Icam1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Icam1
Entrez Gene ID	25464
Full Name	intercellular adhesion molecule 1
Synonyms	CD54,ICAM
General protein information	Preferred Names intercellular adhesion molecule 1 Names intercellular adhesion molecule 1 ICAM-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q13
Summary	cell adhesion molecule; ligand for leukocyte adhesion molecule LFA-1 [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012967.1	NP_037099.1	intercellular adhesion molecule 1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ICAM1	NP_776773.1
Rattus norvegicus (Norway rat)	Icam1	NP_037099.1
Homo sapiens (human)	ICAM1	NP_000192.2
	ICAM1	NP_001040600.1
Canis lupus familiaris (dog)	ICAM1	NP_001003291.1
Pan troglodytes (chimpanzee)	ICAM1	NP_001009946.1
Mus musculus (house mouse)	Icam1	NP_034623.1

Gene Ontology
Bibliography

Related articles in PubMed

MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5.
Chen Q, Huang J, Gong W, Chen Z, Huang J, Liu P, Huang H
Molecular and cellular endocrinology460123-133(2018 Jan)

Essential role of ICAM-1 in aldosterone-induced atherosclerosis.
Marzolla V, Armani A, Mammi C, Moss ME, Pagliarini V, Pontecorvo L, Antelmi A, Fabbri A, Rosano G, Jaffe IZ, Caprio M
International journal of cardiology232233-242(2017 Apr)

Specific inhibition of ICAM-1 effectively reduces bladder inflammation in a rat model of severe non-bacterial cystitis.
Zhang X, He H, Lu G, Xu T, Qin L, Wang X, Jin X, Liu B, Zhao Z, Shen Z, Shao Y
Scientific reports635672(2016 Oct)

MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway.
Yin Y, Li F, Shi J, Li S, Cai J, Jiang Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(3-4)486-498(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pro-atherogenic effects of aldosterone are mediated by increased ICAM-1 expression, through transcriptional regulation by endothelial MR.
Title: Essential role of ICAM-1 in aldosterone-induced atherosclerosis.

Quercetin might protect against acute lung injury in rats with sepsis by suppressing ICAM-1 and MIP-2 expression.
Title: Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.

MiR-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 and affecting the IL-17/ICAM-1 pathway.
Title: MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway.

The combination of DC vaccination and antiangionesis inhibited the rats with malignant glioma by stimulating immune response, supressing the expression of angiogenesis-related proteins VEGF, VCAM, and ICAM-1
Title: Dendritic cell vaccination enhances antiangiogenesis induced by endostatin in rat glioma.

The results of this study showed that ICAM-1 up regulation in both sexs rats with aneurysmal subarachnoid hemorrhage.
Title: Sexual dimorphism in gene expression after aneurysmal subarachnoid hemorrhage.

The following Icam1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Icam1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13167	NM_012967.1 Latest version!	Rattus norvegicus intercellular adhesion molecule 1 (Icam1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Icam1 ( NM_012967.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037099.1 Rattus norvegicus intercellular adhesion molecule 1 (Icam1), mRNA.

