Dync2li1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dync2li1
Entrez Gene ID	298767
Full Name	dynein cytoplasmic 2 light intermediate chain 1
Synonyms	RGD1310286
General protein information	Preferred Names dynein cytoplasmic 2 light intermediate chain 1 Names cytoplasmic dynein 2 light intermediate chain 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013940.1	NP_001013962.1	cytoplasmic dynein 2 light intermediate chain 1
XM_006239695.3	XP_006239757.1	cytoplasmic dynein 2 light intermediate chain 1 isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Kessler K, Wunderlich I, Uebe S, Falk NS, Gie?l A, Brandst?tter JH, Popp B, Klinger P, Ekici AB, Sticht H, D?rr HG, Reis A, Roepman R, Seemanov? E, Thiel CT
Scientific reports511649(2015 Jul)

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
Taylor SP, Dantas TJ, Duran I, Wu S, Lachman RS, , Nelson SF, Cohn DH, Vallee RB, Krakow D
Nature communications67092(2015 Jun)

Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.
Ichikawa M, Watanabe Y, Murayama T, Toyoshima YY
FEBS letters585(15)2419-23(2011 Aug)

Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.
Rana AA, Barbera JP, Rodriguez TA, Lynch D, Hirst E, Smith JC, Beddington RS
Development (Cambridge, England)131(20)4999-5007(2004 Oct)

A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells.
Perrone CA, Tritschler D, Taulman P, Bower R, Yoder BK, Porter ME
Molecular biology of the cell14(5)2041-56(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dync2li1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dync2li1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04358	NM_001013940.1 Latest version!	Rattus norvegicus dynein cytoplasmic 2 light intermediate chain 1 (Dync2li1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa29094	XM_006239695.3 Latest version!	Rattus norvegicus dynein cytoplasmic 2 light intermediate chain 1 (Dync2li1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dync2li1 ( NM_001013940.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013962.1 Rattus norvegicus dynein cytoplasmic 2 light intermediate chain 1 (Dync2li1), mRNA.

Price & Availability↑

CloneID	ORa04358
Clone ID Related Accession (Same CDS sequence)	NM_001013940.1
Accession Version	NM_001013940.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	cytoplasmic dynein 2 light intermediate chain 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079201.1. On Apr 20, 2005 this sequence version replaced XM_216632.3. ##Evidence-Data-START## Transcript exon combination :: BC079201.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAGTG AAACTCTCTG GGAAATCGCG AAGGCCGAGG TAGAGAAACG GAGATGCCAT 
GGAAGTGACG GGGATGGAAT GGAGATCGGA GAAAAATCTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACGAT TATTCTACGG TGTCTTGACA GGGATGAGCC GGCAAAGCCG 
ACCTTAGCTC TGGAATACAC GTACGGAAGG AAAACCAAGG GGCATAACAC ACCAAAAGAC 
ATTGCTCACT TTTGGGAGCT GGGTGGAGGA ACCTCGTTAC TGGACTTAAT CAGCATCCCA 
ATTACAGTCG ACACCTTAAG GACGTTTTCT ATTGTTCTTG TTTTGGATCT TTCCAAACCT 
AATGATCTTT GGCCCACCAT GGAAAATCTG TTGCAAGCCA CAAAAAGCCA CGTAGACAAG 
GTGACAATGA AGCTGGGCAA GGCCAACTCG AAGGCCTCGT CTGAGATGAG GCAGAGGATG 
TGGAGCGTCA TGCAGAAGGA CCATCCGGAT CGTGAATTAA TTGACCCATT TCCAATACCT 
CTGGTCATTA TTGGAAGTAA ATATGACATT TTCCAGGATT TTGACCCTGA GAAGAGAAAG 
GTGATCTGTA AGACCCTGCG CTTTGTGGCG CATTACTACG GAGCCTCGCT GATGTTTACC 
AGCAAATCAG AAGCTCTGCT ACTGAAGATG CGCGGTGTCA TCAACCAGTT GGCATTTGGT 
ATTGATAAGA GGTATTGGTA CATATTTTCC AATCAGTTCC CCCGTTCCCG GGTGTCTTGT 
CTTCCGCCAC CACTTTCCTC TGCTTGTGAT TTTCCTCTAT TAATTTTTAG CACGTGTCTT 
TTCTGGCTTT GTCCTGCTCG TGGTTTGAGC TGGCTGTGGT GTTGTCTGTC ACAACCAGTG 
TTATTGGCCC ATTTGGGTCA TTGCTTTTAT CCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013962.1
CDS	83..1018
Translation	MPSETLWEIAKAEVEKRRCHGSDGDGMEIGEKSVFFIGSKNGGKTTIILRCLDRDEPAKPTLALEYTYGRKTKGHNTPKDIAHFWELGGGTSLLDLISIPITVDTLRTFSIVLVLDLSKPNDLWPTMENLLQATKSHVDKVTMKLGKANSKASSEMRQRMWSVMQKDHPDRELIDPFPIPLVIIGSKYDIFQDFDPEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKMRGVINQLAFGIDKRYWYIFSNQFPRSRVSCLPPPLSSACDFPLLIFSTCLFWLCPARGLSWLWCCLSQPVLLAHLGHCFYP

