Alk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Alk
Entrez Gene ID	266802
Full Name	ALK receptor tyrosine kinase
General protein information	Preferred Names ALK receptor tyrosine kinase Names ALK tyrosine kinase receptor anaplastic lymphoma kinase anaplastic lymphoma receptor tyrosine kinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q13
Summary	human homolog induces neuronal differentiation; may act as a receptor tyrosine kinase in the mitogen-activated protein kinase cascade [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001169101.2	NP_001162572.1	ALK tyrosine kinase receptor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ALK	XP_003309006.2
Rattus norvegicus (Norway rat)	Alk	NP_001162572.1
Homo sapiens (human)	ALK	NP_004295.2
Danio rerio (zebrafish)	alk	XP_691964.5
Gallus gallus (chicken)	ALK	XP_004940244.1
Canis lupus familiaris (dog)	ALK	XP_540136.3
Mus musculus (house mouse)	Alk	NP_031465.2
Bos taurus (cattle)	LOC536642	XP_002691538.2
Xenopus tropicalis (tropical clawed frog)	LOC100495071	XP_002938468.2

Gene Ontology
Bibliography

Related articles in PubMed

Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition.
Liu CN, Mathialagan N, Lappin P, Fortner J, Somps C, Seitis G, Johnson TR, Hu W, Matsumoto D
Toxicological sciences : an official journal of the Society of Toxicology143(1)116-25(2015 Jan)

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma.
Bresler SC, Weiser DA, Huwe PJ, Park JH, Krytska K, Ryles H, Laudenslager M, Rappaport EF, Wood AC, McGrady PW, Hogarty MD, London WB, Radhakrishnan R, Lemmon MA, Moss? YP
Cancer cell26(5)682-94(2014 Nov)

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)

ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction.
Degoutin J, Brunet-de Carvalho N, Cifuentes-Diaz C, Vigny M
The European journal of neuroscience29(2)275-86(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Electroretinography b-wave amplitude decreases during dark adaption following crizotinib administration may be related to signaling changes within the retina in rats, likely independent of ALK inhibition.
Title: Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition.

We showed that ALK is specifically present in a subtype of neurons during DRG development, and that the majority of these neurons co-expressed TrkA and Ret.
Title: ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction.

ALK has a proapoptotic activity in the absence of ligand, whereas it is antiapoptotic in the presence of its ligand and when the kinase is intrinsically activated.
Title: Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.

analysis of differentiation of PC12 cells and human embryonic kidney 293 cells transfected with ALK shows absence of agonist activity of pleiotrophin
Title: Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.

The following Alk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41747	NM_001169101.2 Latest version!	Rattus norvegicus ALK receptor tyrosine kinase (Alk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$811.30 $1159.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Alk ( NM_001169101.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001162572.1 Rattus norvegicus ALK receptor tyrosine kinase (Alk), mRNA.

