Tnfrsf1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnfrsf1a
Entrez Gene ID	25625
Full Name	TNF receptor superfamily member 1A
Synonyms	TNFR-1,Tnfr1
General protein information	Preferred Names TNF receptor superfamily member 1A Names tumor necrosis factor receptor superfamily member 1A TNF-R1 TNF-RI TNFR-I p55 p60 tumor necrosis factor receptor 1 tumor necrosis factor receptor superfamily, member 1a tumor necrosis factor receptor type I
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	may play a role in TNFalpha mediated inflammatory response to spinal cord injury [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006237334.3	XP_006237396.1	tumor necrosis factor receptor superfamily member 1A isoform X1
NM_013091.1	NP_037223.1	tumor necrosis factor receptor superfamily member 1A precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TNFRSF1A	NP_777099.1
Gallus gallus (chicken)	TNFRSF1A	NP_001025950.1
Homo sapiens (human)	TNFRSF1A	NP_001056.1
	TNFRSF1A	XP_001118232.2
Mus musculus (house mouse)	Tnfrsf1a	NP_035739.2
Danio rerio (zebrafish)	tnfrsf1a	NP_998355.1
Pan troglodytes (chimpanzee)	TNFRSF1A	XP_522334.3
Canis lupus familiaris (dog)	TNFRSF1A	XP_854474.1
Rattus norvegicus (Norway rat)	Tnfrsf1a	NP_037223.1
Xenopus tropicalis (tropical clawed frog)	tnfrsf1a	NP_001119976.1

Gene Ontology
Bibliography

Related articles in PubMed

TNF-? receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats.
Yu Y, Wei SG, Weiss RM, Felder RB
American journal of physiology. Heart and circulatory physiology313(4)H744-H756(2017 Oct)

Notch-Tnf signalling is required for development and homeostasis of arterial valves.
Wang Y, Wu B, Farrar E, Lui W, Lu P, Zhang D, Alfieri CM, Mao K, Chu M, Yang D, Xu D, Rauchman M, Taylor V, Conway SJ, Yutzey KE, Butcher JT, Zhou B
European heart journal38(9)675-686(2017 Mar)

Regulation of myocardial stromal cell-derived factor 1?/CXCL12 by tumor necrosis factor signaling.
Wang M, Wang L, Huang C, Wang IW, Turrentine MW
The Journal of surgical research207155-163(2017 Jan)

miR-29a up-regulation in AR42J cells contributes to apoptosis via targeting TNFRSF1A gene.
Fu Q, Qin T, Chen L, Liu CJ, Zhang X, Wang YZ, Hu MX, Chu HY, Zhang HW
World journal of gastroenterology22(20)4881-90(2016 May)

Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats.
Leo M, Argalski S, Sch?fers M, Hagenacker T
Mediators of inflammation2015124942(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Activation of TNF-alpha receptor 1 in the subfornical organ (SFO) contributes to sympathetic excitation in heart failure rats by increasing inflammation and renin-angiotensin system activity
Title: TNF-? receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats.

TNF plays an inhibitory role in modulating myocardial SDF-1 production and blockade of TNF signaling by ablation of TNFR1 and TNFR2 genes increased SDF-1 expression in the heart. These data expand on TNF signaling-initiated mechanisms in myocardium, which may lend a more complete understanding of SDF-1 and TNFR-derived actions in hopes of advancing ischemic heart injury treatments.
Title: Regulation of myocardial stromal cell-derived factor 1?/CXCL12 by tumor necrosis factor signaling.

Resveratrol restores the antinociceptive effect of morphine by reversing morphine infusion-induced spinal cord neuroinflammation and increase in TNFR1 expression. The reversal of the morphine-induced increase in TNFR1 expression by resveratrol is partially due to reversal of the morphine infusion-induced increase in HDAC1 expression.
Title: Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression.

miR-29a might promote the apoptosis of pancreatic acinar cells via up-regulating the expression of its target gene TNFRSF1A.
Title: miR-29a up-regulation in AR42J cells contributes to apoptosis via targeting TNFRSF1A gene.

