Serpina3m cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina3m
Entrez Gene ID	299276
Full Name	serine (or cysteine) proteinase inhibitor, clade A, member 3M
Synonyms	SPI-2.4
General protein information	Preferred Names serine (or cysteine) proteinase inhibitor, clade A, member 3M Names serine protease inhibitor A3M serine protease inhibitor 2.4 serpin A3M
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32
Summary	mouse homolog is a serine proteinase inhibitor expressed in liver [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001270982.1	NP_001257911.1	serine protease inhibitor A3M precursor
XM_006240466.3	XP_006240528.1	serine protease inhibitor A3M isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Serpina3m	NP_001257911.1
Rattus norvegicus (Norway rat)	Serpina3c	NP_036789.2

Gene Ontology
Bibliography

Related articles in PubMed

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel S, Parker BL, Packer NH
The Journal of biological chemistry290(14)8789-802(2015 Apr)

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez L, Borras FE, Falcon-Perez JM
Journal of proteomics75(12)3574-84(2012 Jun)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Palmer DJ, Kelly VC, Smit AM, Kuy S, Knight CG, Cooper GJ
Proteomics6(7)2208-16(2006 Apr)

Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus.
Horvath AJ, Forsyth SL, Coughlin PB
Journal of molecular evolution59(4)488-97(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Serpina3m gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina3m cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10015	NM_001270982.1 Latest version!	Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade A, member 3M (Serpina3m), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa10015	XM_006240466.3 Latest version!	Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade A, member 3M (Serpina3m), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina3m ( NM_001270982.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257911.1 Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade A, member 3M (Serpina3m), mRNA.

Price & Availability↑

CloneID	ORa10015
Clone ID Related Accession (Same CDS sequence)	NM_001270982.1 , XM_006240466.3
Accession Version	NM_001270982.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Rattus norvegicus(Norway rat)
Product	serine protease inhibitor A3M precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC119346.6. On Aug 17, 2012 this sequence version replaced XM_216782.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01906357, SAMN01906358 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTTCA TTGCAGCTTT GGGGCTCCTG ATGGCTGGGA TCTGCCCTGC TGTCCTTGGC 
TTCCCAGATG GCACACTGGG AAATGACACT CTACTCCATA AAGATCAAGA CAAGGGGACA 
CAACTGGACA GTCTCACATT GGAGTCCATC AACACTGACT TTGCCTTCAG CCTTTACAAG 
ATGCTGGCTT TGAAGAATCC AGATAAAAAT GTTGTCTTCT CCCCACTTAG CATCTCAGCT 
GCCTTGGCCA TTGTGTCCCT GGGAGCAAAG GGCAACACCC TGGAAGAGAT TCTAGAAGTT 
CTCAGGTTCA ATCTCACAGA GAGCTATGAG ACAGACATCC ACCAGGGCTT TGGGCACCTC 
CTCCAGAGGC TCAGTCAGCC AGGGGACCAG GTAAAGATCA TCACAGGCAA TGCTCTGTTT 
ATTGATAAGA ACCTTCAGGT CCTGGCAGAG TTCCAGGAGA AGACAAGGGC TCTGTACCAG 
GTTGAGGCCT TCACAGCTGA CTTCCAGCAG CCTCGTGTGA CCGAAAAGCT CATCAATGAC 
TATGTGAGAA ATCAGACCCA GGGGAAGATC CAGGAACTGG TCTCAGGCCT GAAAGAGAGG 
ACATCCATGG TGCTGGTGAA CTACCTCCTC TTTAGAGGCA AATGGAAGGT GCCCTTTGAC 
CCTGATTACA CATTTGAGTC TGAGTTCTAC GTGGATGAGA AGAGGTCTGT GAAGGTGTCC 
ATGATGAAAA TTGAGGAACT GACTACACCT TACTTCCGGG ATGAGGAGCT GTCCTGCTCT 
GTGCTGGAAC TGAAGTACAC AGGAAATTCC AGTGCCCTGT TCATCCTCCC TGATAAGGGC 
AGGATGCAGC AAGTGGAAGC CAGCTTGCAA CCAGAGACCC TGAAGAAGTG GAAGGACTCT 
CTGAGGCCCA GGAAGATAGA TGAGCTCTAC CTGCCCAGGT TATCCATTTC CACTGACTAT 
AGCCTGGAGG AGGTCCTTCC AGAGCTGGGC ATTAGGGATG TCTTCTCCCA GCAAGCTGAT 
CTGAGTAGGA TCACAGGGGC CAAGGACCTG AGTGTCTCTC AGGTGGTCCA CAAGGTTGTG 
CTGGATGTGA ATGAGACAGG CACAGAAGCA GCTGCTGCCA CAGGAGCCAA TTTGGTCCCA 
CGTAGTGGAA GGCCACCTAT GATTGTGTGG TTCAACAGGC CATTCCTGAT AGCTGTCTCT 
CACACACATG GTCAGACTAT CCTCTTTATG GCCAAAGTCA TTAACCCCGT GGGAGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257911.1
CDS	103..1362
Translation	MAFIAALGLLMAGICPAVLGFPDGTLGNDTLLHKDQDKGTQLDSLTLESINTDFAFSLYKMLALKNPDKNVVFSPLSISAALAIVSLGAKGNTLEEILEVLRFNLTESYETDIHQGFGHLLQRLSQPGDQVKIITGNALFIDKNLQVLAEFQEKTRALYQVEAFTADFQQPRVTEKLINDYVRNQTQGKIQELVSGLKERTSMVLVNYLLFRGKWKVPFDPDYTFESEFYVDEKRSVKVSMMKIEELTTPYFRDEELSCSVLELKYTGNSSALFILPDKGRMQQVEASLQPETLKKWKDSLRPRKIDELYLPRLSISTDYSLEEVLPELGIRDVFSQQADLSRITGAKDLSVSQVVHKVVLDVNETGTEAAAATGANLVPRSGRPPMIVWFNRPFLIAVSHTHGQTILFMAKVINPVGA

