Tacr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tacr3
Entrez Gene ID	24808
Full Name	tachykinin receptor 3
Synonyms	Nkr,Nmkr,Tac3r
General protein information	Preferred Names tachykinin receptor 3 Names neuromedin-K receptor NK-3 receptor NK-3R Neuromedin K receptor (Neurokinin B/Tachikin 3) neurokinin B receptor tachikin receptor 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q43
Summary	receptor for the tachykinin neuromedin K (neurokinin B); couples with G protein that activates the phosphatidylinositol-calcium second mesenger system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017053.1	NP_058749.1	neuromedin-K receptor

Pathways from BioSystems

Homologies

	TACR3	NP_001032951.1
Canis lupus familiaris (dog)	TACR3	NP_001091010.1
Gallus gallus (chicken)	TACR3	XP_001232174.2
Anopheles gambiae (African malaria mosquito)	GPRTAK2	XP_321512.5
Caenorhabditis elegans (roundworm)	C49A9.7	NP_500930.1
Bos taurus (cattle)	TACR3	NP_001179262.1
Danio rerio (zebrafish)	tacr3l	NP_001243564.1
Drosophila melanogaster (fruit fly)	Takr99D	NP_001163772.1
Homo sapiens (human)	TACR3	NP_001050.1
Xenopus tropicalis (tropical clawed frog)	tacr3	XP_002934808.1
Mus musculus (house mouse)	Tacr3	NP_067357.1
Rattus norvegicus (Norway rat)	Tacr3	NP_058749.1
Pan troglodytes (chimpanzee)	TACR3	XP_003950435.1
Danio rerio (zebrafish)	tacr3a	NP_001243567.1

Gene Ontology
Bibliography

Related articles in PubMed

Evidence for involvement of NK? receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze.
Duarte FS, Duzzioni M, Leme LR, Smith Sde P, De Lima TC
Behavioural brain research303168-75(2016 Apr)

Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female Rat.
Mittelman-Smith MA, Krajewski-Hall SJ, McMullen NT, Rance NE
Endocrinology156(7)2552-62(2015 Jul)

Neurokinin B receptor antagonism decreases luteinising hormone pulse frequency and amplitude and delays puberty onset in the female rat.
Li SY, Li XF, Hu MH, Shao B, Poston L, Lightman SL, O'Byrne KT
Journal of neuroendocrinology26(8)521-7(2014 Aug)

Neurokinin B signaling in the female rat: a novel link between stress and reproduction.
Grachev P, Li XF, Hu MH, Li SY, Millar RP, Lightman SL, O'Byrne KT
Endocrinology155(7)2589-601(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results give support to the involvement of NK3 receptors in the anxiogenic-like actions of SP6-11(C-terminal), where this metabolite seems to behave as an antagonist, in a way similar to SR142801.
Title: Evidence for involvement of NK? receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze.

Median preoptic nucleus NK3R neurons facilitate cutaneous vasodilation, an important heat-dissipation effector.
Title: Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female Rat.

data suggest that endogenous NeuroKinin B-Neurokinin 3 Receptor signalling plays a role in controlling the timing of puberty.
Title: Neurokinin B receptor antagonism decreases luteinising hormone pulse frequency and amplitude and delays puberty onset in the female rat.

Data indicate that the suppression of the GnRH pulse generator by acute systemic stress equires hypothalamic NKB/neurokinin B (NKB) receptor (NK3R) signaling.
Title: Neurokinin B signaling in the female rat: a novel link between stress and reproduction.

evidence that the neurokinin3 receptors (NK3-R) and their influence on acetylcholine release may represent a crucial mechanism that underlies age-related deficits in learning and memory
Title: Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.

The following Tacr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tacr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12993	NM_017053.1 Latest version!	Rattus norvegicus tachykinin receptor 3 (Tacr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tacr3 ( NM_017053.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058749.1 Rattus norvegicus tachykinin receptor 3 (Tacr3), mRNA.

