Itga1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itga1
Entrez Gene ID	25118
Full Name	integrin subunit alpha 1
General protein information	Preferred Names integrin subunit alpha 1 Names integrin alpha-1 CD49 antigen-like family member A VLA-1 laminin and collagen receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q14
Summary	alpha subunit of the integrin molecule; involved in binding laminin and collagen [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030994.2	NP_112256.1	integrin alpha-1 precursor

Pathways from BioSystems

Homologies

	ITGA1	XP_001094788.1
Rattus norvegicus (Norway rat)	Itga1	NP_112256.1
Gallus gallus (chicken)	ITGA1	NP_990400.1
Pan troglodytes (chimpanzee)	ITGA1	XP_517769.2
Canis lupus familiaris (dog)	ITGA1	XP_005619392.1
Mus musculus (house mouse)	Itga1	NP_001028400.2
Danio rerio (zebrafish)	itga1	XP_699485.4
Xenopus tropicalis (tropical clawed frog)	itga1	XP_002933090.2
Homo sapiens (human)	ITGA1	NP_852478.1

Gene Ontology
Bibliography

Related articles in PubMed

Periodic mechanical stress induces the extracellular matrix expression and migration of rat nucleus pulposus cells by upregulating the expression of intergrin ?1 and phosphorylation of downstream phospholipase C?1.
Gao G, He J, Nong L, Xie H, Huang Y, Xu N, Zhou D
Molecular medicine reports14(3)2457-64(2016 Sep)

17?-Estradiol Protects Rat Annulus Fibrosus Cells Against Apoptosis via ?1 Integrin-Mediated Adhesion to Type I Collagen: An In-vitro Study.
Zhao CM, Chen Q, Zhang WJ, Huang AB, Zhang W, Yang HL, Zhang ZM
Medical science monitor : international medical journal of experimental and clinical research221375-83(2016 Apr)

Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells.
Moraes JA, Frony AC, Dias AM, Renovato-Martins M, Rodrigues G, Marcinkiewicz C, Assreuy J, Barja-Fidalgo C
Atherosclerosis243(2)477-85(2015 Dec)

Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner.
Sipil? K, Haag S, Denessiouk K, K?pyl? J, Peters EC, Denesyuk A, Hansen U, Konttinen Y, Johnson MS, Holmdahl R, Heino J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(8)3758-68(2014 Aug)

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.
Soteriou D, Iskender B, Byron A, Humphries JD, Borg-Bartolo S, Haddock MC, Baxter MA, Knight D, Humphries MJ, Kimber SJ
The Journal of biological chemistry288(26)18716-31(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

periodic mechanical stress induced ECM expression and the migration of NP cells via upregulating the expression of integrin alpha1 and the phosphorylation of downstream PLCgamma1. These findings provide novel information to aid the understanding of the pathogenesis and development of IDD.
Title: Periodic mechanical stress induces the extracellular matrix expression and migration of rat nucleus pulposus cells by upregulating the expression of intergrin ?1 and phosphorylation of downstream phospholipase C?1.

This study shows that E2 protects against apoptosis in a time-dependent manner, and alpha1 integrin-mediated adhesion to collagen II is essential for estrogen-dependent anti-apoptosis in rat annulus fibrosus cells in vitro.
Title: 17?-Estradiol Protects Rat Annulus Fibrosus Cells Against Apoptosis via ?1 Integrin-Mediated Adhesion to Type I Collagen: An In-vitro Study.

Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects on vascular smooth muscle cell proliferation/migration.
Title: Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells.

Dynamic structural changes are observed upon collagen and metal ion binding to the integrin alpha1 I domain.
Title: Dynamic structural changes are observed upon collagen and metal ion binding to the integrin ?1 I domain.

Alpha(1)beta(1)-integrin has a key role in flow (shear stress)-dependent vasodilation in resistance arteries by transmitting the signal to eNOS through activation of PI3-kinase and Akt.
Title: Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries.

The following Itga1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itga1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07299	NM_030994.2 Latest version!	Rattus norvegicus integrin subunit alpha 1 (Itga1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$867.30 $1239.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itga1 ( NM_030994.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112256.1 Rattus norvegicus integrin subunit alpha 1 (Itga1), mRNA.

