Nptx2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nptx2
Entrez Gene ID	288475
Full Name	neuronal pentraxin 2
Synonyms	NP-II,NP2,Narp
General protein information	Preferred Names neuronal pentraxin 2 Names neuronal pentraxin-2 Neuronal activity regulated pentraxin neuro activity regulated petaxin neuronal activity-regulated pentraxin neuronal pentraxin II
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p11
Summary	synaptic organizing molecule that mediates aggregation of NMDA receptors via coupling to synaptic AMPA receptors [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001034199.1	NP_001029371.1	neuronal pentraxin-2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	NPTX2	NP_002514.1
Bos taurus (cattle)	NPTX2	XP_002698264.1
	NPTX2	XP_001111081.2
Rattus norvegicus (Norway rat)	Nptx2	NP_001029371.1
Gallus gallus (chicken)	NPTX2	XP_414750.3
Mus musculus (house mouse)	Nptx2	NP_058069.1
Danio rerio (zebrafish)	nptx2a	NP_001103238.1
Danio rerio (zebrafish)	nptx2b	NP_001165055.1
Pan troglodytes (chimpanzee)	NPTX2	XP_001136152.2
Canis lupus familiaris (dog)	NPTX2	XP_003639131.1
Xenopus tropicalis (tropical clawed frog)	nptx2	NP_001096304.1

Gene Ontology
Bibliography

Related articles in PubMed

Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses.
Lee SJ, Wei M, Zhang C, Maxeiner S, Pak C, Calado Botelho S, Trotter J, Sterky FH, S?dhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience37(5)1062-1080(2017 Feb)

Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration.
Blouin AM, Stern AL, Han S, Theberge FR, Wang C, During MJ, Baraban JM, Reti IM
Behavioural pharmacology24(4)332-6(2013 Aug)

A selective role for neuronal activity regulated pentraxin in the processing of sensory-specific incentive value.
Johnson AW, Crombag HS, Takamiya K, Baraban JM, Holland PC, Huganir RL, Reti IM
The Journal of neuroscience : the official journal of the Society for Neuroscience27(49)13430-5(2007 Dec)

AGS-induced expression of Narp is concomitant with expression of AMPA receptor subunits GluR1 and GluR2 in hippocampus but not inferior colliculus of P77PMC rats.
Li SY, Xu DS, Jia HT
Neurobiology of disease14(3)328-35(2003 Dec)

Prominent expression of Narp in central vestibular pathways: selective effect of labyrinth ablation.
Reti IM, Minor LB, Baraban JM
The European journal of neuroscience16(10)1949-58(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study suggested that mPFC Narp is necessary for extinction of opiate seeking in the Pavlovian-conditioned place preference paradigm but not in the operant paradigm of drug self-administration.
Title: Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration.

Downregulation of GluR2 subunit in the inferior colliculus may contribute to audiogenic seizure mediated epileptogenesis, while upregulation of Narp may also be involved.
Title: AGS-induced expression of Narp is concomitant with expression of AMPA receptor subunits GluR1 and GluR2 in hippocampus but not inferior colliculus of P77PMC rats.

Narp expression is stimulated by naturally occurring vestibular input. Narp may mediate ongoing adjustments in synaptic strength or connectivity in several pathways linked to the vestibular system.
Title: Prominent expression of Narp in central vestibular pathways: selective effect of labyrinth ablation.

The following Nptx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nptx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08124	NM_001034199.1 Latest version!	Rattus norvegicus neuronal pentraxin 2 (Nptx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nptx2 ( NM_001034199.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029371.1 Rattus norvegicus neuronal pentraxin 2 (Nptx2), mRNA.

