Umod cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Umod
Entrez Gene ID	25128
Full Name	uromodulin
Synonyms	THP
General protein information	Preferred Names uromodulin Names uromodulin Urmodulin (Tamm-Horsfall protein) tamm-Horsfall urinary glycoprotein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q35
Summary	mutation of the human homolog is associated with medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006230107.2	XP_006230169.1	uromodulin isoform X1
NM_017082.1	NP_058778.1	uromodulin precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	UMOD	NP_001003003.1
Xenopus tropicalis (tropical clawed frog)	LOC100491925	XP_002932034.2
Xenopus tropicalis (tropical clawed frog)	LOC101731733	XP_004918346.1
Xenopus tropicalis (tropical clawed frog)	LOC101732035	XP_004918350.1
Homo sapiens (human)	UMOD	NP_001265543.1
Pan troglodytes (chimpanzee)	UMOD	XP_003954410.1
	UMOD	XP_001086040.2
Xenopus tropicalis (tropical clawed frog)	LOC101731793	XP_004918347.1
Bos taurus (cattle)	UMOD	NP_776638.1
Mus musculus (house mouse)	Umod	NP_001265534.1
Rattus norvegicus (Norway rat)	Umod	NP_058778.1
Xenopus tropicalis (tropical clawed frog)	LOC100491428	XP_002932031.1
Xenopus tropicalis (tropical clawed frog)	LOC100492097	XP_004918349.1

Gene Ontology
Bibliography

Related articles in PubMed

Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.
Mary S, Small HY, Siwy J, Mullen W, Giri A, Delles C
Hypertension (Dallas, Tex. : 1979)69(5)910-918(2017 05)

CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia.
Stuiver M, Lainez S, Will C, Terryn S, G?nzel D, Debaix H, Sommer K, Kopplin K, Thumfart J, Kampik NB, Querfeld U, Willnow TE, N?mec V, Wagner CA, Hoenderop JG, Devuyst O, Knoers NV, Bindels RJ, Meij IC, M?ller D
American journal of human genetics88(3)333-43(2011 Mar)

Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression.
Zaucke F, Boehnlein JM, Steffens S, Polishchuk RS, Rampoldi L, Fischer A, Pasch A, Boehm CW, Baasner A, Attanasio M, Hoppe B, Hopfer H, Beck BB, Sayer JA, Hildebrandt F, Wolf MT
Human molecular genetics19(10)1985-97(2010 May)

Uromodulin facilitates neutrophil migration across renal epithelial monolayers.
Schmid M, Prajczer S, Gruber LN, Bertocchi C, Gandini R, Pfaller W, Jennings P, Joannidis M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology26(3)311-8(2010)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two forms of uromodulin (polymerization competent and polymerization incompetent) were found in urine from both Wistar-Kyoto and SHRSP, where the polymerization-incompetent form was increased in a pregnancy-specific manner in stroke-prone spontaneously hypertensive rats.
Title: Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.

The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens.
Title: Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules.

Sepsis-induced renal Cox-2 expression on TLR4 is tubule specific. The TLR4-dependent Cox-2 expression is mostly restricted to cortical and medullary thick ascending loops of Henle that characteristically express and secrete Tamm-Horsfall protein.
Title: Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent.

Tamm-Horsfall protein derived from hyperoxaluric rats exhibited 2-fold increase in the Ca*Ox binding when compared to controls
Title: Oral L-arginine supplementation ameliorates urinary risk factors and kinetic modulation of Tamm-Horsfall glycoprotein in experimental hyperoxaluric rats.

results demonstrate a selective decrease in medullary THP synthesis, suggesting a potential involvement of THP in the renal functional changes associated with hypothyroidism
Title: Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys.

