Mcm6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mcm6
Entrez Gene ID	29685
Full Name	minichromosome maintenance complex component 6
Synonyms	Mcmd6
General protein information	Preferred Names minichromosome maintenance complex component 6 Names DNA replication licensing factor MCM6 intestinal DNA replication protein mini chromosome maintenance deficient 6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13
Summary	belongs to a family of early S-phase proteins required for DNA replication; may play a role in cell-cycle progression and DNA replication [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017287.1	NP_058983.1	DNA replication licensing factor MCM6

Pathways from BioSystems

Homologies

Homo sapiens (human)	MCM6	NP_005906.2
Pan troglodytes (chimpanzee)	MCM6	XP_001154732.1
Anopheles gambiae (African malaria mosquito)	MCM6_ANOGA	XP_319406.3
Xenopus tropicalis (tropical clawed frog)	mcm6.2	NP_989393.1
	MCM6	XP_001096068.1
Bos taurus (cattle)	MCM6	NP_001039699.1
Rattus norvegicus (Norway rat)	Mcm6	NP_058983.1
Canis lupus familiaris (dog)	MCM6	XP_533338.3
Mus musculus (house mouse)	Mcm6	NP_032593.1
Gallus gallus (chicken)	MCM6	NP_001006527.1
Danio rerio (zebrafish)	mcm6	NP_001076318.1
Drosophila melanogaster (fruit fly)	Mcm6	NP_511065.1

Gene Ontology
Bibliography

Related articles in PubMed

Purification of proteins associated with specific genomic Loci.
D?jardin J, Kingston RE
Cell136(1)175-86(2009 Jan)

Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats.
Akiyama K, Morita H, Suetsugu S, Kuraba S, Numata Y, Yamamoto Y, Inui K, Ideura T, Wakisaka N, Nakano K, Oniki H, Takenawa T, Matsuyama M, Yoshimura A
Mammalian genome : official journal of the International Mammalian Genome Society19(1)41-50(2008 Jan)

Identification and characterization of a novel component of the human minichromosome maintenance complex.
Sakwe AM, Nguyen T, Athanasopoulos V, Shire K, Frappier L
Molecular and cellular biology27(8)3044-55(2007 Apr)

Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
Tsuji T, Ficarro SB, Jiang W
Molecular biology of the cell17(10)4459-72(2006 Oct)

DNA binding and helicase actions of mouse MCM4/6/7 helicase.
You Z, Masai H
Nucleic acids research33(9)3033-47(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mcm6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mcm6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03545	NM_017287.1 Latest version!	Rattus norvegicus minichromosome maintenance complex component 6 (Mcm6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$482.30 $689.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mcm6 ( NM_017287.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058983.1 Rattus norvegicus minichromosome maintenance complex component 6 (Mcm6), mRNA.

