Akr1c2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akr1c2
Entrez Gene ID	291283
Full Name	aldo-keto reductase family 1, member C2
Synonyms	Akr1c21
General protein information	Preferred Names aldo-keto reductase family 1, member C2 Names aldo-keto reductase family 1 member C21 17-alpha-HSD 17-alpha-hydroxysteroid dehydrogenase 3(or 17)-alpha-hydroxysteroid dehydrogenase 3-alpha-hydroxysteroid dehydrogenase aldo-keto reductase family 1, member C21
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013057.1	NP_001013075.1	aldo-keto reductase family 1 member C21
XM_006254183.3	XP_006254245.1	aldo-keto reductase family 1 member C21 isoform X1
XM_006254185.3	XP_006254247.1	aldo-keto reductase family 1 member C21 isoform X2
XM_006254184.3	XP_006254246.1	aldo-keto reductase family 1 member C21 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	AKR1C1	NP_001344.2
Arabidopsis thaliana (thale cress)	AT1G59950	NP_176203.1
Rattus norvegicus (Norway rat)	Akr1c2	NP_001013075.1
Arabidopsis thaliana (thale cress)	AT1G59960	NP_176204.1
Homo sapiens (human)	AKR1C2	NP_995317.1
Mus musculus (house mouse)	Akr1c21	NP_084177.2
	AKR1C4	XP_001104300.1
Pan troglodytes (chimpanzee)	AKR1C1	XP_003951630.1

Gene Ontology
Bibliography

Related articles in PubMed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.
Ruiz FX, Port? S, Gallego O, Moro A, Ard?vol A, Del R?o-Esp?nola A, Rovira C, Farr?s J, Par?s X
The Biochemical journal440(3)335-44(2011 Dec)

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.
Hevir N, Vouk K, Sinkovec J, Ribi?-Pucelj M, Ri?ner TL
Chemico-biological interactions191(1-3)217-26(2011 May)

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Buhrke T, Lengler I, Lampen A
Development, growth & differentiation53(3)411-26(2011 Apr)

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.
Bains OS, Grigliatti TA, Reid RE, Riggs KW
The Journal of pharmacology and experimental therapeutics335(3)533-45(2010 Dec)

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.
Dhagat U, Endo S, Mamiya H, Hara A, El-Kabbani O
Acta crystallographica. Section D, Biological crystallography66(Pt 2)198-204(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Akr1c2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akr1c2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa03116	NM_001013057.1 Latest version!	Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa38010	XM_006254183.3 Latest version!	Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa38010	XM_006254184.3 Latest version!	Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa38011	XM_006254185.3 Latest version!	Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akr1c2 ( NM_001013057.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013075.1 Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), mRNA.

Price & Availability↑

CloneID	ORa03116
Clone ID Related Accession (Same CDS sequence)	NM_001013057.1
Accession Version	NM_001013057.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	aldo-keto reductase family 1 member C21
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078957.1. On Apr 20, 2005 this sequence version replaced XM_225537.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078957.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642749 [ECO:0000348] ##Evidence-Data-END##

