Cyp3a23/3a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyp3a23/3a1
Entrez Gene ID	25642
Full Name	cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1
Synonyms	CYP,CYP3A23,Cyp3a1,Cyp3a3,RL33,cDEX
General protein information	Preferred Names cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 Names cytochrome P450 3A1 CYPIIIA1 Cytochrome P450, subfamily IIIA, polypeptide 3 P450 IIIA P450-PCN1 cytochrome P-450PCN (PNCN inducible) cytochrome P450, family 3, subfamily a, polypeptide 1 cytochrome P450, subfamily 3A, polypeptide 3 cytochrome P450-PCN1 cytochrome P450/6 beta B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p11
Summary	steroid-inducible member of p450 subfamily 3A; induced by pregnenolone 16 alpha-carbonitrile, dexamethasone (DEX), phenobarbital (PB) and triacetyloleandomycin [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013105.2	NP_037237.2	cytochrome P450 3A1

Pathways from BioSystems

Homologies

	CYP3A5	NP_001035309.1
Rattus norvegicus (Norway rat)	Cyp3a23/3a1	NP_037237.2
Drosophila melanogaster (fruit fly)	Cyp9c1	NP_523850.1
Mus musculus (house mouse)	Cyp3a41b	NP_001098629.1
Mus musculus (house mouse)	Cyp3a16	NP_031846.2
Drosophila melanogaster (fruit fly)	Cyp9b2	NP_523646.1
Pan troglodytes (chimpanzee)	CYP3A5	NP_001087246.1
Drosophila melanogaster (fruit fly)	Cyp9h1	NP_610820.1
Mus musculus (house mouse)	Cyp3a41a	NP_059092.2
Mus musculus (house mouse)	Cyp3a44	NP_796354.1
Drosophila melanogaster (fruit fly)	Cyp9b1	NP_523645.1
Homo sapiens (human)	CYP3A5	NP_000768.1
Mus musculus (house mouse)	Cyp3a11	NP_031844.1
Rattus norvegicus (Norway rat)	LOC100910877	XP_003751175.1

Gene Ontology
Bibliography

Related articles in PubMed

Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis.
Gabbia D, Pozza AD, Albertoni L, Lazzari R, Zigiotto G, Carrara M, Baldo V, Baldovin T, Floreani A, Martin S
World journal of gastroenterology23(42)7519-7530(2017 Nov)

Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression.
Abdelhadya DH, El-Magd MA, Elbialy ZI, Saleh AA
Toxicology mechanisms and methods27(7)544-550(2017 Sep)

The effects of metronidazole on Cytochrome P450 Activity and Expression in rats after acute exposure to high altitude of 4300m.
Wang R, Sun Y, Yin Q, Xie H, Li W, Wang C, Guo J, Hao Y, Tao R, Jia Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie85296-302(2017 Jan)

Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction.
Santoh M, Sanoh S, Takagi M, Ejiri Y, Kotake Y, Ohta S
Scientific reports621373(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CYP3A1 activity was reduced in rats after acute exposure to high altitude of 4300m and metronidazole.
Title: The effects of metronidazole on Cytochrome P450 Activity and Expression in rats after acute exposure to high altitude of 4300m.

These findings demonstrate that Acetaminophen (APAP) induces accumulation of functional CYP3A protein via inhibition of protein degradation. Our findings may lead to the determination of novel drug-drug interactions with APAP
Title: Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction.

Report a CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat CYP3A1 gene.
Title: A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene.

Low-birth-weight offspring with postnatal catch-up growth may have a diminished response to xenobiotics metabolized by CYP3A23 and CYP2C11 enzymes.
Title: Protein restoration in low-birth-weight rat offspring derived from maternal low-protein diet leads to elevated hepatic CYP3A and CYP2C11 activity in adulthood.

These findings suggest that Valeriana officinalis extract can decrease the CYP3A4 expression and therefore may lead to interactions with synthetic drugs metabolized by this enzyme.
Title: The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.