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CloneID	ORa41747
Clone ID Related Accession (Same CDS sequence)	NM_001169101.2
Accession Version	NM_001169101.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4854bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	ALK tyrosine kinase receptor precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01042238.1, AAHX01042243.1, AAHX01042247.1, AAHX01042253.1, AAHX01042254.1 and AAHX01042255.1. On Oct 12, 2012 this sequence version replaced NM_001169101.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGGAGCCC TTGGGTTCCT GTGGCTGCTG CCGCCGCTGC TTTTGACAGC AGCCTCGTAC 
TCCGGAGCTG CAACCGATCA GCGCGCGGGT TCTCCAGCCT CAGGGCCGCC TCTGCAGCCC 
CGGGAGCCGC TCAGCTATTC GCGCCTGCAG AGGAAGAGTC TGGCGGTGGA CTTCGTGGTG 
CCCTCACTCT TCCGCGTCTA TGCCCGAGAC CTGCTGCTGC CGCAGCCACC GTCCCCCTCG 
GAGCCCGGGG CTGGCGGGCT GGAGGCGCGG GGATCACTGG CTCTGGACTG CGACCCTCTG 
CTCAGGTTGC TGGGGCCATC GCCTGGAATC TCCTGGGCAG AGGGAGCCAG TTCTCCTAGT 
CCGGAGGCGG CTCCGACGCT GTCCAGGGTG CTGAAGGGCG GCTCGGTGCG CAAGCTCAGG 
CGTGCCAAAC AGCTGGTGCT GGAGCTGGGC GAGGAGACGA TCCTTGAAGG CTGCATTGGT 
CCCCCAGAGG AGGCGGCGGC TGTGGGGATA CTCCAGTTCA ACCTTAGCGA GCTGTTCAGC 
TGGTGGATTC TACACGGCGA AGGGCGGCTG AGGATCCGCC TGATGCCTGA GAAGAAGGCA 
TCGGAAGTGG GCAGGGAGGG AAGGCTATCC ACTGCGATCC GAGCCTCCCA GCCCCGCCTT 
CTCTTCCAGA TCTTCGGGAC CGGTCACAGC TCCTTGGAAT CACCCTCAGA AATGCCTTCT 
CCTCCTGGTA ACTTTCTATG GAATCTCACC TGGACAATGA AAGACTCCTT CCCTTTCCTT 
TCCCACCGCA GTCGATATGG TCTGGAGTGC AGCTTCGATT TTCCCTGTGA GCTAGAATAC 
TCCCCTCCCC TCCACACCCA TGGGAACCAG AGCTGGTCCT GGCGCCGTGT GCCCTCTGAG 
GAGGCCTCGA GGATGAACTT GTTGGATGGG CCAGAGGCAG AGCATTTGAA AGAGATGCCC 
AGAGGCTCCT TCCTCCTCCT GAACACCTCT GCAGATTCCA AGCATACCAT CCTGAGCCCC 
TGGATGAGGA GCAGTAGTGA GCACTGCACG CTGGCTGTCT CAGTGCACAG ACATCTACAG 
CCTTCTGGGA GATATGTTGC CCAGCTCCTA CCCCACAATG AAGCTGGAAG AGAGATTCTT 
CTGGTGCCTA CCCCGGGGAA ACATGGCTGG ACAGTGCTGC ATGGGAGAGT CGGGCGCCCA 
GAGAACCCAT TCCGAGTGGC CCTGGAATAC ATCTCGAGTG GAAACCGGAG CTTGTCTGCG 
GTGGATTTCT TTGCCCTGAA GAACTGCAGT GAAGGAACAT CCCCAGGCTC CAAGATGGCC 
TTGCAGAGTT CCTTCACTTG TTGGAACGGG ACAGTCCTCC AGCTCGGGCA AGCCTGTGAC 
TTCCACCAGA ACTGTGCCCA AGGAGAAGAT GAGGGTCAGC TATGCAGTAA ACTTCCTGCT 
GGGTTTTACT GTAACTTCGA GGATGGCTTC TGTGGCTGGA CCCAAAGTCC ACTCTCACCC 
CGTGTGCCCC GATGGCAAGT GAAGACCCTG AAAGATACCC ATTCCCAGGG CCACCAAGGC 
CATGCCCTGT TGCTCAGCAC CACTGACGAC CCCACTTCAG AAAGTGCAAC AGTGACCAGT 
GCTACATTCC CCGCACCAAT GAAGAGCTCT CCTTGTGAGC TCCGGATGTC CTGGCTCATC 