The following Umod gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Umod cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa23342	XM_006230107.2 Latest version!	Rattus norvegicus uromodulin (Umod), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
ORa02761	NM_017082.1 Latest version!	Rattus norvegicus uromodulin (Umod), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$377.30 $539.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Umod ( XM_006230107.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230169.1 Rattus norvegicus uromodulin (Umod), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23342
Clone ID Related Accession (Same CDS sequence)	XM_006230107.2
Accession Version	XM_006230107.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1935bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	uromodulin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006230107.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCAGC TGCTCTCTTT GACCTGGCTG CTGCTGGTTA TGGTGGTAAC TCCCTGGTTC 
ACTGTAGCTG GAGCCAATGA CTCACCAGAA GCAAGAAGGT GTTCTGAATG CCACGACAAT 
GCCACCTGTG TGTTGGATGG GGTGGTCACC ACATGCTCCT GCCAGGCAGG CTTCACTGGA 
GATGGGCTGG TGTGTGAGGA CATAGATGAG TGTGCCACCC CGTGGACTCA CAACTGCTCC 
AACAGCATCT GCATGAACAC ACTGGGCTCC TACGAGTGCT CCTGTCAGGA TGGCTTTCGT 
CTGACGCCTG GGCTGGGCTG CATTGATGTG AATGAGTGCA CAGAGCAGGG GCTCAGTAAC 
TGTCATTCCC TGGCTACCTG TGTCAACACG GAAGGCAGCT ACTCATGCGT GTGTCCCAAG 
GGCTATAGAG GGGATGGTTG GTACTGTGAG TGCTCCCCTG GCTCCTGTGA GCCAGGGCTG 
GACTGCTTGC CTCAGGGTCC CAGTGGAAAG CTGGTGTGCC AAGACCCCTG CAATGTCTAT 
GAAACCCTGA CTGAGTACTG GCGCAGCACA GACTATGGTG CCGGCTACTC CTGTGACTCA 
GATATGCACG GCTGGTACCG GTTCACAGGC CAGGGTGGCG TTCGCATGGC TGAGACCTGT 
GTGCCCGTAC TGAGGTGCAA CACGGCTGCA CCCATGTGGC TCAATGGCTC GCATCCTTCG 
AGCAGAGAGG GCATTGTGAG CCGCACAGCC TGCGCACACT GGAGCGACCA CTGCTGCCTG 
TGGTCCACAG AGATCCAGGT GAAGGCCTGC CCTGGTGGCT TCTATGTTTA CAACTTGACA 
GAGCCCCCTG AGTGCAATCT GGCTTACTGC ACCGATCCTA GCTCCGTGGA GGGGACTTGC 