ATGAACTCCA AATGTCATTG TGTGAAACTG AACGATGGTC ATTTCATTCC GGTGCTGGGT 
TTTGGAACTG CTATGCCTTC AGAGTTACCC AAGAGTAAAG CTAAGGAGGT CACCAAAATA 
GCTATAGATG CTGGTTTCCA TCATTTTGAT TCTGCTTTTG TCTACAATAC CGAAGATCAT 
GTAGGAGAGG CCATCCGAGA GAAGATTGCC AATGGCACTA CAAGGAGAGA AGATATATTT 
TACACATCAA AGCTTTGGTG TACGAGCCTT CACCCAGAAC TGGTGAGATC TTCCTTGGAA 
TGTTCACTGA AGAAACTTCA GTTGGACTAT GTGGACCTGT ATCTCATACA TTTTCCGATG 
GCCTTGAAAC CAGGAGATGA AAATTTTCCA GTAGATGAAC ATGGAAAGTT ACTATTTGAC 
ACAGTAGATC TCTGTGCTAC CTGGGAGGCC ATGGAGAAGT GTAAGGATGC AGGACTGGCC 
AAGTCCATCG GGGTGTCCAA CTTTAACCGC AGGCAGCTGG AGAAGATCCT GAACAAGCCG 
GGGCTCAAAT ACAAGCCTGT GTGCAACCAG GTAGAATGCC ATCTTTATCT CAACCAAATG 
AAACTGCTGG ATTTCTGCAA GACAAATGGC ATTATACTGG TTGCCTATGG AGTTCTGGGA 
ACACAACGAT ATAACGGATG GGTAGACCAG AACTCCCCTG TTCTCTTGAA TGAACCAGTT 
CTTAGTTCCA TGGCAAAAAA ATACAATCAA ACTCCAGCCT TGATTGCCCT TCGCCATCAG 
TTGCAGCGTG GGATTGTGGT ACTTAACACC AGTCTCAAAG AAGAGCGGAT CAAAGAGAAC 
ATGAAGCTGA GTCCAGAAGA TATGAAAGTC CTTGATGACC TGAACAGAAA TTTGCGGTAC 
ATAGCTGGTG GAATATTTGA AGGCCACCCT AATTTTCCGT TTTTGGATGA ATACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013075.1
CDS	200..1156
Translation	MNSKCHCVKLNDGHFIPVLGFGTAMPSELPKSKAKEVTKIAIDAGFHHFDSAFVYNTEDHVGEAIREKIANGTTRREDIFYTSKLWCTSLHPELVRSSLECSLKKLQLDYVDLYLIHFPMALKPGDENFPVDEHGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKYKPVCNQVECHLYLNQMKLLDFCKTNGIILVAYGVLGTQRYNGWVDQNSPVLLNEPVLSSMAKKYNQTPALIALRHQLQRGIVVLNTSLKEERIKENMKLSPEDMKVLDDLNRNLRYIAGGIFEGHPNFPFLDEY

Target ORF information:

RefSeq Version	NM_001013057.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013057.1

ORF Insert Sequence:

ATGAACTCCA AATGTCATTG TGTGAAACTG AACGATGGTC ATTTCATTCC GGTGCTGGGT 
TTTGGAACTG CTATGCCTTC AGAGTTACCC AAGAGTAAAG CTAAGGAGGT CACCAAAATA 
GCTATAGATG CTGGTTTCCA TCATTTTGAT TCTGCTTTTG TCTACAATAC CGAAGATCAT 
GTAGGAGAGG CCATCCGAGA GAAGATTGCC AATGGCACTA CAAGGAGAGA AGATATATTT 
TACACATCAA AGCTTTGGTG TACGAGCCTT CACCCAGAAC TGGTGAGATC TTCCTTGGAA 
TGTTCACTGA AGAAACTTCA GTTGGACTAT GTGGACCTGT ATCTCATACA TTTTCCGATG 
GCCTTGAAAC CAGGAGATGA AAATTTTCCA GTAGATGAAC ATGGAAAGTT ACTATTTGAC 
ACAGTAGATC TCTGTGCTAC CTGGGAGGCC ATGGAGAAGT GTAAGGATGC AGGACTGGCC 
AAGTCCATCG GGGTGTCCAA CTTTAACCGC AGGCAGCTGG AGAAGATCCT GAACAAGCCG 
GGGCTCAAAT ACAAGCCTGT GTGCAACCAG GTAGAATGCC ATCTTTATCT CAACCAAATG 
AAACTGCTGG ATTTCTGCAA GACAAATGGC ATTATACTGG TTGCCTATGG AGTTCTGGGA 
ACACAACGAT ATAACGGATG GGTAGACCAG AACTCCCCTG TTCTCTTGAA TGAACCAGTT 
CTTAGTTCCA TGGCAAAAAA ATACAATCAA ACTCCAGCCT TGATTGCCCT TCGCCATCAG 
TTGCAGCGTG GGATTGTGGT ACTTAACACC AGTCTCAAAG AAGAGCGGAT CAAAGAGAAC 
ATGAAGCTGA GTCCAGAAGA TATGAAAGTC CTTGATGACC TGAACAGAAA TTTGCGGTAC 
ATAGCTGGTG GAATATTTGA AGGCCACCCT AATTTTCCGT TTTTGGATGA ATACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Akr1c2 ( XM_006254183.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254245.1 Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38010
Clone ID Related Accession (Same CDS sequence)	XM_006254183.3 , XM_006254184.3
Accession Version	XM_006254183.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	aldo-keto reductase family 1 member C21 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254183.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTCCA AATGTCATTG TGTGAAACTG AACGATGGTC ATTTCATTCC GGTGCTGGGT 
TTTGGAACTG CTATGCCTTC AGAGTTACCC AAGAGTAAAG CTAAGGAGGT CACCAAAATA 
GCTATAGATG CTGGTTTCCA TCATTTTGAT TCTGCTTTTG TCTACAATAC CGAAGATCAT 
GTAGGAGAGG CCATCCGAGA GAAGATTGCC AATGGCACTA CAAGGAGAGA AGATATATTT 
TACACATCAA AGCTTTGGTG TACGAGCCTT CACCCAGAAC TGGTGAGATC TTCCTTGGAA 
TGTTCACTGA AGAAACTTCA GTTGGACTAT GTGGACCTGT ATCTCATACA TTTTCCGATG 
GCCTTGAAAC CAGGAGATGA AAATTTTCCA GTAGATGAAC ATGGAAAGTT ACTATTTGAC 
ACAGTAGATC TCTGTGCTAC CTGGGAGGCC ATGGAGAAGT GTAAGGATGC AGGACTGGCC 
AAGTCCATCG GGGTGTCCAA CTTTAACCGC AGGCAGCTGG AGAAGATCCT GAACAAGCCG 
GGGCTCAAAT ACAAGCCTGT GTGCAACCAG GTAGAATGCC ATCTTTATCT CAACCAAATG 
AAACTGCTGG ATTTCTGCAA GACAAATGGC ATTATACTGG TTGCCTATGG AGTTCTGGGA 
ACACAACGAT ATAACGGATG GGTAGACCAG AACTCCCCTG TTCTCTTGAA TGAACCAGTT 
CTTAGTTCCA TGGCAAAAAA ATACAATCAA ACTCCAGCCT TGATTGCCCT TCGCCATCAG 
TTGCAGCGTG GGATTGTGGT ACTTAACACC AGTCTCAAAG AAGAGCGGAT CAAAGAGAAC 
ATGAAGGTTT TTGAATTCCA GCTGAGTCCA GAAGATATGA AAGTCCTTGA TGACCTGAAC 
AGAAATTTGC GGTACATAGC TGGTGGAATA TTTGAAGGCC ACCCTAATTT TCCGTTTTTG 
GATGAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254245.1
CDS	212..1183
Translation	MNSKCHCVKLNDGHFIPVLGFGTAMPSELPKSKAKEVTKIAIDAGFHHFDSAFVYNTEDHVGEAIREKIANGTTRREDIFYTSKLWCTSLHPELVRSSLECSLKKLQLDYVDLYLIHFPMALKPGDENFPVDEHGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKYKPVCNQVECHLYLNQMKLLDFCKTNGIILVAYGVLGTQRYNGWVDQNSPVLLNEPVLSSMAKKYNQTPALIALRHQLQRGIVVLNTSLKEERIKENMKVFEFQLSPEDMKVLDDLNRNLRYIAGGIFEGHPNFPFLDEY

Target ORF information:

RefSeq Version	XM_006254183.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254183.3

ORF Insert Sequence:

ATGAACTCCA AATGTCATTG TGTGAAACTG AACGATGGTC ATTTCATTCC GGTGCTGGGT 
TTTGGAACTG CTATGCCTTC AGAGTTACCC AAGAGTAAAG CTAAGGAGGT CACCAAAATA 
GCTATAGATG CTGGTTTCCA TCATTTTGAT TCTGCTTTTG TCTACAATAC CGAAGATCAT 
GTAGGAGAGG CCATCCGAGA GAAGATTGCC AATGGCACTA CAAGGAGAGA AGATATATTT 
TACACATCAA AGCTTTGGTG TACGAGCCTT CACCCAGAAC TGGTGAGATC TTCCTTGGAA 
TGTTCACTGA AGAAACTTCA GTTGGACTAT GTGGACCTGT ATCTCATACA TTTTCCGATG 
GCCTTGAAAC CAGGAGATGA AAATTTTCCA GTAGATGAAC ATGGAAAGTT ACTATTTGAC 
ACAGTAGATC TCTGTGCTAC CTGGGAGGCC ATGGAGAAGT GTAAGGATGC AGGACTGGCC 
AAGTCCATCG GGGTGTCCAA CTTTAACCGC AGGCAGCTGG AGAAGATCCT GAACAAGCCG 
GGGCTCAAAT ACAAGCCTGT GTGCAACCAG GTAGAATGCC ATCTTTATCT CAACCAAATG 
AAACTGCTGG ATTTCTGCAA GACAAATGGC ATTATACTGG TTGCCTATGG AGTTCTGGGA 
ACACAACGAT ATAACGGATG GGTAGACCAG AACTCCCCTG TTCTCTTGAA TGAACCAGTT 
CTTAGTTCCA TGGCAAAAAA ATACAATCAA ACTCCAGCCT TGATTGCCCT TCGCCATCAG 
TTGCAGCGTG GGATTGTGGT ACTTAACACC AGTCTCAAAG AAGAGCGGAT CAAAGAGAAC 
ATGAAGGTTT TTGAATTCCA GCTGAGTCCA GAAGATATGA AAGTCCTTGA TGACCTGAAC 
AGAAATTTGC GGTACATAGC TGGTGGAATA TTTGAAGGCC ACCCTAATTT TCCGTTTTTG 
GATGAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Akr1c2 ( XM_006254184.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254246.1 Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa38010
Clone ID Related Accession (Same CDS sequence)	XM_006254183.3 , XM_006254184.3
Accession Version	XM_006254184.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	aldo-keto reductase family 1 member C21 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254184.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTCCA AATGTCATTG TGTGAAACTG AACGATGGTC ATTTCATTCC GGTGCTGGGT 
TTTGGAACTG CTATGCCTTC AGAGTTACCC AAGAGTAAAG CTAAGGAGGT CACCAAAATA 
GCTATAGATG CTGGTTTCCA TCATTTTGAT TCTGCTTTTG TCTACAATAC CGAAGATCAT 
GTAGGAGAGG CCATCCGAGA GAAGATTGCC AATGGCACTA CAAGGAGAGA AGATATATTT 
TACACATCAA AGCTTTGGTG TACGAGCCTT CACCCAGAAC TGGTGAGATC TTCCTTGGAA 
TGTTCACTGA AGAAACTTCA GTTGGACTAT GTGGACCTGT ATCTCATACA TTTTCCGATG 
GCCTTGAAAC CAGGAGATGA AAATTTTCCA GTAGATGAAC ATGGAAAGTT ACTATTTGAC 
ACAGTAGATC TCTGTGCTAC CTGGGAGGCC ATGGAGAAGT GTAAGGATGC AGGACTGGCC 
AAGTCCATCG GGGTGTCCAA CTTTAACCGC AGGCAGCTGG AGAAGATCCT GAACAAGCCG 
GGGCTCAAAT ACAAGCCTGT GTGCAACCAG GTAGAATGCC ATCTTTATCT CAACCAAATG 
AAACTGCTGG ATTTCTGCAA GACAAATGGC ATTATACTGG TTGCCTATGG AGTTCTGGGA 
ACACAACGAT ATAACGGATG GGTAGACCAG AACTCCCCTG TTCTCTTGAA TGAACCAGTT 
CTTAGTTCCA TGGCAAAAAA ATACAATCAA ACTCCAGCCT TGATTGCCCT TCGCCATCAG 
TTGCAGCGTG GGATTGTGGT ACTTAACACC AGTCTCAAAG AAGAGCGGAT CAAAGAGAAC 
ATGAAGGTTT TTGAATTCCA GCTGAGTCCA GAAGATATGA AAGTCCTTGA TGACCTGAAC 
AGAAATTTGC GGTACATAGC TGGTGGAATA TTTGAAGGCC ACCCTAATTT TCCGTTTTTG 
GATGAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254246.1
CDS	191..1162
Translation	MNSKCHCVKLNDGHFIPVLGFGTAMPSELPKSKAKEVTKIAIDAGFHHFDSAFVYNTEDHVGEAIREKIANGTTRREDIFYTSKLWCTSLHPELVRSSLECSLKKLQLDYVDLYLIHFPMALKPGDENFPVDEHGKLLFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKYKPVCNQVECHLYLNQMKLLDFCKTNGIILVAYGVLGTQRYNGWVDQNSPVLLNEPVLSSMAKKYNQTPALIALRHQLQRGIVVLNTSLKEERIKENMKVFEFQLSPEDMKVLDDLNRNLRYIAGGIFEGHPNFPFLDEY

