Nfkb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nfkb2
Entrez Gene ID	309452
Full Name	nuclear factor kappa B subunit 2
Synonyms	RGD1307189
General protein information	Preferred Names nuclear factor kappa B subunit 2 Names nuclear factor NF-kappa-B p100 subunit nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54

mRNA and Protein(s)

mRNA	Protein	Name
XM_006231503.3	XP_006231565.1	nuclear factor NF-kappa-B p100 subunit isoform X1
NM_001008349.1	NP_001008350.1	nuclear factor NF-kappa-B p100 subunit

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NFKB2	XP_003312809.1
	NFKB2	XP_001104566.1
Rattus norvegicus (Norway rat)	Nfkb2	NP_001008350.1
Anopheles gambiae (African malaria mosquito)	REL2	XP_308995.3
Homo sapiens (human)	NFKB2	NP_001070962.1
Mus musculus (house mouse)	Nfkb2	NP_001170841.1
Gallus gallus (chicken)	NFKB2	NP_989744.1
Danio rerio (zebrafish)	nfkb2	NP_001001840.2
Xenopus tropicalis (tropical clawed frog)	nfkb2	NP_001005032.1
Bos taurus (cattle)	NFKB2	NP_001095571.1
Canis lupus familiaris (dog)	NFKB2	XP_005637727.1

Gene Ontology
Bibliography

Related articles in PubMed

TNF? up-regulates COX-2 in chronic progressive nephropathy through nuclear accumulation of RelB and NF-?B2.
Qiu J, Yuan H, Chen S, Zhou Y, Song D, Chen R
Archives of physiology and biochemistry122(2)88-93(2016)

Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor ?B (NF-?B) pathway: involvement of extracellular signal-regulated kinase (ERK), calcium, and c-REL.
Manecka DL, Mahmood SF, Grumolato L, Lihrmann I, Anouar Y
The Journal of biological chemistry288(21)14936-48(2013 May)

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Z?ller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenw?lder M, Schmidt-Supprian M, Heissmeyer V
Immunity38(4)655-68(2013 Apr)

Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathway.
Wang HJ, Cao JP, Yu JK, Zhang LC, Jiang ZJ, Gao DS
European journal of pharmacology595(1-3)7-12(2008 Oct)

Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-kappaB activation and expression.
Frier BC, Noble EG, Locke M
Cell stress & chaperones13(3)287-96(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TNFalpha-RelB/p52 pathway may be involved in the early stages of renal damage, in part by stimulating COX-2 and inflammatory responses
Title: TNF? up-regulates COX-2 in chronic progressive nephropathy through nuclear accumulation of RelB and NF-?B2.

PACAP promotes both survival and neuritogenesis in PC12 cells by activating NF-kappaB pathway, most likely via classical and alternative signaling cascades involving ERK1/2 kinases, Ca(2+), and c-Rel/p52 dimers.
Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor ?B (NF-?B) pathway: involvement of extracellular signal-regulated kinase (ERK), calcium, and c-REL.

Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB(p65/p52) signaling pathway.
Title: Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathway.

results indicate GDNF could activate the NF-kappaB signaling pathway in degenerating dopaminergic neurons; the NF-kappaB noncanonical signaling pathway, which contained the NF-kappaB p65/p52 complex that was involved in the effects of GDNF on DA neurons
Title: The involvement of NF-kappaB p65/p52 in the effects of GDNF on DA neurons in early PD rats.

The following Nfkb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nfkb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11694	NM_001008349.1 Latest version!	Rattus norvegicus nuclear factor kappa B subunit 2 (Nfkb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00
ORa11694	XM_006231503.3 Latest version!	Rattus norvegicus nuclear factor kappa B subunit 2 (Nfkb2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nfkb2 ( NM_001008349.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001008350.1 Rattus norvegicus nuclear factor kappa B subunit 2 (Nfkb2), mRNA.

