Gimap4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gimap4
Entrez Gene ID	286938
Full Name	GTPase, IMAP family member 4
Synonyms	Ian1
General protein information	Preferred Names GTPase, IMAP family member 4 Names GTPase IMAP family member 4 IAN-1 immune-associated nucleotide 1 immunity-associated nucleotide 1 protein immunity-associated protein 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q24
Summary	functions in T-cell lineage; may have a role in apoptosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_173153.2	NP_775176.2	GTPase IMAP family member 4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC768255	XP_005205999.1
Canis lupus familiaris (dog)	GIMAP4	XP_005629727.1
Mus musculus (house mouse)	Gimap4	NP_778155.2
Oryza sativa (rice)	Os02g0557100	NP_001047136.1
	GIMAP4	XP_001098713.1
Rattus norvegicus (Norway rat)	Gimap4	NP_775176.2
Homo sapiens (human)	GIMAP4	NP_060796.1
Pan troglodytes (chimpanzee)	GIMAP4	XP_003318946.1
Bos taurus (cattle)	GIMAP4	NP_001039525.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural insights into the mechanism of GTPase activation in the GIMAP family.
Schwefel D, Arasu BS, Marino SF, Lamprecht B, K?chert K, Rosenbaum E, Eichhorst J, Wiesner B, Behlke J, Rocks O, Mathas S, Daumke O
Structure (London, England : 1993)21(4)550-9(2013 Apr)

A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1.
Carter C, Dion C, Schnell S, Coadwell WJ, Graham M, Hepburn L, Morgan G, Hutchings A, Pascall JC, Jacobs H, Miller JR, Butcher GW
Journal of immunology (Baltimore, Md. : 1950)179(3)1784-95(2007 Aug)

IAN family critically regulates survival and development of T lymphocytes.
Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama Y
PLoS biology4(4)e103(2006 Apr)

The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.
Hornum L, R?mer J, Markholst H
Diabetes51(6)1972-9(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A severe deficiency of Gimap4 expression in the inbred Brown Norway (BN) rat links this trait to the Gimap gene cluster on rat chromosome 4, the probable cause being an AT dinucleotide insertion in the BN Gimap4 allele.
Title: A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1.

The following Gimap4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gimap4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03583	NM_173153.2 Latest version!	Rattus norvegicus GTPase, IMAP family member 4 (Gimap4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gimap4 ( NM_173153.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_775176.2 Rattus norvegicus GTPase, IMAP family member 4 (Gimap4), mRNA.

Price & Availability↑

CloneID	ORa03583
Clone ID Related Accession (Same CDS sequence)	NM_173153.2
Accession Version	NM_173153.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	GTPase IMAP family member 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK479589.1, BC070952.1 and AY070268.1. On Oct 1, 2005 this sequence version replaced NM_173153.1. ##Evidence-Data-START## Transcript exon combination :: AM285343.1, AY070268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689596 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGCCC AGTACAGTGG TGTGGGGTCC ATCCCGGAAA ATTCAAGGAG CAGCCATGAG 
CTTGGAATAC AAGATCAAGG AAGTCCCCAA CTGAGAATTG TCCTACTTGG AAAAACTGGA 
GCAGGAAAGA GTTCAACAGG GAACAGCATC CTTGGAAGAA AAGCATTTCT TTCTGGCATT 
TGTGCAAAAT CCATTACCAA GGTCTGTGAG AAAGGAGTGA GCATCTGGGA TGGGAAAGAG 
CTCGTTGTTG TGGATACACC TGGCATTTTC GACACTGAGG TACCAGATGC TGACACACAA 
AAGGAGATCA CTCGCTGTGT TGCTCTGACC TCTCCAGGGC CTCATGCTCT GCTTCTGGTC 
ATCCCACTGG GGCGTTATAC TGTGGAAGAA CACAAGGCCA CACGGAAACT TCTGAGCATG 
TTTGAAAAAA AGGCTAGAAG ATTCATGATA CTCTTGCTCA CCAGGAAGGA TGACTTGGAA 
GACACAGATA TCCATGAGTA CTTAGAGACG GCTCCTGAAG TCCTTCAAGA GTTGATCTAT 
GAGTTCCGGA ATCGCTACTG TTTGTTCAAT AACAAAGCAT CAGGAGCTGA ACAGGAAGAG 
CAGAAGAGGC AGCTGTTGAC CTTAGTTCAG AGCATGGTGA GGGAAAATGG TGGAAAATAC 
TTTACTAACA AGATGTATGA AAGTGCTGAG GGTGTGATTC AGAAACAAAC CTGGAAGAAG 
AAAGAATTTT ACAGAGAGGA ACTGGAGAGA GAGAGAGCAC GGATAAGACG GGAGTATGAA 
GCAGAGATTC AAGATCTGAG AGATGAGCTG GAAAGGGAAA GGAGAAGGGC ACGTATGGAG 
AGGGAGTTCA ATGAGAACGA GCTTATCTTT GCAGAGAGAC AACAAAATGC TAGGAGGGAA 
GTTGAGAACA CAAGTATGAT ATACTTGAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775176.2
CDS	47..979
Translation	MEAQYSGVGSIPENSRSSHELGIQDQGSPQLRIVLLGKTGAGKSSTGNSILGRKAFLSGICAKSITKVCEKGVSIWDGKELVVVDTPGIFDTEVPDADTQKEITRCVALTSPGPHALLLVIPLGRYTVEEHKATRKLLSMFEKKARRFMILLLTRKDDLEDTDIHEYLETAPEVLQELIYEFRNRYCLFNNKASGAEQEEQKRQLLTLVQSMVRENGGKYFTNKMYESAEGVIQKQTWKKKEFYREELERERARIRREYEAEIQDLRDELERERRRARMEREFNENELIFAERQQNARREVENTSMIYLN

