Prrx1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prrx1
Entrez Gene ID	266813
Full Name	paired related homeobox 1
Synonyms	Pmx1,Prx-1
General protein information	Preferred Names paired related homeobox 1 Names paired mesoderm homeobox protein 1 paired mesoderm homeobox 1 paired-related homeobox protein 1 rHox
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q22
Summary	binds the collagen I alpha 1 and the osteocalcin promoters; acts as a negative regulator of transcription [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006250151.3	XP_006250213.1	paired mesoderm homeobox protein 1 isoform X1
NM_153821.1	NP_722543.1	paired mesoderm homeobox protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PRRX1	NP_073207.1
Mus musculus (house mouse)	Prrx1	NP_035257.1
Gallus gallus (chicken)	PRRX1	NP_001007822.1
Danio rerio (zebrafish)	prrx1a	NP_999899.1
Pan troglodytes (chimpanzee)	PRRX1	XP_001141191.1
	PRRX1	XP_001097390.1
Bos taurus (cattle)	PRRX1	NP_001075208.1
Rattus norvegicus (Norway rat)	Prrx1	NP_722543.1
Canis lupus familiaris (dog)	PRRX1	XP_850725.1
Danio rerio (zebrafish)	prrx1b	NP_956344.1
Xenopus tropicalis (tropical clawed frog)	prrx1	XP_004913839.1

Gene Ontology
Bibliography

Related articles in PubMed

Paired related homeobox protein 1 regulates PDGF-induced chemotaxis of hepatic stellate cells in liver fibrosis.
Gong J, Han J, He J, Liu J, Han P, Wang Y, Li M, Li D, Ding X, Du Z, Liao J, Tian D
Laboratory investigation; a journal of technical methods and pathology97(9)1020-1032(2017 Sep)

Expression of Prx1 and Tcf4 is decreased in the diaphragmatic muscle connective tissue of nitrofen-induced congenital diaphragmatic hernia.
Takahashi T, Zimmer J, Friedmacher F, Puri P
Journal of pediatric surgery51(12)1931-1935(2016 Dec)

Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.
Liu N, Xue L, Guan Y, Li QZ, Cao FY, Pang SL, Guan WJ
Biomedical and environmental sciences : BES29(8)584-588(2016 Aug)

PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are involved in vasculogenesis during rat embryonic pituitary development.
Higuchi M, Kato T, Yoshida S, Ueharu H, Nishimura N, Kato Y
Cell and tissue research361(2)557-65(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studied and identified Prrx1 as a novel valuable target in liver fibrosis. Prxx1 was found to have a major role in PDGF-induced migration and chemotaxis.
Title: Paired related homeobox protein 1 regulates PDGF-induced chemotaxis of hepatic stellate cells in liver fibrosis.

expression of Prx1 and Tcf4 is decreased in the developing diaphragm in the nitrofen-induced congenital diaphragmatic hernia in Sprague- Dawley rats animal model.
Title: Expression of Prx1 and Tcf4 is decreased in the diaphragmatic muscle connective tissue of nitrofen-induced congenital diaphragmatic hernia.

Prdx1 and Prdx6 proteins is involved in pulmonary fibrosis induced by silica.
Title: Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.

PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are present at the periphery of the embryonic pituitary and participate in pituitary vasculogenesis by differentiation into vascular endothelial cells and pericytes.
Title: PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are involved in vasculogenesis during rat embryonic pituitary development.

expression not stimulated by Klf6
Title: Expression of Kr?ppel-like factor 6, KLF6, in rat pituitary stem/progenitor cells and its regulation of the PRRX2 gene.

The following Prrx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prrx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03205	NM_153821.1 Latest version!	Rattus norvegicus paired related homeobox 1 (Prrx1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa35553	XM_006250151.3 Latest version!	Rattus norvegicus paired related homeobox 1 (Prrx1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prrx1 ( NM_153821.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_722543.1 Rattus norvegicus paired related homeobox 1 (Prrx1), mRNA.