TNFR1 and TNFR2 regulate voltage-gated sodium channels in rat dorsal root ganglia
Title: Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats.

The following Tnfrsf1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnfrsf1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13696	NM_013091.1 Latest version!	Rattus norvegicus TNF receptor superfamily member 1A (Tnfrsf1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00
ORa27752	XM_006237334.3 Latest version!	Rattus norvegicus TNF receptor superfamily member 1A (Tnfrsf1a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnfrsf1a ( NM_013091.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037223.1 Rattus norvegicus TNF receptor superfamily member 1A (Tnfrsf1a), mRNA.

Price & Availability↑

CloneID	ORa13696
Clone ID Related Accession (Same CDS sequence)	NM_013091.1
Accession Version	NM_013091.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	tumor necrosis factor receptor superfamily member 1A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M63122.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M63122.1, BC086413.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGTCTCC CCATCGTGCC TGGCCTGCTG CTGTCACTGG TGCTCCTGGC TCTGCTGATG 
GGGATACACC CATCAGGGGT CACCGGACTG GTTCCTTCTC TTGGTGACCG GGAGAAGAGG 
GATAATTTGT GTCCCCAGGG AAAGTATGCC CATCCAAAGA ATAATTCCAT CTGCTGCACC 
AAGTGCCACA AAGGAACCTA CTTGGTGAGT GACTGTCCAA GCCCAGGGCA GGAAACAGTC 
TGCGAGGTGT GTGATAAAGG CACCTTTACA GCTTCGCAGA ACCACGTCAG ACAGTGTCTC 
AGTTGCAAGA CATGTCGGAA AGAAATGTTC CAGGTGGAGA TTTCTCCTTG CAAAGCTGAC 
ATGGACACCG TGTGTGGCTG CAAGAAGAAC CAATTCCAGC GCTACCTGAG TGAGACGCAT 
