Meox2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Meox2
Entrez Gene ID	29279
Full Name	mesenchyme homeobox 2
General protein information	Preferred Names mesenchyme homeobox 2 Names homeobox protein MOX-2 growth arrest-specific homeobox mesenchyme homeo box 2 (growth arrest-specific homeo box)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q21
Summary	homeobox gene; may have a regulatory function in the G0-to-G1 transition of the cell cycle in vascular smooth muscle cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017149.1	NP_058845.1	homeobox protein MOX-2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MEOX2	NP_001091514.1
	MEOX2	XP_001105568.1
Mus musculus (house mouse)	Meox2	NP_032610.1
Danio rerio (zebrafish)	LOC556898	XP_684924.1
Pan troglodytes (chimpanzee)	MEOX2	XP_518979.2
Rattus norvegicus (Norway rat)	Meox2	NP_058845.1
Gallus gallus (chicken)	MEOX2	NP_001005427.1
Xenopus tropicalis (tropical clawed frog)	meox2	NP_001116898.1
Homo sapiens (human)	MEOX2	NP_005915.2
Canis lupus familiaris (dog)	MEOX2	XP_539446.2

Gene Ontology
Bibliography

Related articles in PubMed

Gax inhibits perivascular preadipocyte biofunction mediated by IGF-1 induced FAK/Pyk2 and ERK2 cooperative pathways.
Liu P, Feng J, Kong F, Lu Q, Xu H, Meng J, Jiang Y
Cellular signalling26(12)3036-45(2014 Dec)

The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype.
Cunnington RH, Northcott JM, Ghavami S, Filomeno KL, Jahan F, Kavosh MS, Davies JJ, Wigle JT, Dixon IM
Journal of cell science127(Pt 1)40-9(2014 Jan)

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
Rovelet-Lecrux A, Legallic S, Wallon D, Flaman JM, Martinaud O, Bombois S, Rollin-Sillaire A, Michon A, Le Ber I, Pariente J, Puel M, Paquet C, Croisile B, Thomas-Ant?rion C, Vercelletto M, L?vy R, Fr?bourg T, Hannequin D, Campion D,
European journal of human genetics : EJHG20(6)613-7(2012 Jun)

Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.
Douville JM, Cheung DY, Herbert KL, Moffatt T, Wigle JT
PloS one6(12)e29099(2011)

Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221.
Chen Y, Banda M, Speyer CL, Smith JS, Rabson AB, Gorski DH
Molecular and cellular biology30(15)3902-13(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present study was designed to investigate whether FAK/Pyk2 and ERK1/2 MAPK signaling pathways participate in Perivascular adipocyte functions, which is activated by insulin-like growth factor 1(IGF-1) and inhibited by Gax.
Title: Gax inhibits perivascular preadipocyte biofunction mediated by IGF-1 induced FAK/Pyk2 and ERK2 cooperative pathways.

Ski modulates the cardiac myofibroblast phenotype and function through suppression of Zeb2 by upregulating the expression of Meox2.
Title: The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype.

Hypoxia suppressed the expression of endogenous Gax in rats, but not in those pretreated intratracheally with a Gax construct.
Title: Involvement of Gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells.

Report of an interaction between a homeobox protein and IkappaBbeta in endothelial cells and suggest that MEOX2 modulates the activity of the RelA complex through direct interaction with its components.
Title: MEOX2 regulates nuclear factor-kappaB activity in vascular endothelial cells through interactions with p65 and IkappaBbeta.

demonstrated that Ang II down-regulated Gax expression via redox-sensitive ERK1/2 activation in vascular smooth muscle cells [Gax]
Title: Angiotensin II suppresses growth arrest specific homeobox (Gax) expression via redox-sensitive mitogen-activated protein kinase (MAPK).

The following Meox2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Meox2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03036	NM_017149.1 Latest version!	Rattus norvegicus mesenchyme homeobox 2 (Meox2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Meox2 ( NM_017149.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058845.1 Rattus norvegicus mesenchyme homeobox 2 (Meox2), mRNA.

