The following Kdm5a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kdm5a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa11636 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001277178.1 | |
| Accession Version | NM_001277178.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-10-27 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | lysine-specific demethylase 5A isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07061907.1, AABR07061908.1 and AABR07061909.1. Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC169044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGGGCG TGGGCCCGGG GGGCTACGCG GCGGAGTTCG TGCCGCCGCC CGAGTGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001264107.1 |
| CDS | 409..2148 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001277178.1 |
1 | ATGGCGGGCG TGGGCCCGGG GGGCTACGCG GCGGAGTTCG TGCCGCCGCC CGAGTGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa11630 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001277177.1 | |
| Accession Version | NM_001277177.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 5073bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-10-27 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | lysine-specific demethylase 5A isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07061907.1, AABR07061908.1, AABR07061909.1 and AABR07061910.1. On or before Mar 17, 2013 this sequence version replaced XM_002729425.2, XM_002726483.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. There are no full-length transcripts supporting this RefSeq in rat and it is unknown if this exon combination exists in rat; however, it is predicted based on partial transcript alignments and on full-length transcript support from the human homolog (GeneID 5927, AB209999.1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGGGCG TGGGCCCGGG GGGCTACGCG GCGGAGTTCG TGCCGCCGCC CGAGTGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001264106.1 |
| CDS | 409..5481 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001277177.1 |
1 | ATGGCGGGCG TGGGCCCGGG GGGCTACGCG GCGGAGTTCG TGCCGCCGCC CGAGTGCCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The histone demethylase KDM5A is required for the repression of astrocytogenesis and regulated by the translational machinery in neural progenitor cells. |
Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors. |
Distinctive changes in histone H3K4 modification mediated via Kdm5a expression in spermatogonial stem cells of cryptorchid testes. |
Deregulated expression of selected histone methylases and demethylases in prostate carcinoma. |
Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway. |