Price & Availability↑

CloneID	ORa08124
Clone ID Related Accession (Same CDS sequence)	NM_001034199.1
Accession Version	NM_001034199.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	neuronal pentraxin-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB578587.1, CO403402.1, CO395871.1 and CO388671.1. On Oct 17, 2005 this sequence version replaced XM_221901.3. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGCGC TGCTGACCGC CGGCGTGGCG CTCGCCGTGG CCGCGGGACA AGCCCAGGAT 
AACCCGATAC CTGGCAGTCG CTTCGTGTGC ACCGCGCTGC CCCCCGAAGC GGCGCGCGCC 
GGCTGCCCGC TGCCCGCGAT GCCCATGCAG GGAGGCGCGC TGAGCCCTGA GGAGGAGCTG 
CGAGCCGCTG TGCTGCAGCT GCGCGAGACC GTCGTGCAGC AGAAGGAGAC GCTGGGCGCT 
CAGCGAGAAG CCATCCGAGA ACTCACCAGC AAGCTGGCCC GCTGTGAGGG ACTAGCCGGC 
GGTAAGGCGC GCGGCACGGG GGCCACGGGC AAGGACACCA TGGGCGACCT GCCGCGGGAC 
CCGGGCCACG TCGTGGAGCA GCTTAGCCGC TCGCTGCAGA CCCTCAAGGA CCGCTTGGAG 
AGCCTCGAGC TCCAACTCCA CACCAACGCG TCTAATGCCG GGCTGCCGAG CGACTTCCGA 
GAGGTGCTCC AGCGGAGGCT GGGGGAGCTG GAGAGGCAGT TGCTACGCAA GGTGGCCGAG 
CTGGAAGACG AGAAGTCCCT GCTCCACAAT GAGACCTCGG CTCACCGGCA GAAGACAGAG 
AACACACTGA ATGCACTGCT GCAGAGGGTG ACTGAGCTGG AGAGAGGCAA CAGTGCATTC 
AAGTCACCAG ATGCATTCAA AGTGTCCCTC CCTCTCCGTA CAAACTACCT ATACGGCAAG 
ATCAAGAAGA CGTTGCCCGA GCTGTATGCC TTCACCATCT GCCTGTGGCT GCGGTCCAGC 
GCCTCGCCAG GCATCGGCAC GCCATTCTCC TACGCTGTGC CTGGGCAAGC CAATGAGATT 
GTGCTGATAG AGTGGGGTAA CAATCCCATA GAGCTGCTTA TCAACGACAA GGTCGCACAG 
CTGCCCCTGT TTGTCAGCGA TGGCAAGTGG CACCATATCT GCATCACCTG GACCACTCGA 
GACGGCATGT GGGAAGCATT CCAGGACGGG GAGAAGCTGG GCACCGGGGA GAACCTGGCA 
CCCTGGCATC CCATCAAGCC AGGGGGTGTG CTCATCCTGG GGCAGGAGCA GGACACTGTG 
GGAGGCAGAT TTGATGCCAC ACAGGCCTTC GTTGGAGAGC TTAGCCAGTT CAACATATGG 
GACCGTGTCC TCCGGGCACA AGAGATCATC AACATCGCCA ACTGCTCCAC GAACATGCCT 
GGAAACATCA TCCCATGGGT GGACAACAAT GTCGATGTGT TTGGAGGGGC TTCCAAGTGG 
CCTGTGGAGA CGTGCGAAGA GCGTCTCCTG GACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029371.1
CDS	194..1492
Translation	MLALLTAGVALAVAAGQAQDNPIPGSRFVCTALPPEAARAGCPLPAMPMQGGALSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTSKLARCEGLAGGKARGTGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLELQLHTNASNAGLPSDFREVLQRRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTENTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICITWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIINIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL

Target ORF information:

RefSeq Version	NM_001034199.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuronal pentraxin 2 (Nptx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034199.1

ORF Insert Sequence:

ATGCTGGCGC TGCTGACCGC CGGCGTGGCG CTCGCCGTGG CCGCGGGACA AGCCCAGGAT 
AACCCGATAC CTGGCAGTCG CTTCGTGTGC ACCGCGCTGC CCCCCGAAGC GGCGCGCGCC 
GGCTGCCCGC TGCCCGCGAT GCCCATGCAG GGAGGCGCGC TGAGCCCTGA GGAGGAGCTG 
CGAGCCGCTG TGCTGCAGCT GCGCGAGACC GTCGTGCAGC AGAAGGAGAC GCTGGGCGCT 
CAGCGAGAAG CCATCCGAGA ACTCACCAGC AAGCTGGCCC GCTGTGAGGG ACTAGCCGGC 
GGTAAGGCGC GCGGCACGGG GGCCACGGGC AAGGACACCA TGGGCGACCT GCCGCGGGAC 
CCGGGCCACG TCGTGGAGCA GCTTAGCCGC TCGCTGCAGA CCCTCAAGGA CCGCTTGGAG 
AGCCTCGAGC TCCAACTCCA CACCAACGCG TCTAATGCCG GGCTGCCGAG CGACTTCCGA 
GAGGTGCTCC AGCGGAGGCT GGGGGAGCTG GAGAGGCAGT TGCTACGCAA GGTGGCCGAG 
CTGGAAGACG AGAAGTCCCT GCTCCACAAT GAGACCTCGG CTCACCGGCA GAAGACAGAG 
AACACACTGA ATGCACTGCT GCAGAGGGTG ACTGAGCTGG AGAGAGGCAA CAGTGCATTC 
AAGTCACCAG ATGCATTCAA AGTGTCCCTC CCTCTCCGTA CAAACTACCT ATACGGCAAG 
ATCAAGAAGA CGTTGCCCGA GCTGTATGCC TTCACCATCT GCCTGTGGCT GCGGTCCAGC 
GCCTCGCCAG GCATCGGCAC GCCATTCTCC TACGCTGTGC CTGGGCAAGC CAATGAGATT 
GTGCTGATAG AGTGGGGTAA CAATCCCATA GAGCTGCTTA TCAACGACAA GGTCGCACAG 
CTGCCCCTGT TTGTCAGCGA TGGCAAGTGG CACCATATCT GCATCACCTG GACCACTCGA 
GACGGCATGT GGGAAGCATT CCAGGACGGG GAGAAGCTGG GCACCGGGGA GAACCTGGCA 
CCCTGGCATC CCATCAAGCC AGGGGGTGTG CTCATCCTGG GGCAGGAGCA GGACACTGTG 
GGAGGCAGAT TTGATGCCAC ACAGGCCTTC GTTGGAGAGC TTAGCCAGTT CAACATATGG 
GACCGTGTCC TCCGGGCACA AGAGATCATC AACATCGCCA ACTGCTCCAC GAACATGCCT 
GGAAACATCA TCCCATGGGT GGACAACAAT GTCGATGTGT TTGGAGGGGC TTCCAAGTGG 
CCTGTGGAGA CGTGCGAAGA GCGTCTCCTG GACTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(5)1062-1080(2017 Feb)
Lee SJ,Wei M,Zhang C,Maxeiner S,Pak C,Calado Botelho S,Trotter J,Sterky FH,S?dhof TC

Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration.
Behavioural pharmacology24(4)332-6(2013 Aug)
Blouin AM,Stern AL,Han S,Theberge FR,Wang C,During MJ,Baraban JM,Reti IM

A selective role for neuronal activity regulated pentraxin in the processing of sensory-specific incentive value.
The Journal of neuroscience : the official journal of the Society for Neuroscience27(49)13430-5(2007 Dec)
Johnson AW,Crombag HS,Takamiya K,Baraban JM,Holland PC,Huganir RL,Reti IM

AGS-induced expression of Narp is concomitant with expression of AMPA receptor subunits GluR1 and GluR2 in hippocampus but not inferior colliculus of P77PMC rats.
Neurobiology of disease14(3)328-35(2003 Dec)
Li SY,Xu DS,Jia HT

Prominent expression of Narp in central vestibular pathways: selective effect of labyrinth ablation.
The European journal of neuroscience16(10)1949-58(2002 Nov)
Reti IM,Minor LB,Baraban JM