GAAGAATGCG GGGTAGATGA AGACTGCGTA TCTGATAACG GCAGATGGCG CTGCCAGTGT 
AAACAGGACT TCAACATTAC AGATGTCTCC CTCCTGGAGC ACAGGCTGGA GTGTGAGGCC 
AATGAAATCA AGATATCCCT CAGCAAGTGC CAGCTACAGA GTTTGGGCTT TATGAAGGTC 
TTCATGTACC TGAATGACAG ACAGTGCTCA GGCTTCAGTG AGAGGGGTGA ACGAGACTGG 
ATGTCCATAG TGACTCCTGC CAGGGATGGT CCCTGTGGGA CAGTATTGAG GAGAAATGAA 
ACCCACGCCA CCTACAGCAA CACCCTCTAC CTGGCAAGTG AGATCATCAT CAGGGATATC 
AACATCAGAA TCAACTTTGA ATGCTCTTAC CCTCTGGACA TGAAAGTCAG TCTGAAGACC 
TCCCTACAGC CTATGGTTAG TGCCTTGAAC ATCAGCTTGG GTGGGACAGG CAAGTTCACT 
GTGCAGATGG CACTGTTCCA GAACCCTACC TACACACAGC CCTACCAAGG TCCTTCTGTG 
ATGCTCTCCA CTGAGGCTTT TCTGTATGTG GGCACCATGC TGGATGGGGG TGACTTGTCC 
CGGTTTGTAC TGCTAATGAC CAACTGCTAT GCCACACCCA GTAGCAACTC CACGGACCCT 
GTAAAATACT TCATTATCCA GGACAGATGT CCACATACAG AAGATACAAC CATTCAGGTG 
ACAGAGAATG GCGAGTCCTC TCAGGCCCGG TTCTCTATTC AGATGTTCCG GTTTGCAGGA 
AACTCCGACC TTGTCTACCT TCACTGCGAG GTGTACCTGT GTGACACTAT GAGTGAGCAG 
TGTAAACCTA CCTGTTCTGG TACTAGATAT CGAAGTGGGA ACTTCATAGA TCAGACCCGT 
GTCCTGAACT TGGGTCCCAT CACACGACAA GGTGTCCAGG CCTCAGTGTC CAAGGCTGCT 
TCCAGCAACT TGGGGTTCCT GAGCATCTGG CTGCTGCTGT TTCTCTCAGC TACTTTGACC 
CTGATGGTTC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230169.1
CDS	147..2081
Translation	MGQLLSLTWLLLVMVVTPWFTVAGANDSPEARRCSECHDNATCVLDGVVTTCSCQAGFTGDGLVCEDIDECATPWTHNCSNSICMNTLGSYECSCQDGFRLTPGLGCIDVNECTEQGLSNCHSLATCVNTEGSYSCVCPKGYRGDGWYCECSPGSCEPGLDCLPQGPSGKLVCQDPCNVYETLTEYWRSTDYGAGYSCDSDMHGWYRFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSREGIVSRTACAHWSDHCCLWSTEIQVKACPGGFYVYNLTEPPECNLAYCTDPSSVEGTCEECGVDEDCVSDNGRWRCQCKQDFNITDVSLLEHRLECEANEIKISLSKCQLQSLGFMKVFMYLNDRQCSGFSERGERDWMSIVTPARDGPCGTVLRRNETHATYSNTLYLASEIIIRDINIRINFECSYPLDMKVSLKTSLQPMVSALNISLGGTGKFTVQMALFQNPTYTQPYQGPSVMLSTEAFLYVGTMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDRCPHTEDTTIQVTENGESSQARFSIQMFRFAGNSDLVYLHCEVYLCDTMSEQCKPTCSGTRYRSGNFIDQTRVLNLGPITRQGVQASVSKAASSNLGFLSIWLLLFLSATLTLMVH

