Gstp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gstp1
Entrez Gene ID	24426
Full Name	glutathione S-transferase pi 1
Synonyms	GST-P,Gst3,Gstp,Gstp2
General protein information	Preferred Names glutathione S-transferase pi 1 Names glutathione S-transferase P GST 7-7 GST class-pi Glutathione-S-transferase, placental enzyme pi type chain 7 glutathione S-transferase, pi 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43
Summary	may play a role in drug and xenobiotic metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012577.2	NP_036709.1	glutathione S-transferase P

Pathways from BioSystems

Homologies

Homo sapiens (human)	GSTP1	NP_000843.1
Mus musculus (house mouse)	Gm3934	XP_001478705.1
Canis lupus familiaris (dog)	GSTP1	NP_001239096.1
Bos taurus (cattle)	GSTP1	NP_803482.1
Mus musculus (house mouse)	Gstp1	NP_038569.1
Mus musculus (house mouse)	Gstp2	NP_861461.1
Rattus norvegicus (Norway rat)	Gstp1	NP_036709.1
Danio rerio (zebrafish)	gstp2	NP_001018349.1
Pan troglodytes (chimpanzee)	GSTP1	XP_001152516.2
	GSTP1	NP_001036141.1
Xenopus tropicalis (tropical clawed frog)	LOC101730710	XP_004917627.1
Xenopus tropicalis (tropical clawed frog)	gstp1	NP_001016641.1
Canis lupus familiaris (dog)	LOC611366	XP_854117.1
Danio rerio (zebrafish)	gstp1	NP_571809.1
Xenopus tropicalis (tropical clawed frog)	LOC100490385	XP_002941992.2

Gene Ontology
Bibliography

Related articles in PubMed

Glutathione s-transferase m1, t1, and p1 gene polymorphism in exudative age-related macular degeneration: a preliminary report.
Oz O, Aras Ates N, Tamer L, Yildirim O, Adiguzel U
European journal of ophthalmology16(1)105-110(2006 Jan - Feb)

The Interaction between
Negovan A, Iancu M, Moldovan V, Mocan S, Banescu C
BioMed research international20177365080(2017)

Induction of the pi class of glutathione S-transferase by carnosic acid in rat Clone 9 cells via the p38/Nrf2 pathway.
Lin CY, Wu CR, Chang SW, Wang YJ, Wu JJ, Tsai CW
Food & function6(6)1936-43(2015 Jun)

Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.
Kakehashi A, Kato A, Ishii N, Wei M, Morimura K, Fukushima S, Wanibuchi H
PloS one9(11)e113610(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that expression of Gstp1 can be regulated by dietary factors; here, Gstp1 is induced in hepatocytes by carnosic acid, an anticarcinogenic component of rosemary (Rosmarinus officinalis).
Title: Induction of the pi class of glutathione S-transferase by carnosic acid in rat Clone 9 cells via the p38/Nrf2 pathway.

Cisplatin metabolism in different organs of rats correlated positively with specific GSTP1 activities and this enzyme may be a critical determinant of extent of cellular uptake or retention of cisplatin in renal and liver tissues.
Title: Metabolism of cisplatin in the organs of Rattus norvegicus: role of Glutathione S-transferase P1.

The influence of dietary lipids on the ontogeny of XMEs was also evaluated. mRNA and protein levels of phase I (CYP1A1, CYP1A2, and CYP1B1) and phase II (NAD(P)H:quinone acceptor oxidoreductase 1 and GSTP1) enzymes were analyzed.
Title: Ontogeny of the major xenobiotic-metabolizing enzymes expression and the dietary lipids modulatory effect in the rat dimethylbenz(a)anthracene-induced breast cancer model.

GSTP1 application early after myocardial infarction results in long-term beneficial structural and functional effects that prevent progression to heart faiilure.
Title: Single-dose GSTP1 prevents infarction-induced heart failure.

Data show that Valerian extract inhibits hepatocarcinogenesis by suppressing cell proliferation and inducing apoptosis in glutathione S-transferase pi GST-P(+) foci by activating gamma-aminobutyric acid A receptor GABA(A)RA1-mediated signaling.
Title: Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.

The following Gstp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gstp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12643	NM_012577.2 Latest version!	Rattus norvegicus glutathione S-transferase pi 1 (Gstp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gstp1 ( NM_012577.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036709.1 Rattus norvegicus glutathione S-transferase pi 1 (Gstp1), mRNA.

