Ace cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ace
Entrez Gene ID	24310
Full Name	angiotensin I converting enzyme
Synonyms	CD143,Dcp1,StsRR92
General protein information	Preferred Names angiotensin I converting enzyme Names angiotensin-converting enzyme Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme) angiotensin 1 converting enzyme 1 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 angiotensin I converting enzyme 1 angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1) dipeptidyl carboxypeptidase I kininase II
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1
Summary	catalyzes the conversion of angiotensin I to angiotensin II; plays a role in regulation of blood pressure [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012544.1	NP_036676.1	angiotensin-converting enzyme precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	ace	NP_001116882.1
Canis lupus familiaris (dog)	LOC610668	XP_003639297.1
Rattus norvegicus (Norway rat)	Ace	NP_036676.1
Gallus gallus (chicken)	ACE	NP_001161204.1
Pan troglodytes (chimpanzee)	ACE	NP_001008995.1
Anopheles gambiae (African malaria mosquito)	ANCE9	XP_313865.3
Homo sapiens (human)	ACE	NP_000780.1
Mus musculus (house mouse)	Ace	NP_997507.1
Danio rerio (zebrafish)	ace	XP_694336.5
	LOC100428661	XP_002800616.1
Bos taurus (cattle)	ACE	NP_001193597.1

Gene Ontology
Bibliography

Related articles in PubMed

Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension.
Faulk KE, Nedungadi TP, Cunningham JT
Physiological reports5(10)(2017 May)

Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.
Faulk K, Shell B, Nedungadi TP, Cunningham JT
American journal of physiology. Regulatory, integrative and comparative physiology312(2)R245-R252(2017 Feb)

Ascorbic Acid Protects against Hypertension through Downregulation of ACE1 Gene Expression Mediated by Histone Deacetylation in Prenatal Inflammation-Induced Offspring.
Wang J, Yin N, Deng Y, Wei Y, Huang Y, Pu X, Li L, Zheng Y, Guo J, Yu J, Li X, Yi P
Scientific reports639469(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Chromatin immunoprecipitation (ChIP) assays demonstrated an increase in FosB/DeltaFosB association with the ACE1 gene within the MnPO following CIH. FosB/DeltaFosB may transcriptionally target ACE1 within the MnPO following CIH to affect the downstream PVN region, which may influence SNA and blood pressure.
Title: Role of angiotensin-converting enzyme 1 within the median preoptic nucleus following chronic intermittent hypoxia.

Compared to chymase, ACE-mediated angiotensin-(1-12) metabolism in the heart was several fold lower. Overall our findings suggest that angiotensin-(1-12), not Ang I, is the better substrate for Ang II formation by chymase in adult rats.
Title: Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme.

Pomegranate peel extract consumption conferred protection against hypertension in the spontaneously hypertensive rat model. This finding was demonstrated by marked reduction in coronary ACE activity, oxidative stress, and vascular remodelling.
Title: Pomegranate peel extract attenuates oxidative stress by decreasing coronary angiotensin-converting enzyme (ACE) activity in hypertensive female rats.

Finding suggests the involvement of microRNAs in the cardioprotective action of ACE inhibition in acute renal injury.
Title: MicroRNAs mediate the cardioprotective effect of angiotensin-converting enzyme inhibition in acute kidney injury.

ACE inhibitor treatment could counteract glutamate neurotoxicity by preventing the downregulation of glutamate decarboxylase 2 (Gad2). Taken together, ACE inhibition targets neurodegeneration triggered by environmental stress.
Title: Inhibition of ACE Retards Tau Hyperphosphorylation and Signs of Neuronal Degeneration in Aged Rats Subjected to Chronic Mild Stress.

The following Ace gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ace cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13209	NM_012544.1 Latest version!	Rattus norvegicus angiotensin I converting enzyme (Ace), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ace ( NM_012544.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036676.1 Rattus norvegicus angiotensin I converting enzyme (Ace), mRNA.

