Serpina4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina4
Entrez Gene ID	246328
Full Name	serpin family A member 4
General protein information	Preferred Names serpin family A member 4 Names kallistatin serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 sserpin family A member 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32
Summary	human homolog inhibits tissue kallikrein kininogenase and amidolytic activities [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145097.2	NP_659565.2	kallistatin precursor
XM_008764741.1	XP_008762963.1	kallistatin isoform X1

Pathways from BioSystems

Homologies

	SERPINA4	XP_001099759.1
Rattus norvegicus (Norway rat)	Serpina4	NP_659565.2
Pan troglodytes (chimpanzee)	SERPINA4	XP_522941.2
Homo sapiens (human)	SERPINA4	NP_001275961.1
Canis lupus familiaris (dog)	SERPINA4	XP_005623826.1

Gene Ontology
Bibliography

Related articles in PubMed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M
Cardiovascular research110(3)419-30(2016 06)

Proteomics characterization of extracellular space components in the human aorta.
Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M
Molecular & cellular proteomics : MCP9(9)2048-62(2010 Sep)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

The kallikrein-kinin system: current and future pharmacological targets.
Moreau ME, Garbacki N, Molinaro G, Brown NJ, Marceau F, Adam A
Journal of pharmacological sciences99(1)6-38(2005 Sep)

Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy.
Ma JX, King LP, Yang Z, Crouch RK, Chao L, Chao J
Current eye research15(11)1117-23(1996 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Serpina4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02574	NM_145097.2 Latest version!	Rattus norvegicus serpin family A member 4 (Serpina4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa02574	XM_008764741.1 Latest version!	Rattus norvegicus serpin family A member 4 (Serpina4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina4 ( NM_145097.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_659565.2 Rattus norvegicus serpin family A member 4 (Serpina4), mRNA.

Price & Availability↑

CloneID	ORa02574
Clone ID Related Accession (Same CDS sequence)	NM_145097.2 , XM_008764741.1
Accession Version	NM_145097.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	kallistatin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088111.1. On Jan 2, 2005 this sequence version replaced NM_145097.1. ##Evidence-Data-START## Transcript exon combination :: BC088111.1, FQ218835.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGCATTATA CTCGCTGTCT GCTGCTTCTC CTGGCTGGAC TCTTGGAACT CTCTCACAGT 
CAGCCAGACC AAGAAGAGCC TGACAATACA ACCAACCAAA CCTACAGACA GTTCTCACAG 
CAGAACATCT CCAGCTACCA GATTGCCTCT GGCAATGCCA ACTTTGCCTT CCGCCTCTAC 
CACCTGATAG CGTCCCAAAA CTCTGAGAAG AACATTTTCT TCTCCCCACT CAGCATCTCT 
GTCTCTTTGG CCATACTGTC CACAGGGGCT GGTGGGGACA CCCAGGCTCA GATCCTTGAA 
GGTCTGGGCT TCAACCTCAC AAAGCTGTCA CTGCCTGAAA TTCATGAGGG CTTCAGGTCC 
TTGCAGCACA CAATAGCTCG CCCGTTCACT GAGCCACAGA TCTCTGTAGG CAGTGCGCTG 
ATCCTGAGCC AGAACCTGCA GATCCTCTCT GAGTTTGTCA GTGCCATCGA AACCTCCTAT 
AACAGCAAAG TCTTACATGC TAACTTCAGA GATAAGGAGG CTGCGGTCCA GCTCATCAAC 
AACTATGTCA AGCAGAATAC TCAGGGGAAG ATCAAAAATT TGGTCAGTGA CCTGAGCCCA 
GATGTAAAGA TGGTGCTGGT GAATTACATC TTCTTCCAAG GTCTTTGGAA GAAACCCTTT 
CCTTCTTCCA GAGTCTCTAC CAGTGACTTC TATGTAGATG AGAACACGGT TGTGAAGATA 
CCCATGATGC TGCAAGATAA GGAGGATCAC TGGTATCTTG AGGACAGACG TGTACCCTGC 
ACAGTACTGC GGATGGACTA CAGGGGTGAT GCAGTGGCGT TCTTCATCCT TCCTGACCAG 
GGCAAGATGA ATGAGGTGGA GCAGGTGCTG TCCCCAGGCA TGCTACTAAG GTGGAAACGC 
TTGCTGCAGA ATAGGTTCTT TTACAGAAAG CTCATATTGC AGCTCCCCAA ATTCTCCATT 
TCAAATTCCT ATGAATTGGA TGAGATTTTG CCTGACTTGG GCTTCCAGGA TCTGTTCACC 
CCAAATGCCA ACTTCTCAAA TATCAGCAAA AAGGAGAAAT TGTACTTATC CAAAGTTTTC 
CATAAGACCG TCCTGGATGT GAATGAAGTT GGCACAAAGG CAGCAGCAGC CACCGGCTCC 
TTTGCCACCT TTTTCTCTGC CCAGCCCAAG AAACGTTACC TTATATTCAA CCGGCCCTTC 
TTGGTGATAT TGTATTCCAC CAGCTCCCAG GATATCCTCT TCATGGGGAA GGTGGTCAAC 
CCCACAGCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659565.2
CDS	53..1324
Translation	MHYTRCLLLLLAGLLELSHSQPDQEEPDNTTNQTYRQFSQQNISSYQIASGNANFAFRLYHLIASQNSEKNIFFSPLSISVSLAILSTGAGGDTQAQILEGLGFNLTKLSLPEIHEGFRSLQHTIARPFTEPQISVGSALILSQNLQILSEFVSAIETSYNSKVLHANFRDKEAAVQLINNYVKQNTQGKIKNLVSDLSPDVKMVLVNYIFFQGLWKKPFPSSRVSTSDFYVDENTVVKIPMMLQDKEDHWYLEDRRVPCTVLRMDYRGDAVAFFILPDQGKMNEVEQVLSPGMLLRWKRLLQNRFFYRKLILQLPKFSISNSYELDEILPDLGFQDLFTPNANFSNISKKEKLYLSKVFHKTVLDVNEVGTKAAAATGSFATFFSAQPKKRYLIFNRPFLVILYSTSSQDILFMGKVVNPTA