Price & Availability↑

CloneID	ORa03036
Clone ID Related Accession (Same CDS sequence)	NM_017149.1
Accession Version	NM_017149.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	homeobox protein MOX-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z17223.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z17223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGAACACC CCCTCTTTGG CTGCCTGCGC AGCCCCCACG CCACAGCGCA AGGCTTGCAC 
CCCTTCTCGC AGTCTTCTCT GGCCCTCCAT GGAAGATCTG ACCACATGTC CTACCCCGAA 
CTCTCCACAT CTTCCTCGTC TTGCATAATC GCGGGATACC CCAATGAGGA GGGCATGTTT 
GCCAGCCAGC ATCACAGGGG GCACCACCAC CACCACCACC ACCACCATCA CCACCACCAG 
CAGCAGCAGC ACCAGGCTCT GCAAAGCAAC TGGCACCTCC CGCAGATGTC CTCCCCGCCA 
AGCGCGGCCC GGCACAGCCT TTGCCTGCAG CCTGATTCCG GAGGGCCCCC GGAGCTGGGG 
AGCAGCCCTC CGGTCCTGTG CTCCAACTCT TCTAGCCTGG GCTCCAGCAC CCCGACCGGA 
GCCGCGTGCG CACCAAGGGA TTATGGCCGT CAAGCGCTGT CACCCGCAGA AGTGGAGAAG 
AGAAGTGGCA GCAAAAGAAA AAGCGACAGT TCAGATTCCC AGGAAGGAAA TTACAAGTCA 
GAAGTGAACA GCAAACCTAG GAAGGAAAGA ACAGCTTTCA CCAAAGAGCA AATCAGAGAA 
CTTGAGGCAG AGTTCGCCCA TCATAACTAT CTGACCAGAC TGAGAAGATA TGAGATAGCG 
GTGAACCTAG ACCTCACTGA AAGACAGGTG AAAGTGTGGT TCCAGAACAG GAGAATGAAG 
TGGAAGCGGG TCAAGGGGGG ACAACAAGGA GCTGCAGCCC GAGAAAAGGA ACTGGTGAAT 
GTGAAAAAGG GAACACTTCT TCCATCAGAG CTGTCAGGAA TTGGTGCAGC CACCCTCCAG 
CAGACAGGGG ACTCACTAGC AAATGACGAC AGTCGCGATA GTGACCACAG CTCTGAGCAC 
GCACACTTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058845.1
CDS	197..1108
Translation	MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQSNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPRDYGRQALSPAEVEKRSGSKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSLANDDSRDSDHSSEHAHL

Target ORF information:

RefSeq Version	NM_017149.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mesenchyme homeobox 2 (Meox2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017149.1

ORF Insert Sequence:

ATGGAACACC CCCTCTTTGG CTGCCTGCGC AGCCCCCACG CCACAGCGCA AGGCTTGCAC 
CCCTTCTCGC AGTCTTCTCT GGCCCTCCAT GGAAGATCTG ACCACATGTC CTACCCCGAA 
CTCTCCACAT CTTCCTCGTC TTGCATAATC GCGGGATACC CCAATGAGGA GGGCATGTTT 
GCCAGCCAGC ATCACAGGGG GCACCACCAC CACCACCACC ACCACCATCA CCACCACCAG 
CAGCAGCAGC ACCAGGCTCT GCAAAGCAAC TGGCACCTCC CGCAGATGTC CTCCCCGCCA 
AGCGCGGCCC GGCACAGCCT TTGCCTGCAG CCTGATTCCG GAGGGCCCCC GGAGCTGGGG 
AGCAGCCCTC CGGTCCTGTG CTCCAACTCT TCTAGCCTGG GCTCCAGCAC CCCGACCGGA 
GCCGCGTGCG CACCAAGGGA TTATGGCCGT CAAGCGCTGT CACCCGCAGA AGTGGAGAAG 
AGAAGTGGCA GCAAAAGAAA AAGCGACAGT TCAGATTCCC AGGAAGGAAA TTACAAGTCA 
GAAGTGAACA GCAAACCTAG GAAGGAAAGA ACAGCTTTCA CCAAAGAGCA AATCAGAGAA 
CTTGAGGCAG AGTTCGCCCA TCATAACTAT CTGACCAGAC TGAGAAGATA TGAGATAGCG 
GTGAACCTAG ACCTCACTGA AAGACAGGTG AAAGTGTGGT TCCAGAACAG GAGAATGAAG 
TGGAAGCGGG TCAAGGGGGG ACAACAAGGA GCTGCAGCCC GAGAAAAGGA ACTGGTGAAT 
GTGAAAAAGG GAACACTTCT TCCATCAGAG CTGTCAGGAA TTGGTGCAGC CACCCTCCAG 
CAGACAGGGG ACTCACTAGC AAATGACGAC AGTCGCGATA GTGACCACAG CTCTGAGCAC 
GCACACTTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gax inhibits perivascular preadipocyte biofunction mediated by IGF-1 induced FAK/Pyk2 and ERK2 cooperative pathways.
Cellular signalling26(12)3036-45(2014 Dec)
Liu P,Feng J,Kong F,Lu Q,Xu H,Meng J,Jiang Y

The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype.
Journal of cell science127(Pt 1)40-9(2014 Jan)
Cunnington RH,Northcott JM,Ghavami S,Filomeno KL,Jahan F,Kavosh MS,Davies JJ,Wigle JT,Dixon IM

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
European journal of human genetics : EJHG20(6)613-7(2012 Jun)
Rovelet-Lecrux A,Legallic S,Wallon D,Flaman JM,Martinaud O,Bombois S,Rollin-Sillaire A,Michon A,Le Ber I,Pariente J,Puel M,Paquet C,Croisile B,Thomas-Ant?rion C,Vercelletto M,L?vy R,Fr?bourg T,Hannequin D,Campion D,

Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.
PloS one6(12)e29099(2011)
Douville JM,Cheung DY,Herbert KL,Moffatt T,Wigle JT

Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221.
Molecular and cellular biology30(15)3902-13(2010 Aug)
Chen Y,Banda M,Speyer CL,Smith JS,Rabson AB,Gorski DH