Target ORF information:

RefSeq Version	NM_001013940.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dynein cytoplasmic 2 light intermediate chain 1 (Dync2li1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013940.1

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATCGCG AAGGCCGAGG TAGAGAAACG GAGATGCCAT 
GGAAGTGACG GGGATGGAAT GGAGATCGGA GAAAAATCTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACGAT TATTCTACGG TGTCTTGACA GGGATGAGCC GGCAAAGCCG 
ACCTTAGCTC TGGAATACAC GTACGGAAGG AAAACCAAGG GGCATAACAC ACCAAAAGAC 
ATTGCTCACT TTTGGGAGCT GGGTGGAGGA ACCTCGTTAC TGGACTTAAT CAGCATCCCA 
ATTACAGTCG ACACCTTAAG GACGTTTTCT ATTGTTCTTG TTTTGGATCT TTCCAAACCT 
AATGATCTTT GGCCCACCAT GGAAAATCTG TTGCAAGCCA CAAAAAGCCA CGTAGACAAG 
GTGACAATGA AGCTGGGCAA GGCCAACTCG AAGGCCTCGT CTGAGATGAG GCAGAGGATG 
TGGAGCGTCA TGCAGAAGGA CCATCCGGAT CGTGAATTAA TTGACCCATT TCCAATACCT 
CTGGTCATTA TTGGAAGTAA ATATGACATT TTCCAGGATT TTGACCCTGA GAAGAGAAAG 
GTGATCTGTA AGACCCTGCG CTTTGTGGCG CATTACTACG GAGCCTCGCT GATGTTTACC 
AGCAAATCAG AAGCTCTGCT ACTGAAGATG CGCGGTGTCA TCAACCAGTT GGCATTTGGT 
ATTGATAAGA GGTATTGGTA CATATTTTCC AATCAGTTCC CCCGTTCCCG GGTGTCTTGT 
CTTCCGCCAC CACTTTCCTC TGCTTGTGAT TTTCCTCTAT TAATTTTTAG CACGTGTCTT 
TTCTGGCTTT GTCCTGCTCG TGGTTTGAGC TGGCTGTGGT GTTGTCTGTC ACAACCAGTG 
TTATTGGCCC ATTTGGGTCA TTGCTTTTAT CCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dync2li1 ( XM_006239695.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239757.1 Rattus norvegicus dynein cytoplasmic 2 light intermediate chain 1 (Dync2li1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa29094
Clone ID Related Accession (Same CDS sequence)	XM_006239695.3
Accession Version	XM_006239695.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cytoplasmic dynein 2 light intermediate chain 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239695.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAGTG AAACTCTCTG GGAAATCGCG AAGGCCGAGG TAGAGAAACG GAGATGCCAT 
GGAAGTGACG GGGATGGAAT GGAGATCGGA GAAAAATCTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACGAT TATTCTACGG TGTCTTGACA GGGATGAGCC GGCAAAGCCG 
ACCTTAGCTC TGGAATACAC GTACGGAAGG AAAACCAAGG GGCATAACAC ACCAAAAGAC 
ATTGCTCACT TTTGGGAGCT GGGTGGAGGA ACCTCGTTAC TGGACTTAAT CAGCATCCCA 
ATTACAGTCG ACACCTTAAG GACGTTTTCT ATTGTTCTTG TTTTGGATCT TTCCAAACCT 
AATGATCTTT GGCCCACCAT GGAAAATCTG TTGCAAGCCA CAAAAAGCCA CGTAGACAAG 
GTGACAATGA AGCTGGGCAA GGCCAACTCG AAGGCCTCGT CTGAGATGAG GCAGAGGATG 
TGGAGCGTCA TGCAGAAGGA CCATCCGGAT CGTGAATTAA TTGACCCATT TCCAATACCT 
CTGGTCATTA TTGGAAGTAA ATATGACATT TTCCAGGATT TTGACCCTGA GAAGAGAAAG 
GTGATCTGTA AGACCCTGCG CTTTGTGGCG CATTACTACG GAGCCTCGCT GATGTTTACC 
AGCAAATCAG AAGCTCTGCT ACTGAAGATG CGCGGTGTCA TCAACCAGTT GGCATTTGGT 
ATTGATAAGA GCAAATCAAT GTGTGTGGAT CAAAATAAAC CACTGTTTAT CACAGCAGGA 
TTGGATTCTT TATGTCAAAT AGGGTCTCCT CCTGTTCCTG ATAGTGACAT TGGAAAGCTT 
CAGGCCCACT CACCTATGGA GCTGTGGAAA AAGGTGTATG AAAAGCTCTT CCCACCAAAG 
AGTACCAGCA CCCTGAAGGC CATCCAGGAC CCAGCCCGGG ACCCACAGTA TGCAGAAAGT 
GAAGTGGACG AGATGAGGGT TCAGAAGGAT CAGGAACTAG AGCAATACAA GAGAAGTTCC 
TCCAAGACCT GGAAACAAAT CGAGCTGGAC TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239757.1
CDS	139..1194
Translation	MPSETLWEIAKAEVEKRRCHGSDGDGMEIGEKSVFFIGSKNGGKTTIILRCLDRDEPAKPTLALEYTYGRKTKGHNTPKDIAHFWELGGGTSLLDLISIPITVDTLRTFSIVLVLDLSKPNDLWPTMENLLQATKSHVDKVTMKLGKANSKASSEMRQRMWSVMQKDHPDRELIDPFPIPLVIIGSKYDIFQDFDPEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKMRGVINQLAFGIDKSKSMCVDQNKPLFITAGLDSLCQIGSPPVPDSDIGKLQAHSPMELWKKVYEKLFPPKSTSTLKAIQDPARDPQYAESEVDEMRVQKDQELEQYKRSSSKTWKQIELDS