Price & Availability↑

CloneID	ORa11694
Clone ID Related Accession (Same CDS sequence)	XM_006231503.3 , NM_001008349.1
Accession Version	NM_001008349.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2697bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	nuclear factor NF-kappa-B p100 subunit
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085800.1. On or before Dec 16, 2004 this sequence version replaced XM_219954.2, XM_347195.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085800.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACCGTT GCTACGATCC AGGTTTGGAT GGCATCCCTG AATATGATGA TTTTGAATTC 
AGCCCCTCCA TTGTGGAGCC CAAGGATCCA GCCCCAGAGA CAGCTGATGG CCCCTATCTG 
GTGATTGTGG AACAGCCTAA ACAGCGAGGC TTCAGATTTC GATATGGCTG TGAAGGCCCC 
TCCCATGGAG GTCTGCCAGG TGCCTCCAGT GAGAAGGGCC GGAAGACCTA TCCTACTGTC 
AAGATCTGTA ACTACGAGGG GCCGGCCAAG ATTGAGGTGG ACCTGGTGAC ACACAGTGAC 
CCACCCCGTG CACATGCCCA CAGTCTGGTG GGCAAGCAGT GCTCTGAGCT GGGGGTGTGT 
GCCGTGTCTG TGGGACCCAA GGACATGACT GCTCAATTTA ATAATCTGGG TGTCCTGCAT 
GTAACCAAGA AGAACATGAT GGAGATTATG ATTCAGAAAC TCCAGAGGCA GCGGCTCCGC 
TCCAAGCCTC AGGGCCTTAC AGAGGCCGAG CGCCGGGAGC TGGAGCAGGA GGCCAAGGAG 
CTGAAGAAAG TCATGGATTT GAGCATTGTA CGGCTACGCT TCTCAGCTTT CCTTCGAGCT 
AGTGATGGCT CCTTCTCCCT GCCCCTGAAG CCTGTGATCT CCCAGCCCAT CCACGACAGC 
AAGTCTCCAG GGGCCTCAAA CCTGAAGATT TCCCGAATGG ACAAAACAGC AGGTTCCGTG 
CGCGGTGGAG ACGAAGTTTA TTTGCTTTGC GATAAGGTGC AGAAAGATGA CATTGAGGTT 
CGTTTCTATG AGGATGACGA GAACGGATGG CAAGCCTTTG GGGACTTCTC TCCCACAGAC 
GTTCATAAAC AGTATGCCAT TGTGTTCCGG ACACCGCCCT ATCACAAGAT GAAGATTGAG 
AGGCCTGTAA CGGTGTTCCT GCAGCTGAAA CGCAAGCGTG GGGGCGATGT CTCCGACTCC 
AAACAGTTCA CGTATTACCC TCTGGTGGAA GACAAGGAGG AAGTACAGAG GAAGCGGAGA 
AAGGCCTTGC CTACCTTCTC CCAGCCCTTC GGGGGCGGAT CCCACATGGG TGGAGGTTCT 
GGGGGCTCCG CTGGGGGTTA TGGAGGCGCT GGAGGAGGTG GCAGCCTCGG CTTTTTCTCC 
TCCTTCGCCT ACAGCCCCTA CCAATCCGGT GCAGCCCCAA TGGGCTGCTT CCCGGGTGGG 
GGAGGTGGAG CGCAGATGGC CGGCTCTGGA CGGGACGCGG AGGCTGGCGA GGCAGAGGAG 
CAGCCCAGAG CACCCTCCGA GGCCCCCCAG AGCGAGCAGC AGGCCCTGGA CACGCTGCAG 
CGAGCTCGCG AGTACAACGC GCGCCTGTTC GGTCTGGCGC AGCGCAGCGC CCGAGCGTTG 
CTGGACTACG GCGTCACCGC GGACGCGCGT GCTCTGCTAG CGGGACAGCG CCACCTGCTG 
