Olig2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Olig2
Entrez Gene ID	304103
Full Name	oligodendrocyte transcription factor 2
General protein information	Preferred Names oligodendrocyte transcription factor 2 Names oligodendrocyte transcription factor 2 oligodendrocyte lineage transcription factor 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001100557.1	NP_001094027.1	oligodendrocyte transcription factor 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OLIG2	XP_001172282.1
	LOC700098	XP_002808388.1
Xenopus tropicalis (tropical clawed frog)	olig2	XP_004912201.1
Mus musculus (house mouse)	Olig2	NP_058663.2
Canis lupus familiaris (dog)	OLIG2	XP_005638894.1
Rattus norvegicus (Norway rat)	Olig2	NP_001094027.1
Gallus gallus (chicken)	OLIG3	NP_001026697.1
Homo sapiens (human)	OLIG2	NP_005797.1
Danio rerio (zebrafish)	olig2	NP_835201.1

Gene Ontology
Bibliography

Related articles in PubMed

Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-? and Olig2 with triiodothyronine.
Abbaszadeh HA, Tiraihi T, Delshad A, Saghedizadeh M, Taheri T, Kazemi H, Hassoun HK
Tissue & cell46(6)462-9(2014 Dec)

Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2.
Fang F, Zhang H, Zhang Y, Xu H, Huang Q, Adilijiang A, Wang J, Zhang Z, Zhang D, Tan Q, He J, Kong L, Liu Y, Li XM
Life sciences93(12-14)429-34(2013 Oct)

Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.
Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, Liu L, Liu W, Wu LM, Mao M, Chan JR, Wu J, Lu QR
Cell152(1-2)248-61(2013 Jan)

Effects of Olig2-overexpressing neural stem cells and myelin basic protein-activated T cells on recovery from spinal cord injury.
Hu JG, Shen L, Wang R, Wang QY, Zhang C, Xi J, Ma SF, Zhou JS, L? HZ
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics9(2)422-45(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Replacing heregulin, PDGF-AA and bFGF with T3 for 6 days resulted in repression of O4, O1, Olig2 and PDGFR-a
Title: Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-? and Olig2 with triiodothyronine.

Olig1 and Olig2 expression are enhanced during antipsychotic drug induced differentiation of oligodendrocyte progenitor cells.
Title: Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2.

Study finds that the oligodendrocyte-lineage determination factor Olig2 transcriptionally prepatterns the chromatin-remodeling factor Smarca4/Brg1 to the enhancer elements to control oligodendrocyte differentiation.
Title: Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation.

Olig2 overexpression enhances oligodendrocyte differentiation and myelination with an effect on functional recovery following spinal cord injury.
Title: Effects of Olig2-overexpressing neural stem cells and myelin basic protein-activated T cells on recovery from spinal cord injury.

Pax6 decreases the number of Neuron-Glia 2 progenitor cells and prevents oligodendrocytic lineage commitment, while repression of Olig2 results in an expanded astrocytic lineage.
Title: Modification of pax6 and olig2 expression in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations.

The following Olig2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Olig2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02901	NM_001100557.1 Latest version!	Rattus norvegicus oligodendrocyte transcription factor 2 (Olig2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Olig2 ( NM_001100557.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001094027.1 Rattus norvegicus oligodendrocyte transcription factor 2 (Olig2), mRNA.

