Kptn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kptn
Entrez Gene ID	308107
Full Name	kaptin (actin binding protein)
General protein information	Preferred Names kaptin (actin binding protein) Names kaptin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107457.1	NP_001100927.1	kaptin

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kptn	NP_001100927.1
Gallus gallus (chicken)	LOC101752009	XP_004950815.1

Gene Ontology
Bibliography

Related articles in PubMed

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM
Nature543(7645)438-442(2017 03)

Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures.
Baple EL, Maroofian R, Chioza BA, Izadi M, Cross HE, Al-Turki S, Barwick K, Skrzypiec A, Pawlak R, Wagner K, Coblentz R, Zainy T, Patton MA, Mansour S, Rich P, Qualmann B, Hurles ME, Kessels MM, Crosby AH
American journal of human genetics94(1)87-94(2014 Jan)

2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear.
Bearer EL, Abraham MT
European journal of cell biology78(2)117-26(1999 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kptn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kptn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03582	NM_001107457.1 Latest version!	Rattus norvegicus kaptin (actin binding protein) (Kptn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kptn ( NM_001107457.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100927.1 Rattus norvegicus kaptin (actin binding protein) (Kptn), mRNA.

Price & Availability↑

CloneID	ORa03582
Clone ID Related Accession (Same CDS sequence)	NM_001107457.1
Accession Version	NM_001107457.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	kaptin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473979.2. On or before Oct 4, 2007 this sequence version replaced XM_001074187.1, XM_217806.4. ##Evidence-Data-START## Transcript exon combination :: CB734880.1, CB810022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGAGG CGGCCGTGGC AGAAGGGCCC TGTCCACTGC GAGAGGACAG CTTCACGCGC 
TTCTCGTCGC AGAGCAACGT GTATGGGCTT GCTGGAGGCG CCGACGGGCG AGGGGAGTTG 
CTGGCCGCCA CTCTTAAAGG CAAGGTGCTC GGCTTCCGCT ATCAAGACCT CCGACAGAAA 
ATCAGGCCTG TGGCCAAAGA GCTGCAATTC AACTACATCC CCGTGGATGC TGAGATCGTC 
TCCATCGACA CTTTCAACAA GTCACCCCCA AAACGGGGCC TGGTTGTGGG CATCACTTTT 
ATAAAGGTAC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100927.1
CDS	75..389
Translation	MGEAAVAEGPCPLREDSFTRFSSQSNVYGLAGGADGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKVP

Target ORF information:

RefSeq Version	NM_001107457.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus kaptin (actin binding protein) (Kptn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107457.1

ORF Insert Sequence:

ATGGGGGAGG CGGCCGTGGC AGAAGGGCCC TGTCCACTGC GAGAGGACAG CTTCACGCGC 
TTCTCGTCGC AGAGCAACGT GTATGGGCTT GCTGGAGGCG CCGACGGGCG AGGGGAGTTG 
CTGGCCGCCA CTCTTAAAGG CAAGGTGCTC GGCTTCCGCT ATCAAGACCT CCGACAGAAA 
ATCAGGCCTG TGGCCAAAGA GCTGCAATTC AACTACATCC CCGTGGATGC TGAGATCGTC 
TCCATCGACA CTTTCAACAA GTCACCCCCA AAACGGGGCC TGGTTGTGGG CATCACTTTT 
ATAAAGGTAC CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Nature543(7645)438-442(2017 03)
Wolfson RL,Chantranupong L,Wyant GA,Gu X,Orozco JM,Shen K,Condon KJ,Petri S,Kedir J,Scaria SM,Abu-Remaileh M,Frankel WN,Sabatini DM

Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures.
American journal of human genetics94(1)87-94(2014 Jan)
Baple EL,Maroofian R,Chioza BA,Izadi M,Cross HE,Al-Turki S,Barwick K,Skrzypiec A,Pawlak R,Wagner K,Coblentz R,Zainy T,Patton MA,Mansour S,Rich P,Qualmann B,Hurles ME,Kessels MM,Crosby AH

2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear.
European journal of cell biology78(2)117-26(1999 Feb)
Bearer EL,Abraham MT