ATGGCACAGG ACGAGAACGG AGACACGCCG CTGCACCTGG CCATTATCCA TGGGCAGACT 
GGTGTCATTG AGCAGATAGC CCAAGTCATT TATCATGCTC AGTACCTTGG GGTCATCAAC 
CTCACCAATC ACCTGCACCA GACACCTCTG CACCTGGCAG TAATCACTGG GCAGACACGG 
GTGGTGAGCT TCCTGCTGCA GGTGGGTGCA GACCCCACAC TGCTGGATCG CCATGGTGAC 
TCAGCTGTCC ACTTGGCTCT CCGGGCAGGT GCTGCAGCCC CAGACCTGCT GCAGGCAGTG 
TTGCACAGTG GAGCCCACGC TCTGCCCCAA ATGTTACACA TGCCTGATTT TGAGGGACTA 
TACCCAGTAC ACCTGGCGGT CCATGCCCGA AGCCCTGAGT GCCTGGATCT GTTAGTTGAC 
TGTGGAGCTG AAGTGGAGGC AGCAGAGAGG CAAGGAGGCC GAACCCCACT GCATCTAGCC 
ACAGAGATGG AGGAGCTGGG GTTGGTCACC CATCTGGTCA CCAAGCTCCA TGCTAATGTG 
AATGCCCGGA CCTTTGCTGG AAACACACCC CTCCACCTGG CGGCTGGACT TGGATCCCCA 
ACCCTCACCC GCCTCCTTCT AAAGGCTGGT GCTGACATCC ATGCGGAGAA TGAAGAGCCT 
CTCTGCCCAC TGCCCTCACC CCCTACCTCT GGGAGCGATT CAGACTCTGA GGGGCCTGAG 
ACAGATACCC AAAGAAACTT CCGAGGCCAT ACCCCTCTTG ACCTCACTCG CAGTACCAAG 
GTGAAGACCC TGCTGTTGAA CGCTGCTCAG AACACCACGG AGCCACCCCT GGCCCCACCC 
AGCCCTGCAG GGCCAGGGCT GTCACTGGGG GATGCAGCCC TGCAGAACCT GGAGCAACTG 
CTAGATGGGC CAGAAGCCCA GGGCAGCTGG GCAGAGCTGG CAGAGAGACT GGGGCTGAGG 
AGCCTGGTGG ACACATACAG GAAGACCCCC TCCCCCAGTG GCAGTCTCCT TCGTAGTTAC 
AAGCTGGCTG GTGGAGACTT GGTGGGTCTA TTGGAAGCCT TGTCCGACAT GGGTCTTCAT 
GAGGGAGTTA GGCTGCTGAA GGCGCCTGAG ACCCGAGACA AGCTGCCCAG CACAGAGGTG 
AAAGAAGACA GTGCCTACGG GAGCCAGTCA GTGGAGCAGG AGGCAGAGAA GCTGTGTCCA 
CCCCCTGAGC CTCCAGGAGG GCTCTGCCAC GGGCACCCCC AGCCTCAGGT GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008350.1
CDS	259..2955
Translation	MDRCYDPGLDGIPEYDDFEFSPSIVEPKDPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSKPQGLTEAERRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGSGGSAGGYGGAGGGGSLGFFSSFAYSPYQSGAAPMGCFPGGGGGAQMAGSGRDAEAGEAEEQPRAPSEAPQSEQQALDTLQRAREYNARLFGLAQRSARALLDYGVTADARALLAGQRHLLMAQDENGDTPLHLAIIHGQTGVIEQIAQVIYHAQYLGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSAVHLALRAGAAAPDLLQAVLHSGAHALPQMLHMPDFEGLYPVHLAVHARSPECLDLLVDCGAEVEAAERQGGRTPLHLATEMEELGLVTHLVTKLHANVNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADIHAENEEPLCPLPSPPTSGSDSDSEGPETDTQRNFRGHTPLDLTRSTKVKTLLLNAAQNTTEPPLAPPSPAGPGLSLGDAALQNLEQLLDGPEAQGSWAELAERLGLRSLVDTYRKTPSPSGSLLRSYKLAGGDLVGLLEALSDMGLHEGVRLLKAPETRDKLPSTEVKEDSAYGSQSVEQEAEKLCPPPEPPGGLCHGHPQPQVH

