Psmb6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psmb6
Entrez Gene ID	29666
Full Name	proteasome subunit beta 6
Synonyms	Psmb6l
General protein information	Preferred Names proteasome subunit beta 6 Names proteasome subunit beta type-6 macropain delta chain multicatalytic endopeptidase complex delta chain proteasome (prosome, macropain) subunit, beta type 6 proteasome beta 6 subunit proteasome chain 5 proteasome delta chain proteasome subunit Y
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	subunit of the proteasome complex, which may play a role in protein catabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057099.3	NP_476440.2	proteasome subunit beta type-6
XM_008767811.2	XP_008766033.1	proteasome subunit beta type-6 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	LOC100360846	XP_002729074.2
Rattus norvegicus (Norway rat)	Psmb6	NP_476440.2
Drosophila melanogaster (fruit fly)	Prosbeta1	NP_652031.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009271	XP_320065.4
Caenorhabditis elegans (roundworm)	pbs-1	NP_500125.1

Gene Ontology
Bibliography

Related articles in PubMed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Proteomic analysis reveals that proteasome subunit beta 6 is involved in hypoxia-induced pulmonary vascular remodeling in rats.
Wang J, Xu L, Yun X, Yang K, Liao D, Tian L, Jiang H, Lu W
PloS one8(7)e67942(2013)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S
Molecular and cellular biology30(15)3864-74(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the present study revealed for the first time that one of the proteasome subunits, PSMB6, was increased in the distal PA from a CHPH rat model.
Title: Proteomic analysis reveals that proteasome subunit beta 6 is involved in hypoxia-induced pulmonary vascular remodeling in rats.

The following Psmb6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psmb6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09253	NM_057099.3 Latest version!	Rattus norvegicus proteasome 20S subunit beta 6 (Psmb6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa43341	XM_008767811.2 Latest version!	Rattus norvegicus proteasome subunit beta 6 (Psmb6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psmb6 ( NM_057099.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476440.2 Rattus norvegicus proteasome 20S subunit beta 6 (Psmb6), mRNA.

Price & Availability↑

CloneID	ORa09253
Clone ID Related Accession (Same CDS sequence)	NM_057099.3
Accession Version	NM_057099.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	proteasome subunit beta type-6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC058451.1. On Aug 31, 2012 this sequence version replaced NM_057099.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058451.1, FQ217385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCCG CCTTAGCTGT TCGTGGAGCC GTCTCTGCAC CGGCCTTTGG GCCGGAGGCG 
CTCACTCCAG ACTGGGAAAA CCGAGAAGTC TCCACAGGGA CCACGATCAT GGCTGTGCAA 
TTTGACGGGG GCGTGGTTCT AGGAGCAGAC TCCAGAACAA CCACTGGGTC GTACATCGCC 
AATCGAGTGA CTGACAAGCT GACCCCTATC CACGATCACA TCTTCTGCTG CCGCTCAGGC 
TCGGCAGCTG ATACCCAAGC AGTAGCTGAT GCTGTCACGT ACCAGCTTGG TTTCCACAGT 
ATTGAGCTGA ACGAGCCTCC ACTAGTGCAC ACAGCTGCCA GTCTCTTTAA GGAGATGTGT 
TACCGCTACA GAGAAGATCT GATGGCAGGA ATCATCATCG CAGGCTGGGA CCCTCAAGAA 
GGAGGGCAGG TGTACTCTGT TCCCATGGGA GGTATGATGG TAAGACAGTC CTTTGCCATC 
GGAGGCTCCG GGAGCTCATA TATCTATGGC TATGTTGATG CTACCTATCG GGAAGGCATG 
ACCAAGGATG AATGTCTGCA ATTCACTGCC AATGCTCTTG CTTTGGCTAT GGAACGGGAT 
GGCTCCAGTG GAGGAGTGAT CCGCTTGGCA GCCATTCAAC AGTCGGGGGT AGAGCGGCAG 
GTGCTTTTGG GAGACCAGAT CCCCAAGGTC ACCATCTCCA CTTTGCCACC TCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476440.2
CDS	9..725
Translation	MAAALAVRGAVSAPAFGPEALTPDWENREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQQSGVERQVLLGDQIPKVTISTLPPP

Target ORF information:

RefSeq Version	NM_057099.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proteasome 20S subunit beta 6 (Psmb6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057099.3

ORF Insert Sequence:

ATGGCGGCCG CCTTAGCTGT TCGTGGAGCC GTCTCTGCAC CGGCCTTTGG GCCGGAGGCG 
CTCACTCCAG ACTGGGAAAA CCGAGAAGTC TCCACAGGGA CCACGATCAT GGCTGTGCAA 
TTTGACGGGG GCGTGGTTCT AGGAGCAGAC TCCAGAACAA CCACTGGGTC GTACATCGCC 
AATCGAGTGA CTGACAAGCT GACCCCTATC CACGATCACA TCTTCTGCTG CCGCTCAGGC 
TCGGCAGCTG ATACCCAAGC AGTAGCTGAT GCTGTCACGT ACCAGCTTGG TTTCCACAGT 
ATTGAGCTGA ACGAGCCTCC ACTAGTGCAC ACAGCTGCCA GTCTCTTTAA GGAGATGTGT 
TACCGCTACA GAGAAGATCT GATGGCAGGA ATCATCATCG CAGGCTGGGA CCCTCAAGAA 
GGAGGGCAGG TGTACTCTGT TCCCATGGGA GGTATGATGG TAAGACAGTC CTTTGCCATC 
GGAGGCTCCG GGAGCTCATA TATCTATGGC TATGTTGATG CTACCTATCG GGAAGGCATG 
ACCAAGGATG AATGTCTGCA ATTCACTGCC AATGCTCTTG CTTTGGCTAT GGAACGGGAT 
GGCTCCAGTG GAGGAGTGAT CCGCTTGGCA GCCATTCAAC AGTCGGGGGT AGAGCGGCAG 
GTGCTTTTGG GAGACCAGAT CCCCAAGGTC ACCATCTCCA CTTTGCCACC TCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psmb6 ( XM_008767811.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766033.1 Rattus norvegicus proteasome subunit beta 6 (Psmb6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43341
Clone ID Related Accession (Same CDS sequence)	XM_008767811.2
Accession Version	XM_008767811.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	proteasome subunit beta type-6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767811.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCCG CCTTAGCTGT TCGTGGAGCC GTCTCTGCAC CGGCCTTTGG GCCGGAGGCG 
CTCACTCCAG ACTGGGAAAA CCGAGAAGTC TCCACAGGGA CCACGATCAT GGCTGTGCAA 
TTTGACGGGG GCGTGGTTCT AGGAGCAGAC TCCAGAACAA CCACTGGGTC GTACATCGCC 
AATCGAGTGA CTGACAAGCT GACCCCTATC CACGATCACA TCTTCTGCTG CCGCTCAGGC 
TCGGCAGCTG ATACCCAAGC AGTAGCTGAT GCTGTCACGT ACCAGCTTGG TTTCCACAGT 
ATTGAGCTGA ACGAGCCTCC ACTAGTGCAC ACAGCCGCCA GTCTCTTTAA GGAGATGTGT 
TACCGCTACA GAGAAGATCT GATGGCAGGA ATCATCATCG CAGGCTGGGA CCCTCAAGAA 
GGAGGGCAGG TGTACTCTGT TCCCATGGGA GGTATGATGG TAAGACAGTC CTTTGCCATC 
GGAGGCTCCG GGAGCTCATA TATCTATGGC TATGTTGATG CTACCTATCG GGAAGGCATG 
ACCAAGGATG AATGTCTGCA ATTCACTGCC AATGTCTCCC TGTTTTCTCT ACAGCTCTTG 
CTTTGGCTAT GGAACGGGAT GGCTCCAGTG GAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766033.1
CDS	48..686
Translation	MAAALAVRGAVSAPAFGPEALTPDWENREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKDECLQFTANVSLFSLQLLLWLWNGMAPVEE

Target ORF information:

RefSeq Version	XM_008767811.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proteasome subunit beta 6 (Psmb6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767811.2

ORF Insert Sequence:

ATGGCGGCCG CCTTAGCTGT TCGTGGAGCC GTCTCTGCAC CGGCCTTTGG GCCGGAGGCG 
CTCACTCCAG ACTGGGAAAA CCGAGAAGTC TCCACAGGGA CCACGATCAT GGCTGTGCAA 
TTTGACGGGG GCGTGGTTCT AGGAGCAGAC TCCAGAACAA CCACTGGGTC GTACATCGCC 
AATCGAGTGA CTGACAAGCT GACCCCTATC CACGATCACA TCTTCTGCTG CCGCTCAGGC 
TCGGCAGCTG ATACCCAAGC AGTAGCTGAT GCTGTCACGT ACCAGCTTGG TTTCCACAGT 
ATTGAGCTGA ACGAGCCTCC ACTAGTGCAC ACAGCCGCCA GTCTCTTTAA GGAGATGTGT 
TACCGCTACA GAGAAGATCT GATGGCAGGA ATCATCATCG CAGGCTGGGA CCCTCAAGAA 
GGAGGGCAGG TGTACTCTGT TCCCATGGGA GGTATGATGG TAAGACAGTC CTTTGCCATC 
GGAGGCTCCG GGAGCTCATA TATCTATGGC TATGTTGATG CTACCTATCG GGAAGGCATG 
ACCAAGGATG AATGTCTGCA ATTCACTGCC AATGTCTCCC TGTTTTCTCT ACAGCTCTTG 
CTTTGGCTAT GGAACGGGAT GGCTCCAGTG GAGGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Proteomic analysis reveals that proteasome subunit beta 6 is involved in hypoxia-induced pulmonary vascular remodeling in rats.
PloS one8(7)e67942(2013)
Wang J,Xu L,Yun X,Yang K,Liao D,Tian L,Jiang H,Lu W

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
Molecular and cellular biology30(15)3864-74(2010 Aug)
Sasaki K,Hamazaki J,Koike M,Hirano Y,Komatsu M,Uchiyama Y,Tanaka K,Murata S