Target ORF information:

RefSeq Version	NM_145097.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serpin family A member 4 (Serpina4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145097.2

ORF Insert Sequence:

ATGCATTATA CTCGCTGTCT GCTGCTTCTC CTGGCTGGAC TCTTGGAACT CTCTCACAGT 
CAGCCAGACC AAGAAGAGCC TGACAATACA ACCAACCAAA CCTACAGACA GTTCTCACAG 
CAGAACATCT CCAGCTACCA GATTGCCTCT GGCAATGCCA ACTTTGCCTT CCGCCTCTAC 
CACCTGATAG CGTCCCAAAA CTCTGAGAAG AACATTTTCT TCTCCCCACT CAGCATCTCT 
GTCTCTTTGG CCATACTGTC CACAGGGGCT GGTGGGGACA CCCAGGCTCA GATCCTTGAA 
GGTCTGGGCT TCAACCTCAC AAAGCTGTCA CTGCCTGAAA TTCATGAGGG CTTCAGGTCC 
TTGCAGCACA CAATAGCTCG CCCGTTCACT GAGCCACAGA TCTCTGTAGG CAGTGCGCTG 
ATCCTGAGCC AGAACCTGCA GATCCTCTCT GAGTTTGTCA GTGCCATCGA AACCTCCTAT 
AACAGCAAAG TCTTACATGC TAACTTCAGA GATAAGGAGG CTGCGGTCCA GCTCATCAAC 
AACTATGTCA AGCAGAATAC TCAGGGGAAG ATCAAAAATT TGGTCAGTGA CCTGAGCCCA 
GATGTAAAGA TGGTGCTGGT GAATTACATC TTCTTCCAAG GTCTTTGGAA GAAACCCTTT 
CCTTCTTCCA GAGTCTCTAC CAGTGACTTC TATGTAGATG AGAACACGGT TGTGAAGATA 
CCCATGATGC TGCAAGATAA GGAGGATCAC TGGTATCTTG AGGACAGACG TGTACCCTGC 
ACAGTACTGC GGATGGACTA CAGGGGTGAT GCAGTGGCGT TCTTCATCCT TCCTGACCAG 
GGCAAGATGA ATGAGGTGGA GCAGGTGCTG TCCCCAGGCA TGCTACTAAG GTGGAAACGC 
TTGCTGCAGA ATAGGTTCTT TTACAGAAAG CTCATATTGC AGCTCCCCAA ATTCTCCATT 
TCAAATTCCT ATGAATTGGA TGAGATTTTG CCTGACTTGG GCTTCCAGGA TCTGTTCACC 
CCAAATGCCA ACTTCTCAAA TATCAGCAAA AAGGAGAAAT TGTACTTATC CAAAGTTTTC 
CATAAGACCG TCCTGGATGT GAATGAAGTT GGCACAAAGG CAGCAGCAGC CACCGGCTCC 
TTTGCCACCT TTTTCTCTGC CCAGCCCAAG AAACGTTACC TTATATTCAA CCGGCCCTTC 
TTGGTGATAT TGTATTCCAC CAGCTCCCAG GATATCCTCT TCATGGGGAA GGTGGTCAAC 
CCCACAGCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Serpina4 ( XM_008764741.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008762963.1 Rattus norvegicus serpin family A member 4 (Serpina4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa02574
Clone ID Related Accession (Same CDS sequence)	NM_145097.2 , XM_008764741.1