Target ORF information:

RefSeq Version	NM_001008349.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear factor kappa B subunit 2 (Nfkb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008349.1

ORF Insert Sequence:

ATGGACCGTT GCTACGATCC AGGTTTGGAT GGCATCCCTG AATATGATGA TTTTGAATTC 
AGCCCCTCCA TTGTGGAGCC CAAGGATCCA GCCCCAGAGA CAGCTGATGG CCCCTATCTG 
GTGATTGTGG AACAGCCTAA ACAGCGAGGC TTCAGATTTC GATATGGCTG TGAAGGCCCC 
TCCCATGGAG GTCTGCCAGG TGCCTCCAGT GAGAAGGGCC GGAAGACCTA TCCTACTGTC 
AAGATCTGTA ACTACGAGGG GCCGGCCAAG ATTGAGGTGG ACCTGGTGAC ACACAGTGAC 
CCACCCCGTG CACATGCCCA CAGTCTGGTG GGCAAGCAGT GCTCTGAGCT GGGGGTGTGT 
GCCGTGTCTG TGGGACCCAA GGACATGACT GCTCAATTTA ATAATCTGGG TGTCCTGCAT 
GTAACCAAGA AGAACATGAT GGAGATTATG ATTCAGAAAC TCCAGAGGCA GCGGCTCCGC 
TCCAAGCCTC AGGGCCTTAC AGAGGCCGAG CGCCGGGAGC TGGAGCAGGA GGCCAAGGAG 
CTGAAGAAAG TCATGGATTT GAGCATTGTA CGGCTACGCT TCTCAGCTTT CCTTCGAGCT 
AGTGATGGCT CCTTCTCCCT GCCCCTGAAG CCTGTGATCT CCCAGCCCAT CCACGACAGC 
AAGTCTCCAG GGGCCTCAAA CCTGAAGATT TCCCGAATGG ACAAAACAGC AGGTTCCGTG 
CGCGGTGGAG ACGAAGTTTA TTTGCTTTGC GATAAGGTGC AGAAAGATGA CATTGAGGTT 
CGTTTCTATG AGGATGACGA GAACGGATGG CAAGCCTTTG GGGACTTCTC TCCCACAGAC 
GTTCATAAAC AGTATGCCAT TGTGTTCCGG ACACCGCCCT ATCACAAGAT GAAGATTGAG 
AGGCCTGTAA CGGTGTTCCT GCAGCTGAAA CGCAAGCGTG GGGGCGATGT CTCCGACTCC 
AAACAGTTCA CGTATTACCC TCTGGTGGAA GACAAGGAGG AAGTACAGAG GAAGCGGAGA 
AAGGCCTTGC CTACCTTCTC CCAGCCCTTC GGGGGCGGAT CCCACATGGG TGGAGGTTCT 
GGGGGCTCCG CTGGGGGTTA TGGAGGCGCT GGAGGAGGTG GCAGCCTCGG CTTTTTCTCC 
TCCTTCGCCT ACAGCCCCTA CCAATCCGGT GCAGCCCCAA TGGGCTGCTT CCCGGGTGGG 
GGAGGTGGAG CGCAGATGGC CGGCTCTGGA CGGGACGCGG AGGCTGGCGA GGCAGAGGAG 
CAGCCCAGAG CACCCTCCGA GGCCCCCCAG AGCGAGCAGC AGGCCCTGGA CACGCTGCAG 
CGAGCTCGCG AGTACAACGC GCGCCTGTTC GGTCTGGCGC AGCGCAGCGC CCGAGCGTTG 
CTGGACTACG GCGTCACCGC GGACGCGCGT GCTCTGCTAG CGGGACAGCG CCACCTGCTG 
ATGGCACAGG ACGAGAACGG AGACACGCCG CTGCACCTGG CCATTATCCA TGGGCAGACT 
GGTGTCATTG AGCAGATAGC CCAAGTCATT TATCATGCTC AGTACCTTGG GGTCATCAAC 
CTCACCAATC ACCTGCACCA GACACCTCTG CACCTGGCAG TAATCACTGG GCAGACACGG 
GTGGTGAGCT TCCTGCTGCA GGTGGGTGCA GACCCCACAC TGCTGGATCG CCATGGTGAC 
TCAGCTGTCC ACTTGGCTCT CCGGGCAGGT GCTGCAGCCC CAGACCTGCT GCAGGCAGTG 
TTGCACAGTG GAGCCCACGC TCTGCCCCAA ATGTTACACA TGCCTGATTT TGAGGGACTA 
TACCCAGTAC ACCTGGCGGT CCATGCCCGA AGCCCTGAGT GCCTGGATCT GTTAGTTGAC 
TGTGGAGCTG AAGTGGAGGC AGCAGAGAGG CAAGGAGGCC GAACCCCACT GCATCTAGCC 
ACAGAGATGG AGGAGCTGGG GTTGGTCACC CATCTGGTCA CCAAGCTCCA TGCTAATGTG 
AATGCCCGGA CCTTTGCTGG AAACACACCC CTCCACCTGG CGGCTGGACT TGGATCCCCA 
ACCCTCACCC GCCTCCTTCT AAAGGCTGGT GCTGACATCC ATGCGGAGAA TGAAGAGCCT 