TTCCAGTGTG TGGACTGCAG CCCCTGCTTC AATGGCACCG TGACAATCCC CTGTAAGGAG 
AAACAGAACA CCGTGTGTAA CTGCCACGCA GGATTCTTTC TAAGCGGAAA TGAGTGCACC 
CCTTGCAGCC ACTGCAAGAA AAATCAGGAA TGTATGAAGC TGTGCCTACC TCCAGTTGCA 
AATGTCACAA ACCCCCAGGA CTCAGGTACT GCCGTGCTGT TGCCTCTGGT TATCTTCCTA 
GGTCTTTGCC TTTTATTCTT TATCTGCATC AGTCTACTGT GCCGATATCC CCAGTGGAGG 
CCCAGGGTCT ACTCCATCAT TTGTAGGGAT TCAGCTCCTG TCAAAGAGGT GGAGGGTGAA 
GGAATTGTTA CTAAGCCCCT AACTCCAGCC TCTATCCCAG CCTTCAGCCC CAACCCCGGC 
TTCAACCCCA CTCTGGGCTT CAGCACCACC CCACGCTTCA GTCATCCTGT CTCCAGTACC 
CCCATCAGCC CCGTCTTCGG TCCTAGTAAC TGGCACAACT TCGTGCCACC TGTAAGAGAG 
GTGGTCCCAA CCCAGGGTGC TGACCCTCTC CTCTACGGAT CCCTCAACCC TGTGCCAATC 
CCCGCCCCTG TTCGGAAATG GGAAGACGTC GTCGCGGCCC AGCCACAACG GCTTGACACT 
GCAGACCCTG CGATGCTGTA TGCTGTGGTG GATGGCGTGC CTCCGACACG CTGGAAGGAG 
TTCATGCGGC TCCTGGGGCT GAGCGAGCAC GAGATCGAGC GGCTGGAGCT GCAGAACGGG 
CGTTGCCTCC GCGAGGCTCA TTACAGCATG CTGGAAGCCT GGCGGCGCCG CACACCGCGA 
CACGAGGCCA CGCTGGACGT AGTGGGCCGC GTGCTTTGCG ACATGAACCT GCGTGGCTGC 
CTGGAGAACA TCCGCGAGAC TCTAGAAAGC CCTGCCCACT CGTCCACGAC CCACCTCCCG 
CGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037223.1
CDS	238..1623
Translation	MGLPIVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDNLCPQGKYAHPKNNSICCTKCHKGTYLVSDCPSPGQETVCEVCDKGTFTASQNHVRQCLSCKTCRKEMFQVEISPCKADMDTVCGCKKNQFQRYLSETHFQCVDCSPCFNGTVTIPCKEKQNTVCNCHAGFFLSGNECTPCSHCKKNQECMKLCLPPVANVTNPQDSGTAVLLPLVIFLGLCLLFFICISLLCRYPQWRPRVYSIICRDSAPVKEVEGEGIVTKPLTPASIPAFSPNPGFNPTLGFSTTPRFSHPVSSTPISPVFGPSNWHNFVPPVREVVPTQGADPLLYGSLNPVPIPAPVRKWEDVVAAQPQRLDTADPAMLYAVVDGVPPTRWKEFMRLLGLSEHEIERLELQNGRCLREAHYSMLEAWRRRTPRHEATLDVVGRVLCDMNLRGCLENIRETLESPAHSSTTHLPR