Accession Version	XM_008764741.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	kallistatin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCATTATA CTCGCTGTCT GCTGCTTCTC CTGGCTGGAC TCTTGGAACT CTCTCACAGT 
CAGCCAGACC AAGAAGAGCC TGACAATACA ACCAACCAAA CCTACAGACA GTTCTCACAG 
CAGAACATCT CCAGCTACCA GATTGCCTCT GGCAATGCCA ACTTTGCCTT CCGCCTCTAC 
CACCTGATAG CGTCCCAAAA CTCTGAGAAG AACATTTTCT TCTCCCCACT CAGCATCTCT 
GTCTCTTTGG CCATACTGTC CACAGGGGCT GGTGGGGACA CCCAGGCTCA GATCCTTGAA 
GGTCTGGGCT TCAACCTCAC AAAGCTGTCA CTGCCTGAAA TTCATGAGGG CTTCAGGTCC 
TTGCAGCACA CAATAGCTCG CCCGTTCACT GAGCCACAGA TCTCTGTAGG CAGTGCGCTG 
ATCCTGAGCC AGAACCTGCA GATCCTCTCT GAGTTTGTCA GTGCCATCGA AACCTCCTAT 
AACAGCAAAG TCTTACATGC TAACTTCAGA GATAAGGAGG CTGCGGTCCA GCTCATCAAC 
AACTATGTCA AGCAGAATAC TCAGGGGAAG ATCAAAAATT TGGTCAGTGA CCTGAGCCCA 
GATGTAAAGA TGGTGCTGGT GAATTACATC TTCTTCCAAG GTCTTTGGAA GAAACCCTTT 
CCTTCTTCCA GAGTCTCTAC CAGTGACTTC TATGTAGATG AGAACACGGT TGTGAAGATA 
CCCATGATGC TGCAAGATAA GGAGGATCAC TGGTATCTTG AGGACAGACG TGTACCCTGC 
ACAGTACTGC GGATGGACTA CAGGGGTGAT GCAGTGGCGT TCTTCATCCT TCCTGACCAG 
GGCAAGATGA ATGAGGTGGA GCAGGTGCTG TCCCCAGGCA TGCTACTAAG GTGGAAACGC 
TTGCTGCAGA ATAGGTTCTT TTACAGAAAG CTCATATTGC AGCTCCCCAA ATTCTCCATT 
TCAAATTCCT ATGAATTGGA TGAGATTTTG CCTGACTTGG GCTTCCAGGA TCTGTTCACC 
CCAAATGCCA ACTTCTCAAA TATCAGCAAA AAGGAGAAAT TGTACTTATC CAAAGTTTTC 
CATAAGACCG TCCTGGATGT GAATGAAGTT GGCACAAAGG CAGCAGCAGC CACCGGCTCC 
TTTGCCACCT TTTTCTCTGC CCAGCCCAAG AAACGTTACC TTATATTCAA CCGGCCCTTC 
TTGGTGATAT TGTATTCCAC CAGCTCCCAG GATATCCTCT TCATGGGGAA GGTGGTCAAC 
CCCACAGCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008762963.1
CDS	281..1552
Translation	MHYTRCLLLLLAGLLELSHSQPDQEEPDNTTNQTYRQFSQQNISSYQIASGNANFAFRLYHLIASQNSEKNIFFSPLSISVSLAILSTGAGGDTQAQILEGLGFNLTKLSLPEIHEGFRSLQHTIARPFTEPQISVGSALILSQNLQILSEFVSAIETSYNSKVLHANFRDKEAAVQLINNYVKQNTQGKIKNLVSDLSPDVKMVLVNYIFFQGLWKKPFPSSRVSTSDFYVDENTVVKIPMMLQDKEDHWYLEDRRVPCTVLRMDYRGDAVAFFILPDQGKMNEVEQVLSPGMLLRWKRLLQNRFFYRKLILQLPKFSISNSYELDEILPDLGFQDLFTPNANFSNISKKEKLYLSKVFHKTVLDVNEVGTKAAAATGSFATFFSAQPKKRYLIFNRPFLVILYSTSSQDILFMGKVVNPTA

