Uqcrc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Uqcrc1
Entrez Gene ID	301011
Full Name	ubiquinol-cytochrome c reductase core protein 1
General protein information	Preferred Names ubiquinol-cytochrome c reductase core protein 1 Names cytochrome b-c1 complex subunit 1, mitochondrial complex III subunit 1 core protein I ubiquinol-cytochrome c reductase core protein I ubiquinol-cytochrome-c reductase complex core protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	human homolog catalyzes the transfer of electrons from coenzyme QH2 to ferricytochrome c in mitochondrial electron transport [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004250.2	NP_001004250.1	cytochrome b-c1 complex subunit 1, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	UQCRC1	XP_516440.4
Danio rerio (zebrafish)	uqcrc1	NP_957114.1
Rattus norvegicus (Norway rat)	Uqcrc1	NP_001004250.1
Gallus gallus (chicken)	UQCRC1	XP_414356.2
Mus musculus (house mouse)	Uqcrc1	NP_079683.2
Homo sapiens (human)	UQCRC1	NP_003356.2
Canis lupus familiaris (dog)	UQCRC1	XP_851209.1
	UQCRC1	NP_001035208.1
Bos taurus (cattle)	UQCRC1	NP_777054.1
Caenorhabditis elegans (roundworm)	ucr-1	NP_498202.1
Xenopus tropicalis (tropical clawed frog)	uqcrc1	NP_001016710.1

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquinol-cytochrome c reductase core protein 1 may be involved in delayed cardioprotection from preconditioning induced by diazoxide.
Long Z, Duan G, Li H, Yi T, Wu X, Chen F, Wu Z, Gao Y
PloS one12(7)e0181903(2017)

Overexpression of Ubiquinol-Cytochrome c Reductase Core Protein 1 May Protect H9c2 Cardiac Cells by Binding with Zinc.
Yi T, Wu X, Long Z, Duan G, Wu Z, Li H, Chen H, Zhou X
BioMed research international20171314297(2017)

Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer's disease in a Chinese population.
Ma SL, Tang NL, Lam LC
Journal of psychiatric research76143-7(2016 May)

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Zhao X, Le?n IR, Bak S, Mogensen M, Wrzesinski K, H?jlund K, Jensen ON
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)

Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function.
Davison EJ, Pennington K, Hung CC, Peng J, Rafiq R, Ostareck-Lederer A, Ostareck DH, Ardley HC, Banks RE, Robinson PA
Proteomics9(18)4284-97(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results showed that UQCRC1 might contribute to the loss-of-cardioprotection model induced by long-term diazoxide treatment and play a role in delayed cardioprotection.
Title: Ubiquinol-cytochrome c reductase core protein 1 may be involved in delayed cardioprotection from preconditioning induced by diazoxide.

reduced expression in myocardial mitochondria after TNF administration
Title: TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction.

The following Uqcrc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Uqcrc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12270	NM_001004250.2 Latest version!	Rattus norvegicus ubiquinol-cytochrome c reductase core protein 1 (Uqcrc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Uqcrc1 ( NM_001004250.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004250.1 Rattus norvegicus ubiquinol-cytochrome c reductase core protein 1 (Uqcrc1), mRNA.