Price & Availability↑

CloneID	ORa07299
Clone ID Related Accession (Same CDS sequence)	NM_030994.2
Accession Version	NM_030994.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	integrin alpha-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X52140.1. On Apr 19, 2007 this sequence version replaced NM_030994.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X52140.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGTCCCCA GGCGTCCTGC CAGCCTAGAG GTCACTGTAG CCTGCATATG GCTTCTCACG 
GTCATCCTAG GCTTCTGCGT CTCCTTCAAT GTTGATGTGA AAAACTCAAT GAGTTTCAGT 
GGCCCAGTAG AGGACATGTT TGGATACACT GTTCAACAAT ATGAAAACGA AGAAGGCAAA 
TGGGTTCTTA TTGGTTCTCC TTTAGTTGGC CAACCCAAAG CAAGAACTGG AGATGTCTAT 
AAGTGTCCGG TTGGGAGAGA GAGAGCAATG CCTTGCGTGA AGTTGGACTT GCCAGTTAAC 
ACATCGATCC CCAATGTCAC AGAAATAAAG GAAAACATGA CATTTGGATC AACTTTAGTC 
ACCAACCCGA ATGGAGGATT TCTGGCATGT GGGCCCTTGT ATGCCTATAG ATGTGGACAT 
TTGCATTATA CAACTGGAAT ATGTTCTGAT GTCAGTCCTA CATTTCAAGT TGTGAACTCC 
TTTGCCCCTG TACAAGAATG CAGCACCCAG CTGGACATAG TCATCGTCCT GGATGGCTCC 
AACAGCATCT ACCCCTGGGA AAGTGTCATC GCCTTTTTAA ACGACCTTCT TAAGAGGATG 
GATATTGGCC CTAAGCAGAC ACAGGTCGGG ATTGTACAGT ATGGAGAGAA TGTAACCCAT 
GAGTTCAACC TCAATAAGTA TTCATCCACA GAAGAGGTCC TTGTCGCAGC AAACAAAATA 
GGCCGACAGG GAGGCCTCCA AACGATGACA GCCCTTGGAA TAGACACAGC CAGGAAAGAG 
GCATTCACTG AAGCTCGGGG TGCCAGGAGG GGAGTTAAAA AAGTCATGGT TATTGTGACC 
GACGGAGAAT CGCATGACAA CTATCGCCTG AAACAGGTCA TCCAAGACTG CGAGGACGAA 
AACATTCAGC GATTTTCCAT AGCTATCCTT GGCCACTATA ACAGGGGGAA CTTAAGCACT 
GAAAAATTTG TGGAGGAAAT AAAATCGATC GCAAGCGAGC CCACGGAAAA GCACTTCTTC 
AATGTCTCGG ATGAGTTGGC CCTGGTCACT ATTGTTAAAG CTCTGGGAGA AAGGATATTC 
GCTTTGGAAG CGACAGCTGA CCAGTCAGCA GCTTCATTTG AGATGGAAAT GTCTCAGACT 
GGCTTCAGTG CTCACTACTC CCAGGACTGG GTCATGCTTG GAGCGGTGGG AGCCTATGAC 
TGGAACGGAA CTGTGGTCAT GCAGAAGGCT AACCAGATGG TCATCCCTCA TAACACCACC 
TTTCAAACTG AGCCCGCCAA GATGAACGAG CCTCTGGCTT CTTATTTAGG TTACACAGTG 