Price & Availability↑

CloneID	ORa12993
Clone ID Related Accession (Same CDS sequence)	NM_017053.1
Accession Version	NM_017053.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1359bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	neuromedin-K receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J05189.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J05189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCAG TCCCCAGGGG CGAAAACTGG ACCGACGGGA CGGTGGAAGT GGGGACCCAT 
ACAGGGAATC TGAGCTCCGC GCTGGGGGTC ACTGAGTGGC TTGCGCTCCA AGCTGGCAAC 
TTCTCTTCAG CGCTGGGGTT GCCGGCGACA ACCCAGGCAC CTTCCCAGGT CCGGGCTAAC 
CTGACCAACC AGTTCGTGCA GCCGTCCTGG CGGATCGCGC TCTGGTCCCT GGCCTATGGC 
TTGGTGGTGG CCGTGGCAGT CTTCGGAAAC CTCATCGTTA TCTGGATCAT CCTAGCCCAC 
AAGCGCATGA GAACTGTCAC CAACTATTTC CTGGTAAACC TGGCTTTCTC CGACGCCTCC 
GTGGCTGCCT TCAACACCTT GATCAATTTC ATCTATGGTC TTCACAGCGA GTGGTACTTT 
GGCGCCAACT ACTGCCGCTT CCAGAACTTC TTTCCCATCA CAGCGGTGTT TGCCAGCATC 
TACTCTATGA CAGCCATTGC AGTGGACAGG TATATGGCTA TTATTGATCC GTTGAAACCC 
AGACTTTCTG CCACAGCCAC TAAGATTGTC ATTGGAAGTA TTTGGATTTT GGCATTTCTA 
CTTGCCTTCC CTCAATGCCT TTATTCCAAA ATAAAAGTCA TGCCGGGCCG TACTCTTTGC 
TACGTGCAGT GGCCAGAAGG TCCCAAGCAA CATTTCACGT ACCACATCAT TGTGATCATC 
CTGGTGTACT GTTTCCCACT GCTCATCATG GGTGTCACCT ACACCATCGT TGGAATTACT 
CTCTGGGGAG GAGAGATCCC AGGAGACACC TGTGACAAGT ACCATGAGCA GCTGAAGGCT 
AAACGAAAGG TGGTAAAGAT GATGATCATT GTGGTGGTGA CGTTTGCCAT CTGCTGGCTG 
CCCTATCACG TGTATTTCAT TCTCACTGCG ATCTACCAAC AGTTAAACAG ATGGAAATAC 
ATTCAACAGG TCTACCTGGC TAGCTTCTGG CTGGCAATGA GCTCGACCAT GTACAACCCC 
ATCATCTACT GCTGTTTGAA CAAAAGATTC CGCGCAGGCT TCAAGAGAGC ATTTCGCTGG 
TGTCCTTTCA TCCAAGTCTC CAGCTACGAT GAGCTGGAGC TCAAGACCAC CAGGTTTCAT 
CCCACACGAC AGAGCAGCCT GTACACCGTG AGCAGGATGG AGTCGGTGAC CGTGCTGTTT 
GACCCCAATG ATGGAGACCC AACCAAATCC AGCCGCAAGA AGAGGGCGGT GCCCAGAGAC 
CCCAGTGCCA ATGGCTGTTC CCACAGAGGT TCCAAATCTG CCTCCACCAC ATCAAGTTTC 
ATAAGCTCAC CCTATACCTC TGTGGATGAA TATTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058749.1
CDS	227..1585
Translation	MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS

Target ORF information:

RefSeq Version	NM_017053.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tachykinin receptor 3 (Tacr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017053.1

ORF Insert Sequence:

ATGGCCTCAG TCCCCAGGGG CGAAAACTGG ACCGACGGGA CGGTGGAAGT GGGGACCCAT 
ACAGGGAATC TGAGCTCCGC GCTGGGGGTC ACTGAGTGGC TTGCGCTCCA AGCTGGCAAC 
TTCTCTTCAG CGCTGGGGTT GCCGGCGACA ACCCAGGCAC CTTCCCAGGT CCGGGCTAAC 
CTGACCAACC AGTTCGTGCA GCCGTCCTGG CGGATCGCGC TCTGGTCCCT GGCCTATGGC 
TTGGTGGTGG CCGTGGCAGT CTTCGGAAAC CTCATCGTTA TCTGGATCAT CCTAGCCCAC 
AAGCGCATGA GAACTGTCAC CAACTATTTC CTGGTAAACC TGGCTTTCTC CGACGCCTCC 
GTGGCTGCCT TCAACACCTT GATCAATTTC ATCTATGGTC TTCACAGCGA GTGGTACTTT 
GGCGCCAACT ACTGCCGCTT CCAGAACTTC TTTCCCATCA CAGCGGTGTT TGCCAGCATC 
TACTCTATGA CAGCCATTGC AGTGGACAGG TATATGGCTA TTATTGATCC GTTGAAACCC 
AGACTTTCTG CCACAGCCAC TAAGATTGTC ATTGGAAGTA TTTGGATTTT GGCATTTCTA 
CTTGCCTTCC CTCAATGCCT TTATTCCAAA ATAAAAGTCA TGCCGGGCCG TACTCTTTGC 
TACGTGCAGT GGCCAGAAGG TCCCAAGCAA CATTTCACGT ACCACATCAT TGTGATCATC 
CTGGTGTACT GTTTCCCACT GCTCATCATG GGTGTCACCT ACACCATCGT TGGAATTACT 
CTCTGGGGAG GAGAGATCCC AGGAGACACC TGTGACAAGT ACCATGAGCA GCTGAAGGCT 
AAACGAAAGG TGGTAAAGAT GATGATCATT GTGGTGGTGA CGTTTGCCAT CTGCTGGCTG 
CCCTATCACG TGTATTTCAT TCTCACTGCG ATCTACCAAC AGTTAAACAG ATGGAAATAC 
ATTCAACAGG TCTACCTGGC TAGCTTCTGG CTGGCAATGA GCTCGACCAT GTACAACCCC 
ATCATCTACT GCTGTTTGAA CAAAAGATTC CGCGCAGGCT TCAAGAGAGC ATTTCGCTGG 
TGTCCTTTCA TCCAAGTCTC CAGCTACGAT GAGCTGGAGC TCAAGACCAC CAGGTTTCAT 
CCCACACGAC AGAGCAGCCT GTACACCGTG AGCAGGATGG AGTCGGTGAC CGTGCTGTTT 
GACCCCAATG ATGGAGACCC AACCAAATCC AGCCGCAAGA AGAGGGCGGT GCCCAGAGAC 
CCCAGTGCCA ATGGCTGTTC CCACAGAGGT TCCAAATCTG CCTCCACCAC ATCAAGTTTC 
ATAAGCTCAC CCTATACCTC TGTGGATGAA TATTCCTAA