Price & Availability↑

CloneID	ORa13209
Clone ID Related Accession (Same CDS sequence)	NM_012544.1
Accession Version	NM_012544.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Rattus norvegicus(Norway rat)
Product	angiotensin-converting enzyme precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U03734.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085760.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGCCG CGTCCGGCCA GCGGGGGCGG TGGCCGTTGT CACCGCCGCT CTTGATGCTG 
TCGCTGCTGC TGCTGCTGCT GCTGCCGCCG TCGCCCGCCC CGGCGCTTGA CCCTGGATTG 
CAGCCGGGCA ACTTTTCCGC GGACGAGGCA GGGGCGCAGC TCTTCGCTGA CAGCTATAAC 
TCGAGTGCCG AGGTGGTGAT GTTCCAGAGC ACCGCAGCCA GCTGGGCGCA CGACACCAAC 
ATCACGGAGG AGAATGCGCG GCTCCAGGAG GAAGCGGCCC TGATCAACCA GGAGTTTGCA 
GAGGTCTGGG GCAAGAAGGC CAAGGAGCTG TATGAGTCCA TCTGGCAGAA CTTCACTGAC 
CAAAAGCTGC GAAGGATCAT CGGATCCGTA CAGACCCTAG GACCTGCCAA CCTGCCCCTG 
ACCCAGCGGC TGCAGTACAA CTCTCTGCTA AGCAACATGA GCAGAATCTA CTCCACCGGC 
AAGGTCTGCT TCCCCAACAA GACTGCCACC TGCTGGTCCC TGGACCCAGA GCTCACCAAC 
ATCCTGGCTT CCTCACGAAA CTATGCCAAG GTGCTGTTTG CCTGGGAAGG CTGGCATGAT 
GCTGTGGGTA TCCCACTGAA GCCCCTCTAT CAGGACTTTA CTGCCCTCAG TAATGAAGCC 
TACAGACAAG ATGGCTTCTC AGACACAGGA GCCTACTGGC GCTCCTGGTA TGAGTCCCCC 
TCCTTTGAAG AGAGTTTGGA GCATCTCTAC CACCAAGTCG AGCCCCTCTA CCTGAACCTC 
CATGCCTTTG TCCGTCGCGC ACTGCACCGC CGCTATGGGG ACAAATACAT CAATCTCAGA 
GGTCCTATTC CCGCTCATCT GCTGGGAGAC ATGTGGGCGC AGAGCTGGGA GAACATTTAC 
GACATGGTAG TGCCTTTCCC GGACAAACCC AACCTCGATG TCACCAGTAC AATGGTACAG 
AAGGGCTGGA ATGCCACGCA CATGTTCCGG GTCGCAGAGG AATTCTTTAC CTCGCTGGGG 
CTCTCCCCCA TGCCTCCAGA GTTCTGGGCG GAGTCGATGC TGGAGAAACC AGCTGATGGA 
CGGGAGGTGG TGTGCCATGC CTCTGCGTGG GACTTCTACA ACAGGAAGGA CTTCAGGATT 
AAGCAGTGCA CGCGGGTCAC GATGGACCAG CTGTCCACAG TACACCACGA GATGGGCCAC 
GTGCAGTACT ATCTCCAGTA CAAGGACCTG CACGTCTCTC TGCGTCGAGG TGCCAACCCT 
GGCTTCCACG AGGCCATCGG GGATGTACTC GCTCTCTCTG TCTCTACCCC AGCACATCTG 
CACAAAATTG GCCTGCTAGA CCGTGTTGCC AATGACATAG AAAGTGACAT CAATTACTTG 