CTCTGCCCAC TGCCCTCACC CCCTACCTCT GGGAGCGATT CAGACTCTGA GGGGCCTGAG 
ACAGATACCC AAAGAAACTT CCGAGGCCAT ACCCCTCTTG ACCTCACTCG CAGTACCAAG 
GTGAAGACCC TGCTGTTGAA CGCTGCTCAG AACACCACGG AGCCACCCCT GGCCCCACCC 
AGCCCTGCAG GGCCAGGGCT GTCACTGGGG GATGCAGCCC TGCAGAACCT GGAGCAACTG 
CTAGATGGGC CAGAAGCCCA GGGCAGCTGG GCAGAGCTGG CAGAGAGACT GGGGCTGAGG 
AGCCTGGTGG ACACATACAG GAAGACCCCC TCCCCCAGTG GCAGTCTCCT TCGTAGTTAC 
AAGCTGGCTG GTGGAGACTT GGTGGGTCTA TTGGAAGCCT TGTCCGACAT GGGTCTTCAT 
GAGGGAGTTA GGCTGCTGAA GGCGCCTGAG ACCCGAGACA AGCTGCCCAG CACAGAGGTG 
AAAGAAGACA GTGCCTACGG GAGCCAGTCA GTGGAGCAGG AGGCAGAGAA GCTGTGTCCA 
CCCCCTGAGC CTCCAGGAGG GCTCTGCCAC GGGCACCCCC AGCCTCAGGT GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nfkb2 ( XM_006231503.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006231565.1 Rattus norvegicus nuclear factor kappa B subunit 2 (Nfkb2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa11694
Clone ID Related Accession (Same CDS sequence)	XM_006231503.3 , NM_001008349.1
Accession Version	XM_006231503.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2697bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	nuclear factor NF-kappa-B p100 subunit isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006231503.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCGTT GCTACGATCC AGGTTTGGAT GGCATCCCTG AATATGATGA TTTTGAATTC 
AGCCCCTCCA TTGTGGAGCC CAAGGATCCA GCCCCAGAGA CAGCTGATGG CCCCTATCTG 
GTGATTGTGG AACAGCCTAA ACAGCGAGGC TTCAGATTTC GATATGGCTG TGAAGGCCCC 
TCCCATGGAG GTCTGCCAGG TGCCTCCAGT GAGAAGGGCC GGAAGACCTA TCCTACTGTC 
AAGATCTGTA ACTACGAGGG GCCGGCCAAG ATTGAGGTGG ACCTGGTGAC ACACAGTGAC 
CCACCCCGTG CACATGCCCA CAGTCTGGTG GGCAAGCAGT GCTCTGAGCT GGGGGTGTGT 
GCCGTGTCTG TGGGACCCAA GGACATGACT GCTCAATTTA ATAATCTGGG TGTCCTGCAT 
GTAACCAAGA AGAACATGAT GGAGATTATG ATTCAGAAAC TCCAGAGGCA GCGGCTCCGC 
TCCAAGCCTC AGGGCCTTAC AGAGGCCGAG CGCCGGGAGC TGGAGCAGGA GGCCAAGGAG 
CTGAAGAAAG TCATGGATTT GAGCATTGTA CGGCTACGCT TCTCAGCTTT CCTTCGAGCT 
AGTGATGGCT CCTTCTCCCT GCCCCTGAAG CCTGTGATCT CCCAGCCCAT CCACGACAGC 
AAGTCTCCAG GGGCCTCAAA CCTGAAGATT TCCCGAATGG ACAAAACAGC AGGTTCCGTG 
CGCGGTGGAG ACGAAGTTTA TTTGCTTTGC GATAAGGTGC AGAAAGATGA CATTGAGGTT 
CGTTTCTATG AGGATGACGA GAACGGATGG CAAGCCTTTG GGGACTTCTC TCCCACAGAC 
GTTCATAAAC AGTATGCCAT TGTGTTCCGG ACACCGCCCT ATCACAAGAT GAAGATTGAG 
AGGCCTGTAA CGGTGTTCCT GCAGCTGAAA CGCAAGCGTG GGGGCGATGT CTCCGACTCC 
AAACAGTTCA CGTATTACCC TCTGGTGGAA GACAAGGAGG AAGTACAGAG GAAGCGGAGA 
AAGGCCTTGC CTACCTTCTC CCAGCCCTTC GGGGGCGGAT CCCACATGGG TGGAGGTTCT 
GGGGGCTCCG CTGGGGGTTA TGGAGGCGCT GGAGGAGGTG GCAGCCTCGG CTTTTTCTCC 