CGTGGGGTTC TGAAAGGAAA TGTATCTTTG GTGCTGGTGG AGAACAAAAC TGGAAAGGAG 
CAAAGCCGGA CCGTCTGGCA TGTTGCCACC AATGAAGGCC TAAGCCTGTG GCAGTGGACA 
GTGTTGTCGC TCCTCGATGT GACTGACAGG TTCTGGCTGC AAATAGTCAC ATGGTGGGGC 
CCAGGATCCA GGGCAACCGT GGCATTTGAC AACATTTCCA TCAGCCTCGA CTGCTACCTC 
ACCATCAGTG GGGAGGAGAA AATGTCCCTG AATGCAGTAC CCAAATCCAG AAATCTGTTT 
GAGAAAAACC CAAACAAGGA GCCAAAACCC TGGGCAAACA TATCAGGACC AACTCCCATC 
TTCGACCCTA CAGTTCACTG GCTGTTCACC ACATGTGGGG CCAGTGGCCC TCATGGCCCC 
ACACAGGCAC AGTGCAACAA CGCCTACCAG AACTCCAACC TGAGCGTGGT GGTGGGAAGT 
GAAGGGCCCT TGAGGGGCAT CCAGATTTGG AAAGTGCCAG CTACTGACAC CTACAGTATC 
TCAGGCTATG GAGCAGCTGG CGGAAAAGGT GGGAAGAACA CCATGATGCG GTCCCATGGC 
GTGTCTGTCC TGGGCATCTT CAATCTGGAG AAAGATGACA CGCTCTACAT CCTTGTCGGT 
CAACAAGGGG AAGATGCCTG TCCCAGGGCA AACCAACTAA TCCAGAAAGT ATGTGTCGGC 
GAGAACAATG TGATAGAAGA AGAGATCCGA GTGAACAGAA GCGTTCACGA GTGGGCAGGA 
GGAGGAGGAG GTGGGGGTGG AGCCACCTAC GTGTTTAAGA TGAAAGACGG CGTGCCCGTG 
CCCCTGATTA TTGCGGCCGG CGGTGGTGGC AGGGCCTATG GGGCCAAGAC AGAAACGTTC 
CACCCAGAGA GACTGGAGAA TAACTCCTCA GTTCTAGGGC TGAACGGCAA TTCCGGAGCC 
GCAGGTGGTG GAGGCGGCTG GAATGATAAC ACTTCCTTGC TCTGGGCCGG AAAGTCTTTG 
TTGGAGGGCG CCGCCGGAGG ACATTCCTGC CCCCAGGCCA TGAAGAAGTG GGGGTGGGAG 
ACAAGAGGGG GTTTCGGAGG GGGTGGAGGG GGGTGCTCCT CAGGTGGAGG AGGCGGAGGA 
TATATAGGTG GCAACGCAGC ATCAAACAAT GACCCCGAAA TGGATGGGGA AGATGGGGTT 
TCCTTCATCA GTCCATTGGG TATCCTGTAT ACCCCGGCCT TAAAAGTGAT GGAGGGCCAT 
GGGGAAGTGA ATATCAAGCA CTATCTAAAC TGCAGCCACT GTGAGGTAGA CGAATGTCAC 
ATGGACCCCG AGAGCCACAA AGTCATCTGC TTCTGTGACC ATGGGACCGT GCTGGCTGAC 
GATGGTGTCT CCTGCATTGT GTCGCCCACC CCGGAACCCC ACCTGCCGCT CTCATTGATC 
CTCTCCGTCG TGACCTCTGC CCTGGTGGCC GCTCTCGTTC TGGCATTCTC CGGCATCATG 
ATTGTGTACC GCCGGAAGCA CCAGGAGTTG CAAGCTATGC AGATGGAGCT GCAGAGCCCT 
GAGTATAAGC TGAGCAAGCT ACGGACCTCG ACCATCATGA CAGACTACAA CCCCAACTAC 
TGCTTTGCTG GCAAGACTTC ATCCATCAGT GACCTGAAGG AGGTGCCTCG GAAAAACATC 
ACCCTCATCC GGGGCCTAGG CCATGGCGCA TTTGGGGAGG TGTATGAAGG CCAGGTATCT 
GGAATGCCCA ATGACCCAAG CCCTCTACAA GTGGCTGTAA AGACGCTGCC GGAAGTGTGT 
TCAGAGCAAG ATGAGCTGGA CTTCCTCATG GAAGCTCTGA TCATCAGTAA ATTCAACCAC 
CAGAACATTG TCCGCTGCAT CGGGGTGAGT CTGCAAGCCC TGCCCCGCTT CATCCTGCTG 
GAGCTCATGG CTGGTGGAGA CCTCAAGTCC TTCCTCAGGG AGACACGTCC TCGCCCGAAC 
CAGCCCACCT CCCTGGCCAT GTTGGATCTT CTGCACGTAG CTCGGGACAT TGCCTGTGGC 
TGTCAGTACC TGGAGGAAAA TCACTTTATC CACCGCGATA TTGCTGCTAG AAACTGTCTG 
CTGACCTGTC CGGGAGCTGG GAGGATAGCG AAGATCGGAG ACTTCGGGAT GGCCCGAGAT 
ATCTACAGGG CCAGCTACTA CAGAAAGGGA GGCTGTGCCA TGCTGCCAGT GAAGTGGATG 