Target ORF information:

RefSeq Version	NM_001270982.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade A, member 3M (Serpina3m), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270982.1

ORF Insert Sequence:

ATGGCCTTCA TTGCAGCTTT GGGGCTCCTG ATGGCTGGGA TCTGCCCTGC TGTCCTTGGC 
TTCCCAGATG GCACACTGGG AAATGACACT CTACTCCATA AAGATCAAGA CAAGGGGACA 
CAACTGGACA GTCTCACATT GGAGTCCATC AACACTGACT TTGCCTTCAG CCTTTACAAG 
ATGCTGGCTT TGAAGAATCC AGATAAAAAT GTTGTCTTCT CCCCACTTAG CATCTCAGCT 
GCCTTGGCCA TTGTGTCCCT GGGAGCAAAG GGCAACACCC TGGAAGAGAT TCTAGAAGTT 
CTCAGGTTCA ATCTCACAGA GAGCTATGAG ACAGACATCC ACCAGGGCTT TGGGCACCTC 
CTCCAGAGGC TCAGTCAGCC AGGGGACCAG GTAAAGATCA TCACAGGCAA TGCTCTGTTT 
ATTGATAAGA ACCTTCAGGT CCTGGCAGAG TTCCAGGAGA AGACAAGGGC TCTGTACCAG 
GTTGAGGCCT TCACAGCTGA CTTCCAGCAG CCTCGTGTGA CCGAAAAGCT CATCAATGAC 
TATGTGAGAA ATCAGACCCA GGGGAAGATC CAGGAACTGG TCTCAGGCCT GAAAGAGAGG 
ACATCCATGG TGCTGGTGAA CTACCTCCTC TTTAGAGGCA AATGGAAGGT GCCCTTTGAC 
CCTGATTACA CATTTGAGTC TGAGTTCTAC GTGGATGAGA AGAGGTCTGT GAAGGTGTCC 
ATGATGAAAA TTGAGGAACT GACTACACCT TACTTCCGGG ATGAGGAGCT GTCCTGCTCT 
GTGCTGGAAC TGAAGTACAC AGGAAATTCC AGTGCCCTGT TCATCCTCCC TGATAAGGGC 
AGGATGCAGC AAGTGGAAGC CAGCTTGCAA CCAGAGACCC TGAAGAAGTG GAAGGACTCT 
CTGAGGCCCA GGAAGATAGA TGAGCTCTAC CTGCCCAGGT TATCCATTTC CACTGACTAT 
AGCCTGGAGG AGGTCCTTCC AGAGCTGGGC ATTAGGGATG TCTTCTCCCA GCAAGCTGAT 
CTGAGTAGGA TCACAGGGGC CAAGGACCTG AGTGTCTCTC AGGTGGTCCA CAAGGTTGTG 
CTGGATGTGA ATGAGACAGG CACAGAAGCA GCTGCTGCCA CAGGAGCCAA TTTGGTCCCA 
CGTAGTGGAA GGCCACCTAT GATTGTGTGG TTCAACAGGC CATTCCTGAT AGCTGTCTCT 
CACACACATG GTCAGACTAT CCTCTTTATG GCCAAAGTCA TTAACCCCGT GGGAGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Serpina3m ( XM_006240466.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006240528.1 Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade A, member 3M (Serpina3m), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa10015
Clone ID Related Accession (Same CDS sequence)	NM_001270982.1 , XM_006240466.3