TCCTTCGCCT ACAGCCCCTA CCAATCCGGT GCAGCCCCAA TGGGCTGCTT CCCGGGTGGG 
GGAGGTGGAG CGCAGATGGC CGGCTCTGGA CGGGACGCGG AGGCTGGCGA GGCAGAGGAG 
CAGCCCAGAG CACCCTCCGA GGCCCCCCAG AGCGAGCAGC AGGCCCTGGA CACGCTGCAG 
CGAGCTCGCG AGTACAACGC GCGCCTGTTC GGTCTGGCGC AGCGCAGCGC CCGAGCGTTG 
CTGGACTACG GCGTCACCGC GGACGCGCGT GCTCTGCTAG CGGGACAGCG CCACCTGCTG 
ATGGCACAGG ACGAGAACGG AGACACGCCG CTGCACCTGG CCATTATCCA TGGGCAGACT 
GGTGTCATTG AGCAGATAGC CCAAGTCATT TATCATGCTC AGTACCTTGG GGTCATCAAC 
CTCACCAATC ACCTGCACCA GACACCTCTG CACCTGGCAG TAATCACTGG GCAGACACGG 
GTGGTGAGCT TCCTGCTGCA GGTGGGTGCA GACCCCACAC TGCTGGATCG CCATGGTGAC 
TCAGCTGTCC ACTTGGCTCT CCGGGCAGGT GCTGCAGCCC CAGACCTGCT GCAGGCAGTG 
TTGCACAGTG GAGCCCACGC TCTGCCCCAA ATGTTACACA TGCCTGATTT TGAGGGACTA 
TACCCAGTAC ACCTGGCGGT CCATGCCCGA AGCCCTGAGT GCCTGGATCT GTTAGTTGAC 
TGTGGAGCTG AAGTGGAGGC AGCAGAGAGG CAAGGAGGCC GAACCCCACT GCATCTAGCC 
ACAGAGATGG AGGAGCTGGG GTTGGTCACC CATCTGGTCA CCAAGCTCCA TGCTAATGTG 
AATGCCCGGA CCTTTGCTGG AAACACACCC CTCCACCTGG CGGCTGGACT TGGATCCCCA 
ACCCTCACCC GCCTCCTTCT AAAGGCTGGT GCTGACATCC ATGCGGAGAA TGAAGAGCCT 
CTCTGCCCAC TGCCCTCACC CCCTACCTCT GGGAGCGATT CAGACTCTGA GGGGCCTGAG 
ACAGATACCC AAAGAAACTT CCGAGGCCAT ACCCCTCTTG ACCTCACTCG CAGTACCAAG 
GTGAAGACCC TGCTGTTGAA CGCTGCTCAG AACACCACGG AGCCACCCCT GGCCCCACCC 
AGCCCTGCAG GGCCAGGGCT GTCACTGGGG GATGCAGCCC TGCAGAACCT GGAGCAACTG 
CTAGATGGGC CAGAAGCCCA GGGCAGCTGG GCAGAGCTGG CAGAGAGACT GGGGCTGAGG 
AGCCTGGTGG ACACATACAG GAAGACCCCC TCCCCCAGTG GCAGTCTCCT TCGTAGTTAC 
AAGCTGGCTG GTGGAGACTT GGTGGGTCTA TTGGAAGCCT TGTCCGACAT GGGTCTTCAT 
GAGGGAGTTA GGCTGCTGAA GGCGCCTGAG ACCCGAGACA AGCTGCCCAG CACAGAGGTG 
AAAGAAGACA GTGCCTACGG GAGCCAGTCA GTGGAGCAGG AGGCAGAGAA GCTGTGTCCA 
CCCCCTGAGC CTCCAGGAGG GCTCTGCCAC GGGCACCCCC AGCCTCAGGT GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006231565.1
CDS	1522..4218
Translation	MDRCYDPGLDGIPEYDDFEFSPSIVEPKDPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLRSKPQGLTEAERRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQPFGGGSHMGGGSGGSAGGYGGAGGGGSLGFFSSFAYSPYQSGAAPMGCFPGGGGGAQMAGSGRDAEAGEAEEQPRAPSEAPQSEQQALDTLQRAREYNARLFGLAQRSARALLDYGVTADARALLAGQRHLLMAQDENGDTPLHLAIIHGQTGVIEQIAQVIYHAQYLGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSAVHLALRAGAAAPDLLQAVLHSGAHALPQMLHMPDFEGLYPVHLAVHARSPECLDLLVDCGAEVEAAERQGGRTPLHLATEMEELGLVTHLVTKLHANVNARTFAGNTPLHLAAGLGSPTLTRLLLKAGADIHAENEEPLCPLPSPPTSGSDSDSEGPETDTQRNFRGHTPLDLTRSTKVKTLLLNAAQNTTEPPLAPPSPAGPGLSLGDAALQNLEQLLDGPEAQGSWAELAERLGLRSLVDTYRKTPSPSGSLLRSYKLAGGDLVGLLEALSDMGLHEGVRLLKAPETRDKLPSTEVKEDSAYGSQSVEQEAEKLCPPPEPPGGLCHGHPQPQVH

Target ORF information:

RefSeq Version	XM_006231503.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear factor kappa B subunit 2 (Nfkb2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006231503.3

ORF Insert Sequence:

ATGGACCGTT GCTACGATCC AGGTTTGGAT GGCATCCCTG AATATGATGA TTTTGAATTC 
AGCCCCTCCA TTGTGGAGCC CAAGGATCCA GCCCCAGAGA CAGCTGATGG CCCCTATCTG 
GTGATTGTGG AACAGCCTAA ACAGCGAGGC TTCAGATTTC GATATGGCTG TGAAGGCCCC 
TCCCATGGAG GTCTGCCAGG TGCCTCCAGT GAGAAGGGCC GGAAGACCTA TCCTACTGTC 
AAGATCTGTA ACTACGAGGG GCCGGCCAAG ATTGAGGTGG ACCTGGTGAC ACACAGTGAC 
CCACCCCGTG CACATGCCCA CAGTCTGGTG GGCAAGCAGT GCTCTGAGCT GGGGGTGTGT 
GCCGTGTCTG TGGGACCCAA GGACATGACT GCTCAATTTA ATAATCTGGG TGTCCTGCAT 
GTAACCAAGA AGAACATGAT GGAGATTATG ATTCAGAAAC TCCAGAGGCA GCGGCTCCGC 
TCCAAGCCTC AGGGCCTTAC AGAGGCCGAG CGCCGGGAGC TGGAGCAGGA GGCCAAGGAG 
CTGAAGAAAG TCATGGATTT GAGCATTGTA CGGCTACGCT TCTCAGCTTT CCTTCGAGCT 
AGTGATGGCT CCTTCTCCCT GCCCCTGAAG CCTGTGATCT CCCAGCCCAT CCACGACAGC 
AAGTCTCCAG GGGCCTCAAA CCTGAAGATT TCCCGAATGG ACAAAACAGC AGGTTCCGTG 
CGCGGTGGAG ACGAAGTTTA TTTGCTTTGC GATAAGGTGC AGAAAGATGA CATTGAGGTT 
CGTTTCTATG AGGATGACGA GAACGGATGG CAAGCCTTTG GGGACTTCTC TCCCACAGAC 
GTTCATAAAC AGTATGCCAT TGTGTTCCGG ACACCGCCCT ATCACAAGAT GAAGATTGAG 
AGGCCTGTAA CGGTGTTCCT GCAGCTGAAA CGCAAGCGTG GGGGCGATGT CTCCGACTCC 
AAACAGTTCA CGTATTACCC TCTGGTGGAA GACAAGGAGG AAGTACAGAG GAAGCGGAGA 
AAGGCCTTGC CTACCTTCTC CCAGCCCTTC GGGGGCGGAT CCCACATGGG TGGAGGTTCT 
GGGGGCTCCG CTGGGGGTTA TGGAGGCGCT GGAGGAGGTG GCAGCCTCGG CTTTTTCTCC 
TCCTTCGCCT ACAGCCCCTA CCAATCCGGT GCAGCCCCAA TGGGCTGCTT CCCGGGTGGG 
GGAGGTGGAG CGCAGATGGC CGGCTCTGGA CGGGACGCGG AGGCTGGCGA GGCAGAGGAG 
CAGCCCAGAG CACCCTCCGA GGCCCCCCAG AGCGAGCAGC AGGCCCTGGA CACGCTGCAG 
CGAGCTCGCG AGTACAACGC GCGCCTGTTC GGTCTGGCGC AGCGCAGCGC CCGAGCGTTG 
CTGGACTACG GCGTCACCGC GGACGCGCGT GCTCTGCTAG CGGGACAGCG CCACCTGCTG 
ATGGCACAGG ACGAGAACGG AGACACGCCG CTGCACCTGG CCATTATCCA TGGGCAGACT 
GGTGTCATTG AGCAGATAGC CCAAGTCATT TATCATGCTC AGTACCTTGG GGTCATCAAC 
CTCACCAATC ACCTGCACCA GACACCTCTG CACCTGGCAG TAATCACTGG GCAGACACGG 
GTGGTGAGCT TCCTGCTGCA GGTGGGTGCA GACCCCACAC TGCTGGATCG CCATGGTGAC 
TCAGCTGTCC ACTTGGCTCT CCGGGCAGGT GCTGCAGCCC CAGACCTGCT GCAGGCAGTG 
TTGCACAGTG GAGCCCACGC TCTGCCCCAA ATGTTACACA TGCCTGATTT TGAGGGACTA 
TACCCAGTAC ACCTGGCGGT CCATGCCCGA AGCCCTGAGT GCCTGGATCT GTTAGTTGAC 
