFRL1	NP_989787.1
Canis lupus familiaris (dog)	LOC102151155	XP_005618732.1
Mus musculus (house mouse)	Fgfrl1	NP_473412.1

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of FGFRL1 contributes to the development of the diaphragmatic defect in the nitrofen model of congenital diaphragmatic hernia.
Dingemann J, Doi T, Ruttenstock EM, Puri P
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie21(1)46-9(2011 Jan)

Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice.
Catela C, Bilbao-Cortes D, Slonimsky E, Kratsios P, Rosenthal N, Te Welscher P
Disease models & mechanisms2(5-6)283-94(2009 May-Jun)

The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion.
Rieckmann T, Kotevic I, Trueb B
Experimental cell research314(5)1071-81(2008 Mar)

Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm.
Baertschi S, Zhuang L, Trueb B
The FEBS journal274(23)6241-53(2007 Dec)

Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors.
Baier P, Wolf-Vorbeck G, Hempel S, Hopt UT, von Dobschuetz E
World journal of gastroenterology12(24)3835-40(2006 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

downregulation of the FGFRL1 gene during the late stages of gestation may contribute to the development of the diaphragmatic defect in nitrofen-induced CDH
Title: Downregulation of FGFRL1 contributes to the development of the diaphragmatic defect in the nitrofen model of congenital diaphragmatic hernia.

EGFR, FGFR and TNFR1 mRNA expression was equal or lower than in resting liver, HGFR expression after I/R was stronger than in the control.
Title: Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors.

Analysis of Fgf18 and Fgfr5 (Fgfrl1) expression in primary endothelial cells and vascular smooth muscle cells.
Title: Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells.

The following Fgfrl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgfrl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05103	NM_199114.1 Latest version!	Rattus norvegicus fibroblast growth factor receptor-like 1 (Fgfrl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgfrl1 ( NM_199114.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_954545.1 Rattus norvegicus fibroblast growth factor receptor-like 1 (Fgfrl1), mRNA.