Target ORF information:

RefSeq Version	XM_006254184.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254184.3

ORF Insert Sequence:

ATGAACTCCA AATGTCATTG TGTGAAACTG AACGATGGTC ATTTCATTCC GGTGCTGGGT 
TTTGGAACTG CTATGCCTTC AGAGTTACCC AAGAGTAAAG CTAAGGAGGT CACCAAAATA 
GCTATAGATG CTGGTTTCCA TCATTTTGAT TCTGCTTTTG TCTACAATAC CGAAGATCAT 
GTAGGAGAGG CCATCCGAGA GAAGATTGCC AATGGCACTA CAAGGAGAGA AGATATATTT 
TACACATCAA AGCTTTGGTG TACGAGCCTT CACCCAGAAC TGGTGAGATC TTCCTTGGAA 
TGTTCACTGA AGAAACTTCA GTTGGACTAT GTGGACCTGT ATCTCATACA TTTTCCGATG 
GCCTTGAAAC CAGGAGATGA AAATTTTCCA GTAGATGAAC ATGGAAAGTT ACTATTTGAC 
ACAGTAGATC TCTGTGCTAC CTGGGAGGCC ATGGAGAAGT GTAAGGATGC AGGACTGGCC 
AAGTCCATCG GGGTGTCCAA CTTTAACCGC AGGCAGCTGG AGAAGATCCT GAACAAGCCG 
GGGCTCAAAT ACAAGCCTGT GTGCAACCAG GTAGAATGCC ATCTTTATCT CAACCAAATG 
AAACTGCTGG ATTTCTGCAA GACAAATGGC ATTATACTGG TTGCCTATGG AGTTCTGGGA 
ACACAACGAT ATAACGGATG GGTAGACCAG AACTCCCCTG TTCTCTTGAA TGAACCAGTT 
CTTAGTTCCA TGGCAAAAAA ATACAATCAA ACTCCAGCCT TGATTGCCCT TCGCCATCAG 
TTGCAGCGTG GGATTGTGGT ACTTAACACC AGTCTCAAAG AAGAGCGGAT CAAAGAGAAC 
ATGAAGGTTT TTGAATTCCA GCTGAGTCCA GAAGATATGA AAGTCCTTGA TGACCTGAAC 
AGAAATTTGC GGTACATAGC TGGTGGAATA TTTGAAGGCC ACCCTAATTT TCCGTTTTTG 
GATGAATACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Akr1c2 ( XM_006254185.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006254247.1 Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa38011
Clone ID Related Accession (Same CDS sequence)	XM_006254185.3
Accession Version	XM_006254185.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	aldo-keto reductase family 1 member C21 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006254185.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACTCCA AATGTCATTG TGTGAAACTG AACGATGGTC ATTTCATTCC GGTGCTGGGT 
TTTGGAACTG CTATGCCTTC AGAGTTACCC AAGAGTAAAG CTAAGGAGGT CACCAAAATA 
GCTATAGATG CTGGTTTCCA TCATTTTGAT TCTGCTTTTG TCTACAATAC CGAAGATCAT 
GTAGGAGAGG CCATCCGAGA GAAGATTGCC AATGGCACTA CAAGGAGAGA AGATATATTT 
TACACATCAA AGCTTTGGTG TACGAGCCTT CACCCAGAAC TGGTGAGATC TTCCTTGGAA 
TGTTCACTGA AGAAACTTCA GTTGGACTAT GTGGACCTGT ATCTCATACA TTTTCCGATG 
GCCTTGAAAG CCATGGAGAA GTGTAAGGAT GCAGGACTGG CCAAGTCCAT CGGGGTGTCC 
AACTTTAACC GCAGGCAGCT GGAGAAGATC CTGAACAAGC CGGGGCTCAA ATACAAGCCT 
GTGTGCAACC AGGTAGAATG CCATCTTTAT CTCAACCAAA TGAAACTGCT GGATTTCTGC 
AAGACAAATG GCATTATACT GGTTGCCTAT GGAGTTCTGG GAACACAACG ATATAACGGA 
TGGGTAGACC AGAACTCCCC TGTTCTCTTG AATGAACCAG TTCTTAGTTC CATGGCAAAA 
AAATACAATC AAACTCCAGC CTTGATTGCC CTTCGCCATC AGTTGCAGCG TGGGATTGTG 
GTACTTAACA CCAGTCTCAA AGAAGAGCGG ATCAAAGAGA ACATGAAGGT TTTTGAATTC 
CAGCTGAGTC CAGAAGATAT GAAAGTCCTT GATGACCTGA ACAGAAATTT GCGGTACATA 
GCTGGTGGAA TATTTGAAGG CCACCCTAAT TTTCCGTTTT TGGATGAATA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006254247.1
CDS	212..1105
Translation	MNSKCHCVKLNDGHFIPVLGFGTAMPSELPKSKAKEVTKIAIDAGFHHFDSAFVYNTEDHVGEAIREKIANGTTRREDIFYTSKLWCTSLHPELVRSSLECSLKKLQLDYVDLYLIHFPMALKAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKYKPVCNQVECHLYLNQMKLLDFCKTNGIILVAYGVLGTQRYNGWVDQNSPVLLNEPVLSSMAKKYNQTPALIALRHQLQRGIVVLNTSLKEERIKENMKVFEFQLSPEDMKVLDDLNRNLRYIAGGIFEGHPNFPFLDEY