CCCCCGGAGG CCTTCATGGA AGGAATATTT ACTTCTAAAA CAGATACATG GTCTTTTGGA 
GTGTTGCTGT GGGAAATATT TTCTCTTGGA TATATGCCAT ACCCCAGCAA GAGCAACCAG 
GAAGTTCTGG AGTTTGTCAC CAGTGGAGGA CGGATGGACC CACCTAAGAA CTGCCCCGGA 
CCTGTATACC GGATAATGAC TCAGTGCTGG CAGCATCAGC CTGAGGACAG ACCCAACTTT 
GCCATCATTC TGGAGAGGAT CGAATACTGC ACCCAGGACC CCGATGTCAT CAATACAGCT 
CTGCCCATCG AATATGGCCC CGTAGTAGAG GAGGAGGAGA AAGTGCCCAT GCGCCCCAAA 
GACCCTGAGG GGATGCCTCC TCTGCTGGTG TCTCCCCAGT CTGCGAAGCA CGAGGAGGCG 
TCCTCAGCCC CCCAACCCTC AGCCCTGGCA GCGCCAGGCC CGCTGGTGAA GAAGCCCTCG 
GGTGCAGGCG CGGGAGCGGG TGCCGGTCCG GTGCCCCGAG GTGCAGCCGA TCGGGGCCAC 
GTGAACATGG CGTTCTCTCA GCCCAACCCT CCCCCAGAGC TGCACAAAGG CCCGGGCTCC 
AGAAACAAGC CGACCAGCCT GTGGAACCCC ACCTACGGCT CGTGGTTCAC CGAGAAGCCA 
GCCAAAAAGA CCCATCCCCC ACCGGGCGCG GAGCCGCAGG CCCGGGCAGG AGCGGCGGAG 
GGTGGCTGGA CCGGGCCGGG TGCGGGGCCC CGCAGAGCCG AGGCTGCGCT GCTGCTCGAG 
CCGTCGGCGC TCAGCGCCAC CATGAAGGAG GTGCCCCTGT TCAGGCTGCG CCACTTCCCC 
TGCGGCAACG TCAACTATGG TTACCAGCAA CAGGGTCTCC CCTTGGAAGC CACTGCTGCC 
CCGGGGGACA CCGTGCTGAA AAGCAAGACT AAGGTCACCC AGCCAGGGCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001162572.1
CDS	917..5770
Translation	MGALGFLWLLPPLLLTAASYSGAATDQRAGSPASGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPQPPSPSEPGAGGLEARGSLALDCDPLLRLLGPSPGISWAEGASSPSPEAAPTLSRVLKGGSVRKLRRAKQLVLELGEETILEGCIGPPEEAAAVGILQFNLSELFSWWILHGEGRLRIRLMPEKKASEVGREGRLSTAIRASQPRLLFQIFGTGHSSLESPSEMPSPPGNFLWNLTWTMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHTHGNQSWSWRRVPSEEASRMNLLDGPEAEHLKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYVAQLLPHNEAGREILLVPTPGKHGWTVLHGRVGRPENPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQNCAQGEDEGQLCSKLPAGFYCNFEDGFCGWTQSPLSPRVPRWQVKTLKDTHSQGHQGHALLLSTTDDPTSESATVTSATFPAPMKSSPCELRMSWLIRGVLKGNVSLVLVENKTGKEQSRTVWHVATNEGLSLWQWTVLSLLDVTDRFWLQIVTWWGPGSRATVAFDNISISLDCYLTISGEEKMSLNAVPKSRNLFEKNPNKEPKPWANISGPTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVVVGSEGPLRGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDTLYILVGQQGEDACPRANQLIQKVCVGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTETFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLLEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLADDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQSAKHEEASSAPQPSALAAPGPLVKKPSGAGAGAGAGPVPRGAADRGHVNMAFSQPNPPPELHKGPGSRNKPTSLWNPTYGSWFTEKPAKKTHPPPGAEPQARAGAAEGGWTGPGAGPRRAEAALLLEPSALSATMKEVPLFRLRHFPCGNVNYGYQQQGLPLEATAAPGDTVLKSKTKVTQPGP