Accession Version	XM_006240466.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serine protease inhibitor A3M isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240466.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTTCA TTGCAGCTTT GGGGCTCCTG ATGGCTGGGA TCTGCCCTGC TGTCCTTGGC 
TTCCCAGATG GCACACTGGG AAATGACACT CTACTCCATA AAGATCAAGA CAAGGGGACA 
CAACTGGACA GTCTCACATT GGAGTCCATC AACACTGACT TTGCCTTCAG CCTTTACAAG 
ATGCTGGCTT TGAAGAATCC AGATAAAAAT GTTGTCTTCT CCCCACTTAG CATCTCAGCT 
GCCTTGGCCA TTGTGTCCCT GGGAGCAAAG GGCAACACCC TGGAAGAGAT TCTAGAAGTT 
CTCAGGTTCA ATCTCACAGA GAGCTATGAG ACAGACATCC ACCAGGGCTT TGGGCACCTC 
CTCCAGAGGC TCAGTCAGCC AGGGGACCAG GTAAAGATCA TCACAGGCAA TGCTCTGTTT 
ATTGATAAGA ACCTTCAGGT CCTGGCAGAG TTCCAGGAGA AGACAAGGGC TCTGTACCAG 
GTTGAGGCCT TCACAGCTGA CTTCCAGCAG CCTCGTGTGA CCGAAAAGCT CATCAATGAC 
TATGTGAGAA ATCAGACCCA GGGGAAGATC CAGGAACTGG TCTCAGGCCT GAAAGAGAGG 
ACATCCATGG TGCTGGTGAA CTACCTCCTC TTTAGAGGCA AATGGAAGGT GCCCTTTGAC 
CCTGATTACA CATTTGAGTC TGAGTTCTAC GTGGATGAGA AGAGGTCTGT GAAGGTGTCC 
ATGATGAAAA TTGAGGAACT GACTACACCT TACTTCCGGG ATGAGGAGCT GTCCTGCTCT 
GTGCTGGAAC TGAAGTACAC AGGAAATTCC AGTGCCCTGT TCATCCTCCC TGATAAGGGC 
AGGATGCAGC AAGTGGAAGC CAGCTTGCAA CCAGAGACCC TGAAGAAGTG GAAGGACTCT 
CTGAGGCCCA GGAAGATAGA TGAGCTCTAC CTGCCCAGGT TATCCATTTC CACTGACTAT 
AGCCTGGAGG AGGTCCTTCC AGAGCTGGGC ATTAGGGATG TCTTCTCCCA GCAAGCTGAT 
CTGAGTAGGA TCACAGGGGC CAAGGACCTG AGTGTCTCTC AGGTGGTCCA CAAGGTTGTG 
CTGGATGTGA ATGAGACAGG CACAGAAGCA GCTGCTGCCA CAGGAGCCAA TTTGGTCCCA 
CGTAGTGGAA GGCCACCTAT GATTGTGTGG TTCAACAGGC CATTCCTGAT AGCTGTCTCT 
CACACACATG GTCAGACTAT CCTCTTTATG GCCAAAGTCA TTAACCCCGT GGGAGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006240528.1
CDS	108..1367
Translation	MAFIAALGLLMAGICPAVLGFPDGTLGNDTLLHKDQDKGTQLDSLTLESINTDFAFSLYKMLALKNPDKNVVFSPLSISAALAIVSLGAKGNTLEEILEVLRFNLTESYETDIHQGFGHLLQRLSQPGDQVKIITGNALFIDKNLQVLAEFQEKTRALYQVEAFTADFQQPRVTEKLINDYVRNQTQGKIQELVSGLKERTSMVLVNYLLFRGKWKVPFDPDYTFESEFYVDEKRSVKVSMMKIEELTTPYFRDEELSCSVLELKYTGNSSALFILPDKGRMQQVEASLQPETLKKWKDSLRPRKIDELYLPRLSISTDYSLEEVLPELGIRDVFSQQADLSRITGAKDLSVSQVVHKVVLDVNETGTEAAAATGANLVPRSGRPPMIVWFNRPFLIAVSHTHGQTILFMAKVINPVGA