Target ORF information:

RefSeq Version	XM_006230107.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus uromodulin (Umod), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230107.2

ORF Insert Sequence:

ATGGGGCAGC TGCTCTCTTT GACCTGGCTG CTGCTGGTTA TGGTGGTAAC TCCCTGGTTC 
ACTGTAGCTG GAGCCAATGA CTCACCAGAA GCAAGAAGGT GTTCTGAATG CCACGACAAT 
GCCACCTGTG TGTTGGATGG GGTGGTCACC ACATGCTCCT GCCAGGCAGG CTTCACTGGA 
GATGGGCTGG TGTGTGAGGA CATAGATGAG TGTGCCACCC CGTGGACTCA CAACTGCTCC 
AACAGCATCT GCATGAACAC ACTGGGCTCC TACGAGTGCT CCTGTCAGGA TGGCTTTCGT 
CTGACGCCTG GGCTGGGCTG CATTGATGTG AATGAGTGCA CAGAGCAGGG GCTCAGTAAC 
TGTCATTCCC TGGCTACCTG TGTCAACACG GAAGGCAGCT ACTCATGCGT GTGTCCCAAG 
GGCTATAGAG GGGATGGTTG GTACTGTGAG TGCTCCCCTG GCTCCTGTGA GCCAGGGCTG 
GACTGCTTGC CTCAGGGTCC CAGTGGAAAG CTGGTGTGCC AAGACCCCTG CAATGTCTAT 
GAAACCCTGA CTGAGTACTG GCGCAGCACA GACTATGGTG CCGGCTACTC CTGTGACTCA 
GATATGCACG GCTGGTACCG GTTCACAGGC CAGGGTGGCG TTCGCATGGC TGAGACCTGT 
GTGCCCGTAC TGAGGTGCAA CACGGCTGCA CCCATGTGGC TCAATGGCTC GCATCCTTCG 
AGCAGAGAGG GCATTGTGAG CCGCACAGCC TGCGCACACT GGAGCGACCA CTGCTGCCTG 
TGGTCCACAG AGATCCAGGT GAAGGCCTGC CCTGGTGGCT TCTATGTTTA CAACTTGACA 
GAGCCCCCTG AGTGCAATCT GGCTTACTGC ACCGATCCTA GCTCCGTGGA GGGGACTTGC 
GAAGAATGCG GGGTAGATGA AGACTGCGTA TCTGATAACG GCAGATGGCG CTGCCAGTGT 
AAACAGGACT TCAACATTAC AGATGTCTCC CTCCTGGAGC ACAGGCTGGA GTGTGAGGCC 
AATGAAATCA AGATATCCCT CAGCAAGTGC CAGCTACAGA GTTTGGGCTT TATGAAGGTC 
TTCATGTACC TGAATGACAG ACAGTGCTCA GGCTTCAGTG AGAGGGGTGA ACGAGACTGG 
ATGTCCATAG TGACTCCTGC CAGGGATGGT CCCTGTGGGA CAGTATTGAG GAGAAATGAA 
ACCCACGCCA CCTACAGCAA CACCCTCTAC CTGGCAAGTG AGATCATCAT CAGGGATATC 
AACATCAGAA TCAACTTTGA ATGCTCTTAC CCTCTGGACA TGAAAGTCAG TCTGAAGACC 
TCCCTACAGC CTATGGTTAG TGCCTTGAAC ATCAGCTTGG GTGGGACAGG CAAGTTCACT 
GTGCAGATGG CACTGTTCCA GAACCCTACC TACACACAGC CCTACCAAGG TCCTTCTGTG 
ATGCTCTCCA CTGAGGCTTT TCTGTATGTG GGCACCATGC TGGATGGGGG TGACTTGTCC 
CGGTTTGTAC TGCTAATGAC CAACTGCTAT GCCACACCCA GTAGCAACTC CACGGACCCT 
GTAAAATACT TCATTATCCA GGACAGATGT CCACATACAG AAGATACAAC CATTCAGGTG 
ACAGAGAATG GCGAGTCCTC TCAGGCCCGG TTCTCTATTC AGATGTTCCG GTTTGCAGGA 
AACTCCGACC TTGTCTACCT TCACTGCGAG GTGTACCTGT GTGACACTAT GAGTGAGCAG 
TGTAAACCTA CCTGTTCTGG TACTAGATAT CGAAGTGGGA ACTTCATAGA TCAGACCCGT 
GTCCTGAACT TGGGTCCCAT CACACGACAA GGTGTCCAGG CCTCAGTGTC CAAGGCTGCT 
TCCAGCAACT TGGGGTTCCT GAGCATCTGG CTGCTGCTGT TTCTCTCAGC TACTTTGACC 
CTGATGGTTC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Umod ( NM_017082.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058778.1 Rattus norvegicus uromodulin (Umod), mRNA.