Target ORF information:

RefSeq Version	NM_013091.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TNF receptor superfamily member 1A (Tnfrsf1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013091.1

ORF Insert Sequence:

ATGGGTCTCC CCATCGTGCC TGGCCTGCTG CTGTCACTGG TGCTCCTGGC TCTGCTGATG 
GGGATACACC CATCAGGGGT CACCGGACTG GTTCCTTCTC TTGGTGACCG GGAGAAGAGG 
GATAATTTGT GTCCCCAGGG AAAGTATGCC CATCCAAAGA ATAATTCCAT CTGCTGCACC 
AAGTGCCACA AAGGAACCTA CTTGGTGAGT GACTGTCCAA GCCCAGGGCA GGAAACAGTC 
TGCGAGGTGT GTGATAAAGG CACCTTTACA GCTTCGCAGA ACCACGTCAG ACAGTGTCTC 
AGTTGCAAGA CATGTCGGAA AGAAATGTTC CAGGTGGAGA TTTCTCCTTG CAAAGCTGAC 
ATGGACACCG TGTGTGGCTG CAAGAAGAAC CAATTCCAGC GCTACCTGAG TGAGACGCAT 
TTCCAGTGTG TGGACTGCAG CCCCTGCTTC AATGGCACCG TGACAATCCC CTGTAAGGAG 
AAACAGAACA CCGTGTGTAA CTGCCACGCA GGATTCTTTC TAAGCGGAAA TGAGTGCACC 
CCTTGCAGCC ACTGCAAGAA AAATCAGGAA TGTATGAAGC TGTGCCTACC TCCAGTTGCA 
AATGTCACAA ACCCCCAGGA CTCAGGTACT GCCGTGCTGT TGCCTCTGGT TATCTTCCTA 
GGTCTTTGCC TTTTATTCTT TATCTGCATC AGTCTACTGT GCCGATATCC CCAGTGGAGG 
CCCAGGGTCT ACTCCATCAT TTGTAGGGAT TCAGCTCCTG TCAAAGAGGT GGAGGGTGAA 
GGAATTGTTA CTAAGCCCCT AACTCCAGCC TCTATCCCAG CCTTCAGCCC CAACCCCGGC 
TTCAACCCCA CTCTGGGCTT CAGCACCACC CCACGCTTCA GTCATCCTGT CTCCAGTACC 
CCCATCAGCC CCGTCTTCGG TCCTAGTAAC TGGCACAACT TCGTGCCACC TGTAAGAGAG 
GTGGTCCCAA CCCAGGGTGC TGACCCTCTC CTCTACGGAT CCCTCAACCC TGTGCCAATC 
CCCGCCCCTG TTCGGAAATG GGAAGACGTC GTCGCGGCCC AGCCACAACG GCTTGACACT 
GCAGACCCTG CGATGCTGTA TGCTGTGGTG GATGGCGTGC CTCCGACACG CTGGAAGGAG 
TTCATGCGGC TCCTGGGGCT GAGCGAGCAC GAGATCGAGC GGCTGGAGCT GCAGAACGGG 
CGTTGCCTCC GCGAGGCTCA TTACAGCATG CTGGAAGCCT GGCGGCGCCG CACACCGCGA 
CACGAGGCCA CGCTGGACGT AGTGGGCCGC GTGCTTTGCG ACATGAACCT GCGTGGCTGC 
CTGGAGAACA TCCGCGAGAC TCTAGAAAGC CCTGCCCACT CGTCCACGAC CCACCTCCCG 
CGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tnfrsf1a ( XM_006237334.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006237396.1 Rattus norvegicus TNF receptor superfamily member 1A (Tnfrsf1a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa27752
Clone ID Related Accession (Same CDS sequence)	XM_006237334.3
Accession Version	XM_006237334.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1548bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tumor necrosis factor receptor superfamily member 1A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237334.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTCTCC CCATCGTGCC TGGCCTGCTG CTGTCACTGG TGCTCCTGGC TCTGCTGATG 