The following Cyp3a23/3a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp3a23/3a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01996	NM_013105.2 Latest version!	Rattus norvegicus cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 (Cyp3a23/3a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyp3a23/3a1 ( NM_013105.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037237.2 Rattus norvegicus cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 (Cyp3a23/3a1), mRNA.

Price & Availability↑

CloneID	ORa01996
Clone ID Related Accession (Same CDS sequence)	NM_013105.2
Accession Version	NM_013105.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1509bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome P450 3A1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088163.1. On or before Sep 28, 2007 this sequence version replaced NM_173144.1, NM_013105.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC088163.1, FQ211106.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689598, SAMEA2689599 [ECO:0000350] ##Evidence-Data-END##

ATGGACCTGC TTTCAGCTCT CACACTGGAA ACCTGGGTCC TCCTGGCAGT CGTCCTGGTG 
CTCCTCTACG GATTTGGGAC CCGCACACAT GGACTTTTCA AGAAACAGGG GATTCCTGGG 
CCCAAACCTC TGCCTTTTTT TGGCACTGTG CTGAATTACT ATATGGGTTT ATGGAAATTC 
GATGTGGAGT GCCATAAAAA GTATGGAAAA ATATGGGGGT TGTTTGATGG TCAAATGCCT 
CTGTTTGCCA TCACGGACAC AGAAATGATC AAGAATGTGC TAGTGAAGGA ATGCTTTTCT 
GTCTTCACAA ACCGGCGGGA TTTTGGCCCA GTGGGGATTA TGGGGAAAGC CATCTCTGTA 
TCTAAGGATG AGGAGTGGAA GAGATATAGA GCCTTGCTGT CACCCACGTT CACCAGTGGA 
AGACTCAAGG AGATGTTCCC TGTCATCGAA CAGTATGGAG ACATTTTGGT AAAATACTTG 
AGGCAAGAGA AAGGCAAACC TGTCCCTGTG AAAGAAGTGT TTGGTGCCTA CAGCATGGAT 
GTGATCACCA GCACATCATT TGGAGTGAAT GTTGATTCCC TCAACAACCC GAAGGATCCT 
TTTGTGGAGA AAGCCAAGAA GCTCTTAAGA ATTGATTTTT TTGATCCGTT GTTCTTGTCA 
GTAGTACTCT TTCCATTCCT CACGCCAGTA TATGAGATGT TAAACATCTG CATGTTCCCA 
AAAGATTCAA TAGAATTTTT CAAAAAATTT GTGTACAGAA TGAAGGAAAC CCGCCTGGAT 
TCTGTGCAGA AGCATCGAGT GGATTTTCTT CAGCTGATGA TGAATGCTCA TAATGATTCT 
AAAGACAAAG AATCTCATAC AGCCCTATCC GATATGGAGA TCACAGCCCA GTCAATCATT 
TTTATTTTTG CTGGATATGA ACCCACCAGC AGCACACTTT CCTTTGTCCT GCATTCCCTG 
GCCACTCACC CAGATACACA GAAGAAACTG CAGGAGGAGA TCGACAGGGC TCTGCCCAAT 
AAGGCACCTC CCACCTATGA TACTGTGATG GAAATGGAAT ACCTGGATAT GGTGTTGAAT 
GAAACCCTCA GATTGTATCC AATTGGTAAT AGACTTGAGA GAGTCTGTAA AAAAGATGTT 
GAAATCAATG GTGTGTTTAT GCCCAAAGGG TCAGTGGTCA TGATTCCATC TTATGCTCTT 
CACCGTGATC CACAGCACTG GCCAGAGCCT GAGGAATTTC GCCCAGAAAG GTTCAGCAAG 
GAGAACAAGG GCAGCATTGA TCCTTATGTA TATCTGCCCT TTGGAAATGG ACCCAGGAAC 
TGCATTGGCA TGAGGTTTGC TCTCATGAAT ATGAAACTCG CTCTCACTAA AGTTCTGCAA 
AACTTCTCCT TCCAGCCTTG TAAGGAAACA CAGATACCTC TGAAATTAAG CAGACAAGGA 
CTTCTTCAAC CAACAAAACC CATTATTCTA AAGGTTGTGC CACGGGATGA AATCATAACT 
GGATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037237.2
CDS	80..1588
Translation	MDLLSALTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKFDVECHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAISVSKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEKGKPVPVKEVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSRQGLLQPTKPIILKVVPRDEIITGS