Price & Availability↑

CloneID	ORa02761
Clone ID Related Accession (Same CDS sequence)	NM_017082.1
Accession Version	NM_017082.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1935bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	uromodulin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M63510.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M63510.1, BC081814.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGCAGC TGCTCTCTTT GACCTGGCTG CTGCTGGTTA TGGTGGTAAC TCCCTGGTTC 
ACTGTAGCTG GAGCCAATGA CTCACCAGAA GCAAGAAGGT GTTCTGAATG CCACGACAAT 
GCCACCTGTG TGTTGGATGG GGTGGTCACC ACATGCTCCT GCCAGGCAGG CTTCACTGGA 
GATGGGCTGG TGTGTGAGGA CATAGATGAG TGTGCCACCC CGTGGACTCA CAACTGCTCC 
AACAGCATCT GCATGAACAC ACTGGGCTCC TACGAGTGCT CCTGTCAGGA TGGCTTTCGT 
CTGACGCCTG GGCTGGGCTG CATTGATGTG AATGAGTGCA CAGAGCAGGG GCTCAGTAAC 
TGTCATTCCC TGGCTACCTG TGTCAACACG GAAGGCAGCT ACTCATGCGT GTGTCCCAAG 
GGCTATAGAG GGGATGGTTG GTACTGTGAG TGCTCCCCTG GCTTCTGTGA GCCAGGGCTG 
GACTGCTTGC CTCAGGGTCC CAGTGGAAAG CTGGTGTGCC AAGACCCCTG CAATGTCTAT 
GAAACCCTGA CTGAGTACTG GCGCAGCACA GACTATGGTG CCGGCTACTC CTGTGACTCA 
GATATGCACG GCTGGTACCG GTTCACAGGC CAGGGTGGCG TTCGCATGGC TGAGACCTGT 
GTGCCCGTAC TGAGGTGCAA CACGGCTGCA CCCATGTGGC TCAATGGCTC GCATCCTTCG 
AGCAGAGAGG GCATTGTGAG CCGCACAGCC TGCGCACACT GGAGCGACCA CTGCTGCCTG 
TGGTCCACAG AGATCCAGGT GAAGGCCTGC CCTGGTGGCT TCTATGTTTA CAACTTGACA 
GAGCCCCCTG AGTGCAATCT GGCTTACTGC ACCGATCCTA GCTCCGTGGA GGGGACTTGC 
GAAGAATGCG GGGTAGATGA AGACTGCGTA TCTGATAACG GCAGATGGCG CTGCCAGTGT 
AAACAGGACT TCAACGTTAC AGATGTCTCC CTCCTGGAGC ACAGGCTGGA GTGTGAGGCC 
AATGAAATCA AGATATCCCT CAGCAAGTGC CAGCTACAGA GTTTGGGCTT TATGAAGGTC 