CTAAAGATGG CCCTAGAGAA AATTGCCTTC TTGCCCTTTG GTTACCTGGT GGACCAGTGG 
CGCTGGGGGG TCTTCAGTGG ACGTACCCCA CCCTCTCGCT ACAACTACGA CTGGTGGTAT 
CTTCGAACCA AGTATCAGGG GATCTGCCCA CCAGTTGCTC GGAATGAAAC CCATTTTGAC 
GCTGGGGCCA AGTTTCACAT CCCAAGCGTG ACACCATACA TCAGGTACTT TGTGAGTTTC 
GTGCTACAGT TCCAGTTCCA TCAAGCGCTG TGCAAGGAGG CAGGCCACCA GGGTCCACTA 
CACCAGTGTG ACATCTACCA GTCCACCAAG GCAGGGGCCA AGCTCCAACA GGTGCTGCAG 
GCTGGCTGCT CCAGGCCCTG GCAGGAGGTG CTGAAGGACC TGGTGGGTTC AGATGCGCTG 
GATGCCAGTG CGCTAATGGA GTACTTCCAA CCAGTAAGCC AGTGGCTGCA GGAGCAGAAT 
CAGCGGAATG GCGAGGTCCT AGGCTGGCCG GAGTATCAGT GGCGTCCACC GTTACCAGAC 
AACTATCCAG AGGGAATTGA CCTAGAGACT GATGAAGCCA AGGCTAACAG GTTCGTGGAG 
GAGTATGACC GGACAGCCAA GGTGTTGTGG AACGAATACG CAGAGGCCAA CTGGCATTAT 
AACACCAACA TTACCATAGA GGGCAGCAAG ATCCTGCTTC AGAAAAACAA GGAAGTGTCC 
AACCATACCT TGAAATATGG CACCTGGGCC AAGACATTTG ACGTGAGCAA CTTCCAGAAC 
TCTACCATCA AGCGGATCAT AAAGAAGGTT CAGAACGTGG ACCGGGCAGT GCTGCCTCCC 
AACGAGTTAG AAGAGTACAA CCAGATCCTG CTAGACATGG AGACGACTTA CAGTGTAGCC 
AATGTTTGCT ACACAAATGG CACTTGTCTG TCACTGGAGC CTGATCTGAC AAATATAATG 
GCCACGTCCC GGAAATACGA AGAATTGCTT TGGGTGTGGA AGAGCTGGCG AGACAAGGTG 
GGGAGAGCCA TCCTTCCCTT TTTCCCAAAG TACGTGGACT TCTCCAACAA GATCGCCAAG 
CTCAACGGCT ACTCTGATGC AGGGGATTCC TGGAGATCCT CATATGAGTC CGACGACTTG 
GAGCAAGACC TGGAAAAACT ATACCAGGAG CTGCAGCCGC TCTACCTGAA CCTGCATGCC 
TATGTGCGCC GCTCCCTGCA CCGCCATTAT GGGTCTGAGT ACATCAACCT GGATGGTCCC 
ATTCCTGCTC ACCTGCTAGG GAACATGTGG GCACAGACTT GGTCCAACAT CTATGACTTG 
GTGGCACCCT TCCCTTCCGC CCCCAGTATA GATGCCACGG AGGCCATGAT AAAGCAGGGA 
TGGACACCCA GAAGGATATT TAAGGAAGCT GACAATTTTT TTACCTCCCT GGGGCTGTTA 
CCTGTGCCCC CTGAGTTCTG GAACAAGTCA ATGTTAGAGA AGCCAACCGA TGGGAGGGAG 
GTGGTGTGCC ATGCCTCAGC CTGGGACTTC TACAACGGCA AGGACTTCAG GATCAAGCAG 
TGTACCTCTG TGAACATGGA GGAATTGGTG ATAGCCCACC ACGAAATGGG CCACATCCAG 
TATTTCATGC AGTACAAAGA CTTGCCTGTG ACCTTTCGGG AGGGCGCCAA CCCCGGTTTT 
CATGAGGCTA TTGGAGATGT TTTGGCTCTG TCTGTGTCTA CACCCAAGCA TCTACACAGT 
CTCAACCTGC TCAGCAGTGA GGGCAGTGGC TACGAGCATG ACATCAACTT TCTAATGAAG 