AACTCGGCCA CCATCCCTGG AGATGTGCTC TACATCGCTG GGCAGCCTCG GTACAATCAT 
ACGGGCCAGG TCGTCATCTA CAAGATGGAG GATGGGAACA TCAACATTCT GCAGACACTC 
GGCGGAGAGC AGATTGGTTC CTACTTTGGT AGTGTCTTAA CAACAATTGA CATCGACAAA 
GATTCTTATA CTGATCTGCT TCTCGTCGGG GCCCCCATGT ACATGGGGAC AGAGAAAGAG 
GAACAGGGCA AGGTGTACGT GTACGCTGTG AATCAGACAA GGTTTGAATA TCAAATGAGC 
CTGGAACCAA TTAGGCAGAC CTGCTGCTCA TCCCTGAAGG ATAATTCATG CACGAAAGAA 
AACAAGAATG AGCCCTGCGG GGCCCGCTTC GGAACAGCAA TTGCTGCTGT AAAAGACCTC 
AACGTGGATG GATTTAATGA CGTCGTGATT GGAGCTCCGC TGGAAGATGA CCACGCAGGA 
GCTGTGTACA TTTATCATGG CAGTGGCAAG ACCATAAGGG AGGCGTATGC ACAACGCATT 
CCATCAGGTG GGGATGGCAA GACCCTGAAA TTTTTCGGCC AGTCTATCCA CGGAGAGATG 
GATTTAAATG GTGACGGTCT GACTGACGTG ACCATTGGAG GCCTTGGTGG AGCAGCCCTC 
TTCTGGGCCA GAGATGTGGC TGTAGTTAAA GTGACCATGA ATTTTGAACC CAATAAAGTG 
AATATTCAAA AGAAAAACTG CCGTGTGGAG GGCAAAGAAA CAGTGTGCAT AAATGCTACA 
ATGTGTTTTC ATGTGAAATT AAAGTCTAAA GAGGACTCAA TTTACGAGGC TGATCTGCAG 
TACCGTGTCA CCCTTGATTC ACTGAGGCAG ATATCACGGA GCTTTTTTTC TGGAACTCAG 
GAAAGGAAGA TTCAAAGAAA TATCACCGTT CGAGAATCAG AATGCATCAG GCACTCCTTC 
TACATGTTGG ACAAACATGA CTTTCAGGAC TCTGTGAGAG TGACTCTGGA TTTTAATCTC 
ACTGATCCAG AAAATGGTCC TGTACTTGAT GACGCTCTGC CAAACTCAGT CCACGAACAC 
ATTCCCTTTG CCAAAGACTG TGGAAACAAG GAAAGATGCA TTTCAGACCT CACTCTGAAT 
GTGTCCACCA CAGAAAAGAG CCTGCTGATC GTCAAGTCCC AGCATGACAA GTTCAACGTT 
AGCCTCACCG TCAAAAACAA AGGAGACAGT GCGTACAACA CCAGGACAGT GGTGCAGCAT 
TCACCAAATC TGATTTTTTC GGGAATTGAG GAGATCCAAA AAGATAGCTG TGAATCTAAT 
CAAAATATCA CTTGCAGAGT TGGATATCCT TTCCTAAGAG CAGGAGAAAC GGTTACCTTC 
AAAATAATAT TCCAGTTTAA CACATCCCAT CTCTCGGAAA ATGCAATCAT TCACTTAAGT 
GCAACAAGTG ACAGTGAGGA GCCCCTGGAA TCTCTTAATG ATAATGAAGT AAATATTTCC 
ATCCCAGTAA AATATGAAGT TGGACTGCAG TTTTACAGTT CTGCGAGTGA ACATCACATT 
TCAGTCGCTG CCAATGAGAC GATCCCTGAG TTTATTAACT CCACTGAGGA CATTGGGAAT 
GAAATTAATG TCTTCTATAC GATTAGAAAG AGGGGGCATT TCCCAATGCC AGAACTTCAG 