Target ORF information:

RefSeq Version	XM_006240466.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade A, member 3M (Serpina3m), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006240466.3

ORF Insert Sequence:

ATGGCCTTCA TTGCAGCTTT GGGGCTCCTG ATGGCTGGGA TCTGCCCTGC TGTCCTTGGC 
TTCCCAGATG GCACACTGGG AAATGACACT CTACTCCATA AAGATCAAGA CAAGGGGACA 
CAACTGGACA GTCTCACATT GGAGTCCATC AACACTGACT TTGCCTTCAG CCTTTACAAG 
ATGCTGGCTT TGAAGAATCC AGATAAAAAT GTTGTCTTCT CCCCACTTAG CATCTCAGCT 
GCCTTGGCCA TTGTGTCCCT GGGAGCAAAG GGCAACACCC TGGAAGAGAT TCTAGAAGTT 
CTCAGGTTCA ATCTCACAGA GAGCTATGAG ACAGACATCC ACCAGGGCTT TGGGCACCTC 
CTCCAGAGGC TCAGTCAGCC AGGGGACCAG GTAAAGATCA TCACAGGCAA TGCTCTGTTT 
ATTGATAAGA ACCTTCAGGT CCTGGCAGAG TTCCAGGAGA AGACAAGGGC TCTGTACCAG 
GTTGAGGCCT TCACAGCTGA CTTCCAGCAG CCTCGTGTGA CCGAAAAGCT CATCAATGAC 
TATGTGAGAA ATCAGACCCA GGGGAAGATC CAGGAACTGG TCTCAGGCCT GAAAGAGAGG 
ACATCCATGG TGCTGGTGAA CTACCTCCTC TTTAGAGGCA AATGGAAGGT GCCCTTTGAC 
CCTGATTACA CATTTGAGTC TGAGTTCTAC GTGGATGAGA AGAGGTCTGT GAAGGTGTCC 
ATGATGAAAA TTGAGGAACT GACTACACCT TACTTCCGGG ATGAGGAGCT GTCCTGCTCT 
GTGCTGGAAC TGAAGTACAC AGGAAATTCC AGTGCCCTGT TCATCCTCCC TGATAAGGGC 
AGGATGCAGC AAGTGGAAGC CAGCTTGCAA CCAGAGACCC TGAAGAAGTG GAAGGACTCT 
CTGAGGCCCA GGAAGATAGA TGAGCTCTAC CTGCCCAGGT TATCCATTTC CACTGACTAT 
AGCCTGGAGG AGGTCCTTCC AGAGCTGGGC ATTAGGGATG TCTTCTCCCA GCAAGCTGAT 
CTGAGTAGGA TCACAGGGGC CAAGGACCTG AGTGTCTCTC AGGTGGTCCA CAAGGTTGTG 
CTGGATGTGA ATGAGACAGG CACAGAAGCA GCTGCTGCCA CAGGAGCCAA TTTGGTCCCA 
CGTAGTGGAA GGCCACCTAT GATTGTGTGG TTCAACAGGC CATTCCTGAT AGCTGTCTCT 
CACACACATG GTCAGACTAT CCTCTTTATG GCCAAAGTCA TTAACCCCGT GGGAGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
The Journal of biological chemistry290(14)8789-802(2015 Apr)
Thaysen-Andersen M,Venkatakrishnan V,Loke I,Laurini C,Diestel S,Parker BL,Packer NH

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Journal of proteomics75(12)3574-84(2012 Jun)
Bastos-Amador P,Royo F,Gonzalez E,Conde-Vancells J,Palomo-Diez L,Borras FE,Falcon-Perez JM

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Proteomics6(7)2208-16(2006 Apr)
Palmer DJ,Kelly VC,Smit AM,Kuy S,Knight CG,Cooper GJ

Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus.
Journal of molecular evolution59(4)488-97(2004 Oct)
Horvath AJ,Forsyth SL,Coughlin PB