Price & Availability↑

CloneID	ORa05103
Clone ID Related Accession (Same CDS sequence)	NM_199114.1
Accession Version	NM_199114.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor receptor-like 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ536020.1. On Jan 1, 2004 this sequence version replaced XM_341178.1. ##Evidence-Data-START## Transcript exon combination :: AJ536020.1, BC097261.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGACGCGGA GCCCCGCGCT GCTGCTGCTG CTATTGGGGG CCCTCCCGTC GGCTGAGGCG 
GCGCGAGGAC CCCCAAGAAT GGCAGACAAA GTGGTCCCAC GGCAGGTGGC CCGCCTGGGC 
CGCACTGTGC GGCTACAGTG CCCAGTGGAG GGGGACCCAC CACCGTTGAC CATGTGGACC 
AAAGATGGCC GCACGATCCA CAGTGGCTGG AGCCGCTTCC GTGTGCTGCC CCAGGGGCTG 
AAGGTGAAGG AGGTGGAGGC CGAGGATGCC GGTGTTTATG TGTGCAAGGC CACCAATGGC 
TTCGGCAGCC TCAGCGTCAA CTATACTCTC ATCATCATGG ATGACATTAG TCCAGGGAAG 
GAGAACCCTG GACCAGGTGG CTCTTCTGGG GGCCAGGAAG ACCCAGTCAG CCAGCAGTGG 
GCACGGCCTC GCTTCACACA GCCCTCCAAG ATGAGGCGCC GAGTGATTGC ACGGCCCGTG 
GGTAGCTCTG TGCGGCTCAA GTGTGTGGCC AGTGGGCACC CACGGCCTGA CATCATGTGG 
ATGAAGGATG ACCAGACCTT GACACGTCTA GAGGCCAGTG AACACAGAAA GAAGAAGTGG 
ACGCTGAGCT TGAAGAACCT GAAGCCTGAA GACAGTGGCA AGTACACGTG CCGTGTATCC 
AACCGGGCAG GTGCCATCAA CGCCACCTAC AAAGTGGATG TAATCCAGCG TACTCGTTCC 
AAGCCTGTGC TCACGGGGAC ACACCCTGTG AACACAACGG TGGACTTCGG TGGGACAACG 
TCCTTCCAGT GCAAGGTGCG CAGCGACGTG AAGCCTGTGA TCCAATGGCT AAAGCGGGTG 
GAGTACGGCT CTGAGGGTCG CCACAACTCC ACCATTGATG TGGGTGGCCA GAAGTTTGTG 
GTGTTGCCCA CGGGTGATGT GTGGTCACGG CCTGACGGCT CCTACCTCAA CAAGCTGCTC 
ATCTCTCGGG CCCGCCAGGA TGATGCTGGC ATGTACATCT GCCTGGGTGC AAACACCATG 
GGCTACAGTT TCCGTAGCGC CTTCCTCACT GTATTACCAG ACCCCAAACC TCCAGGGCCT 
CCTGTGGCTC ATTCATCCTC AACCACCAGC CTGCCGTGGC CTGTGGTGAT CGGCATCCCA 
GCAGGTGCTG TCTTCATCCT AGGCACGGTG TTGCTCTGGC TTTGCCAGAC TAAGAAGAAG 
CCATGTGCCC CTGCATCCAC ACTTCCTGTG CCTGGGCATC GTCCCCCAGG GACATCCCGA 
GAACGCAGTG GTGACAAGGA CCTGCCCTCA TTGGCTGTGG GCATATGTGA GGAGCATGGA 
TCCACCATGG CCCCCCAGCA CATCCTGGCC CCAGGCTCAA CTGCCGGCCC CAAGCTGTAC 
CCTAAGCTGT ACACAGATGT GCACACGCAC ACGCATACGC ACACATGCAC ACACACGCTC 
TCATGTGGAG GGCAAGGCTC ATCAGCACCA GCATGTCCAC TATCAGTGCT AAATACAGCC 
AATCTCCAAG CACTGTGTCC CGAGGTGGGC GTATGGGGGC CAAGGCAGCA GGTTGGGAGG 
ATTGAGAACA ATGGAGGAAG AGTATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_954545.1
CDS	143..1732
Translation	MTRSPALLLLLLGALPSAEAARGPPRMADKVVPRQVARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKEVEAEDAGVYVCKATNGFGSLSVNYTLIIMDDISPGKENPGPGGSSGGQEDPVSQQWARPRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDIMWMKDDQTLTRLEASEHRKKKWTLSLKNLKPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPVAHSSSTTSLPWPVVIGIPAGAVFILGTVLLWLCQTKKKPCAPASTLPVPGHRPPGTSRERSGDKDLPSLAVGICEEHGSTMAPQHILAPGSTAGPKLYPKLYTDVHTHTHTHTCTHTLSCGGQGSSAPACPLSVLNTANLQALCPEVGVWGPRQQVGRIENNGGRVS

Target ORF information:

RefSeq Version	NM_199114.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor receptor-like 1 (Fgfrl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199114.1

ORF Insert Sequence:

ATGACGCGGA GCCCCGCGCT GCTGCTGCTG CTATTGGGGG CCCTCCCGTC GGCTGAGGCG 
GCGCGAGGAC CCCCAAGAAT GGCAGACAAA GTGGTCCCAC GGCAGGTGGC CCGCCTGGGC 
CGCACTGTGC GGCTACAGTG CCCAGTGGAG GGGGACCCAC CACCGTTGAC CATGTGGACC 
AAAGATGGCC GCACGATCCA CAGTGGCTGG AGCCGCTTCC GTGTGCTGCC CCAGGGGCTG 
AAGGTGAAGG AGGTGGAGGC CGAGGATGCC GGTGTTTATG TGTGCAAGGC CACCAATGGC 
TTCGGCAGCC TCAGCGTCAA CTATACTCTC ATCATCATGG ATGACATTAG TCCAGGGAAG 
GAGAACCCTG GACCAGGTGG CTCTTCTGGG GGCCAGGAAG ACCCAGTCAG CCAGCAGTGG 
GCACGGCCTC GCTTCACACA GCCCTCCAAG ATGAGGCGCC GAGTGATTGC ACGGCCCGTG 
GGTAGCTCTG TGCGGCTCAA GTGTGTGGCC AGTGGGCACC CACGGCCTGA CATCATGTGG 
ATGAAGGATG ACCAGACCTT GACACGTCTA GAGGCCAGTG AACACAGAAA GAAGAAGTGG 
ACGCTGAGCT TGAAGAACCT GAAGCCTGAA GACAGTGGCA AGTACACGTG CCGTGTATCC 
AACCGGGCAG GTGCCATCAA CGCCACCTAC AAAGTGGATG TAATCCAGCG TACTCGTTCC 
AAGCCTGTGC TCACGGGGAC ACACCCTGTG AACACAACGG TGGACTTCGG TGGGACAACG 
TCCTTCCAGT GCAAGGTGCG CAGCGACGTG AAGCCTGTGA TCCAATGGCT AAAGCGGGTG 
GAGTACGGCT CTGAGGGTCG CCACAACTCC ACCATTGATG TGGGTGGCCA GAAGTTTGTG 
GTGTTGCCCA CGGGTGATGT GTGGTCACGG CCTGACGGCT CCTACCTCAA CAAGCTGCTC 
ATCTCTCGGG CCCGCCAGGA TGATGCTGGC ATGTACATCT GCCTGGGTGC AAACACCATG 
GGCTACAGTT TCCGTAGCGC CTTCCTCACT GTATTACCAG ACCCCAAACC TCCAGGGCCT 
CCTGTGGCTC ATTCATCCTC AACCACCAGC CTGCCGTGGC CTGTGGTGAT CGGCATCCCA 
GCAGGTGCTG TCTTCATCCT AGGCACGGTG TTGCTCTGGC TTTGCCAGAC TAAGAAGAAG 
CCATGTGCCC CTGCATCCAC ACTTCCTGTG CCTGGGCATC GTCCCCCAGG GACATCCCGA 
GAACGCAGTG GTGACAAGGA CCTGCCCTCA TTGGCTGTGG GCATATGTGA GGAGCATGGA 
TCCACCATGG CCCCCCAGCA CATCCTGGCC CCAGGCTCAA CTGCCGGCCC CAAGCTGTAC 
CCTAAGCTGT ACACAGATGT GCACACGCAC ACGCATACGC ACACATGCAC ACACACGCTC 
TCATGTGGAG GGCAAGGCTC ATCAGCACCA GCATGTCCAC TATCAGTGCT AAATACAGCC 
AATCTCCAAG CACTGTGTCC CGAGGTGGGC GTATGGGGGC CAAGGCAGCA GGTTGGGAGG 
ATTGAGAACA ATGGAGGAAG AGTATCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of FGFRL1 contributes to the development of the diaphragmatic defect in the nitrofen model of congenital diaphragmatic hernia.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie21(1)46-9(2011 Jan)
Dingemann J,Doi T,Ruttenstock EM,Puri P

Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice.
Disease models & mechanisms2(5-6)283-94(2009 May-Jun)
Catela C,Bilbao-Cortes D,Slonimsky E,Kratsios P,Rosenthal N,Te Welscher P

The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion.
Experimental cell research314(5)1071-81(2008 Mar)
Rieckmann T,Kotevic I,Trueb B

Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm.
The FEBS journal274(23)6241-53(2007 Dec)
Baertschi S,Zhuang L,Trueb B

Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors.
World journal of gastroenterology12(24)3835-40(2006 Jun)
Baier P,Wolf-Vorbeck G,Hempel S,Hopt UT,von Dobschuetz E

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Fgfrl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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