Price & Availability↑

CloneID	ORa03545
Clone ID Related Accession (Same CDS sequence)	NM_017287.1
Accession Version	NM_017287.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2466bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	DNA replication licensing factor MCM6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB737064.1, EV766384.1, CD371511.1, CD373304.1, CF109502.1, BQ194934.1 and BE096847.1. On or before Oct 28, 2007 this sequence version replaced XM_001055953.1, XM_344135.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC166822.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCTCG CAGCGGCTGC GGAGCCCGGT GCGGGAAGCC AGCACCCGGA GGTGCGCGAT 
GAGGTGGCCG AGAAATGTCA GAAGCTGTTC CTAGACTTCC TGGAAGAGTT CCAGGGTAGC 
GATGGAGAAA TTAAATACTT GCAGTTCGCA GAGGAGCTGA TTCGTCCTGA GAGAAACACA 
CTGGTTGTGA GTTTTGCAGA CCTGGAACAA TTTAACCAAC AACTTTCTAC CACCATTCAG 
GAAGAGTTCT ACAGAGTCTA CCCTTACCTG TGTCGAGCCT TGAAGACCTT TGTCAAAGAC 
CGAAAGGAGA TCCCTTTTGC TAAGGATTTT TATGTTGCGT TCCAAGACCT ACCCACTAGA 
CACAAGATTC GTGAGCTCAC TTCCTCCAGG ATCGGGCTAC TCACTCGCAT CAGTGGGCAG 
GTGGTGCGCA CTCACCCAGT GCACCCCGAG CTTGTGAGTG GGACTTTCCT GTGCCTCGAC 
TGCCAAACAG TGATCAAGGA CGTAGAGCAG CAGTTCAAAT ACACACAGCC GAGCATCTGC 
CGCAATCCAG TATGCGCCAA CAGGAAGAGG TTCCTTCTAG ACACCAATAA ATCGAGATTC 
GTTGATTTTC AAAAGGTTCG TATTCAAGAG ACTCAAGCGG AGCTTCCCCG GGGAAGCATC 
CCCCGGAGTT TGGAGGTTGT CCTGAGGGCC GAAGCCGTGG AGTCAGCCCA GGCTGGTGAC 
AGGTGTGACT TCACGGGGAC GCTGATTGTT GTGCCGGACG TCTCCAAGCT TAGCACACCA 
GGAGCACGTG CGGAGACCAA CTCCCGAGTC AGTGGCGCTG ACGGGTATGA GACAGAAGGC 
ATCCGAGGGC TCCGAGCCCT GGGTGTCAGA GACCTGTCAT ACAGGCTGGT CTTCCTTGCC 
TGCTATGTTG CACCAACCAA CCCACGATTT GGAGGGAAAG AACTCAGAGA TGAGGAGCAG 
ACAGCTGAGA GCATTAAGAA CCAAATGACG GTGAAGGAAT GGGAAAAGGT GTTTGAAATG 
AGTCAGGACA AAAACCTGTA CCACAATCTC TGCACTAGCC TCTTCCCTAC GATCCACGGC 
AATGATGAAG TAAAACGTGG CGTCTTGCTG ATGCTGTTCG GTGGCGTTCC CAAGACAACA 
GGGGAAGGAA CCTCTCTTCG TGGGGATATA AATGTTTGCA TTGTTGGGGA TCCAAGTACA 
GCTAAGAGCC AGTTTCTCAA GCATGTGGAT GAGTTCAGTC CCAGAGCTGT GTATACCAGT 