Target ORF information:

RefSeq Version	NM_001169101.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ALK receptor tyrosine kinase (Alk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001169101.2

ORF Insert Sequence:

ATGGGAGCCC TTGGGTTCCT GTGGCTGCTG CCGCCGCTGC TTTTGACAGC AGCCTCGTAC 
TCCGGAGCTG CAACCGATCA GCGCGCGGGT TCTCCAGCCT CAGGGCCGCC TCTGCAGCCC 
CGGGAGCCGC TCAGCTATTC GCGCCTGCAG AGGAAGAGTC TGGCGGTGGA CTTCGTGGTG 
CCCTCACTCT TCCGCGTCTA TGCCCGAGAC CTGCTGCTGC CGCAGCCACC GTCCCCCTCG 
GAGCCCGGGG CTGGCGGGCT GGAGGCGCGG GGATCACTGG CTCTGGACTG CGACCCTCTG 
CTCAGGTTGC TGGGGCCATC GCCTGGAATC TCCTGGGCAG AGGGAGCCAG TTCTCCTAGT 
CCGGAGGCGG CTCCGACGCT GTCCAGGGTG CTGAAGGGCG GCTCGGTGCG CAAGCTCAGG 
CGTGCCAAAC AGCTGGTGCT GGAGCTGGGC GAGGAGACGA TCCTTGAAGG CTGCATTGGT 
CCCCCAGAGG AGGCGGCGGC TGTGGGGATA CTCCAGTTCA ACCTTAGCGA GCTGTTCAGC 
TGGTGGATTC TACACGGCGA AGGGCGGCTG AGGATCCGCC TGATGCCTGA GAAGAAGGCA 
TCGGAAGTGG GCAGGGAGGG AAGGCTATCC ACTGCGATCC GAGCCTCCCA GCCCCGCCTT 
CTCTTCCAGA TCTTCGGGAC CGGTCACAGC TCCTTGGAAT CACCCTCAGA AATGCCTTCT 
CCTCCTGGTA ACTTTCTATG GAATCTCACC TGGACAATGA AAGACTCCTT CCCTTTCCTT 
TCCCACCGCA GTCGATATGG TCTGGAGTGC AGCTTCGATT TTCCCTGTGA GCTAGAATAC 
TCCCCTCCCC TCCACACCCA TGGGAACCAG AGCTGGTCCT GGCGCCGTGT GCCCTCTGAG 
GAGGCCTCGA GGATGAACTT GTTGGATGGG CCAGAGGCAG AGCATTTGAA AGAGATGCCC 
AGAGGCTCCT TCCTCCTCCT GAACACCTCT GCAGATTCCA AGCATACCAT CCTGAGCCCC 
TGGATGAGGA GCAGTAGTGA GCACTGCACG CTGGCTGTCT CAGTGCACAG ACATCTACAG 
CCTTCTGGGA GATATGTTGC CCAGCTCCTA CCCCACAATG AAGCTGGAAG AGAGATTCTT 
CTGGTGCCTA CCCCGGGGAA ACATGGCTGG ACAGTGCTGC ATGGGAGAGT CGGGCGCCCA 
GAGAACCCAT TCCGAGTGGC CCTGGAATAC ATCTCGAGTG GAAACCGGAG CTTGTCTGCG 
GTGGATTTCT TTGCCCTGAA GAACTGCAGT GAAGGAACAT CCCCAGGCTC CAAGATGGCC 
TTGCAGAGTT CCTTCACTTG TTGGAACGGG ACAGTCCTCC AGCTCGGGCA AGCCTGTGAC 
TTCCACCAGA ACTGTGCCCA AGGAGAAGAT GAGGGTCAGC TATGCAGTAA ACTTCCTGCT 
GGGTTTTACT GTAACTTCGA GGATGGCTTC TGTGGCTGGA CCCAAAGTCC ACTCTCACCC 
CGTGTGCCCC GATGGCAAGT GAAGACCCTG AAAGATACCC ATTCCCAGGG CCACCAAGGC 