Target ORF information:

RefSeq Version	NM_173153.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GTPase, IMAP family member 4 (Gimap4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173153.2

ORF Insert Sequence:

ATGGAAGCCC AGTACAGTGG TGTGGGGTCC ATCCCGGAAA ATTCAAGGAG CAGCCATGAG 
CTTGGAATAC AAGATCAAGG AAGTCCCCAA CTGAGAATTG TCCTACTTGG AAAAACTGGA 
GCAGGAAAGA GTTCAACAGG GAACAGCATC CTTGGAAGAA AAGCATTTCT TTCTGGCATT 
TGTGCAAAAT CCATTACCAA GGTCTGTGAG AAAGGAGTGA GCATCTGGGA TGGGAAAGAG 
CTCGTTGTTG TGGATACACC TGGCATTTTC GACACTGAGG TACCAGATGC TGACACACAA 
AAGGAGATCA CTCGCTGTGT TGCTCTGACC TCTCCAGGGC CTCATGCTCT GCTTCTGGTC 
ATCCCACTGG GGCGTTATAC TGTGGAAGAA CACAAGGCCA CACGGAAACT TCTGAGCATG 
TTTGAAAAAA AGGCTAGAAG ATTCATGATA CTCTTGCTCA CCAGGAAGGA TGACTTGGAA 
GACACAGATA TCCATGAGTA CTTAGAGACG GCTCCTGAAG TCCTTCAAGA GTTGATCTAT 
GAGTTCCGGA ATCGCTACTG TTTGTTCAAT AACAAAGCAT CAGGAGCTGA ACAGGAAGAG 
CAGAAGAGGC AGCTGTTGAC CTTAGTTCAG AGCATGGTGA GGGAAAATGG TGGAAAATAC 
TTTACTAACA AGATGTATGA AAGTGCTGAG GGTGTGATTC AGAAACAAAC CTGGAAGAAG 
AAAGAATTTT ACAGAGAGGA ACTGGAGAGA GAGAGAGCAC GGATAAGACG GGAGTATGAA 
GCAGAGATTC AAGATCTGAG AGATGAGCTG GAAAGGGAAA GGAGAAGGGC ACGTATGGAG 
AGGGAGTTCA ATGAGAACGA GCTTATCTTT GCAGAGAGAC AACAAAATGC TAGGAGGGAA 
GTTGAGAACA CAAGTATGAT ATACTTGAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural insights into the mechanism of GTPase activation in the GIMAP family.
Structure (London, England : 1993)21(4)550-9(2013 Apr)
Schwefel D,Arasu BS,Marino SF,Lamprecht B,K?chert K,Rosenbaum E,Eichhorst J,Wiesner B,Behlke J,Rocks O,Mathas S,Daumke O

A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1.
Journal of immunology (Baltimore, Md. : 1950)179(3)1784-95(2007 Aug)
Carter C,Dion C,Schnell S,Coadwell WJ,Graham M,Hepburn L,Morgan G,Hutchings A,Pascall JC,Jacobs H,Miller JR,Butcher GW

IAN family critically regulates survival and development of T lymphocytes.
PLoS biology4(4)e103(2006 Apr)
Nitta T,Nasreen M,Seike T,Goji A,Ohigashi I,Miyazaki T,Ohta T,Kanno M,Takahama Y

The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.
Diabetes51(6)1972-9(2002 Jun)
Hornum L,R?mer J,Markholst H