Price & Availability↑

CloneID	ORa03205
Clone ID Related Accession (Same CDS sequence)	NM_153821.1
Accession Version	NM_153821.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	paired mesoderm homeobox protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S82911.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S82911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGACCTCCA GCTACGGGCA CGTTCTGGAG CGGCAACCGG CTCTGGGCGG CCGCTTGGAT 
AGCCCTGGCA ACCTCGACAC CCTGCAGGCG AAAAAGAACT TCTCCGTCAG TCACCTGCTA 
GACCTGGAGG AGGCCGGGGA CATGGTGGCG GCACAGGCGG ACGAAAGCGT GGGCGAGGCG 
GGCCGGAGCC TGCTGGAGTC ACCGGGACTG ACCAGTGGCA GCGACACCCC TCAGCAGGAC 
AATGATCAGC TGAACTCTGA GGAGAAGAAG AAGAGAAAGC AACGGAGAAA CAGGACAACC 
TTCAATAGCA GCCAGCTGCA GGCCTTGGAG CGTGTCTTCG AGAGGACCCA TTACCCGGAT 
GCTTTTGTAC GGGAAGATCT TGCACGTCGG GTGAACCTCA CGGAGGCCAG AGTGCAGGTG 
TGGTTTCAGA ACCGAAGAGC CAAGTTCCGC AGGAATGAGC GAGCCATGCT GGCCAATAAA 
AACGCTTCTC TCCTCAAGTC CTACTCAGGA GACGTGACTG CCGTGGAACA ACCCATTGTA 
CCTCGTCCTG CTCCCAGACC CACCGATTAT CTCTCCTGGG GGACAGCCTC TCCGTACAGC 
GCCATGGCTA CTTATTCTGC CACATGTGCC AACAATAGCC CTGCGCAGGG TATCAACATG 
GCCAACAGCA TTGCCAACCT GAGACTGAAG GCCAAGGAAT ATAGTTTACA GAGGAACCAG 
GTGCCAACAG TCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_722543.1
CDS	329..1066
Translation	MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN

Target ORF information:

RefSeq Version	NM_153821.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus paired related homeobox 1 (Prrx1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153821.1

ORF Insert Sequence:

ATGACCTCCA GCTACGGGCA CGTTCTGGAG CGGCAACCGG CTCTGGGCGG CCGCTTGGAT 
AGCCCTGGCA ACCTCGACAC CCTGCAGGCG AAAAAGAACT TCTCCGTCAG TCACCTGCTA 
GACCTGGAGG AGGCCGGGGA CATGGTGGCG GCACAGGCGG ACGAAAGCGT GGGCGAGGCG 
GGCCGGAGCC TGCTGGAGTC ACCGGGACTG ACCAGTGGCA GCGACACCCC TCAGCAGGAC 
AATGATCAGC TGAACTCTGA GGAGAAGAAG AAGAGAAAGC AACGGAGAAA CAGGACAACC 
TTCAATAGCA GCCAGCTGCA GGCCTTGGAG CGTGTCTTCG AGAGGACCCA TTACCCGGAT 
GCTTTTGTAC GGGAAGATCT TGCACGTCGG GTGAACCTCA CGGAGGCCAG AGTGCAGGTG 
TGGTTTCAGA ACCGAAGAGC CAAGTTCCGC AGGAATGAGC GAGCCATGCT GGCCAATAAA 
AACGCTTCTC TCCTCAAGTC CTACTCAGGA GACGTGACTG CCGTGGAACA ACCCATTGTA 
CCTCGTCCTG CTCCCAGACC CACCGATTAT CTCTCCTGGG GGACAGCCTC TCCGTACAGC 
GCCATGGCTA CTTATTCTGC CACATGTGCC AACAATAGCC CTGCGCAGGG TATCAACATG 
GCCAACAGCA TTGCCAACCT GAGACTGAAG GCCAAGGAAT ATAGTTTACA GAGGAACCAG 
GTGCCAACAG TCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prrx1 ( XM_006250151.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006250213.1 Rattus norvegicus paired related homeobox 1 (Prrx1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa35553
Clone ID Related Accession (Same CDS sequence)	XM_006250151.3
Accession Version	XM_006250151.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	paired mesoderm homeobox protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250151.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCTCCA GCTACGGGCA CGTTCTGGAG CGGCAACCGG CTCTGGGCGG CCGCTTGGAT 
AGCCCTGGCA ACCTCGACAC CCTGCAGGCG AAAAAGAACT TCTCCGTCAG TCACCTGCTA 
GACCTGGAGG AGGCCGGGGA CATGGTGGCG GCACAGGCGG ACGAAAGCGT GGGCGAGGCG 
GGCCGGAGCC TGCTGGAGTC ACCGGGACTG ACCAGTGGCA GCGACACCCC TCAGCAGGAC 
AATGATCAGC TGAACTCTGA GGAGAAGAAG AAGAGAAAGC AACGGAGAAA CAGGACAACC 
TTCAATAGCA GCCAGCTGCA GGCCTTGGAG CGTGTCTTCG AGAGGACCCA TTACCCGGAT 
GCTTTTGTAC GGGAAGATCT TGCACGTCGG GTGAACCTCA CGGAGGCCAG AGTGCAGGTG 
TGGTTTCAGA ACCGAAGAGC CAAGTTCCGC AGGAATGAGC GAGCCATGCT GGCCAATAAA 
AACGCTTCTC TCCTCAAGTC CTACTCAGGA GACGTGACTG CCGTGGAACA ACCCATTGTA 
CCTCGTCCTG CTCCCAGACC CACCGATTAT CTCTCCTGGG GGACAGCCTC TCCGTACAGA 
TCTTCGTCCC TCCCAAGATG TTGTTTACAC GAGGGGCTTC ATAACGGATT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006250213.1
CDS	1066..1719
Translation	MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYRSSSLPRCCLHEGLHNGF

Target ORF information:

RefSeq Version	XM_006250151.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus paired related homeobox 1 (Prrx1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006250151.3

ORF Insert Sequence:

ATGACCTCCA GCTACGGGCA CGTTCTGGAG CGGCAACCGG CTCTGGGCGG CCGCTTGGAT 
AGCCCTGGCA ACCTCGACAC CCTGCAGGCG AAAAAGAACT TCTCCGTCAG TCACCTGCTA 
GACCTGGAGG AGGCCGGGGA CATGGTGGCG GCACAGGCGG ACGAAAGCGT GGGCGAGGCG 
GGCCGGAGCC TGCTGGAGTC ACCGGGACTG ACCAGTGGCA GCGACACCCC TCAGCAGGAC 
AATGATCAGC TGAACTCTGA GGAGAAGAAG AAGAGAAAGC AACGGAGAAA CAGGACAACC 
TTCAATAGCA GCCAGCTGCA GGCCTTGGAG CGTGTCTTCG AGAGGACCCA TTACCCGGAT 
GCTTTTGTAC GGGAAGATCT TGCACGTCGG GTGAACCTCA CGGAGGCCAG AGTGCAGGTG 
TGGTTTCAGA ACCGAAGAGC CAAGTTCCGC AGGAATGAGC GAGCCATGCT GGCCAATAAA 
AACGCTTCTC TCCTCAAGTC CTACTCAGGA GACGTGACTG CCGTGGAACA ACCCATTGTA 
CCTCGTCCTG CTCCCAGACC CACCGATTAT CTCTCCTGGG GGACAGCCTC TCCGTACAGA 
TCTTCGTCCC TCCCAAGATG TTGTTTACAC GAGGGGCTTC ATAACGGATT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Paired related homeobox protein 1 regulates PDGF-induced chemotaxis of hepatic stellate cells in liver fibrosis.
Laboratory investigation; a journal of technical methods and pathology97(9)1020-1032(2017 Sep)
Gong J,Han J,He J,Liu J,Han P,Wang Y,Li M,Li D,Ding X,Du Z,Liao J,Tian D

Expression of Prx1 and Tcf4 is decreased in the diaphragmatic muscle connective tissue of nitrofen-induced congenital diaphragmatic hernia.
Journal of pediatric surgery51(12)1931-1935(2016 Dec)
Takahashi T,Zimmer J,Friedmacher F,Puri P

Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.
Biomedical and environmental sciences : BES29(8)584-588(2016 Aug)
Liu N,Xue L,Guan Y,Li QZ,Cao FY,Pang SL,Guan WJ

PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are involved in vasculogenesis during rat embryonic pituitary development.
Cell and tissue research361(2)557-65(2015 Aug)
Higuchi M,Kato T,Yoshida S,Ueharu H,Nishimura N,Kato Y