Price & Availability↑

CloneID	ORa02901
Clone ID Related Accession (Same CDS sequence)	NM_001100557.1
Accession Version	NM_001100557.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Rattus norvegicus(Norway rat)
Product	oligodendrocyte transcription factor 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC112633.6. On or before Dec 19, 2009 this sequence version replaced XM_001073459.1, XM_221668.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW141166.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACTCGG ACGCCAGCCT GGTGTCTAGT CGCCCGTCGT CGCCAGAACC CGATGATCTT 
TTTCTGCCGG CCCGGAGCAA GGGGGGAAGC AGCAGCGGCT TCACAGGAGG AACCGTGTCC 
TCATCCACGC CGAGCGACTG CCCGCCAGAG CTGAGCTCCG AGCTGCGAGG AGCCATGGGC 
ACGGCGGGCG CGCATCCCGG GGACAAACTG GGCGGCGGTG GCTTCAAGTC ATCTTCCTCC 
AGCACCTCCT CGTCCACGTC GTCGGCGGCC ACGTCTTCCA CCAAGAAAGA TAAGAAGCAG 
ATGACTGAGC CCGAGCTGCA GCAGCTGCGC CTGAAGATCA ACAGCCGCGA GCGCAAGCGC 
ATGCACGACC TCAACATCGC CATGGACGGC CTGAGGGAGG TCATGCCGTA CGCGCACGGC 
CCGTCGGTGC GCAAGCTCTC CAAGATCGCC ACGCTGCTGC TGGCGCGAAA CTACATCCTG 
ATGCTCACCA ACTCGCTGGA GGAGATGAAG AGACTGGTGA GCGAGATTTA CGGGGGTCAC 
CACGCCGGCT TCCACCCGTC GGCCTGTGGC GGGCTGGCAC ACTCGACGCC TCTACCCACC 
GCCACGGCGC ACCCTGCAGC CGCCGCGCAC GCCGCGCACC ACCCGGCGGT GCATCACCCC 
ATCCTCCCTC CAGCAGCCGC GGCCGCAGCC GCCGCAGCCG CTGCCGCAGC GGTGTCCAGC 
GCTTCTCTGC CGGGCTCCGG GCTGTCCTCG GTCGGATCCA TCCGGCCTCC TCACGGCCTG 
CTCAAGTCTC CATCGGCAGC CGCGGCCGCC CCTCTCGGAG GCGGGGGTGG AGGCAGCGGT 
GGCAGCGGTG GCTTCCAGCA CTGGGGTGGC ATGCCGTGCC CCTGCAGCAT GTGCCAGGTG 
CCGCCGCCAC ACCACCACGT GTCGGCTATG GGCGCCGGCA CCTTGCCGCG CCTCACCTCC 
GACGCCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094027.1
CDS	303..1274
Translation	MDSDASLVSSRPSSPEPDDLFLPARSKGGSSSGFTGGTVSSSTPSDCPPELSSELRGAMGTAGAHPGDKLGGGGFKSSSSSTSSSTSSAATSSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSTPLPTATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLSSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGGSGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGTLPRLTSDAK

Target ORF information:

RefSeq Version	NM_001100557.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus oligodendrocyte transcription factor 2 (Olig2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100557.1

ORF Insert Sequence:

ATGGACTCGG ACGCCAGCCT GGTGTCTAGT CGCCCGTCGT CGCCAGAACC CGATGATCTT 
TTTCTGCCGG CCCGGAGCAA GGGGGGAAGC AGCAGCGGCT TCACAGGAGG AACCGTGTCC 
TCATCCACGC CGAGCGACTG CCCGCCAGAG CTGAGCTCCG AGCTGCGAGG AGCCATGGGC 
ACGGCGGGCG CGCATCCCGG GGACAAACTG GGCGGCGGTG GCTTCAAGTC ATCTTCCTCC 
AGCACCTCCT CGTCCACGTC GTCGGCGGCC ACGTCTTCCA CCAAGAAAGA TAAGAAGCAG 
ATGACTGAGC CCGAGCTGCA GCAGCTGCGC CTGAAGATCA ACAGCCGCGA GCGCAAGCGC 
ATGCACGACC TCAACATCGC CATGGACGGC CTGAGGGAGG TCATGCCGTA CGCGCACGGC 
CCGTCGGTGC GCAAGCTCTC CAAGATCGCC ACGCTGCTGC TGGCGCGAAA CTACATCCTG 
ATGCTCACCA ACTCGCTGGA GGAGATGAAG AGACTGGTGA GCGAGATTTA CGGGGGTCAC 
CACGCCGGCT TCCACCCGTC GGCCTGTGGC GGGCTGGCAC ACTCGACGCC TCTACCCACC 
GCCACGGCGC ACCCTGCAGC CGCCGCGCAC GCCGCGCACC ACCCGGCGGT GCATCACCCC 
ATCCTCCCTC CAGCAGCCGC GGCCGCAGCC GCCGCAGCCG CTGCCGCAGC GGTGTCCAGC 
GCTTCTCTGC CGGGCTCCGG GCTGTCCTCG GTCGGATCCA TCCGGCCTCC TCACGGCCTG 
CTCAAGTCTC CATCGGCAGC CGCGGCCGCC CCTCTCGGAG GCGGGGGTGG AGGCAGCGGT 
GGCAGCGGTG GCTTCCAGCA CTGGGGTGGC ATGCCGTGCC CCTGCAGCAT GTGCCAGGTG 
CCGCCGCCAC ACCACCACGT GTCGGCTATG GGCGCCGGCA CCTTGCCGCG CCTCACCTCC 
GACGCCAAGT GA