GGGATACACC CGTCAGGGGT CACCGGACTG GTTCCTTCTC TTGGTGACCG GGAGAAGAGG 
GATAATTTGT GTCCCCAGGG AAAGTATGCC CATCCAAAGA ATAATTCCAT CTGCTGCACC 
AAGTGCCACA AAGGTAGGAG ACAATGGGGG CAGAGAGTCC TCGTGAGGTT CCTTTTGCTT 
GTTTCTGACG TTCCCAGACC TTGTCCATGG GAGTCCCCTT ACTTTGCTGT TTCCCCCGGA 
GTTGGGCTTT GCTCTTCAGC TCTCAACTAC AGACTAATCC TGACCCCATC CACAGGAACC 
TACTTGGTGA GTGACTGTCC AAGCCCAGGG CAGGAAACAG TCTGCGAGGT GTGTGATAAA 
GGCACCTTTA CAGCTTCGCA GAACCACGTC AGACAGTGTC TCAGTTGCAA GACATGTCGG 
AAAGAAATGT TCCAGGTGGA GATTTCTCCT TGCAAAGCTG ACATGGACAC CGTGTGTGGC 
TGCAAGAAGA ACCAATTCCA GCGCTACCTG AGTGAGACGC ATTTCCAGTG TGTGGACTGC 
AGCCCCTGCT TCAATGGCAC CGTGACAATC CCCTGTAAGG AGAAACAGAA CACCGTGTGT 
AACTGCCACG CAGGATTCTT TCTAAGCGGA AATGAGTGCA CCCCTTGCAG CCACTGCAAG 
AAAAATCAGG AATGTATGAA GCTGTGCCTA CCTCCAGTTG CAAATGTCAC AAACCCCCAG 
GACTCAGGTA CTGCCGTGCT GTTGCCTCTG GTTATCTTCC TAGGTCTTTG CCTTTTATTC 
TTTATCTGCA TCAGTCTACT GTGCCGATAT CCCCAGTGGA GGCCCAGGGT CTACTCCATC 
ATTTGTAGGG ATTCAGCTCC TGTCAAAGAG GTGGAGGGTG AAGGAATTGT TACTAAGCCC 
CTAACTCCAG CCTCTATCCC AGCCTTCAGC CCCAACCCCG GCTTCAACCC CACTCTGGGC 
TTCAGCACCA CCCCACGCTT CAGTCCTCCT GTCTCCAGTA CCCCCATCAG CCCCGTCTTC 
GGTCCTAGTA ACTGGCACAA CTTCGTGCCA CCTGTAAGAG AGGTGGTCCC AACCCAGGGT 
GCTGACCCTC TCCTCTACGG ATCCCTCAAC CCTGTGCCAA TCCCCGCCCC TGTTCGGAAA 
TGGGAAGACG TCGTCGCGGC CCAGCCACAA CGGCTTGACA CTGCAGACCC TGCGATGCTG 
TATGCTGTGG TGGATGGCGT GCCTCCGACA CGCTGGAAGG AGTTCATGCG GCTCCTGGGG 
CTGAGCGAGC ACGAGATCGA GCGGCTGGAG CTGCAGAACG GGCGTTGCCT CCGCGAGGCT 
CATTACAGCA TGCTGGAAGC CTGGCGGCGC CGCACACCGC GACACGAGGC CACGCTGGAC 
GTAGTGGGCC GCGTGCTTTG CGACATGAAC CTGCGTGGCT GCCTGGAGAA CATCCGCGAG 
ACTCTAGAAA GCCCTGCCCA CTCGTCCACG ACCCACCTCC CGCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006237396.1
CDS	322..1869
Translation	MGLPIVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDNLCPQGKYAHPKNNSICCTKCHKGRRQWGQRVLVRFLLLVSDVPRPCPWESPYFAVSPGVGLCSSALNYRLILTPSTGTYLVSDCPSPGQETVCEVCDKGTFTASQNHVRQCLSCKTCRKEMFQVEISPCKADMDTVCGCKKNQFQRYLSETHFQCVDCSPCFNGTVTIPCKEKQNTVCNCHAGFFLSGNECTPCSHCKKNQECMKLCLPPVANVTNPQDSGTAVLLPLVIFLGLCLLFFICISLLCRYPQWRPRVYSIICRDSAPVKEVEGEGIVTKPLTPASIPAFSPNPGFNPTLGFSTTPRFSPPVSSTPISPVFGPSNWHNFVPPVREVVPTQGADPLLYGSLNPVPIPAPVRKWEDVVAAQPQRLDTADPAMLYAVVDGVPPTRWKEFMRLLGLSEHEIERLELQNGRCLREAHYSMLEAWRRRTPRHEATLDVVGRVLCDMNLRGCLENIRETLESPAHSSTTHLPR