Price & Availability↑

CloneID	ORa12270
Clone ID Related Accession (Same CDS sequence)	NM_001004250.2
Accession Version	NM_001004250.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome b-c1 complex subunit 1, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078923.1. On Aug 31, 2012 this sequence version replaced NM_001004250.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078923.1, FQ213124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCGGCGT CCGCAGTCTG CCGAGCGGCC TGCTCTGGGA CGCAAGCGCT ACTTCGCACC 
TGCCGCTCGC CGGCCCTGCT GAGGCTACCT GCCTTGCGGG GTACCGCAAC CTTCGTCCAG 
GCCCTCCAGA GCGTGCCGGA GACACAGGTC AGCGTATTGG ACAACGGGCT GCGTGTGGCC 
TCGGAGCAGT CCTCGCATCC TACCTGCACG GTGGGAGTGT GGATTGACGT TGGCAGTCGC 
TATGAGACTG AGAAGAACAA TGGAGCAGGC TACTTTTTGG AACATCTGGC TTTCAAGGGA 
ACAAAGAACC GTCCTGGCAA TGCCTTAGAG AAGGAGGTAG AGAGTATTGG CGCCCATCTT 
AATGCCTACA GCACTCGGGA GCACACTGCT TACCTCATCA AGGCACTGTC CAAGGACCTG 
CCAAAAGTTG TGGAGCTCCT GGCAGATATT GTGCAGAACA TTAGTCTGGA AGACTCGCAG 
ATCGAGAAGG AGCGAGATGT GATCCTGCGG GAGATGCAGG AAAACGATGC CTCTATGCAG 
AATGTAGTCT TCGATTACCT GCATGCAACA GCATTCCAGG GCACACCTCT AGCCCAGGCT 
GTGGAGGGGC CCAGTGAGAA CGTCAGGAGG CTGTCGCGCA CAGACTTGAC TGACTACCTC 
AGCAGGCACT ACAAAGCTCC CCGAATGGTG CTGGCTGCCG CTGGAGGGGT GAAGCACCAG 
CAGCTGCTAG ACCTTGCCCA GGATCACTTC AGCAGTGTCT CCCAGGTGTA TGAAGAAGAC 
GCTGTACCTA GTATAACTCC ATGTCGCTTC ACTGGCAGTG AGATCCGACA TCGGGATGAT 
GCCCTGCCCT TGGCCCATGT GGCCATTGCA GTAGAGGGAC CTGGCTGGGC TAACCCAGAC 
AACGTGGCTC TCCAAGTGGC CAATGCCATC ATAGGCCACT ATGACTGCAC TTACGGTGGT 
GGAGTGCACC TGTCCAGCCC GCTGGCTTCC GTTGCTGTAG CTAACAAGCT TTGCCAGAGT 
TTCCAGACCT TCAACATCTC CTACTCTGAG ACCGGGTTGC TGGGCGCACA CTTTGTCTGT 
GATGCCATGA GCATCGATGA CATGATCTTC TTCCTGCAAG GCCAGTGGAT GCGCCTGTGC 
ACCAGCGCTA CAGAGAGTGA GGTGACTCGG GGCAAAAACA TCCTTAGGAA TGCCTTGATA 
TCTCATTTGG ATGGCACCAC CCCTGTGTGT GAAGACATTG GTCGCAGCCT CCTGACTTAT 
GGCCGCCGCA TCCCTCTGGC TGAGTGGGAG AGCCGGATTG AGGAGGTGGA TGCCCAGATG 
GTTCGAGAGG TTTGCTCCAA GTACTTTTAT GACCAATGTC CAGCAGTGGC TGGATATGGC 
CCCATCGAAC AGCTCTCAGA CTACAACCGG ATTCGCAGTG GCATGTTCTG GCTGCGCTTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004250.1
CDS	3..1445
Translation	MAASAVCRAACSGTQALLRTCRSPALLRLPALRGTATFVQALQSVPETQVSVLDNGLRVASEQSSHPTCTVGVWIDVGSRYETEKNNGAGYFLEHLAFKGTKNRPGNALEKEVESIGAHLNAYSTREHTAYLIKALSKDLPKVVELLADIVQNISLEDSQIEKERDVILREMQENDASMQNVVFDYLHATAFQGTPLAQAVEGPSENVRRLSRTDLTDYLSRHYKAPRMVLAAAGGVKHQQLLDLAQDHFSSVSQVYEEDAVPSITPCRFTGSEIRHRDDALPLAHVAIAVEGPGWANPDNVALQVANAIIGHYDCTYGGGVHLSSPLASVAVANKLCQSFQTFNISYSETGLLGAHFVCDAMSIDDMIFFLQGQWMRLCTSATESEVTRGKNILRNALISHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIEEVDAQMVREVCSKYFYDQCPAVAGYGPIEQLSDYNRIRSGMFWLRF