TTCATGTACC TGAATGACAG ACAGTGCTCA GGCTTCAGTG AGAGGGGTGA ACGAGACTGG 
ATGTCCATAG TGACTCCTGC CAGGGATGGT CCCTGTGGGA CAGTATTGAG GAGAAATGAA 
ACCCACGCCA CCTACAGCAA CACCCTCTAC CTGGCAAGTG AGATCATCAT CAGGGATATC 
AACATCAGAA TCAACTTTGA ATGCTCTTAC CCTCTGGACA TGAAAGTCAG TCTGAAGACC 
TCCCTACAGC CTATGGTTAG TGCCTTGAAC ATCAGCTTGG GTGGGACAGG CAAGTTCACT 
GTGCAGATGG CACTGTTCCA GAACCCTACC TACACACAGC CCTACCAAGG TCCTTCTGTG 
ATGCTCTCCA CTGAGGCTTT TCTGTATGTG GGCACCATGC TGGATGGGGG TGACTTGTCC 
CGGTTTGTAC TGCTAATGAC CAACTGCTAT GCCACACCCA GTAGCAACTC CACGGACCCT 
GTAAAATACT TCATTATCCA GGACAGATGT CCACATACAG AAGATACAAC CATTCAGGTG 
ACAGAGAATG GCGAGTCCTC TCAGGCCCGG TTCTCTATTC AGATGTTCCG GTTTGCAGGA 
AACTCCGACC TTGTCTACCT TCACTGCGAG GTGTACCTGT GTGACACTAT GAGTGAGCAG 
TGTAAACCTA CCTGTTCTGG TACTAGATAT CGAAGTGGGA ACTTCATAGA TCAGACCCGT 
GTCCTGAACT TGGGTCCCAT CACACGACAA GGTGTCCAGG CCTCAGTGTC CAAGGCTGCT 
TCCAGCAACT TGGGGTTCCT GAGCATCTGG CTGCTGCTGT TTCTCTCAGC TACTTTGACC 
CTGATGGTTC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058778.1
CDS	25..1959
Translation	MGQLLSLTWLLLVMVVTPWFTVAGANDSPEARRCSECHDNATCVLDGVVTTCSCQAGFTGDGLVCEDIDECATPWTHNCSNSICMNTLGSYECSCQDGFRLTPGLGCIDVNECTEQGLSNCHSLATCVNTEGSYSCVCPKGYRGDGWYCECSPGFCEPGLDCLPQGPSGKLVCQDPCNVYETLTEYWRSTDYGAGYSCDSDMHGWYRFTGQGGVRMAETCVPVLRCNTAAPMWLNGSHPSSREGIVSRTACAHWSDHCCLWSTEIQVKACPGGFYVYNLTEPPECNLAYCTDPSSVEGTCEECGVDEDCVSDNGRWRCQCKQDFNVTDVSLLEHRLECEANEIKISLSKCQLQSLGFMKVFMYLNDRQCSGFSERGERDWMSIVTPARDGPCGTVLRRNETHATYSNTLYLASEIIIRDINIRINFECSYPLDMKVSLKTSLQPMVSALNISLGGTGKFTVQMALFQNPTYTQPYQGPSVMLSTEAFLYVGTMLDGGDLSRFVLLMTNCYATPSSNSTDPVKYFIIQDRCPHTEDTTIQVTENGESSQARFSIQMFRFAGNSDLVYLHCEVYLCDTMSEQCKPTCSGTRYRSGNFIDQTRVLNLGPITRQGVQASVSKAASSNLGFLSIWLLLFLSATLTLMVH