Price & Availability↑

CloneID	ORa13167
Clone ID Related Accession (Same CDS sequence)	NM_012967.1
Accession Version	NM_012967.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	intercellular adhesion molecule 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D00913.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081837.1, FQ228241.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCAA CCCGTGCCAG GCCCATGCTG CCTCTGCTCC TGGTCCTGGT CGCCGTTGTG 
ATCCCCGGGC CTGTCGGTGC TCAGGTATCC ATCCATCCCA CAGAAGCCTT CCTGCCTCGG 
GGTGGATCCG TGCAGGTGAA CTGCTCTTCC TCTTGCGAAG ACGAGAACCT CGGCCTGGGG 
TTGGAGACTA ACTGGATGAA AGACGAACTA TCGAGTGGAC ACAACTGGAA GCTCTTCAAG 
CTGAGCGACA TTGGGGAAGA CAGCAGACCA CTGTGCTTTG AGAACTGTGG CACCACGCAG 
TCCTCGGCTT CTGCCACCAT CACTGTGTAT TCGTTCCCAG AGCGAGTGGA GCTGGATCCT 
CTGCCCGCCT GGCAGCAGGT GGGCAAGAAC CTCATCCTGC GCTGCCTGGT GGAAGGCGGA 
GCACCGCGGA CACAGCTCTC AGTAGTGCTG CTCCGTGGGA ATGAGACACT GAGCCGCCAG 
GCAGTGGATG GGGACCCCAA GGAGATCACA TTCACGGTGC TGGCCAGCAG AGGCGACCAC 
GGAGCCAATT TCTCATGCTT CACAGAACTG GACCTCAGGC CACAAGGGCT GTCACTGTTC 
AAGAATGTCT CCGAGGTCAG GCAGCTCCGG ACTTTCGATC TTCCGACTAG GGTCCTGAAG 
CTCGACACCC CTGACCTCCT GGAGGTGGGC ACCCAGCAGA AGTTCTTGTG TTCCCTGGAA 
GGCCTGTTTC CTGCCTCTGA AGCTCAGATA TACCTGGAGA TGGGAGGCCA GATGCTGACC 
CTGGAGAGCA CAAACAGCAG AGATTTTGTG TCAGCCACTG CCTCAGTGGA GGTGACTGAG 
AAGTTGGACA GAACCCTGCA GCTGCGCTGT GTTTTGGAGC TGGCGGACCA GACCCTGGAG 
ATGGAGAAGA CCTTGAGAAT CTACAACTTT TCAGCTCCCA TCCTGACCCT GAGCCAGCCG 
GAGGTCTCAG AAGGGGACCA AGTAACTGTG AAGTGTGAAG CCCACGGTGG GGCACAGGTG 
GTGCTTCTGA ACAGTACTTC CCCCAGGCCA CCCACCTCAC AGGGTACTTC CCCCAGGCCA 
CCCACCTCAC AGATCCAATT CACACTGAAT GCCAGCCCGG AGGATCACAA ACGACGCTTC 
TTTTGCTCTG CGGCCTTGGA GGTGGATGGG AAGTCCCTGT TTAAAAACCA GACCTTGGAA 
CTCCATGTGC TATATGGTCC TCACCTGGAC AAGAAGGACT GCTTGGGGAA CTGGACCTGG 
CAAGAGGGGT CTCAGCAGAC TCTTACATGC CAGCCCCAGG GGAATCCAGC CCCTAATCTG 
ACCTGCAGCC GGAAAGCAGA TGGTGTCCCG CTGCCTATCG GGATGGTGAA GTCTGTCAAA 
CGGGAGATGA ATGGTACCTA CAAGTGCCGT GCCTTTAGCT CCCGTGGGAG TATCACCAGG 
GACGTGCACC TGACAGTGCT GTACCATGAT CAGAATACCT GGGTCATAAT TGTTGGTGTG 
TTGGTACTGA TCATTGCGGG CTTCGTGATC GTGGCGTCCA TTTACACCTA TTACCGCCAG 
AGGAAGATCA GGATATACAA GTTACAGAAG GCTCAGGAGG AGGCCCTAAA ACTCAAGGTA 
CAAGCCCCGC CTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037099.1
CDS	31..1668
Translation	MASTRARPMLPLLLVLVAVVIPGPVGAQVSIHPTEAFLPRGGSVQVNCSSSCEDENLGLGLETNWMKDELSSGHNWKLFKLSDIGEDSRPLCFENCGTTQSSASATITVYSFPERVELDPLPAWQQVGKNLILRCLVEGGAPRTQLSVVLLRGNETLSRQAVDGDPKEITFTVLASRGDHGANFSCFTELDLRPQGLSLFKNVSEVRQLRTFDLPTRVLKLDTPDLLEVGTQQKFLCSLEGLFPASEAQIYLEMGGQMLTLESTNSRDFVSATASVEVTEKLDRTLQLRCVLELADQTLEMEKTLRIYNFSAPILTLSQPEVSEGDQVTVKCEAHGGAQVVLLNSTSPRPPTSQGTSPRPPTSQIQFTLNASPEDHKRRFFCSAALEVDGKSLFKNQTLELHVLYGPHLDKKDCLGNWTWQEGSQQTLTCQPQGNPAPNLTCSRKADGVPLPIGMVKSVKREMNGTYKCRAFSSRGSITRDVHLTVLYHDQNTWVIIVGVLVLIIAGFVIVASIYTYYRQRKIRIYKLQKAQEEALKLKVQAPPP

Target ORF information:

RefSeq Version	NM_012967.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus intercellular adhesion molecule 1 (Icam1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012967.1

ORF Insert Sequence:

ATGGCTTCAA CCCGTGCCAG GCCCATGCTG CCTCTGCTCC TGGTCCTGGT CGCCGTTGTG 
ATCCCCGGGC CTGTCGGTGC TCAGGTATCC ATCCATCCCA CAGAAGCCTT CCTGCCTCGG 
GGTGGATCCG TGCAGGTGAA CTGCTCTTCC TCTTGCGAAG ACGAGAACCT CGGCCTGGGG 
TTGGAGACTA ACTGGATGAA AGACGAACTA TCGAGTGGAC ACAACTGGAA GCTCTTCAAG 
CTGAGCGACA TTGGGGAAGA CAGCAGACCA CTGTGCTTTG AGAACTGTGG CACCACGCAG 
TCCTCGGCTT CTGCCACCAT CACTGTGTAT TCGTTCCCAG AGCGAGTGGA GCTGGATCCT 
CTGCCCGCCT GGCAGCAGGT GGGCAAGAAC CTCATCCTGC GCTGCCTGGT GGAAGGCGGA 
GCACCGCGGA CACAGCTCTC AGTAGTGCTG CTCCGTGGGA ATGAGACACT GAGCCGCCAG 
GCAGTGGATG GGGACCCCAA GGAGATCACA TTCACGGTGC TGGCCAGCAG AGGCGACCAC 
GGAGCCAATT TCTCATGCTT CACAGAACTG GACCTCAGGC CACAAGGGCT GTCACTGTTC 
AAGAATGTCT CCGAGGTCAG GCAGCTCCGG ACTTTCGATC TTCCGACTAG GGTCCTGAAG 
CTCGACACCC CTGACCTCCT GGAGGTGGGC ACCCAGCAGA AGTTCTTGTG TTCCCTGGAA 
GGCCTGTTTC CTGCCTCTGA AGCTCAGATA TACCTGGAGA TGGGAGGCCA GATGCTGACC 
CTGGAGAGCA CAAACAGCAG AGATTTTGTG TCAGCCACTG CCTCAGTGGA GGTGACTGAG 
AAGTTGGACA GAACCCTGCA GCTGCGCTGT GTTTTGGAGC TGGCGGACCA GACCCTGGAG 
ATGGAGAAGA CCTTGAGAAT CTACAACTTT TCAGCTCCCA TCCTGACCCT GAGCCAGCCG 
GAGGTCTCAG AAGGGGACCA AGTAACTGTG AAGTGTGAAG CCCACGGTGG GGCACAGGTG 
GTGCTTCTGA ACAGTACTTC CCCCAGGCCA CCCACCTCAC AGGGTACTTC CCCCAGGCCA 
CCCACCTCAC AGATCCAATT CACACTGAAT GCCAGCCCGG AGGATCACAA ACGACGCTTC 
TTTTGCTCTG CGGCCTTGGA GGTGGATGGG AAGTCCCTGT TTAAAAACCA GACCTTGGAA 
CTCCATGTGC TATATGGTCC TCACCTGGAC AAGAAGGACT GCTTGGGGAA CTGGACCTGG 
CAAGAGGGGT CTCAGCAGAC TCTTACATGC CAGCCCCAGG GGAATCCAGC CCCTAATCTG 
ACCTGCAGCC GGAAAGCAGA TGGTGTCCCG CTGCCTATCG GGATGGTGAA GTCTGTCAAA 
CGGGAGATGA ATGGTACCTA CAAGTGCCGT GCCTTTAGCT CCCGTGGGAG TATCACCAGG 
GACGTGCACC TGACAGTGCT GTACCATGAT CAGAATACCT GGGTCATAAT TGTTGGTGTG 
TTGGTACTGA TCATTGCGGG CTTCGTGATC GTGGCGTCCA TTTACACCTA TTACCGCCAG 
AGGAAGATCA GGATATACAA GTTACAGAAG GCTCAGGAGG AGGCCCTAAA ACTCAAGGTA 
CAAGCCCCGC CTCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5.
Molecular and cellular endocrinology460123-133(2018 Jan)
Chen Q,Huang J,Gong W,Chen Z,Huang J,Liu P,Huang H

Essential role of ICAM-1 in aldosterone-induced atherosclerosis.
International journal of cardiology232233-242(2017 Apr)
Marzolla V,Armani A,Mammi C,Moss ME,Pagliarini V,Pontecorvo L,Antelmi A,Fabbri A,Rosano G,Jaffe IZ,Caprio M

Specific inhibition of ICAM-1 effectively reduces bladder inflammation in a rat model of severe non-bacterial cystitis.
Scientific reports635672(2016 Oct)
Zhang X,He H,Lu G,Xu T,Qin L,Wang X,Jin X,Liu B,Zhao Z,Shen Z,Shao Y

MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(3-4)486-498(2016)
Yin Y,Li F,Shi J,Li S,Cai J,Jiang Y