Target ORF information:

RefSeq Version	NM_001004250.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ubiquinol-cytochrome c reductase core protein 1 (Uqcrc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004250.2

ORF Insert Sequence:

ATGGCGGCGT CCGCAGTCTG CCGAGCGGCC TGCTCTGGGA CGCAAGCGCT ACTTCGCACC 
TGCCGCTCGC CGGCCCTGCT GAGGCTACCT GCCTTGCGGG GTACCGCAAC CTTCGTCCAG 
GCCCTCCAGA GCGTGCCGGA GACACAGGTC AGCGTATTGG ACAACGGGCT GCGTGTGGCC 
TCGGAGCAGT CCTCGCATCC TACCTGCACG GTGGGAGTGT GGATTGACGT TGGCAGTCGC 
TATGAGACTG AGAAGAACAA TGGAGCAGGC TACTTTTTGG AACATCTGGC TTTCAAGGGA 
ACAAAGAACC GTCCTGGCAA TGCCTTAGAG AAGGAGGTAG AGAGTATTGG CGCCCATCTT 
AATGCCTACA GCACTCGGGA GCACACTGCT TACCTCATCA AGGCACTGTC CAAGGACCTG 
CCAAAAGTTG TGGAGCTCCT GGCAGATATT GTGCAGAACA TTAGTCTGGA AGACTCGCAG 
ATCGAGAAGG AGCGAGATGT GATCCTGCGG GAGATGCAGG AAAACGATGC CTCTATGCAG 
AATGTAGTCT TCGATTACCT GCATGCAACA GCATTCCAGG GCACACCTCT AGCCCAGGCT 
GTGGAGGGGC CCAGTGAGAA CGTCAGGAGG CTGTCGCGCA CAGACTTGAC TGACTACCTC 
AGCAGGCACT ACAAAGCTCC CCGAATGGTG CTGGCTGCCG CTGGAGGGGT GAAGCACCAG 
CAGCTGCTAG ACCTTGCCCA GGATCACTTC AGCAGTGTCT CCCAGGTGTA TGAAGAAGAC 
GCTGTACCTA GTATAACTCC ATGTCGCTTC ACTGGCAGTG AGATCCGACA TCGGGATGAT 
GCCCTGCCCT TGGCCCATGT GGCCATTGCA GTAGAGGGAC CTGGCTGGGC TAACCCAGAC 
AACGTGGCTC TCCAAGTGGC CAATGCCATC ATAGGCCACT ATGACTGCAC TTACGGTGGT 
GGAGTGCACC TGTCCAGCCC GCTGGCTTCC GTTGCTGTAG CTAACAAGCT TTGCCAGAGT 
TTCCAGACCT TCAACATCTC CTACTCTGAG ACCGGGTTGC TGGGCGCACA CTTTGTCTGT 
GATGCCATGA GCATCGATGA CATGATCTTC TTCCTGCAAG GCCAGTGGAT GCGCCTGTGC 
ACCAGCGCTA CAGAGAGTGA GGTGACTCGG GGCAAAAACA TCCTTAGGAA TGCCTTGATA 
TCTCATTTGG ATGGCACCAC CCCTGTGTGT GAAGACATTG GTCGCAGCCT CCTGACTTAT 
GGCCGCCGCA TCCCTCTGGC TGAGTGGGAG AGCCGGATTG AGGAGGTGGA TGCCCAGATG 
GTTCGAGAGG TTTGCTCCAA GTACTTTTAT GACCAATGTC CAGCAGTGGC TGGATATGGC 
CCCATCGAAC AGCTCTCAGA CTACAACCGG ATTCGCAGTG GCATGTTCTG GCTGCGCTTC 
TAG