CTGTCAATTT CATTCCCCAA TTTGACGGCA GATGGTTATC CTGTACTGTA CCCAATTGGA 
TGGTCATCTT CAGATAATGT GAACTGTAGA CCCCGGAGCC TTGAGGACCC CTTTGGCATC 
AACTCTGGGA AGAAAATGAC AATATCGAAG TCTGAGGTTC TCAAAAGAGG CACAATCCAG 
GACTGCAGTA GTACGTGTGG AGTTGCCACC ATCACGTGTA GCCTCCTTCC TTCCGACCTG 
AGTCAAGTGA ATGTCTCGCT CCTCCTGTGG AAACCGACTT TCATAAGAGC ACATTTTTCC 
AGCTTAAACC TTACTCTAAG AGGAGAACTT AAGAGTGAAA ATTCATCGCT GACTTTAAGT 
AGCAGCAACC GGAAGCGAGA GCTGGCTATT CAGATATCCA AAGACGGGCT CCCAGGCAGA 
GTGCCGCTGT GGGTTATCCT CCTGAGCGCC TTCGCGGGGC TACTGCTGCT AATGCTCCTT 
ATATTGGCTC TGTGGAAGAT TGGATTCTTC AAAAGGCCAC TGAAGAAGAA AATGGAGAAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112256.1
CDS	396..3938
Translation	MVPRRPASLEVTVACIWLLTVILGFCVSFNVDVKNSMSFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKARTGDVYKCPVGRERAMPCVKLDLPVNTSIPNVTEIKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSFAPVQECSTQLDIVIVLDGSNSIYPWESVIAFLNDLLKRMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAANKIGRQGGLQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQRFSIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKANQMVIPHNTTFQTEPAKMNEPLASYLGYTVNSATIPGDVLYIAGQPRYNHTGQVVIYKMEDGNINILQTLGGEQIGSYFGSVLTTIDIDKDSYTDLLLVGAPMYMGTEKEEQGKVYVYAVNQTRFEYQMSLEPIRQTCCSSLKDNSCTKENKNEPCGARFGTAIAAVKDLNVDGFNDVVIGAPLEDDHAGAVYIYHGSGKTIREAYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWARDVAVVKVTMNFEPNKVNIQKKNCRVEGKETVCINATMCFHVKLKSKEDSIYEADLQYRVTLDSLRQISRSFFSGTQERKIQRNITVRESECIRHSFYMLDKHDFQDSVRVTLDFNLTDPENGPVLDDALPNSVHEHIPFAKDCGNKERCISDLTLNVSTTEKSLLIVKSQHDKFNVSLTVKNKGDSAYNTRTVVQHSPNLIFSGIEEIQKDSCESNQNITCRVGYPFLRAGETVTFKIIFQFNTSHLSENAIIHLSATSDSEEPLESLNDNEVNISIPVKYEVGLQFYSSASEHHISVAANETIPEFINSTEDIGNEINVFYTIRKRGHFPMPELQLSISFPNLTADGYPVLYPIGWSSSDNVNCRPRSLEDPFGINSGKKMTISKSEVLKRGTIQDCSSTCGVATITCSLLPSDLSQVNVSLLLWKPTFIRAHFSSLNLTLRGELKSENSSLTLSSSNRKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK

Target ORF information:

RefSeq Version	NM_030994.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit alpha 1 (Itga1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030994.2

ORF Insert Sequence:

ATGGTCCCCA GGCGTCCTGC CAGCCTAGAG GTCACTGTAG CCTGCATATG GCTTCTCACG 
GTCATCCTAG GCTTCTGCGT CTCCTTCAAT GTTGATGTGA AAAACTCAAT GAGTTTCAGT 
GGCCCAGTAG AGGACATGTT TGGATACACT GTTCAACAAT ATGAAAACGA AGAAGGCAAA 
TGGGTTCTTA TTGGTTCTCC TTTAGTTGGC CAACCCAAAG CAAGAACTGG AGATGTCTAT 
AAGTGTCCGG TTGGGAGAGA GAGAGCAATG CCTTGCGTGA AGTTGGACTT GCCAGTTAAC 
ACATCGATCC CCAATGTCAC AGAAATAAAG GAAAACATGA CATTTGGATC AACTTTAGTC 
ACCAACCCGA ATGGAGGATT TCTGGCATGT GGGCCCTTGT ATGCCTATAG ATGTGGACAT 
TTGCATTATA CAACTGGAAT ATGTTCTGAT GTCAGTCCTA CATTTCAAGT TGTGAACTCC 
TTTGCCCCTG TACAAGAATG CAGCACCCAG CTGGACATAG TCATCGTCCT GGATGGCTCC 
AACAGCATCT ACCCCTGGGA AAGTGTCATC GCCTTTTTAA ACGACCTTCT TAAGAGGATG 
GATATTGGCC CTAAGCAGAC ACAGGTCGGG ATTGTACAGT ATGGAGAGAA TGTAACCCAT 
GAGTTCAACC TCAATAAGTA TTCATCCACA GAAGAGGTCC TTGTCGCAGC AAACAAAATA 
GGCCGACAGG GAGGCCTCCA AACGATGACA GCCCTTGGAA TAGACACAGC CAGGAAAGAG 
GCATTCACTG AAGCTCGGGG TGCCAGGAGG GGAGTTAAAA AAGTCATGGT TATTGTGACC 
GACGGAGAAT CGCATGACAA CTATCGCCTG AAACAGGTCA TCCAAGACTG CGAGGACGAA 
AACATTCAGC GATTTTCCAT AGCTATCCTT GGCCACTATA ACAGGGGGAA CTTAAGCACT 
GAAAAATTTG TGGAGGAAAT AAAATCGATC GCAAGCGAGC CCACGGAAAA GCACTTCTTC 
AATGTCTCGG ATGAGTTGGC CCTGGTCACT ATTGTTAAAG CTCTGGGAGA AAGGATATTC 
GCTTTGGAAG CGACAGCTGA CCAGTCAGCA GCTTCATTTG AGATGGAAAT GTCTCAGACT 
GGCTTCAGTG CTCACTACTC CCAGGACTGG GTCATGCTTG GAGCGGTGGG AGCCTATGAC 
TGGAACGGAA CTGTGGTCAT GCAGAAGGCT AACCAGATGG TCATCCCTCA TAACACCACC 
TTTCAAACTG AGCCCGCCAA GATGAACGAG CCTCTGGCTT CTTATTTAGG TTACACAGTG 
AACTCGGCCA CCATCCCTGG AGATGTGCTC TACATCGCTG GGCAGCCTCG GTACAATCAT 
ACGGGCCAGG TCGTCATCTA CAAGATGGAG GATGGGAACA TCAACATTCT GCAGACACTC 
GGCGGAGAGC AGATTGGTTC CTACTTTGGT AGTGTCTTAA CAACAATTGA CATCGACAAA 
GATTCTTATA CTGATCTGCT TCTCGTCGGG GCCCCCATGT ACATGGGGAC AGAGAAAGAG 
GAACAGGGCA AGGTGTACGT GTACGCTGTG AATCAGACAA GGTTTGAATA TCAAATGAGC 
CTGGAACCAA TTAGGCAGAC CTGCTGCTCA TCCCTGAAGG ATAATTCATG CACGAAAGAA 
AACAAGAATG AGCCCTGCGG GGCCCGCTTC GGAACAGCAA TTGCTGCTGT AAAAGACCTC 
AACGTGGATG GATTTAATGA CGTCGTGATT GGAGCTCCGC TGGAAGATGA CCACGCAGGA 
GCTGTGTACA TTTATCATGG CAGTGGCAAG ACCATAAGGG AGGCGTATGC ACAACGCATT 
CCATCAGGTG GGGATGGCAA GACCCTGAAA TTTTTCGGCC AGTCTATCCA CGGAGAGATG 
GATTTAAATG GTGACGGTCT GACTGACGTG ACCATTGGAG GCCTTGGTGG AGCAGCCCTC 
TTCTGGGCCA GAGATGTGGC TGTAGTTAAA GTGACCATGA ATTTTGAACC CAATAAAGTG 
AATATTCAAA AGAAAAACTG CCGTGTGGAG GGCAAAGAAA CAGTGTGCAT AAATGCTACA 
ATGTGTTTTC ATGTGAAATT AAAGTCTAAA GAGGACTCAA TTTACGAGGC TGATCTGCAG 
TACCGTGTCA CCCTTGATTC ACTGAGGCAG ATATCACGGA GCTTTTTTTC TGGAACTCAG 
GAAAGGAAGA TTCAAAGAAA TATCACCGTT CGAGAATCAG AATGCATCAG GCACTCCTTC 
TACATGTTGG ACAAACATGA CTTTCAGGAC TCTGTGAGAG TGACTCTGGA TTTTAATCTC 