Target ORF information:

RefSeq Version	NM_017082.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus uromodulin (Umod), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017082.1

ORF Insert Sequence:

ATGGGGCAGC TGCTCTCTTT GACCTGGCTG CTGCTGGTTA TGGTGGTAAC TCCCTGGTTC 
ACTGTAGCTG GAGCCAATGA CTCACCAGAA GCAAGAAGGT GTTCTGAATG CCACGACAAT 
GCCACCTGTG TGTTGGATGG GGTGGTCACC ACATGCTCCT GCCAGGCAGG CTTCACTGGA 
GATGGGCTGG TGTGTGAGGA CATAGATGAG TGTGCCACCC CGTGGACTCA CAACTGCTCC 
AACAGCATCT GCATGAACAC ACTGGGCTCC TACGAGTGCT CCTGTCAGGA TGGCTTTCGT 
CTGACGCCTG GGCTGGGCTG CATTGATGTG AATGAGTGCA CAGAGCAGGG GCTCAGTAAC 
TGTCATTCCC TGGCTACCTG TGTCAACACG GAAGGCAGCT ACTCATGCGT GTGTCCCAAG 
GGCTATAGAG GGGATGGTTG GTACTGTGAG TGCTCCCCTG GCTTCTGTGA GCCAGGGCTG 
GACTGCTTGC CTCAGGGTCC CAGTGGAAAG CTGGTGTGCC AAGACCCCTG CAATGTCTAT 
GAAACCCTGA CTGAGTACTG GCGCAGCACA GACTATGGTG CCGGCTACTC CTGTGACTCA 
GATATGCACG GCTGGTACCG GTTCACAGGC CAGGGTGGCG TTCGCATGGC TGAGACCTGT 
GTGCCCGTAC TGAGGTGCAA CACGGCTGCA CCCATGTGGC TCAATGGCTC GCATCCTTCG 
AGCAGAGAGG GCATTGTGAG CCGCACAGCC TGCGCACACT GGAGCGACCA CTGCTGCCTG 
TGGTCCACAG AGATCCAGGT GAAGGCCTGC CCTGGTGGCT TCTATGTTTA CAACTTGACA 
GAGCCCCCTG AGTGCAATCT GGCTTACTGC ACCGATCCTA GCTCCGTGGA GGGGACTTGC 
GAAGAATGCG GGGTAGATGA AGACTGCGTA TCTGATAACG GCAGATGGCG CTGCCAGTGT 
AAACAGGACT TCAACGTTAC AGATGTCTCC CTCCTGGAGC ACAGGCTGGA GTGTGAGGCC 
AATGAAATCA AGATATCCCT CAGCAAGTGC CAGCTACAGA GTTTGGGCTT TATGAAGGTC 
TTCATGTACC TGAATGACAG ACAGTGCTCA GGCTTCAGTG AGAGGGGTGA ACGAGACTGG 
ATGTCCATAG TGACTCCTGC CAGGGATGGT CCCTGTGGGA CAGTATTGAG GAGAAATGAA 
ACCCACGCCA CCTACAGCAA CACCCTCTAC CTGGCAAGTG AGATCATCAT CAGGGATATC 
AACATCAGAA TCAACTTTGA ATGCTCTTAC CCTCTGGACA TGAAAGTCAG TCTGAAGACC 
TCCCTACAGC CTATGGTTAG TGCCTTGAAC ATCAGCTTGG GTGGGACAGG CAAGTTCACT 
GTGCAGATGG CACTGTTCCA GAACCCTACC TACACACAGC CCTACCAAGG TCCTTCTGTG 
ATGCTCTCCA CTGAGGCTTT TCTGTATGTG GGCACCATGC TGGATGGGGG TGACTTGTCC 
CGGTTTGTAC TGCTAATGAC CAACTGCTAT GCCACACCCA GTAGCAACTC CACGGACCCT 
GTAAAATACT TCATTATCCA GGACAGATGT CCACATACAG AAGATACAAC CATTCAGGTG 
ACAGAGAATG GCGAGTCCTC TCAGGCCCGG TTCTCTATTC AGATGTTCCG GTTTGCAGGA 
AACTCCGACC TTGTCTACCT TCACTGCGAG GTGTACCTGT GTGACACTAT GAGTGAGCAG 
TGTAAACCTA CCTGTTCTGG TACTAGATAT CGAAGTGGGA ACTTCATAGA TCAGACCCGT 
GTCCTGAACT TGGGTCCCAT CACACGACAA GGTGTCCAGG CCTCAGTGTC CAAGGCTGCT 
TCCAGCAACT TGGGGTTCCT GAGCATCTGG CTGCTGCTGT TTCTCTCAGC TACTTTGACC 
CTGATGGTTC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.
Hypertension (Dallas, Tex. : 1979)69(5)910-918(2017 05)
Mary S,Small HY,Siwy J,Mullen W,Giri A,Delles C

CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia.
American journal of human genetics88(3)333-43(2011 Mar)
Stuiver M,Lainez S,Will C,Terryn S,G?nzel D,Debaix H,Sommer K,Kopplin K,Thumfart J,Kampik NB,Querfeld U,Willnow TE,N?mec V,Wagner CA,Hoenderop JG,Devuyst O,Knoers NV,Bindels RJ,Meij IC,M?ller D

Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression.
Human molecular genetics19(10)1985-97(2010 May)
Zaucke F,Boehnlein JM,Steffens S,Polishchuk RS,Rampoldi L,Fischer A,Pasch A,Boehm CW,Baasner A,Attanasio M,Hoppe B,Hopfer H,Beck BB,Sayer JA,Hildebrandt F,Wolf MT

Uromodulin facilitates neutrophil migration across renal epithelial monolayers.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology26(3)311-8(2010)
Schmid M,Prajczer S,Gruber LN,Bertocchi C,Gandini R,Pfaller W,Jennings P,Joannidis M

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

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Umod cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

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ORF Insert Sequence:

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