GGCAAGGCCT CCAGTGCTGC CGGCTTGACA GCAGCTGTGG TGAGAGATGA GGAATCTCAC 
GAGTTTGTCA TCGAGGCTGG AGCGTTGATG CTGGCTGATA ACGGTGTCTG TTGCATTGAT 
GAGTTTGATA AGATGGACAT GCGGGACCAA GTTGCTATTC ACGAAGCTAT GGAGCAGCAG 
ACCATATCTA TCACTAAAGC CGGAGTGAAG GCAACTCTGA ATGCCAGGAC ATCCATTTTA 
GCTGCAGCAA ACCCTGTCAG CGGACACTAC GACAGGTCAA AATCTCTGAA ACAGAACATC 
AATCTGTCAG CGCCCATCAT GTCCCGCTTT GACCTCTTCT TCATTTTGGT GGATGAGTGC 
AATGAGGTGA CAGATTATGC TATTGCCAGG CGCATAGTAG ACTTGCATTC GAGGATCGAA 
GAATCGATAG ACCGGGTTTA TTCCCTTGAT GATATAAGAA GGTATCTTCT CTTCGCCCGA 
CAGTTTAAGC CCAAGATTTC CAAAGAGTCA GAGGACTTCA TTGTGGAGCA GTACAAACGC 
CTCCGCCAGA GGGATGGCTC TGGGATCACC AAGTCGTCGT GGAGAATCAC TGTGAGACAG 
CTTGAGAGCA TGATCCGACT CTCAGAATCG ATGGCCCGCA TGCACTGCTG TGATGAGGTC 
CAGCCTAAAC ATGTGAAGGA AGCTTTTCGA TTACTGAATA AATCGATCAT CCGTGTAGAA 
ACGCCTGACG TCAATCTAGA TCAAGAGGAA GAGATCCAGA TGGAGACGGA TGAGGGACCA 
GGAGGCATCA ATGGTCATGC TGACAGCCCT GCCCCTGTGA ACGGGTTCAA TGGCTCTGGT 
GAAGATGCCA GTCAGGAGAC CGTTCCCAAG CCCTCCCTTA GGCTGGGCTT TGCTGAATAC 
TGCCGAATCT CTAACCTCAT CGTGCTTCAC CTCAGGAAAA TGGAAGAAGA GGAGGATGAG 
TCAGCCCTAA AGAGGAGCGA GCTGGTCAAC TGGTACCTGA AGGAAATCGA GTCGGAAATC 
GACTCTGAAG AAGAGCTCAT AAATAAGAAG AGGATCATAG AGAAGGTTGT TCATCGTCTC 
ACACACTACG ATCACGTTCT GATTGAGCTC ACCCAGGCTG GACTGAAAGG CTCCAGTGAA 
GGAAGCGAGA GCTATGAGGA AGATCCTTAC CTGGTAGTCA ACCCGAACTA CTTGCTTGAA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058983.1
CDS	109..2574
Translation	MDLAAAAEPGAGSQHPEVRDEVAEKCQKLFLDFLEEFQGSDGEIKYLQFAEELIRPERNTLVVSFADLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPFAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIKDVEQQFKYTQPSICRNPVCANRKRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVVLRAEAVESAQAGDRCDFTGTLIVVPDVSKLSTPGARAETNSRVSGADGYETEGIRGLRALGVRDLSYRLVFLACYVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKRLRQRDGSGITKSSWRITVRQLESMIRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMETDEGPGGINGHADSPAPVNGFNGSGEDASQETVPKPSLRLGFAEYCRISNLIVLHLRKMEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVVHRLTHYDHVLIELTQAGLKGSSEGSESYEEDPYLVVNPNYLLED