Target ORF information:

RefSeq Version	NM_013105.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 (Cyp3a23/3a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013105.2

ORF Insert Sequence:

ATGGACCTGC TTTCAGCTCT CACACTGGAA ACCTGGGTCC TCCTGGCAGT CGTCCTGGTG 
CTCCTCTACG GATTTGGGAC CCGCACACAT GGACTTTTCA AGAAACAGGG GATTCCTGGG 
CCCAAACCTC TGCCTTTTTT TGGCACTGTG CTGAATTACT ATATGGGTTT ATGGAAATTC 
GATGTGGAGT GCCATAAAAA GTATGGAAAA ATATGGGGGT TGTTTGATGG TCAAATGCCT 
CTGTTTGCCA TCACGGACAC AGAAATGATC AAGAATGTGC TAGTGAAGGA ATGCTTTTCT 
GTCTTCACAA ACCGGCGGGA TTTTGGCCCA GTGGGGATTA TGGGGAAAGC CATCTCTGTA 
TCTAAGGATG AGGAGTGGAA GAGATATAGA GCCTTGCTGT CACCCACGTT CACCAGTGGA 
AGACTCAAGG AGATGTTCCC TGTCATCGAA CAGTATGGAG ACATTTTGGT AAAATACTTG 
AGGCAAGAGA AAGGCAAACC TGTCCCTGTG AAAGAAGTGT TTGGTGCCTA CAGCATGGAT 
GTGATCACCA GCACATCATT TGGAGTGAAT GTTGATTCCC TCAACAACCC GAAGGATCCT 
TTTGTGGAGA AAGCCAAGAA GCTCTTAAGA ATTGATTTTT TTGATCCGTT GTTCTTGTCA 
GTAGTACTCT TTCCATTCCT CACGCCAGTA TATGAGATGT TAAACATCTG CATGTTCCCA 
AAAGATTCAA TAGAATTTTT CAAAAAATTT GTGTACAGAA TGAAGGAAAC CCGCCTGGAT 
TCTGTGCAGA AGCATCGAGT GGATTTTCTT CAGCTGATGA TGAATGCTCA TAATGATTCT 
AAAGACAAAG AATCTCATAC AGCCCTATCC GATATGGAGA TCACAGCCCA GTCAATCATT 
TTTATTTTTG CTGGATATGA ACCCACCAGC AGCACACTTT CCTTTGTCCT GCATTCCCTG 
GCCACTCACC CAGATACACA GAAGAAACTG CAGGAGGAGA TCGACAGGGC TCTGCCCAAT 
AAGGCACCTC CCACCTATGA TACTGTGATG GAAATGGAAT ACCTGGATAT GGTGTTGAAT 
GAAACCCTCA GATTGTATCC AATTGGTAAT AGACTTGAGA GAGTCTGTAA AAAAGATGTT 
GAAATCAATG GTGTGTTTAT GCCCAAAGGG TCAGTGGTCA TGATTCCATC TTATGCTCTT 
CACCGTGATC CACAGCACTG GCCAGAGCCT GAGGAATTTC GCCCAGAAAG GTTCAGCAAG 
GAGAACAAGG GCAGCATTGA TCCTTATGTA TATCTGCCCT TTGGAAATGG ACCCAGGAAC 
TGCATTGGCA TGAGGTTTGC TCTCATGAAT ATGAAACTCG CTCTCACTAA AGTTCTGCAA 
AACTTCTCCT TCCAGCCTTG TAAGGAAACA CAGATACCTC TGAAATTAAG CAGACAAGGA 
CTTCTTCAAC CAACAAAACC CATTATTCTA AAGGTTGTGC CACGGGATGA AATCATAACT 
GGATCATGA