Eif2b5 cDNA ORF clone, Rattus norvegicus(Norway rat)

The mechanism of eukaryotic translation initiation: new insights and challenges.
Hinnebusch AG, Lorsch JR
Cold Spring Harbor perspectives in biology4(10)(2012 Oct)

Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.
Tuckow AP, Vary TC, Kimball SR, Jefferson LS
American journal of physiology. Endocrinology and metabolism299(2)E241-8(2010 Aug)

A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.
Kantor L, Pinchasi D, Mintz M, Hathout Y, Vanderver A, Elroy-Stein O
PloS one3(11)e3783(2008)

Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis.
Kubica N, Crispino JL, Gallagher JW, Kimball SR, Jefferson LS
The international journal of biochemistry & cell biology40(11)2522-33(2008)

Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging.
Hussain SG, Ramaiah KV
Biochemical and biophysical research communications355(2)365-70(2007 Apr)

modulation of eIF2Bepsilon expression may be sufficient to correct deficits in skeletal muscle protein synthesis associated with sepsis and other muscle-wasting conditions
Title: Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.

oligodendroglial-derived cells expressing a mutated eIF2B5 constantly use their stress response mechanism as an adaptation mean in order to survive
Title: A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.

Data show that activation of mTORC1 is necessary and sufficient to stimulate eIF2Bepsilon mRNA translation.
Title: Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis.

mTOR signaling and eIF2Bepsilon mRNA translation are linked and could have roles in the stimulation of protein synthesis following acute resistance exercise
Title: Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner.