Ltk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ltk
Entrez Gene ID	311337
Full Name	leukocyte receptor tyrosine kinase
General protein information	Preferred Names leukocyte receptor tyrosine kinase Names leukocyte tyrosine kinase receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35
Summary	The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. The mRNA for this gene initiates translation from a non-AUG (CUG) start codon. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107763.2	NP_001101233.2	leukocyte tyrosine kinase receptor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ltk	NP_001101233.2
Homo sapiens (human)	LTK	NP_002335.2
Pan troglodytes (chimpanzee)	LTK	XP_001149706.1
	LTK	XP_001099288.2
Mus musculus (house mouse)	Ltk	NP_976220.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen.
Yamada S, Uchimura E, Ueda T, Nomura T, Fujita S, Matsumoto K, Funeriu DP, Miyake M, Miyake J
Biochemical and biophysical research communications363(4)926-30(2007 Nov)

Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.
Honda H, Harada K, Komuro I, Terasaki F, Ueno H, Tanaka Y, Kawamura K, Yazaki Y, Hirai H
Oncogene18(26)3821-30(1999 Jul)

The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H
Oncogene14(25)3067-72(1997 Jun)

Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.
Ben-Neriah Y, Bauskin AR
Nature333(6174)672-6(1988 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ltk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ltk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05901	NM_001107763.2 Latest version!	Rattus norvegicus leukocyte receptor tyrosine kinase (Ltk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ltk ( NM_001107763.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101233.2 Rattus norvegicus leukocyte receptor tyrosine kinase (Ltk), mRNA.