Target ORF information:

RefSeq Version	XM_006254185.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006254185.3

ORF Insert Sequence:

ATGAACTCCA AATGTCATTG TGTGAAACTG AACGATGGTC ATTTCATTCC GGTGCTGGGT 
TTTGGAACTG CTATGCCTTC AGAGTTACCC AAGAGTAAAG CTAAGGAGGT CACCAAAATA 
GCTATAGATG CTGGTTTCCA TCATTTTGAT TCTGCTTTTG TCTACAATAC CGAAGATCAT 
GTAGGAGAGG CCATCCGAGA GAAGATTGCC AATGGCACTA CAAGGAGAGA AGATATATTT 
TACACATCAA AGCTTTGGTG TACGAGCCTT CACCCAGAAC TGGTGAGATC TTCCTTGGAA 
TGTTCACTGA AGAAACTTCA GTTGGACTAT GTGGACCTGT ATCTCATACA TTTTCCGATG 
GCCTTGAAAG CCATGGAGAA GTGTAAGGAT GCAGGACTGG CCAAGTCCAT CGGGGTGTCC 
AACTTTAACC GCAGGCAGCT GGAGAAGATC CTGAACAAGC CGGGGCTCAA ATACAAGCCT 
GTGTGCAACC AGGTAGAATG CCATCTTTAT CTCAACCAAA TGAAACTGCT GGATTTCTGC 
AAGACAAATG GCATTATACT GGTTGCCTAT GGAGTTCTGG GAACACAACG ATATAACGGA 
TGGGTAGACC AGAACTCCCC TGTTCTCTTG AATGAACCAG TTCTTAGTTC CATGGCAAAA 
AAATACAATC AAACTCCAGC CTTGATTGCC CTTCGCCATC AGTTGCAGCG TGGGATTGTG 
GTACTTAACA CCAGTCTCAA AGAAGAGCGG ATCAAAGAGA ACATGAAGGT TTTTGAATTC 
CAGCTGAGTC CAGAAGATAT GAAAGTCCTT GATGACCTGA ACAGAAATTT GCGGTACATA 
GCTGGTGGAA TATTTGAAGG CCACCCTAAT TTTCCGTTTT TGGATGAATA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.
The Biochemical journal440(3)335-44(2011 Dec)
Ruiz FX,Port? S,Gallego O,Moro A,Ard?vol A,Del R?o-Esp?nola A,Rovira C,Farr?s J,Par?s X

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.
Chemico-biological interactions191(1-3)217-26(2011 May)
Hevir N,Vouk K,Sinkovec J,Ribi?-Pucelj M,Ri?ner TL

Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Development, growth & differentiation53(3)411-26(2011 Apr)
Buhrke T,Lengler I,Lampen A

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.
The Journal of pharmacology and experimental therapeutics335(3)533-45(2010 Dec)
Bains OS,Grigliatti TA,Reid RE,Riggs KW

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.
Acta crystallographica. Section D, Biological crystallography66(Pt 2)198-204(2010 Feb)
Dhagat U,Endo S,Mamiya H,Hara A,El-Kabbani O