Target ORF information:

RefSeq Version	XM_006239695.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dynein cytoplasmic 2 light intermediate chain 1 (Dync2li1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239695.3

ORF Insert Sequence:

ATGCCCAGTG AAACTCTCTG GGAAATCGCG AAGGCCGAGG TAGAGAAACG GAGATGCCAT 
GGAAGTGACG GGGATGGAAT GGAGATCGGA GAAAAATCTG TTTTCTTCAT TGGCAGTAAA 
AATGGGGGAA AGACTACGAT TATTCTACGG TGTCTTGACA GGGATGAGCC GGCAAAGCCG 
ACCTTAGCTC TGGAATACAC GTACGGAAGG AAAACCAAGG GGCATAACAC ACCAAAAGAC 
ATTGCTCACT TTTGGGAGCT GGGTGGAGGA ACCTCGTTAC TGGACTTAAT CAGCATCCCA 
ATTACAGTCG ACACCTTAAG GACGTTTTCT ATTGTTCTTG TTTTGGATCT TTCCAAACCT 
AATGATCTTT GGCCCACCAT GGAAAATCTG TTGCAAGCCA CAAAAAGCCA CGTAGACAAG 
GTGACAATGA AGCTGGGCAA GGCCAACTCG AAGGCCTCGT CTGAGATGAG GCAGAGGATG 
TGGAGCGTCA TGCAGAAGGA CCATCCGGAT CGTGAATTAA TTGACCCATT TCCAATACCT 
CTGGTCATTA TTGGAAGTAA ATATGACATT TTCCAGGATT TTGACCCTGA GAAGAGAAAG 
GTGATCTGTA AGACCCTGCG CTTTGTGGCG CATTACTACG GAGCCTCGCT GATGTTTACC 
AGCAAATCAG AAGCTCTGCT ACTGAAGATG CGCGGTGTCA TCAACCAGTT GGCATTTGGT 
ATTGATAAGA GCAAATCAAT GTGTGTGGAT CAAAATAAAC CACTGTTTAT CACAGCAGGA 
TTGGATTCTT TATGTCAAAT AGGGTCTCCT CCTGTTCCTG ATAGTGACAT TGGAAAGCTT 
CAGGCCCACT CACCTATGGA GCTGTGGAAA AAGGTGTATG AAAAGCTCTT CCCACCAAAG 
AGTACCAGCA CCCTGAAGGC CATCCAGGAC CCAGCCCGGG ACCCACAGTA TGCAGAAAGT 
GAAGTGGACG AGATGAGGGT TCAGAAGGAT CAGGAACTAG AGCAATACAA GAGAAGTTCC 
TCCAAGACCT GGAAACAAAT CGAGCTGGAC TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects.
Scientific reports511649(2015 Jul)
Kessler K,Wunderlich I,Uebe S,Falk NS,Gie?l A,Brandst?tter JH,Popp B,Klinger P,Ekici AB,Sticht H,D?rr HG,Reis A,Roepman R,Seemanov? E,Thiel CT

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
Nature communications67092(2015 Jun)
Taylor SP,Dantas TJ,Duran I,Wu S,Lachman RS,,Nelson SF,Cohn DH,Vallee RB,Krakow D

Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro.
FEBS letters585(15)2419-23(2011 Aug)
Ichikawa M,Watanabe Y,Murayama T,Toyoshima YY

Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.
Development (Cambridge, England)131(20)4999-5007(2004 Oct)
Rana AA,Barbera JP,Rodriguez TA,Lynch D,Hirst E,Smith JC,Beddington RS

A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells.
Molecular biology of the cell14(5)2041-56(2003 May)
Perrone CA,Tritschler D,Taulman P,Bower R,Yoder BK,Porter ME