Ahsg cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ahsg
Entrez Gene ID	25373
Full Name	alpha-2-HS-glycoprotein
Synonyms	Aa2-066,pp63
General protein information	Preferred Names alpha-2-HS-glycoprotein Names alpha-2-HS-glycoprotein 59 kDa bone sialic acid-containing protein BSP alpha 2 HS-glycoprotein alpha 2 (fetuin) fetuin-A glycoprotein PP63 phosphorylated N-glycoprotein pp63
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q23
Summary	inhibits insulin receptor tyrosine kinase activity; may be involved in bone mineralization and immune response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012898.4	NP_037030.1	alpha-2-HS-glycoprotein precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ahsg	NP_038493.1
Gallus gallus (chicken)	AHSG	XP_422764.1
Danio rerio (zebrafish)	ahsg	NP_997787.1
Homo sapiens (human)	AHSG	NP_001613.2
Pan troglodytes (chimpanzee)	AHSG	NP_001009098.1
Rattus norvegicus (Norway rat)	Ahsg	NP_037030.1
Xenopus tropicalis (tropical clawed frog)	ahsg	NP_001011278.1
	AHSG	XP_001091623.1
Canis lupus familiaris (dog)	AHSG	XP_005639865.1
Bos taurus (cattle)	AHSG	NP_776409.1

Gene Ontology
Bibliography

Related articles in PubMed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

Facilitatory effects of fetuin-A on atherosclerosis.
Naito C, Hashimoto M, Watanabe K, Shirai R, Takahashi Y, Kojima M, Watanabe R, Sato K, Iso Y, Matsuyama TA, Suzuki H, Ishibashi-Ueda H, Watanabe T
Atherosclerosis246344-51(2016 Mar)

Fetuin A promotes lipotoxicity in ? cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity.
Shen X, Yang L, Yan S, Zheng H, Liang L, Cai X, Liao M
Molecular and cellular endocrinology4121-11(2015 Sep)

Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification.
Lau WL, Liu S, Vaziri ND
American journal of nephrology40(1)51-5(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fetuin-A exerts the stimulatory effects on inflammatory responses in HUVECs, macrophage foam cell formation, and proliferation and collagen production in HASMCs, leading to the development of atherosclerosis.
Title: Facilitatory effects of fetuin-A on atherosclerosis.

The protective effects of pioglitazone on lipotoxicity in beta cells may involve the inhibition of the activation of the Fetuin A and TLR4 signaling pathway.
Title: Fetuin A promotes lipotoxicity in ? cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity.

Plasma levels of the calcification inhibitor fetuin-A were significantly decreased in CKD animals compared to controls.
Title: Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification.

Tubular luminal fetuin-A works as a natural inhibitor against calcification in the proximal tubules under parathyroid hormone-loaded condition.
Title: Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats.

We conclude that elevated fetuin-A levels are associated with microalbuminuria in obese rats, and abnormal albuminuria is reversible by improving hepatic steatosis.
Title: Serum fetuin-A levels related with microalbuminuria in diet-induced obese rats.

The following Ahsg gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ahsg cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01245	NM_012898.4 Latest version!	Rattus norvegicus alpha-2-HS-glycoprotein (Ahsg), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ahsg ( NM_012898.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037030.1 Rattus norvegicus alpha-2-HS-glycoprotein (Ahsg), mRNA.

Price & Availability↑

CloneID	ORa01245
Clone ID Related Accession (Same CDS sequence)	NM_012898.4
Accession Version	NM_012898.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	alpha-2-HS-glycoprotein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M29758.1. On Oct 11, 2005 this sequence version replaced NM_012898.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29758.1, FQ210957.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906347, SAMN01906348 [ECO:0000350] ##Evidence-Data-END##

