Sra1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sra1
Entrez Gene ID	252891
Full Name	steroid receptor RNA activator 1
General protein information	Preferred Names steroid receptor RNA activator 1 Names steroid receptor RNA activator 1 SRAP steroid receptor RNA activator protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p11
Summary	binds androgen receptor; increases transactivation activity of the androgen receptor, glucocorticoid receptor, and the peroxisome proliferator-activated receptor gamma; may play a role in prostate cancer [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_183329.3	NP_899158.3	steroid receptor RNA activator 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SRA1	XP_001137717.2
	SRA1	XP_001086694.2
Homo sapiens (human)	SRA1	NP_001030312.2
Danio rerio (zebrafish)	sra1	NP_001002047.1
Mus musculus (house mouse)	Sra1	NP_079567.2
Canis lupus familiaris (dog)	SRA1	XP_005617340.1
Rattus norvegicus (Norway rat)	Sra1	NP_899158.3
Xenopus tropicalis (tropical clawed frog)	sra1	NP_001107371.1
Bos taurus (cattle)	SRA1	NP_001073110.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA.
McKay DB, Xi L, Barthel KKB, Cech TR
Journal of molecular biology426(8)1766-1785(2014 Apr)

The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region.
Bilinovich SM, Davis CM, Morris DL, Ray LA, Prokop JW, Buchan GJ, Leeper TC
Journal of molecular biology426(8)1753-65(2014 Apr)

Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation.
Hub? F, Velasco G, Rollin J, Furling D, Francastel C
Nucleic acids research39(2)513-25(2011 Jan)

Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching.
Rakeman AS, Anderson KV
Development (Cambridge, England)133(16)3075-83(2006 Aug)

Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.
Hall JM, McDonnell DP
Molecular interventions5(6)343-57(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation
Title: CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation.

The following Sra1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sra1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04664	NM_183329.3 Latest version!	Rattus norvegicus steroid receptor RNA activator 1 (Sra1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sra1 ( NM_183329.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_899158.3 Rattus norvegicus steroid receptor RNA activator 1 (Sra1), mRNA.

Price & Availability↑

CloneID	ORa04664
Clone ID Related Accession (Same CDS sequence)	NM_183329.3
Accession Version	NM_183329.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	steroid receptor RNA activator 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY542868.1 and CB322787.1. On Oct 28, 2005 this sequence version replaced NM_183329.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF110391.1, CB567439.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGTGCT GCCCTGCTGG CGGTGCGGAA GTGGAGATGG CGGAGCTGTA CGTGAAGCCC 
GGCAACAAGG AACGCGGCTG GAACGACCCG CCACAATTCT CCTACGGGCT GCAGACTCAG 
ACTGGTGGAA CCAAACGCAC TCCCCTTACT AAGAGGGTTG CGGCCCCACA GGATGGATCC 
CCTAGAGCCC CAGAAACTTC TGGACCACCT CCAGTGGATC ATCCACCTCC TTCAAGTAAG 
GCTTCCAGGC CTCCACCCAT GGGGAGCTGT CCTGCTTCTG GTGTGGACCC CCCAAGTTCT 
CCAGTCATTG AGTCTGAGAC TCTAATAGAA GACGTGCTAA GACCTCTGGA ACAGGCATTG 
GAGGATTGCC GTGGTCACAC GAAGAAGCAG GTATGTGATG ATATCAGCCG ACGCTTGGCA 
CTGCTTCACG AACAGTGGGA TGGAGGGAAG TTGTCAGTAC CTGTAAAGAA GAGGATGGCA 
CTGCTGGTAC AAGAACTTTT ACACCACCAG TGGGATACAG CAGATGACAT TCATCGATCA 
CTCATGGTTG ACCATGTGAC TGAGGTCAGT CAGTGGATGG TGGGAGTTAA AAGATTAATT 
GCAGAAAAGA GGAGTCTATC TTCAGAGGAG AACAAAGAAG AGACATCTAC AGTGGCACCT 
GAGAACCAGA CAATACCAGG CTTCCAACCA TCTTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_899158.3
CDS	21..719
Translation	MTCCPAGGAEVEMAELYVKPGNKERGWNDPPQFSYGLQTQTGGTKRTPLTKRVAAPQDGSPRAPETSGPPPVDHPPPSSKASRPPPMGSCPASGVDPPSSPVIESETLIEDVLRPLEQALEDCRGHTKKQVCDDISRRLALLHEQWDGGKLSVPVKKRMALLVQELLHHQWDTADDIHRSLMVDHVTEVSQWMVGVKRLIAEKRSLSSEENKEETSTVAPENQTIPGFQPSS

Target ORF information:

RefSeq Version	NM_183329.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus steroid receptor RNA activator 1 (Sra1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_183329.3

ORF Insert Sequence:

ATGACGTGCT GCCCTGCTGG CGGTGCGGAA GTGGAGATGG CGGAGCTGTA CGTGAAGCCC 
GGCAACAAGG AACGCGGCTG GAACGACCCG CCACAATTCT CCTACGGGCT GCAGACTCAG 
ACTGGTGGAA CCAAACGCAC TCCCCTTACT AAGAGGGTTG CGGCCCCACA GGATGGATCC 
CCTAGAGCCC CAGAAACTTC TGGACCACCT CCAGTGGATC ATCCACCTCC TTCAAGTAAG 
GCTTCCAGGC CTCCACCCAT GGGGAGCTGT CCTGCTTCTG GTGTGGACCC CCCAAGTTCT 
CCAGTCATTG AGTCTGAGAC TCTAATAGAA GACGTGCTAA GACCTCTGGA ACAGGCATTG 
GAGGATTGCC GTGGTCACAC GAAGAAGCAG GTATGTGATG ATATCAGCCG ACGCTTGGCA 
CTGCTTCACG AACAGTGGGA TGGAGGGAAG TTGTCAGTAC CTGTAAAGAA GAGGATGGCA 
CTGCTGGTAC AAGAACTTTT ACACCACCAG TGGGATACAG CAGATGACAT TCATCGATCA 
CTCATGGTTG ACCATGTGAC TGAGGTCAGT CAGTGGATGG TGGGAGTTAA AAGATTAATT 
GCAGAAAAGA GGAGTCTATC TTCAGAGGAG AACAAAGAAG AGACATCTAC AGTGGCACCT 
GAGAACCAGA CAATACCAGG CTTCCAACCA TCTTCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure and function of steroid receptor RNA activator protein, the proposed partner of SRA noncoding RNA.
Journal of molecular biology426(8)1766-1785(2014 Apr)
McKay DB,Xi L,Barthel KKB,Cech TR

The C-terminal domain of SRA1p has a fold more similar to PRP18 than to an RRM and does not directly bind to the SRA1 RNA STR7 region.
Journal of molecular biology426(8)1753-65(2014 Apr)
Bilinovich SM,Davis CM,Morris DL,Ray LA,Prokop JW,Buchan GJ,Leeper TC

Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation.
Nucleic acids research39(2)513-25(2011 Jan)
Hub? F,Velasco G,Rollin J,Furling D,Francastel C

Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching.
Development (Cambridge, England)133(16)3075-83(2006 Aug)
Rakeman AS,Anderson KV

Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.
Molecular interventions5(6)343-57(2005 Dec)
Hall JM,McDonnell DP