Price & Availability↑

CloneID	ORa05901
Clone ID Related Accession (Same CDS sequence)	NM_001107763.2
Accession Version	NM_001107763.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	leukocyte tyrosine kinase receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC107565.6 and BE106366.1. On Nov 2, 2007 this sequence version replaced NM_001107763.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by orthologous mouse data. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGGAGACCC GCGCGGCGGC GCAGGGCAGC GGCAGGAGAG GAGGCGCGGC CGGCGGTGAT 
ACTTCTGAGT CTGACCTCCT CTGGGCTGAT GGGGAAGATG GCATATCCTT CGTCCACCCT 
AGTGGCGAGC TTTACCTACA ACCTCTGGCA GTCACAGAGG GCGATGTTGA GGTGGAGATC 
CGAAGGCACC CCAATTGCAG TCACTGCTCT TTCAAAGACT GCCAGTGGCA GGCAGAGCTC 
TGGAGGGCTG AATGCATATG CCCAGAGGGC ATGGAGCTAG CTGTGGATAA TATCACATGC 
ACGGGCCTGC CAACCACCAC AAGCCCTCTG ATAATGATGG GAGCTGTTGT GACAGCCTTG 
ACGCTGAGTC TCCTTATGAT GTGTGGAGTC CTAATTCTAG TGAACCAGAA GAAATGTCAG 
AGCCTGCGGG GAACCAGGCT GCCAGGCCCT GAGCTTGAGC TGAGTAAGCT GAGAACCTCT 
GCCATCAGGA CAGCACCCAA CCCATATTAC TGTCAGGTGG GGCTCAGCCC TGCCCAGGCC 
TGGCCTCTGC CCCAAGGGCT CACTGAGGTT TCCCCAGCCA ATGTCACTCT ACTCAGAGCC 
CTTGGCCATG GTGCCTTTGG GGAAGTGTAT GAGGGACTAG TGATTGGTCT TCCTGGGGAT 
TCCAGCCCTC TTCCGGTGGC TATCAAGACT CTGCCGGAGC TCTGCTCCCC TCAGGATGAG 
CTGGACTTTC TCATGGAGGC TCTCATCATC AGCAAGTTCA GCCATCAGAA TATTGTACGC 
TGTGTGGGGC TCAGCTTCCA GGCTGCCCCT CGCCTCATTC TGCTGGAGCT GATGTCTGGT 
GGGGACATGA AGAGCTTTCT GAGGCATAGC AGACCACACC CGGGACAACT GTCACCTCTG 
ACCATGCAGG ACCTATTACA GTTGGCCCAG GATATAGCTC AGGGCTGCCA CTACTTGGAG 
GAAAATCACT TTATCCACAG AGACATTGCC GCCCGAAACT GTCTGCTTAG CTGCAGTGGA 
GACAGCCGAG TGGCCAAGAT TGGAGACTTT GGAATGGCAA GAGATATCTA CCAGGCCAGT 
TATTATCGCA AAGGGGGCCG GACCTTGCTC CCAGTGAAGT GGATGCCCCC AGAAGCTCTC 
CTGGAGGGCC TTTTCACATC CAAGACGGAC TCCTGGTCTT TTGGGGTCCT GCTCTGGGAG 
ATCTTCTCAC TAGGTTATAT GCCCTACCCT GGACACACCA ACCAGGAGGT TCTAGACTTC 
ATTGCCACAG GGAACAGGAT GGACCCTCCT AGGAACTGTC CTGGGCCAGT GTACCGAATC 
ATGACCCAGT GCTGGCAGCT TCAACCTGAG CTCCGCCCTG ACTTTGCCAG CATCTTGGAG 
CGCATTCAAT ACTGCATTCA GGACCCTGAT GTGCTGAACT CGCCCTTGCC CATGGAACCA 
GGGCCCATTG TGGAGGAGGA AGGGGCCTCT GGGCCGGGGA ACAGGTCACT GGAAGGTCTT 
AGATCCCCAA AGACCCTGGA ACTGAGTTCC CAGAACTTGA AAAGCCGGGG AGGAGACCTT 
CTTGGCTCTC AGCTGCCCTC TGGCCTCAAG ACCCTCACAT CCAGATGCCT TCAACCTCAG 
AACATTTGGA ACCCCACCTA TGGCTCCTGG ACCCCAAGGA GCCCCCAGGG TGAAGATTCA 
GACATTGACC TTAGCAATGG CCCCTCCTCG GATTCCTTTC CAGGCGAGCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101233.2
CDS	221..1954
Translation	LETRAAAQGSGRRGGAAGGDTSESDLLWADGEDGISFVHPSGELYLQPLAVTEGDVEVEIRRHPNCSHCSFKDCQWQAELWRAECICPEGMELAVDNITCTGLPTTTSPLIMMGAVVTALTLSLLMMCGVLILVNQKKCQSLRGTRLPGPELELSKLRTSAIRTAPNPYYCQVGLSPAQAWPLPQGLTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLPVAIKTLPELCSPQDELDFLMEALIISKFSHQNIVRCVGLSFQAAPRLILLELMSGGDMKSFLRHSRPHPGQLSPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGDSRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQLQPELRPDFASILERIQYCIQDPDVLNSPLPMEPGPIVEEEGASGPGNRSLEGLRSPKTLELSSQNLKSRGGDLLGSQLPSGLKTLTSRCLQPQNIWNPTYGSWTPRSPQGEDSDIDLSNGPSSDSFPGEQ

Target ORF information:

RefSeq Version	NM_001107763.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leukocyte receptor tyrosine kinase (Ltk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107763.2

ORF Insert Sequence:

CTGGAGACCC GCGCGGCGGC GCAGGGCAGC GGCAGGAGAG GAGGCGCGGC CGGCGGTGAT 
ACTTCTGAGT CTGACCTCCT CTGGGCTGAT GGGGAAGATG GCATATCCTT CGTCCACCCT 
AGTGGCGAGC TTTACCTACA ACCTCTGGCA GTCACAGAGG GCGATGTTGA GGTGGAGATC 
CGAAGGCACC CCAATTGCAG TCACTGCTCT TTCAAAGACT GCCAGTGGCA GGCAGAGCTC 
TGGAGGGCTG AATGCATATG CCCAGAGGGC ATGGAGCTAG CTGTGGATAA TATCACATGC 
ACGGGCCTGC CAACCACCAC AAGCCCTCTG ATAATGATGG GAGCTGTTGT GACAGCCTTG 
ACGCTGAGTC TCCTTATGAT GTGTGGAGTC CTAATTCTAG TGAACCAGAA GAAATGTCAG 
AGCCTGCGGG GAACCAGGCT GCCAGGCCCT GAGCTTGAGC TGAGTAAGCT GAGAACCTCT 
GCCATCAGGA CAGCACCCAA CCCATATTAC TGTCAGGTGG GGCTCAGCCC TGCCCAGGCC 
TGGCCTCTGC CCCAAGGGCT CACTGAGGTT TCCCCAGCCA ATGTCACTCT ACTCAGAGCC 
CTTGGCCATG GTGCCTTTGG GGAAGTGTAT GAGGGACTAG TGATTGGTCT TCCTGGGGAT 
TCCAGCCCTC TTCCGGTGGC TATCAAGACT CTGCCGGAGC TCTGCTCCCC TCAGGATGAG 
CTGGACTTTC TCATGGAGGC TCTCATCATC AGCAAGTTCA GCCATCAGAA TATTGTACGC 
TGTGTGGGGC TCAGCTTCCA GGCTGCCCCT CGCCTCATTC TGCTGGAGCT GATGTCTGGT 
GGGGACATGA AGAGCTTTCT GAGGCATAGC AGACCACACC CGGGACAACT GTCACCTCTG 
ACCATGCAGG ACCTATTACA GTTGGCCCAG GATATAGCTC AGGGCTGCCA CTACTTGGAG 
GAAAATCACT TTATCCACAG AGACATTGCC GCCCGAAACT GTCTGCTTAG CTGCAGTGGA 
GACAGCCGAG TGGCCAAGAT TGGAGACTTT GGAATGGCAA GAGATATCTA CCAGGCCAGT 
TATTATCGCA AAGGGGGCCG GACCTTGCTC CCAGTGAAGT GGATGCCCCC AGAAGCTCTC 
CTGGAGGGCC TTTTCACATC CAAGACGGAC TCCTGGTCTT TTGGGGTCCT GCTCTGGGAG 
ATCTTCTCAC TAGGTTATAT GCCCTACCCT GGACACACCA ACCAGGAGGT TCTAGACTTC 
ATTGCCACAG GGAACAGGAT GGACCCTCCT AGGAACTGTC CTGGGCCAGT GTACCGAATC 
ATGACCCAGT GCTGGCAGCT TCAACCTGAG CTCCGCCCTG ACTTTGCCAG CATCTTGGAG 
CGCATTCAAT ACTGCATTCA GGACCCTGAT GTGCTGAACT CGCCCTTGCC CATGGAACCA 
GGGCCCATTG TGGAGGAGGA AGGGGCCTCT GGGCCGGGGA ACAGGTCACT GGAAGGTCTT 
AGATCCCCAA AGACCCTGGA ACTGAGTTCC CAGAACTTGA AAAGCCGGGG AGGAGACCTT 
CTTGGCTCTC AGCTGCCCTC TGGCCTCAAG ACCCTCACAT CCAGATGCCT TCAACCTCAG 
AACATTTGGA ACCCCACCTA TGGCTCCTGG ACCCCAAGGA GCCCCCAGGG TGAAGATTCA 
GACATTGACC TTAGCAATGG CCCCTCCTCG GATTCCTTTC CAGGCGAGCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen.
Biochemical and biophysical research communications363(4)926-30(2007 Nov)
Yamada S,Uchimura E,Ueda T,Nomura T,Fujita S,Matsumoto K,Funeriu DP,Miyake M,Miyake J

Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice.
Oncogene18(26)3821-30(1999 Jul)
Honda H,Harada K,Komuro I,Terasaki F,Ueno H,Tanaka Y,Kawamura K,Yazaki Y,Hirai H

The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase.
Oncogene14(25)3067-72(1997 Jun)
Ueno H,Honda H,Nakamoto T,Yamagata T,Sasaki K,Miyagawa K,Mitani K,Yazaki Y,Hirai H

Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain.
Nature333(6174)672-6(1988 Jun)
Ben-Neriah Y,Bauskin AR