ATGGCCCTTG ACAAGATCGC CTTCATCCCC TTCAGCTACC TCATTGACCA GTGGCGCTGG 
AGGGTCTTTG ACGGAAGCAT CACCAAGGAG AACTACAACC AGGAGTGGTG GAGTCTCAGA 
CTGAAGTACC AGGGTCTCTG CCCTCCAGTG CCTAGATCCC AAGGTGACTT TGACCCAGGG 
TCCAAGTTCC ACGTTCCTGC GAATGTGCCA TACATCAGGT ACTTTATCAG CTTCATCATC 
CAGTTCCAGT TCCACGAGGC ACTATGTCGC GCAGCCGGGC ACACCGGCCC CCTGTACAAG 
TGTGATATCT ACCAATCCAA GGAAGCAGGG AAGCTGCTGG CAGATGCCAT GAAGTTGGGC 
TACAGTAAGC AGTGGCCAGA AGCCATGAAG ATAATCACAG GCCAACCTAA CATGTCAGCC 
TCTGCCATTA TGAATTACTT CAAGCCACTG ACTGAATGGC TCGTCACAGA GAACAGGAGA 
CATGGAGAGA CACTGGGCTG GCCGGAGTAC ACCTGGACAC CAAACACGGC TCGTGCAGAA 
GGCTCCCTCC CAGAGTCCAG TCGCGTCAAC TTCCTGGGTA TGTACCTGGA ACCACAGCAG 
GCCCGTGTGG GCCAGTGGGT GCTGCTCTTC CTAGGCGTCG CCCTGCTGGT GGCCACCGTG 
GGTCTCGCCC ACCGACTCTA CAACATCCAT AACCATCACA GCCTCCGCCG GCCCCACCGT 
GGGCCCCAGT TTGGGTCCGA GGTGGAGCTC AGACACTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036676.1
CDS	24..3965
Translation	MGAASGQRGRWPLSPPLLMLSLLLLLLLPPSPAPALDPGLQPGNFSADEAGAQLFADSYNSSAEVVMFQSTAASWAHDTNITEENARLQEEAALINQEFAEVWGKKAKELYESIWQNFTDQKLRRIIGSVQTLGPANLPLTQRLQYNSLLSNMSRIYSTGKVCFPNKTATCWSLDPELTNILASSRNYAKVLFAWEGWHDAVGIPLKPLYQDFTALSNEAYRQDGFSDTGAYWRSWYESPSFEESLEHLYHQVEPLYLNLHAFVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMVQKGWNATHMFRVAEEFFTSLGLSPMPPEFWAESMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVANDIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNYDWWYLRTKYQGICPPVARNETHFDAGAKFHIPSVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQSTKAGAKLQQVLQAGCSRPWQEVLKDLVGSDALDASALMEYFQPVSQWLQEQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKNKEVSNHTLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVCYTNGTCLSLEPDLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSDAGDSWRSSYESDDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRAAGHTGPLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEWLVTENRRHGETLGWPEYTWTPNTARAEGSLPESSRVNFLGMYLEPQQARVGQWVLLFLGVALLVATVGLAHRLYNIHNHHSLRRPHRGPQFGSEVELRHS