CATGCCCTGT TGCTCAGCAC CACTGACGAC CCCACTTCAG AAAGTGCAAC AGTGACCAGT 
GCTACATTCC CCGCACCAAT GAAGAGCTCT CCTTGTGAGC TCCGGATGTC CTGGCTCATC 
CGTGGGGTTC TGAAAGGAAA TGTATCTTTG GTGCTGGTGG AGAACAAAAC TGGAAAGGAG 
CAAAGCCGGA CCGTCTGGCA TGTTGCCACC AATGAAGGCC TAAGCCTGTG GCAGTGGACA 
GTGTTGTCGC TCCTCGATGT GACTGACAGG TTCTGGCTGC AAATAGTCAC ATGGTGGGGC 
CCAGGATCCA GGGCAACCGT GGCATTTGAC AACATTTCCA TCAGCCTCGA CTGCTACCTC 
ACCATCAGTG GGGAGGAGAA AATGTCCCTG AATGCAGTAC CCAAATCCAG AAATCTGTTT 
GAGAAAAACC CAAACAAGGA GCCAAAACCC TGGGCAAACA TATCAGGACC AACTCCCATC 
TTCGACCCTA CAGTTCACTG GCTGTTCACC ACATGTGGGG CCAGTGGCCC TCATGGCCCC 
ACACAGGCAC AGTGCAACAA CGCCTACCAG AACTCCAACC TGAGCGTGGT GGTGGGAAGT 
GAAGGGCCCT TGAGGGGCAT CCAGATTTGG AAAGTGCCAG CTACTGACAC CTACAGTATC 
TCAGGCTATG GAGCAGCTGG CGGAAAAGGT GGGAAGAACA CCATGATGCG GTCCCATGGC 
GTGTCTGTCC TGGGCATCTT CAATCTGGAG AAAGATGACA CGCTCTACAT CCTTGTCGGT 
CAACAAGGGG AAGATGCCTG TCCCAGGGCA AACCAACTAA TCCAGAAAGT ATGTGTCGGC 
GAGAACAATG TGATAGAAGA AGAGATCCGA GTGAACAGAA GCGTTCACGA GTGGGCAGGA 
GGAGGAGGAG GTGGGGGTGG AGCCACCTAC GTGTTTAAGA TGAAAGACGG CGTGCCCGTG 
CCCCTGATTA TTGCGGCCGG CGGTGGTGGC AGGGCCTATG GGGCCAAGAC AGAAACGTTC 
CACCCAGAGA GACTGGAGAA TAACTCCTCA GTTCTAGGGC TGAACGGCAA TTCCGGAGCC 
GCAGGTGGTG GAGGCGGCTG GAATGATAAC ACTTCCTTGC TCTGGGCCGG AAAGTCTTTG 
TTGGAGGGCG CCGCCGGAGG ACATTCCTGC CCCCAGGCCA TGAAGAAGTG GGGGTGGGAG 
ACAAGAGGGG GTTTCGGAGG GGGTGGAGGG GGGTGCTCCT CAGGTGGAGG AGGCGGAGGA 
TATATAGGTG GCAACGCAGC ATCAAACAAT GACCCCGAAA TGGATGGGGA AGATGGGGTT 
TCCTTCATCA GTCCATTGGG TATCCTGTAT ACCCCGGCCT TAAAAGTGAT GGAGGGCCAT 
GGGGAAGTGA ATATCAAGCA CTATCTAAAC TGCAGCCACT GTGAGGTAGA CGAATGTCAC 
ATGGACCCCG AGAGCCACAA AGTCATCTGC TTCTGTGACC ATGGGACCGT GCTGGCTGAC 
GATGGTGTCT CCTGCATTGT GTCGCCCACC CCGGAACCCC ACCTGCCGCT CTCATTGATC 
CTCTCCGTCG TGACCTCTGC CCTGGTGGCC GCTCTCGTTC TGGCATTCTC CGGCATCATG 
ATTGTGTACC GCCGGAAGCA CCAGGAGTTG CAAGCTATGC AGATGGAGCT GCAGAGCCCT 
GAGTATAAGC TGAGCAAGCT ACGGACCTCG ACCATCATGA CAGACTACAA CCCCAACTAC 
TGCTTTGCTG GCAAGACTTC ATCCATCAGT GACCTGAAGG AGGTGCCTCG GAAAAACATC 
