Fnbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fnbp1
Entrez Gene ID	192348
Full Name	formin binding protein 1
General protein information	Preferred Names formin binding protein 1 Names formin-binding protein 1 formin-binding protein 1-like formin-binding protein 17 rapostlin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p12
Summary	member of the Rho family of GTPases, binds effector protein rapostlin and regulates neurite branch formation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138914.1	NP_620269.1	formin-binding protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	FNBP1	NP_055848.1
Pan troglodytes (chimpanzee)	FNBP1	XP_001164874.3
Mus musculus (house mouse)	Fnbp1	NP_001171119.1
Gallus gallus (chicken)	FNBP1	XP_415469.3
Danio rerio (zebrafish)	fnbp1	NP_001116716.1
Canis lupus familiaris (dog)	FNBP1	XP_005625297.1
Bos taurus (cattle)	FNBP1	NP_001193641.1
Xenopus tropicalis (tropical clawed frog)	fnbp1	NP_001072662.1
Rattus norvegicus (Norway rat)	Fnbp1	NP_620269.1
Caenorhabditis elegans (roundworm)	toca-1	NP_741723.1
Caenorhabditis elegans (roundworm)	toca-2	NP_499839.2

Gene Ontology
Bibliography

Related articles in PubMed

The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons.
Wakita Y, Kakimoto T, Katoh H, Negishi M
The Journal of biological chemistry286(37)32672-83(2011 Sep)

Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis.
Shimada A, Niwa H, Tsujita K, Suetsugu S, Nitta K, Hanawa-Suetsugu K, Akasaka R, Nishino Y, Toyama M, Chen L, Liu ZJ, Wang BC, Yamamoto M, Terada T, Miyazawa A, Tanaka A, Sugano S, Shirouzu M, Nagayama K, Takenawa T, Yokoyama S
Cell129(4)761-72(2007 May)

In vivo function of Rnd2 in the development of neocortical pyramidal neurons.
Nakamura K, Yamashita Y, Tamamaki N, Katoh H, Kaneko T, Negishi M
Neuroscience research54(2)149-53(2006 Feb)

The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors.
Houdart F, Girard-Nau N, Morin F, Voisin P, Vannier B
Molecular vision111061-70(2005 Dec)

A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.
Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, Mochizuki N
The Journal of biological chemistry279(38)40091-9(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

F-BAR protein Rapostlin, whose activity is regulated by Rnd2, plays a key role in spine formation through the regulation of membrane dynamics.
Title: The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons.

Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons
Title: In vivo function of Rnd2 in the development of neocortical pyramidal neurons.

functionally different splicing variants of Rapostlin have different responses to Rnd2 in association with N-WASP.
Title: Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching.

Data show that rapostlin is the first effector of Rnd2, regulating neurite branch formation.
Title: Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching.

The following Fnbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fnbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02007	NM_138914.1 Latest version!	Rattus norvegicus formin binding protein 1 (Fnbp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fnbp1 ( NM_138914.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620269.1 Rattus norvegicus formin binding protein 1 (Fnbp1), mRNA.