ACTGATCCAG AAAATGGTCC TGTACTTGAT GACGCTCTGC CAAACTCAGT CCACGAACAC 
ATTCCCTTTG CCAAAGACTG TGGAAACAAG GAAAGATGCA TTTCAGACCT CACTCTGAAT 
GTGTCCACCA CAGAAAAGAG CCTGCTGATC GTCAAGTCCC AGCATGACAA GTTCAACGTT 
AGCCTCACCG TCAAAAACAA AGGAGACAGT GCGTACAACA CCAGGACAGT GGTGCAGCAT 
TCACCAAATC TGATTTTTTC GGGAATTGAG GAGATCCAAA AAGATAGCTG TGAATCTAAT 
CAAAATATCA CTTGCAGAGT TGGATATCCT TTCCTAAGAG CAGGAGAAAC GGTTACCTTC 
AAAATAATAT TCCAGTTTAA CACATCCCAT CTCTCGGAAA ATGCAATCAT TCACTTAAGT 
GCAACAAGTG ACAGTGAGGA GCCCCTGGAA TCTCTTAATG ATAATGAAGT AAATATTTCC 
ATCCCAGTAA AATATGAAGT TGGACTGCAG TTTTACAGTT CTGCGAGTGA ACATCACATT 
TCAGTCGCTG CCAATGAGAC GATCCCTGAG TTTATTAACT CCACTGAGGA CATTGGGAAT 
GAAATTAATG TCTTCTATAC GATTAGAAAG AGGGGGCATT TCCCAATGCC AGAACTTCAG 
CTGTCAATTT CATTCCCCAA TTTGACGGCA GATGGTTATC CTGTACTGTA CCCAATTGGA 
TGGTCATCTT CAGATAATGT GAACTGTAGA CCCCGGAGCC TTGAGGACCC CTTTGGCATC 
AACTCTGGGA AGAAAATGAC AATATCGAAG TCTGAGGTTC TCAAAAGAGG CACAATCCAG 
GACTGCAGTA GTACGTGTGG AGTTGCCACC ATCACGTGTA GCCTCCTTCC TTCCGACCTG 
AGTCAAGTGA ATGTCTCGCT CCTCCTGTGG AAACCGACTT TCATAAGAGC ACATTTTTCC 
AGCTTAAACC TTACTCTAAG AGGAGAACTT AAGAGTGAAA ATTCATCGCT GACTTTAAGT 
AGCAGCAACC GGAAGCGAGA GCTGGCTATT CAGATATCCA AAGACGGGCT CCCAGGCAGA 
GTGCCGCTGT GGGTTATCCT CCTGAGCGCC TTCGCGGGGC TACTGCTGCT AATGCTCCTT 
ATATTGGCTC TGTGGAAGAT TGGATTCTTC AAAAGGCCAC TGAAGAAGAA AATGGAGAAA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Periodic mechanical stress induces the extracellular matrix expression and migration of rat nucleus pulposus cells by upregulating the expression of intergrin ?1 and phosphorylation of downstream phospholipase C?1.
Molecular medicine reports14(3)2457-64(2016 Sep)
Gao G,He J,Nong L,Xie H,Huang Y,Xu N,Zhou D

17?-Estradiol Protects Rat Annulus Fibrosus Cells Against Apoptosis via ?1 Integrin-Mediated Adhesion to Type I Collagen: An In-vitro Study.
Medical science monitor : international medical journal of experimental and clinical research221375-83(2016 Apr)
Zhao CM,Chen Q,Zhang WJ,Huang AB,Zhang W,Yang HL,Zhang ZM

Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells.
Atherosclerosis243(2)477-85(2015 Dec)
Moraes JA,Frony AC,Dias AM,Renovato-Martins M,Rodrigues G,Marcinkiewicz C,Assreuy J,Barja-Fidalgo C

Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(8)3758-68(2014 Aug)
Sipil? K,Haag S,Denessiouk K,K?pyl? J,Peters EC,Denesyuk A,Hansen U,Konttinen Y,Johnson MS,Holmdahl R,Heino J

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.
The Journal of biological chemistry288(26)18716-31(2013 Jun)
Soteriou D,Iskender B,Byron A,Humphries JD,Borg-Bartolo S,Haddock MC,Baxter MA,Knight D,Humphries MJ,Kimber SJ

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Itga1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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