Target ORF information:

RefSeq Version	NM_012544.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus angiotensin I converting enzyme (Ace), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012544.1

ORF Insert Sequence:

ATGGGGGCCG CGTCCGGCCA GCGGGGGCGG TGGCCGTTGT CACCGCCGCT CTTGATGCTG 
TCGCTGCTGC TGCTGCTGCT GCTGCCGCCG TCGCCCGCCC CGGCGCTTGA CCCTGGATTG 
CAGCCGGGCA ACTTTTCCGC GGACGAGGCA GGGGCGCAGC TCTTCGCTGA CAGCTATAAC 
TCGAGTGCCG AGGTGGTGAT GTTCCAGAGC ACCGCAGCCA GCTGGGCGCA CGACACCAAC 
ATCACGGAGG AGAATGCGCG GCTCCAGGAG GAAGCGGCCC TGATCAACCA GGAGTTTGCA 
GAGGTCTGGG GCAAGAAGGC CAAGGAGCTG TATGAGTCCA TCTGGCAGAA CTTCACTGAC 
CAAAAGCTGC GAAGGATCAT CGGATCCGTA CAGACCCTAG GACCTGCCAA CCTGCCCCTG 
ACCCAGCGGC TGCAGTACAA CTCTCTGCTA AGCAACATGA GCAGAATCTA CTCCACCGGC 
AAGGTCTGCT TCCCCAACAA GACTGCCACC TGCTGGTCCC TGGACCCAGA GCTCACCAAC 
ATCCTGGCTT CCTCACGAAA CTATGCCAAG GTGCTGTTTG CCTGGGAAGG CTGGCATGAT 
GCTGTGGGTA TCCCACTGAA GCCCCTCTAT CAGGACTTTA CTGCCCTCAG TAATGAAGCC 
TACAGACAAG ATGGCTTCTC AGACACAGGA GCCTACTGGC GCTCCTGGTA TGAGTCCCCC 
TCCTTTGAAG AGAGTTTGGA GCATCTCTAC CACCAAGTCG AGCCCCTCTA CCTGAACCTC 
CATGCCTTTG TCCGTCGCGC ACTGCACCGC CGCTATGGGG ACAAATACAT CAATCTCAGA 
GGTCCTATTC CCGCTCATCT GCTGGGAGAC ATGTGGGCGC AGAGCTGGGA GAACATTTAC 
GACATGGTAG TGCCTTTCCC GGACAAACCC AACCTCGATG TCACCAGTAC AATGGTACAG 
AAGGGCTGGA ATGCCACGCA CATGTTCCGG GTCGCAGAGG AATTCTTTAC CTCGCTGGGG 
CTCTCCCCCA TGCCTCCAGA GTTCTGGGCG GAGTCGATGC TGGAGAAACC AGCTGATGGA 
CGGGAGGTGG TGTGCCATGC CTCTGCGTGG GACTTCTACA ACAGGAAGGA CTTCAGGATT 
AAGCAGTGCA CGCGGGTCAC GATGGACCAG CTGTCCACAG TACACCACGA GATGGGCCAC 
GTGCAGTACT ATCTCCAGTA CAAGGACCTG CACGTCTCTC TGCGTCGAGG TGCCAACCCT 
GGCTTCCACG AGGCCATCGG GGATGTACTC GCTCTCTCTG TCTCTACCCC AGCACATCTG 
CACAAAATTG GCCTGCTAGA CCGTGTTGCC AATGACATAG AAAGTGACAT CAATTACTTG 
CTAAAGATGG CCCTAGAGAA AATTGCCTTC TTGCCCTTTG GTTACCTGGT GGACCAGTGG 
CGCTGGGGGG TCTTCAGTGG ACGTACCCCA CCCTCTCGCT ACAACTACGA CTGGTGGTAT 
CTTCGAACCA AGTATCAGGG GATCTGCCCA CCAGTTGCTC GGAATGAAAC CCATTTTGAC 
GCTGGGGCCA AGTTTCACAT CCCAAGCGTG ACACCATACA TCAGGTACTT TGTGAGTTTC 
GTGCTACAGT TCCAGTTCCA TCAAGCGCTG TGCAAGGAGG CAGGCCACCA GGGTCCACTA 
CACCAGTGTG ACATCTACCA GTCCACCAAG GCAGGGGCCA AGCTCCAACA GGTGCTGCAG 
GCTGGCTGCT CCAGGCCCTG GCAGGAGGTG CTGAAGGACC TGGTGGGTTC AGATGCGCTG 
GATGCCAGTG CGCTAATGGA GTACTTCCAA CCAGTAAGCC AGTGGCTGCA GGAGCAGAAT 