Target ORF information:

RefSeq Version	XM_008764741.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serpin family A member 4 (Serpina4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764741.1

ORF Insert Sequence:

ATGCATTATA CTCGCTGTCT GCTGCTTCTC CTGGCTGGAC TCTTGGAACT CTCTCACAGT 
CAGCCAGACC AAGAAGAGCC TGACAATACA ACCAACCAAA CCTACAGACA GTTCTCACAG 
CAGAACATCT CCAGCTACCA GATTGCCTCT GGCAATGCCA ACTTTGCCTT CCGCCTCTAC 
CACCTGATAG CGTCCCAAAA CTCTGAGAAG AACATTTTCT TCTCCCCACT CAGCATCTCT 
GTCTCTTTGG CCATACTGTC CACAGGGGCT GGTGGGGACA CCCAGGCTCA GATCCTTGAA 
GGTCTGGGCT TCAACCTCAC AAAGCTGTCA CTGCCTGAAA TTCATGAGGG CTTCAGGTCC 
TTGCAGCACA CAATAGCTCG CCCGTTCACT GAGCCACAGA TCTCTGTAGG CAGTGCGCTG 
ATCCTGAGCC AGAACCTGCA GATCCTCTCT GAGTTTGTCA GTGCCATCGA AACCTCCTAT 
AACAGCAAAG TCTTACATGC TAACTTCAGA GATAAGGAGG CTGCGGTCCA GCTCATCAAC 
AACTATGTCA AGCAGAATAC TCAGGGGAAG ATCAAAAATT TGGTCAGTGA CCTGAGCCCA 
GATGTAAAGA TGGTGCTGGT GAATTACATC TTCTTCCAAG GTCTTTGGAA GAAACCCTTT 
CCTTCTTCCA GAGTCTCTAC CAGTGACTTC TATGTAGATG AGAACACGGT TGTGAAGATA 
CCCATGATGC TGCAAGATAA GGAGGATCAC TGGTATCTTG AGGACAGACG TGTACCCTGC 
ACAGTACTGC GGATGGACTA CAGGGGTGAT GCAGTGGCGT TCTTCATCCT TCCTGACCAG 
GGCAAGATGA ATGAGGTGGA GCAGGTGCTG TCCCCAGGCA TGCTACTAAG GTGGAAACGC 
TTGCTGCAGA ATAGGTTCTT TTACAGAAAG CTCATATTGC AGCTCCCCAA ATTCTCCATT 
TCAAATTCCT ATGAATTGGA TGAGATTTTG CCTGACTTGG GCTTCCAGGA TCTGTTCACC 
CCAAATGCCA ACTTCTCAAA TATCAGCAAA AAGGAGAAAT TGTACTTATC CAAAGTTTTC 
CATAAGACCG TCCTGGATGT GAATGAAGTT GGCACAAAGG CAGCAGCAGC CACCGGCTCC 
TTTGCCACCT TTTTCTCTGC CCAGCCCAAG AAACGTTACC TTATATTCAA CCGGCCCTTC 
TTGGTGATAT TGTATTCCAC CAGCTCCCAG GATATCCTCT TCATGGGGAA GGTGGTCAAC 
CCCACAGCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Cardiovascular research110(3)419-30(2016 06)
Barallobre-Barreiro J,Oklu R,Lynch M,Fava M,Baig F,Yin X,Barwari T,Potier DN,Albadawi H,Jahangiri M,Porter KE,Watkins MT,Misra S,Stoughton J,Mayr M

Proteomics characterization of extracellular space components in the human aorta.
Molecular & cellular proteomics : MCP9(9)2048-62(2010 Sep)
Didangelos A,Yin X,Mandal K,Baumert M,Jahangiri M,Mayr M

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

The kallikrein-kinin system: current and future pharmacological targets.
Journal of pharmacological sciences99(1)6-38(2005 Sep)
Moreau ME,Garbacki N,Molinaro G,Brown NJ,Marceau F,Adam A

Kallistatin in human ocular tissues: reduced levels in vitreous fluids from patients with diabetic retinopathy.
Current eye research15(11)1117-23(1996 Nov)
Ma JX,King LP,Yang Z,Crouch RK,Chao L,Chao J