ATGAAGTCCC TGGTCCTGCT CCTTTGTTTT GCTCAGCTCT GGAGCTGCCA ATCAGCTCCA 
CAAGGTGCAG GGCTGGGTTT TCGAGAATTG GCTTGTGATG ACCCGGAAAC AGAGCATGTA 
GCTTTGATAG CCGTGCACTA CCTCAATAAA CATCTTCTTC AGGGATTCAG GCAGATCTTG 
AATCAGATTG ACAAAGTCAA GGTGTGGTCT CGGCGGCCCT TCGGACAGGT GTATGAGTTG 
GAAATTGACA CGCTGGAGAC AACCTGCCAC GCTCTGGACC CAACCCCCTT AGCAAATTGT 
TCTGTGAGGC AACAGGCCGA GCATGCGGTG GAGGGAGACT GTGACTTCCA CATCCTGAAA 
CAAGATGGCC AGTTCAGGGT GCTACACGCC CAGTGTCATT CCACACCAGA CTCTGCAGAG 
GACGTTCGGA AGTTTTGCCC ACGATGCCCA ATCCTGATCC GGTTCAATGA CACCAACGTG 
GTCCACACTG TCAAAACTGC CCTGGCTGCC TTCAATGCAC AGAATAATGG AACCTATTTT 
AAACTGGTGG AGATTTCCCG AGCTCAAAAT GTGCCTTTCC CGGTGTCTAC TCTCGTGGAG 
TTTGTGATAG CTGCGACTGA CTGTACTGGT CAGGAGGTCA CAGATCCAGC CAAATGCAAC 
CTGCTGGCAG AAAAGCAATA TGGCTTCTGC AAGGCGACTC TCATCCACAG ACTTGGTGGG 
GAAGAGGTTT CAGTGGCCTG CAAGTTATTC CAGACACAGC CCCAGCCAGC CAATGCCAAC 
CCTGCAGGTC CTGCACCCAC AGTGGGCCAA GCTGCGCCTG TAGCCCCACC AGCTGGCCCA 
CCTGAATCCG TGGTGGTAGG ACCCGTGGCA GTTCCTCTAG GACTTCCAGA CCACCGAACC 
CACCATGACC TACGGCATGC CTTCTCTCCT GTGGCTTCTG TGGAGTCGGC CTCAGGAGAA 
GTTCTTCACT CACCTAAGGT GGGCCAGCCT GGTGACGCTG GTGCTGCTGG CCCAGTGGCC 
CCCCTGTGCC CAGGGAGAGT CAGATACTTC AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037030.1
CDS	74..1132
Translation	MKSLVLLLCFAQLWSCQSAPQGAGLGFRELACDDPETEHVALIAVHYLNKHLLQGFRQILNQIDKVKVWSRRPFGQVYELEIDTLETTCHALDPTPLANCSVRQQAEHAVEGDCDFHILKQDGQFRVLHAQCHSTPDSAEDVRKFCPRCPILIRFNDTNVVHTVKTALAAFNAQNNGTYFKLVEISRAQNVPFPVSTLVEFVIAATDCTGQEVTDPAKCNLLAEKQYGFCKATLIHRLGGEEVSVACKLFQTQPQPANANPAGPAPTVGQAAPVAPPAGPPESVVVGPVAVPLGLPDHRTHHDLRHAFSPVASVESASGEVLHSPKVGQPGDAGAAGPVAPLCPGRVRYFKI

Target ORF information:

RefSeq Version	NM_012898.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus alpha-2-HS-glycoprotein (Ahsg), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012898.4

ORF Insert Sequence:

ATGAAGTCCC TGGTCCTGCT CCTTTGTTTT GCTCAGCTCT GGAGCTGCCA ATCAGCTCCA 
CAAGGTGCAG GGCTGGGTTT TCGAGAATTG GCTTGTGATG ACCCGGAAAC AGAGCATGTA 
GCTTTGATAG CCGTGCACTA CCTCAATAAA CATCTTCTTC AGGGATTCAG GCAGATCTTG 
AATCAGATTG ACAAAGTCAA GGTGTGGTCT CGGCGGCCCT TCGGACAGGT GTATGAGTTG 
GAAATTGACA CGCTGGAGAC AACCTGCCAC GCTCTGGACC CAACCCCCTT AGCAAATTGT 
TCTGTGAGGC AACAGGCCGA GCATGCGGTG GAGGGAGACT GTGACTTCCA CATCCTGAAA 
CAAGATGGCC AGTTCAGGGT GCTACACGCC CAGTGTCATT CCACACCAGA CTCTGCAGAG 
GACGTTCGGA AGTTTTGCCC ACGATGCCCA ATCCTGATCC GGTTCAATGA CACCAACGTG 
GTCCACACTG TCAAAACTGC CCTGGCTGCC TTCAATGCAC AGAATAATGG AACCTATTTT 
AAACTGGTGG AGATTTCCCG AGCTCAAAAT GTGCCTTTCC CGGTGTCTAC TCTCGTGGAG 
TTTGTGATAG CTGCGACTGA CTGTACTGGT CAGGAGGTCA CAGATCCAGC CAAATGCAAC 
CTGCTGGCAG AAAAGCAATA TGGCTTCTGC AAGGCGACTC TCATCCACAG ACTTGGTGGG 
GAAGAGGTTT CAGTGGCCTG CAAGTTATTC CAGACACAGC CCCAGCCAGC CAATGCCAAC 
CCTGCAGGTC CTGCACCCAC AGTGGGCCAA GCTGCGCCTG TAGCCCCACC AGCTGGCCCA 
CCTGAATCCG TGGTGGTAGG ACCCGTGGCA GTTCCTCTAG GACTTCCAGA CCACCGAACC 
CACCATGACC TACGGCATGC CTTCTCTCCT GTGGCTTCTG TGGAGTCGGC CTCAGGAGAA 
GTTCTTCACT CACCTAAGGT GGGCCAGCCT GGTGACGCTG GTGCTGCTGG CCCAGTGGCC 
CCCCTGTGCC CAGGGAGAGT CAGATACTTC AAGATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

Facilitatory effects of fetuin-A on atherosclerosis.
Atherosclerosis246344-51(2016 Mar)
Naito C,Hashimoto M,Watanabe K,Shirai R,Takahashi Y,Kojima M,Watanabe R,Sato K,Iso Y,Matsuyama TA,Suzuki H,Ishibashi-Ueda H,Watanabe T

Fetuin A promotes lipotoxicity in ? cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity.
Molecular and cellular endocrinology4121-11(2015 Sep)
Shen X,Yang L,Yan S,Zheng H,Liang L,Cai X,Liao M

Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification.
American journal of nephrology40(1)51-5(2014)
Lau WL,Liu S,Vaziri ND