TGTGGAGCTG AAGTGGAGGC AGCAGAGAGG CAAGGAGGCC GAACCCCACT GCATCTAGCC 
ACAGAGATGG AGGAGCTGGG GTTGGTCACC CATCTGGTCA CCAAGCTCCA TGCTAATGTG 
AATGCCCGGA CCTTTGCTGG AAACACACCC CTCCACCTGG CGGCTGGACT TGGATCCCCA 
ACCCTCACCC GCCTCCTTCT AAAGGCTGGT GCTGACATCC ATGCGGAGAA TGAAGAGCCT 
CTCTGCCCAC TGCCCTCACC CCCTACCTCT GGGAGCGATT CAGACTCTGA GGGGCCTGAG 
ACAGATACCC AAAGAAACTT CCGAGGCCAT ACCCCTCTTG ACCTCACTCG CAGTACCAAG 
GTGAAGACCC TGCTGTTGAA CGCTGCTCAG AACACCACGG AGCCACCCCT GGCCCCACCC 
AGCCCTGCAG GGCCAGGGCT GTCACTGGGG GATGCAGCCC TGCAGAACCT GGAGCAACTG 
CTAGATGGGC CAGAAGCCCA GGGCAGCTGG GCAGAGCTGG CAGAGAGACT GGGGCTGAGG 
AGCCTGGTGG ACACATACAG GAAGACCCCC TCCCCCAGTG GCAGTCTCCT TCGTAGTTAC 
AAGCTGGCTG GTGGAGACTT GGTGGGTCTA TTGGAAGCCT TGTCCGACAT GGGTCTTCAT 
GAGGGAGTTA GGCTGCTGAA GGCGCCTGAG ACCCGAGACA AGCTGCCCAG CACAGAGGTG 
AAAGAAGACA GTGCCTACGG GAGCCAGTCA GTGGAGCAGG AGGCAGAGAA GCTGTGTCCA 
CCCCCTGAGC CTCCAGGAGG GCTCTGCCAC GGGCACCCCC AGCCTCAGGT GCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TNF? up-regulates COX-2 in chronic progressive nephropathy through nuclear accumulation of RelB and NF-?B2.
Archives of physiology and biochemistry122(2)88-93(2016)
Qiu J,Yuan H,Chen S,Zhou Y,Song D,Chen R

Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes both survival and neuritogenesis in PC12 cells through activation of nuclear factor ?B (NF-?B) pathway: involvement of extracellular signal-regulated kinase (ERK), calcium, and c-REL.
The Journal of biological chemistry288(21)14936-48(2013 May)
Manecka DL,Mahmood SF,Grumolato L,Lihrmann I,Anouar Y

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Immunity38(4)655-68(2013 Apr)
Vogel KU,Edelmann SL,Jeltsch KM,Bertossi A,Heger K,Heinz GA,Z?ller J,Warth SC,Hoefig KP,Lohs C,Neff F,Kremmer E,Schick J,Repsilber D,Geerlof A,Blum H,Wurst W,Heikenw?lder M,Schmidt-Supprian M,Heissmeyer V

Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathway.
European journal of pharmacology595(1-3)7-12(2008 Oct)
Wang HJ,Cao JP,Yu JK,Zhang LC,Jiang ZJ,Gao DS

Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-kappaB activation and expression.
Cell stress & chaperones13(3)287-96(2008 Sep)
Frier BC,Noble EG,Locke M

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Nfkb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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