Target ORF information:

RefSeq Version	XM_006237334.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TNF receptor superfamily member 1A (Tnfrsf1a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237334.3

ORF Insert Sequence:

ATGGGTCTCC CCATCGTGCC TGGCCTGCTG CTGTCACTGG TGCTCCTGGC TCTGCTGATG 
GGGATACACC CGTCAGGGGT CACCGGACTG GTTCCTTCTC TTGGTGACCG GGAGAAGAGG 
GATAATTTGT GTCCCCAGGG AAAGTATGCC CATCCAAAGA ATAATTCCAT CTGCTGCACC 
AAGTGCCACA AAGGTAGGAG ACAATGGGGG CAGAGAGTCC TCGTGAGGTT CCTTTTGCTT 
GTTTCTGACG TTCCCAGACC TTGTCCATGG GAGTCCCCTT ACTTTGCTGT TTCCCCCGGA 
GTTGGGCTTT GCTCTTCAGC TCTCAACTAC AGACTAATCC TGACCCCATC CACAGGAACC 
TACTTGGTGA GTGACTGTCC AAGCCCAGGG CAGGAAACAG TCTGCGAGGT GTGTGATAAA 
GGCACCTTTA CAGCTTCGCA GAACCACGTC AGACAGTGTC TCAGTTGCAA GACATGTCGG 
AAAGAAATGT TCCAGGTGGA GATTTCTCCT TGCAAAGCTG ACATGGACAC CGTGTGTGGC 
TGCAAGAAGA ACCAATTCCA GCGCTACCTG AGTGAGACGC ATTTCCAGTG TGTGGACTGC 
AGCCCCTGCT TCAATGGCAC CGTGACAATC CCCTGTAAGG AGAAACAGAA CACCGTGTGT 
AACTGCCACG CAGGATTCTT TCTAAGCGGA AATGAGTGCA CCCCTTGCAG CCACTGCAAG 
AAAAATCAGG AATGTATGAA GCTGTGCCTA CCTCCAGTTG CAAATGTCAC AAACCCCCAG 
GACTCAGGTA CTGCCGTGCT GTTGCCTCTG GTTATCTTCC TAGGTCTTTG CCTTTTATTC 
TTTATCTGCA TCAGTCTACT GTGCCGATAT CCCCAGTGGA GGCCCAGGGT CTACTCCATC 
ATTTGTAGGG ATTCAGCTCC TGTCAAAGAG GTGGAGGGTG AAGGAATTGT TACTAAGCCC 
CTAACTCCAG CCTCTATCCC AGCCTTCAGC CCCAACCCCG GCTTCAACCC CACTCTGGGC 
TTCAGCACCA CCCCACGCTT CAGTCCTCCT GTCTCCAGTA CCCCCATCAG CCCCGTCTTC 
GGTCCTAGTA ACTGGCACAA CTTCGTGCCA CCTGTAAGAG AGGTGGTCCC AACCCAGGGT 
GCTGACCCTC TCCTCTACGG ATCCCTCAAC CCTGTGCCAA TCCCCGCCCC TGTTCGGAAA 
TGGGAAGACG TCGTCGCGGC CCAGCCACAA CGGCTTGACA CTGCAGACCC TGCGATGCTG 
TATGCTGTGG TGGATGGCGT GCCTCCGACA CGCTGGAAGG AGTTCATGCG GCTCCTGGGG 
CTGAGCGAGC ACGAGATCGA GCGGCTGGAG CTGCAGAACG GGCGTTGCCT CCGCGAGGCT 
CATTACAGCA TGCTGGAAGC CTGGCGGCGC CGCACACCGC GACACGAGGC CACGCTGGAC 
GTAGTGGGCC GCGTGCTTTG CGACATGAAC CTGCGTGGCT GCCTGGAGAA CATCCGCGAG 
ACTCTAGAAA GCCCTGCCCA CTCGTCCACG ACCCACCTCC CGCGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TNF-? receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats.
American journal of physiology. Heart and circulatory physiology313(4)H744-H756(2017 Oct)
Yu Y,Wei SG,Weiss RM,Felder RB

Notch-Tnf signalling is required for development and homeostasis of arterial valves.
European heart journal38(9)675-686(2017 Mar)
Wang Y,Wu B,Farrar E,Lui W,Lu P,Zhang D,Alfieri CM,Mao K,Chu M,Yang D,Xu D,Rauchman M,Taylor V,Conway SJ,Yutzey KE,Butcher JT,Zhou B

Regulation of myocardial stromal cell-derived factor 1?/CXCL12 by tumor necrosis factor signaling.
The Journal of surgical research207155-163(2017 Jan)
Wang M,Wang L,Huang C,Wang IW,Turrentine MW

miR-29a up-regulation in AR42J cells contributes to apoptosis via targeting TNFRSF1A gene.
World journal of gastroenterology22(20)4881-90(2016 May)
Fu Q,Qin T,Chen L,Liu CJ,Zhang X,Wang YZ,Hu MX,Chu HY,Zhang HW

Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats.
Mediators of inflammation2015124942(2015)
Leo M,Argalski S,Sch?fers M,Hagenacker T