CAGCGGAATG GCGAGGTCCT AGGCTGGCCG GAGTATCAGT GGCGTCCACC GTTACCAGAC 
AACTATCCAG AGGGAATTGA CCTAGAGACT GATGAAGCCA AGGCTAACAG GTTCGTGGAG 
GAGTATGACC GGACAGCCAA GGTGTTGTGG AACGAATACG CAGAGGCCAA CTGGCATTAT 
AACACCAACA TTACCATAGA GGGCAGCAAG ATCCTGCTTC AGAAAAACAA GGAAGTGTCC 
AACCATACCT TGAAATATGG CACCTGGGCC AAGACATTTG ACGTGAGCAA CTTCCAGAAC 
TCTACCATCA AGCGGATCAT AAAGAAGGTT CAGAACGTGG ACCGGGCAGT GCTGCCTCCC 
AACGAGTTAG AAGAGTACAA CCAGATCCTG CTAGACATGG AGACGACTTA CAGTGTAGCC 
AATGTTTGCT ACACAAATGG CACTTGTCTG TCACTGGAGC CTGATCTGAC AAATATAATG 
GCCACGTCCC GGAAATACGA AGAATTGCTT TGGGTGTGGA AGAGCTGGCG AGACAAGGTG 
GGGAGAGCCA TCCTTCCCTT TTTCCCAAAG TACGTGGACT TCTCCAACAA GATCGCCAAG 
CTCAACGGCT ACTCTGATGC AGGGGATTCC TGGAGATCCT CATATGAGTC CGACGACTTG 
GAGCAAGACC TGGAAAAACT ATACCAGGAG CTGCAGCCGC TCTACCTGAA CCTGCATGCC 
TATGTGCGCC GCTCCCTGCA CCGCCATTAT GGGTCTGAGT ACATCAACCT GGATGGTCCC 
ATTCCTGCTC ACCTGCTAGG GAACATGTGG GCACAGACTT GGTCCAACAT CTATGACTTG 
GTGGCACCCT TCCCTTCCGC CCCCAGTATA GATGCCACGG AGGCCATGAT AAAGCAGGGA 
TGGACACCCA GAAGGATATT TAAGGAAGCT GACAATTTTT TTACCTCCCT GGGGCTGTTA 
CCTGTGCCCC CTGAGTTCTG GAACAAGTCA ATGTTAGAGA AGCCAACCGA TGGGAGGGAG 
GTGGTGTGCC ATGCCTCAGC CTGGGACTTC TACAACGGCA AGGACTTCAG GATCAAGCAG 
TGTACCTCTG TGAACATGGA GGAATTGGTG ATAGCCCACC ACGAAATGGG CCACATCCAG 
TATTTCATGC AGTACAAAGA CTTGCCTGTG ACCTTTCGGG AGGGCGCCAA CCCCGGTTTT 
CATGAGGCTA TTGGAGATGT TTTGGCTCTG TCTGTGTCTA CACCCAAGCA TCTACACAGT 
CTCAACCTGC TCAGCAGTGA GGGCAGTGGC TACGAGCATG ACATCAACTT TCTAATGAAG 
ATGGCCCTTG ACAAGATCGC CTTCATCCCC TTCAGCTACC TCATTGACCA GTGGCGCTGG 
AGGGTCTTTG ACGGAAGCAT CACCAAGGAG AACTACAACC AGGAGTGGTG GAGTCTCAGA 
CTGAAGTACC AGGGTCTCTG CCCTCCAGTG CCTAGATCCC AAGGTGACTT TGACCCAGGG 
TCCAAGTTCC ACGTTCCTGC GAATGTGCCA TACATCAGGT ACTTTATCAG CTTCATCATC 
CAGTTCCAGT TCCACGAGGC ACTATGTCGC GCAGCCGGGC ACACCGGCCC CCTGTACAAG 
TGTGATATCT ACCAATCCAA GGAAGCAGGG AAGCTGCTGG CAGATGCCAT GAAGTTGGGC 
TACAGTAAGC AGTGGCCAGA AGCCATGAAG ATAATCACAG GCCAACCTAA CATGTCAGCC 
TCTGCCATTA TGAATTACTT CAAGCCACTG ACTGAATGGC TCGTCACAGA GAACAGGAGA 
CATGGAGAGA CACTGGGCTG GCCGGAGTAC ACCTGGACAC CAAACACGGC TCGTGCAGAA 
GGCTCCCTCC CAGAGTCCAG TCGCGTCAAC TTCCTGGGTA TGTACCTGGA ACCACAGCAG 
GCCCGTGTGG GCCAGTGGGT GCTGCTCTTC CTAGGCGTCG CCCTGCTGGT GGCCACCGTG 
GGTCTCGCCC ACCGACTCTA CAACATCCAT AACCATCACA GCCTCCGCCG GCCCCACCGT 
GGGCCCCAGT TTGGGTCCGA GGTGGAGCTC AGACACTCCT GA