ACCCTCATCC GGGGCCTAGG CCATGGCGCA TTTGGGGAGG TGTATGAAGG CCAGGTATCT 
GGAATGCCCA ATGACCCAAG CCCTCTACAA GTGGCTGTAA AGACGCTGCC GGAAGTGTGT 
TCAGAGCAAG ATGAGCTGGA CTTCCTCATG GAAGCTCTGA TCATCAGTAA ATTCAACCAC 
CAGAACATTG TCCGCTGCAT CGGGGTGAGT CTGCAAGCCC TGCCCCGCTT CATCCTGCTG 
GAGCTCATGG CTGGTGGAGA CCTCAAGTCC TTCCTCAGGG AGACACGTCC TCGCCCGAAC 
CAGCCCACCT CCCTGGCCAT GTTGGATCTT CTGCACGTAG CTCGGGACAT TGCCTGTGGC 
TGTCAGTACC TGGAGGAAAA TCACTTTATC CACCGCGATA TTGCTGCTAG AAACTGTCTG 
CTGACCTGTC CGGGAGCTGG GAGGATAGCG AAGATCGGAG ACTTCGGGAT GGCCCGAGAT 
ATCTACAGGG CCAGCTACTA CAGAAAGGGA GGCTGTGCCA TGCTGCCAGT GAAGTGGATG 
CCCCCGGAGG CCTTCATGGA AGGAATATTT ACTTCTAAAA CAGATACATG GTCTTTTGGA 
GTGTTGCTGT GGGAAATATT TTCTCTTGGA TATATGCCAT ACCCCAGCAA GAGCAACCAG 
GAAGTTCTGG AGTTTGTCAC CAGTGGAGGA CGGATGGACC CACCTAAGAA CTGCCCCGGA 
CCTGTATACC GGATAATGAC TCAGTGCTGG CAGCATCAGC CTGAGGACAG ACCCAACTTT 
GCCATCATTC TGGAGAGGAT CGAATACTGC ACCCAGGACC CCGATGTCAT CAATACAGCT 
CTGCCCATCG AATATGGCCC CGTAGTAGAG GAGGAGGAGA AAGTGCCCAT GCGCCCCAAA 
GACCCTGAGG GGATGCCTCC TCTGCTGGTG TCTCCCCAGT CTGCGAAGCA CGAGGAGGCG 
TCCTCAGCCC CCCAACCCTC AGCCCTGGCA GCGCCAGGCC CGCTGGTGAA GAAGCCCTCG 
GGTGCAGGCG CGGGAGCGGG TGCCGGTCCG GTGCCCCGAG GTGCAGCCGA TCGGGGCCAC 
GTGAACATGG CGTTCTCTCA GCCCAACCCT CCCCCAGAGC TGCACAAAGG CCCGGGCTCC 
AGAAACAAGC CGACCAGCCT GTGGAACCCC ACCTACGGCT CGTGGTTCAC CGAGAAGCCA 
GCCAAAAAGA CCCATCCCCC ACCGGGCGCG GAGCCGCAGG CCCGGGCAGG AGCGGCGGAG 
GGTGGCTGGA CCGGGCCGGG TGCGGGGCCC CGCAGAGCCG AGGCTGCGCT GCTGCTCGAG 
CCGTCGGCGC TCAGCGCCAC CATGAAGGAG GTGCCCCTGT TCAGGCTGCG CCACTTCCCC 
TGCGGCAACG TCAACTATGG TTACCAGCAA CAGGGTCTCC CCTTGGAAGC CACTGCTGCC 
CCGGGGGACA CCGTGCTGAA AAGCAAGACT AAGGTCACCC AGCCAGGGCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition.
Toxicological sciences : an official journal of the Society of Toxicology143(1)116-25(2015 Jan)
Liu CN,Mathialagan N,Lappin P,Fortner J,Somps C,Seitis G,Johnson TR,Hu W,Matsumoto D

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