Price & Availability↑

CloneID	ORa02007
Clone ID Related Accession (Same CDS sequence)	NM_138914.1
Accession Version	NM_138914.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	formin-binding protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB073208.1. On Jun 26, 2012 this sequence version replaced XM_003749442.1. ##Evidence-Data-START## Transcript exon combination :: AB073208.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGCTGGG GCACTGAGCT CTGGGATCAG TTTGACAACT TGGAAAAACA CACACAGTGG 
GGAATCGACA TTCTTGAGAA ATACATCAAG TTCGTCAAGG AGAGAACGGA GATTGAGCTC 
AGCTATGCCA AACAGCTCAG GAATCTTTCA AAGAAATACC AACCCAAGAA GAACTCGAAG 
GAAGAAGAGG AATACAAGTA CACGGCGTGT AAAGCGTTTC TTTCCACCCT GAATGAGTTG 
AATGACTACG CCGGGCAGCA TGAGGTCATC TCCGAGAACA TGACGTCACA GATCACGGTG 
GACCTGGTGC GCTACGTACA GGAGCTGAAG CAGGAGAGGA AATCGAATTT CCATGATGGA 
CGGAAGGCTC AGCAGCACAT AGAGACGTGC TGGAAGCAGC TGGAGTCGAG TAAGAGGAGG 
TTTGAGCGGG ACTGTAAGGA GGCCGACCGT GCACAGCAGT ACTTTGAGAA AATGGACGCC 
GACATCAATG TGACCAAGGC GGATGTGGAA AAGGCGCGAC AACAAGCTCA GATGCGCCAG 
CAAATGGCAG AGGACAGCAA AGCTGATTAC TCCTTAATCC TGCAGAGGTT CAACCAGGAG 
CAGTGGGAGT ACTACCACAC CCACATCCCC AACATCTTCC AGAAAATCCA AGAGATGGAG 
GAGAGGAGGA TTGTGCGCAT TGGAGAGTCC ATGAAGACGT ATGCAGAGGT GGACCGGCAG 
GTGATACCCA TCATCGGGAA GTGCCTGGAC GGTATAGTGA AGGCGGCCGA GTCTATTGAC 
CAGAAAAACG ACTCCCAGCT AGTCGTAGAA GCCTATAAGT CAGGATTCGA GCCTCCCGGA 
GACATTGAAT TCGAAGATTA CACACAGCCC ATGAAACGCA CGGTGTCAGA CAACAGCCTT 
TCCAGTTCCA AAGAAGGCAA GCCCGAGCTC AAGTTTGGAG GCAAGTCCAG AGGCAAGCTC 
TGGCCGTTCA TCAAGAAAAA CAAGCTTATG ACCCTTTTAA CATCCCCCCA CCAGCCTCCC 
CCTCCTCCCC CTGCCTCTGC CTCACCCTCT GCTGTTCCCA ACGGCCCCCA GTCTCCCAAG 
CAGCAAAAGG AACCCCTCTC CCACCGCTTC AACGAGTTCA TGACCTCCAA ACCCAAAATC 
CACTGCTTCC GGAGCCTAAA GCGTGGGCTT TCGCTCAAGC TGGGTGTCAC CCCGGAAGAC 
TTCAGCAACT TCCCGCCTGA GCAGAGAAGG AAAAAACTAC AACAGAAAGT GGACGATCTC 
AATAAAGAGA TCCAAAAGGA GACCGACCAG AGAGACGCCA TCACTAAAAT GAAAGATGTG 
TACCTAAAGA ACCCTCAGAT GGGAGACCCG GCCAGCTTGG ACCACAAACT CGCCGAAGTC 
ACCCAGAACA TAGAAAAACT GCGGCTGGAG GCTCACAAGT TCGAGGCCTG GCTGGCTGAG 
GTGGAAGGCA GACTCCCAGC TCGGAGTGAG CAGGCACGCC GGCAAAGTGG GCTGTACGAC 
GGCCAGACAC ACCAGACGGT CACTAACTGC GCCCAGGACC GGGAGAGCCC AGATGGTAGT 
TACACAGAAG AGCAAAGCCA GGAGAGCGAG CACAAGGTGC TGGCCACGGA CTTCGACGAT 
GAGTTCGACG ATGAGGAGCC GCTTCCTGCC ATCGGGACCT GCAAGGCCCT CTACACCTTT 
GAAGGTCAGA ACGAAGGCAC CATTTCGGTA GTTGAAGGAG AAACGCTGAG CGTGATTGAG 
GAGGACAAAG GCGATGGGTG GACACGCATC CGCAGAAACG AAGACGAGGA GGGTTACGTC 
CCCACTTCCT ACGTCGAAGT CTATTTAGAC AAAAACGCCA AAGGTGCTAA GACTTATATT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620269.1
CDS	1..1863
Translation	MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTACKAFLSTLNELNDYAGQHEVISENMTSQITVDLVRYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQMRQQMAEDSKADYSLILQRFNQEQWEYYHTHIPNIFQKIQEMEERRIVRIGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVVEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSSSKEGKPELKFGGKSRGKLWPFIKKNKLMTLLTSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGVTPEDFSNFPPEQRRKKLQQKVDDLNKEIQKETDQRDAITKMKDVYLKNPQMGDPASLDHKLAEVTQNIEKLRLEAHKFEAWLAEVEGRLPARSEQARRQSGLYDGQTHQTVTNCAQDRESPDGSYTEEQSQESEHKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLSVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVYLDKNAKGAKTYI

Target ORF information:

RefSeq Version	NM_138914.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus formin binding protein 1 (Fnbp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138914.1

ORF Insert Sequence:

ATGAGCTGGG GCACTGAGCT CTGGGATCAG TTTGACAACT TGGAAAAACA CACACAGTGG 
GGAATCGACA TTCTTGAGAA ATACATCAAG TTCGTCAAGG AGAGAACGGA GATTGAGCTC 
AGCTATGCCA AACAGCTCAG GAATCTTTCA AAGAAATACC AACCCAAGAA GAACTCGAAG 
GAAGAAGAGG AATACAAGTA CACGGCGTGT AAAGCGTTTC TTTCCACCCT GAATGAGTTG 
AATGACTACG CCGGGCAGCA TGAGGTCATC TCCGAGAACA TGACGTCACA GATCACGGTG 
GACCTGGTGC GCTACGTACA GGAGCTGAAG CAGGAGAGGA AATCGAATTT CCATGATGGA 
CGGAAGGCTC AGCAGCACAT AGAGACGTGC TGGAAGCAGC TGGAGTCGAG TAAGAGGAGG 
TTTGAGCGGG ACTGTAAGGA GGCCGACCGT GCACAGCAGT ACTTTGAGAA AATGGACGCC 
GACATCAATG TGACCAAGGC GGATGTGGAA AAGGCGCGAC AACAAGCTCA GATGCGCCAG 
CAAATGGCAG AGGACAGCAA AGCTGATTAC TCCTTAATCC TGCAGAGGTT CAACCAGGAG 
CAGTGGGAGT ACTACCACAC CCACATCCCC AACATCTTCC AGAAAATCCA AGAGATGGAG 
GAGAGGAGGA TTGTGCGCAT TGGAGAGTCC ATGAAGACGT ATGCAGAGGT GGACCGGCAG 
GTGATACCCA TCATCGGGAA GTGCCTGGAC GGTATAGTGA AGGCGGCCGA GTCTATTGAC 
CAGAAAAACG ACTCCCAGCT AGTCGTAGAA GCCTATAAGT CAGGATTCGA GCCTCCCGGA 
GACATTGAAT TCGAAGATTA CACACAGCCC ATGAAACGCA CGGTGTCAGA CAACAGCCTT 
TCCAGTTCCA AAGAAGGCAA GCCCGAGCTC AAGTTTGGAG GCAAGTCCAG AGGCAAGCTC 
TGGCCGTTCA TCAAGAAAAA CAAGCTTATG ACCCTTTTAA CATCCCCCCA CCAGCCTCCC 
CCTCCTCCCC CTGCCTCTGC CTCACCCTCT GCTGTTCCCA ACGGCCCCCA GTCTCCCAAG 
CAGCAAAAGG AACCCCTCTC CCACCGCTTC AACGAGTTCA TGACCTCCAA ACCCAAAATC 
CACTGCTTCC GGAGCCTAAA GCGTGGGCTT TCGCTCAAGC TGGGTGTCAC CCCGGAAGAC 
TTCAGCAACT TCCCGCCTGA GCAGAGAAGG AAAAAACTAC AACAGAAAGT GGACGATCTC 
AATAAAGAGA TCCAAAAGGA GACCGACCAG AGAGACGCCA TCACTAAAAT GAAAGATGTG 
TACCTAAAGA ACCCTCAGAT GGGAGACCCG GCCAGCTTGG ACCACAAACT CGCCGAAGTC 
ACCCAGAACA TAGAAAAACT GCGGCTGGAG GCTCACAAGT TCGAGGCCTG GCTGGCTGAG 
GTGGAAGGCA GACTCCCAGC TCGGAGTGAG CAGGCACGCC GGCAAAGTGG GCTGTACGAC 
GGCCAGACAC ACCAGACGGT CACTAACTGC GCCCAGGACC GGGAGAGCCC AGATGGTAGT 
TACACAGAAG AGCAAAGCCA GGAGAGCGAG CACAAGGTGC TGGCCACGGA CTTCGACGAT 
GAGTTCGACG ATGAGGAGCC GCTTCCTGCC ATCGGGACCT GCAAGGCCCT CTACACCTTT 
GAAGGTCAGA ACGAAGGCAC CATTTCGGTA GTTGAAGGAG AAACGCTGAG CGTGATTGAG 
GAGGACAAAG GCGATGGGTG GACACGCATC CGCAGAAACG AAGACGAGGA GGGTTACGTC 
CCCACTTCCT ACGTCGAAGT CTATTTAGAC AAAAACGCCA AAGGTGCTAA GACTTATATT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons.
The Journal of biological chemistry286(37)32672-83(2011 Sep)
Wakita Y,Kakimoto T,Katoh H,Negishi M

Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis.
Cell129(4)761-72(2007 May)
Shimada A,Niwa H,Tsujita K,Suetsugu S,Nitta K,Hanawa-Suetsugu K,Akasaka R,Nishino Y,Toyama M,Chen L,Liu ZJ,Wang BC,Yamamoto M,Terada T,Miyazawa A,Tanaka A,Sugano S,Shirouzu M,Nagayama K,Takenawa T,Yokoyama S

In vivo function of Rnd2 in the development of neocortical pyramidal neurons.
Neuroscience research54(2)149-53(2006 Feb)
Nakamura K,Yamashita Y,Tamamaki N,Katoh H,Kaneko T,Negishi M

The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors.
Molecular vision111061-70(2005 Dec)
Houdart F,Girard-Nau N,Morin F,Voisin P,Vannier B

A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.
The Journal of biological chemistry279(38)40091-9(2004 Sep)
Kamioka Y,Fukuhara S,Sawa H,Nagashima K,Masuda M,Matsuda M,Mochizuki N