Target ORF information:

RefSeq Version	NM_017287.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus minichromosome maintenance complex component 6 (Mcm6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017287.1

ORF Insert Sequence:

ATGGACCTCG CAGCGGCTGC GGAGCCCGGT GCGGGAAGCC AGCACCCGGA GGTGCGCGAT 
GAGGTGGCCG AGAAATGTCA GAAGCTGTTC CTAGACTTCC TGGAAGAGTT CCAGGGTAGC 
GATGGAGAAA TTAAATACTT GCAGTTCGCA GAGGAGCTGA TTCGTCCTGA GAGAAACACA 
CTGGTTGTGA GTTTTGCAGA CCTGGAACAA TTTAACCAAC AACTTTCTAC CACCATTCAG 
GAAGAGTTCT ACAGAGTCTA CCCTTACCTG TGTCGAGCCT TGAAGACCTT TGTCAAAGAC 
CGAAAGGAGA TCCCTTTTGC TAAGGATTTT TATGTTGCGT TCCAAGACCT ACCCACTAGA 
CACAAGATTC GTGAGCTCAC TTCCTCCAGG ATCGGGCTAC TCACTCGCAT CAGTGGGCAG 
GTGGTGCGCA CTCACCCAGT GCACCCCGAG CTTGTGAGTG GGACTTTCCT GTGCCTCGAC 
TGCCAAACAG TGATCAAGGA CGTAGAGCAG CAGTTCAAAT ACACACAGCC GAGCATCTGC 
CGCAATCCAG TATGCGCCAA CAGGAAGAGG TTCCTTCTAG ACACCAATAA ATCGAGATTC 
GTTGATTTTC AAAAGGTTCG TATTCAAGAG ACTCAAGCGG AGCTTCCCCG GGGAAGCATC 
CCCCGGAGTT TGGAGGTTGT CCTGAGGGCC GAAGCCGTGG AGTCAGCCCA GGCTGGTGAC 
AGGTGTGACT TCACGGGGAC GCTGATTGTT GTGCCGGACG TCTCCAAGCT TAGCACACCA 
GGAGCACGTG CGGAGACCAA CTCCCGAGTC AGTGGCGCTG ACGGGTATGA GACAGAAGGC 
ATCCGAGGGC TCCGAGCCCT GGGTGTCAGA GACCTGTCAT ACAGGCTGGT CTTCCTTGCC 
TGCTATGTTG CACCAACCAA CCCACGATTT GGAGGGAAAG AACTCAGAGA TGAGGAGCAG 
ACAGCTGAGA GCATTAAGAA CCAAATGACG GTGAAGGAAT GGGAAAAGGT GTTTGAAATG 
AGTCAGGACA AAAACCTGTA CCACAATCTC TGCACTAGCC TCTTCCCTAC GATCCACGGC 
AATGATGAAG TAAAACGTGG CGTCTTGCTG ATGCTGTTCG GTGGCGTTCC CAAGACAACA 
GGGGAAGGAA CCTCTCTTCG TGGGGATATA AATGTTTGCA TTGTTGGGGA TCCAAGTACA 
GCTAAGAGCC AGTTTCTCAA GCATGTGGAT GAGTTCAGTC CCAGAGCTGT GTATACCAGT 
GGCAAGGCCT CCAGTGCTGC CGGCTTGACA GCAGCTGTGG TGAGAGATGA GGAATCTCAC 
GAGTTTGTCA TCGAGGCTGG AGCGTTGATG CTGGCTGATA ACGGTGTCTG TTGCATTGAT 
GAGTTTGATA AGATGGACAT GCGGGACCAA GTTGCTATTC ACGAAGCTAT GGAGCAGCAG 
ACCATATCTA TCACTAAAGC CGGAGTGAAG GCAACTCTGA ATGCCAGGAC ATCCATTTTA 
GCTGCAGCAA ACCCTGTCAG CGGACACTAC GACAGGTCAA AATCTCTGAA ACAGAACATC 
AATCTGTCAG CGCCCATCAT GTCCCGCTTT GACCTCTTCT TCATTTTGGT GGATGAGTGC 
AATGAGGTGA CAGATTATGC TATTGCCAGG CGCATAGTAG ACTTGCATTC GAGGATCGAA 
GAATCGATAG ACCGGGTTTA TTCCCTTGAT GATATAAGAA GGTATCTTCT CTTCGCCCGA 
CAGTTTAAGC CCAAGATTTC CAAAGAGTCA GAGGACTTCA TTGTGGAGCA GTACAAACGC 
CTCCGCCAGA GGGATGGCTC TGGGATCACC AAGTCGTCGT GGAGAATCAC TGTGAGACAG 
CTTGAGAGCA TGATCCGACT CTCAGAATCG ATGGCCCGCA TGCACTGCTG TGATGAGGTC 
CAGCCTAAAC ATGTGAAGGA AGCTTTTCGA TTACTGAATA AATCGATCAT CCGTGTAGAA 
ACGCCTGACG TCAATCTAGA TCAAGAGGAA GAGATCCAGA TGGAGACGGA TGAGGGACCA 
GGAGGCATCA ATGGTCATGC TGACAGCCCT GCCCCTGTGA ACGGGTTCAA TGGCTCTGGT 
GAAGATGCCA GTCAGGAGAC CGTTCCCAAG CCCTCCCTTA GGCTGGGCTT TGCTGAATAC 
TGCCGAATCT CTAACCTCAT CGTGCTTCAC CTCAGGAAAA TGGAAGAAGA GGAGGATGAG 
TCAGCCCTAA AGAGGAGCGA GCTGGTCAAC TGGTACCTGA AGGAAATCGA GTCGGAAATC 
GACTCTGAAG AAGAGCTCAT AAATAAGAAG AGGATCATAG AGAAGGTTGT TCATCGTCTC 
ACACACTACG ATCACGTTCT GATTGAGCTC ACCCAGGCTG GACTGAAAGG CTCCAGTGAA 
GGAAGCGAGA GCTATGAGGA AGATCCTTAC CTGGTAGTCA ACCCGAACTA CTTGCTTGAA 
GATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Purification of proteins associated with specific genomic Loci.
Cell136(1)175-86(2009 Jan)
D?jardin J,Kingston RE

Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna rats.
Mammalian genome : official journal of the International Mammalian Genome Society19(1)41-50(2008 Jan)
Akiyama K,Morita H,Suetsugu S,Kuraba S,Numata Y,Yamamoto Y,Inui K,Ideura T,Wakisaka N,Nakano K,Oniki H,Takenawa T,Matsuyama M,Yoshimura A

Identification and characterization of a novel component of the human minichromosome maintenance complex.
Molecular and cellular biology27(8)3044-55(2007 Apr)
Sakwe AM,Nguyen T,Athanasopoulos V,Shire K,Frappier L

Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.
Molecular biology of the cell17(10)4459-72(2006 Oct)
Tsuji T,Ficarro SB,Jiang W

DNA binding and helicase actions of mouse MCM4/6/7 helicase.
Nucleic acids research33(9)3033-47(2005)
You Z,Masai H