Price & Availability↑

CloneID	ORa12643
Clone ID Related Accession (Same CDS sequence)	NM_012577.2
Accession Version	NM_012577.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	glutathione S-transferase P
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC058440.1 and AABR07006090.1. On or before Mar 7, 2008 this sequence version replaced NM_138974.1, NM_012577.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ217279.1, DV728363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCACCGT ACACCATTGT GTACTTCCCA GTTCGAGGGC GCTGTGAGGC CACGCGCATG 
CTGCTGGCTG ACCAGGGCCA GAGCTGGAAG GAGGAGGTGG TTACCATAGA TGTCTGGCTT 
CAAGGCTCGC TCAAGTCCAC TTGTCTGTAT GGGCAGCTCC CCAAGTTTGA AGATGGAGAC 
CTCACCCTTT ACCAATCTAA TGCCATCTTG AGGCACCTGG GTCGCTCTTT AGGGCTTTAT 
GGGAAAGACC AGAAGGAGGC TGCCTTGGTG GATATGGTGA ATGATGGGGT GGAGGACCTT 
CGATGCAAAT ATGGTACCCT CATCTACACT AACTATGAGA ATGGTAAGGA TGACTATGTG 
AAGGCCCTGC CTGGGCATCT GAAACCTTTT GAGACCCTGC TGTCCCAGAA CCAGGGAGGC 
AAAGCTTTCA TTGTGGGTAA CCAGATTTCC TTTGCAGATT ACAACTTGCT GGACCTGCTG 
CTGGTCCACC AAGTCCTGGC CCCTGGCTGC CTGGACAACT TCCCCCTGCT CTCTGCCTAT 
GTGGCTCGCC TCAGTGCCCG CCCCAAGATC AAGGCCTTTC TGTCCTCCCC TGACCATTTG 
AACCGTCCCA TCAACGGCAA TGGTAAACAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036709.1
CDS	71..703
Translation	MPPYTIVYFPVRGRCEATRMLLADQGQSWKEEVVTIDVWLQGSLKSTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKDQKEAALVDMVNDGVEDLRCKYGTLIYTNYENGKDDYVKALPGHLKPFETLLSQNQGGKAFIVGNQISFADYNLLDLLLVHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPDHLNRPINGNGKQ

Target ORF information:

RefSeq Version	NM_012577.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutathione S-transferase pi 1 (Gstp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012577.2

ORF Insert Sequence:

ATGCCACCGT ACACCATTGT GTACTTCCCA GTTCGAGGGC GCTGTGAGGC CACGCGCATG 
CTGCTGGCTG ACCAGGGCCA GAGCTGGAAG GAGGAGGTGG TTACCATAGA TGTCTGGCTT 
CAAGGCTCGC TCAAGTCCAC TTGTCTGTAT GGGCAGCTCC CCAAGTTTGA AGATGGAGAC 
CTCACCCTTT ACCAATCTAA TGCCATCTTG AGGCACCTGG GTCGCTCTTT AGGGCTTTAT 
GGGAAAGACC AGAAGGAGGC TGCCTTGGTG GATATGGTGA ATGATGGGGT GGAGGACCTT 
CGATGCAAAT ATGGTACCCT CATCTACACT AACTATGAGA ATGGTAAGGA TGACTATGTG 
AAGGCCCTGC CTGGGCATCT GAAACCTTTT GAGACCCTGC TGTCCCAGAA CCAGGGAGGC 
AAAGCTTTCA TTGTGGGTAA CCAGATTTCC TTTGCAGATT ACAACTTGCT GGACCTGCTG 
CTGGTCCACC AAGTCCTGGC CCCTGGCTGC CTGGACAACT TCCCCCTGCT CTCTGCCTAT 
GTGGCTCGCC TCAGTGCCCG CCCCAAGATC AAGGCCTTTC TGTCCTCCCC TGACCATTTG 
AACCGTCCCA TCAACGGCAA TGGTAAACAG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glutathione s-transferase m1, t1, and p1 gene polymorphism in exudative age-related macular degeneration: a preliminary report.
European journal of ophthalmology16(1)105-110(2006 Jan - Feb)
Oz O,Aras Ates N,Tamer L,Yildirim O,Adiguzel U

The Interaction between
BioMed research international20177365080(2017)
Negovan A,Iancu M,Moldovan V,Mocan S,Banescu C

Induction of the pi class of glutathione S-transferase by carnosic acid in rat Clone 9 cells via the p38/Nrf2 pathway.
Food & function6(6)1936-43(2015 Jun)
Lin CY,Wu CR,Chang SW,Wang YJ,Wu JJ,Tsai CW

Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling.
PloS one9(11)e113610(2014)
Kakehashi A,Kato A,Ishii N,Wei M,Morimura K,Fukushima S,Wanibuchi H