Nsa2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nsa2
Entrez Gene ID	171456
Full Name	NSA2 ribosome biogenesis homolog
Synonyms	Cdk105,Tinp1
General protein information	Preferred Names NSA2 ribosome biogenesis homolog Names ribosome biogenesis protein NSA2 homolog TGF beta-inducible nuclear protein TGF-beta-inducible nuclear protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_134415.2	NP_599242.2	ribosome biogenesis protein NSA2 homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	NSA2	NP_055701.1
Canis lupus familiaris (dog)	NSA2	XP_850805.1
Gallus gallus (chicken)	NSA2	NP_001006579.1
Danio rerio (zebrafish)	nsa2	NP_955862.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008001	XP_317465.2
Eremothecium gossypii	AGOS_ACL050W	NP_983354.1
Neurospora crassa	NCU00981	XP_965174.1
Arabidopsis thaliana (thale cress)	AT5G06360	NP_196254.1
Xenopus tropicalis (tropical clawed frog)	nsa2	NP_001017326.1
Pan troglodytes (chimpanzee)	NSA2	NP_001233567.1
	NSA2	XP_001103534.1
Magnaporthe oryzae (rice blast fungus)	MGG_10835	XP_003713429.1
Caenorhabditis elegans (roundworm)	CELE_W09C5.1	NP_493387.1
Kluyveromyces lactis	KLLA0E13619g	XP_454564.1
Schizosaccharomyces pombe (fission yeast)	SPCP1E11.08	NP_588561.1
Bos taurus (cattle)	NSA2	NP_001029718.1
Mus musculus (house mouse)	Nsa2	NP_067527.3
Rattus norvegicus (Norway rat)	Nsa2	NP_599242.2
Drosophila melanogaster (fruit fly)	Ip259	NP_001260347.1
Saccharomyces cerevisiae (baker's yeast)	NSA2	NP_011052.1
Oryza sativa (rice)	Os07g0673100	NP_001060605.1

Gene Ontology
Bibliography

Related articles in PubMed

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Elevated levels of renal and circulating Nop-7-associated 2 (NSA2) in rat and mouse models of diabetes, in mesangial cells in vitro and in patients with diabetic nephropathy.
Shahni R, Gnudi L, King A, Jones P, Malik AN
Diabetologia55(3)825-34(2012 Mar)

mRNA expression patterns in different stages of asbestos-induced carcinogenesis in rats.
Sandhu H, Dehnen W, Roller M, Abel J, Unfried K
Carcinogenesis21(5)1023-9(2000 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that renal and circulating NSA2 levels are increased in hyperglycemia in experimental models of diabetes, and that circulating NSA2 is elevated in diabetic nephropathy patients with albuminuria.
Title: Elevated levels of renal and circulating Nop-7-associated 2 (NSA2) in rat and mouse models of diabetes, in mesangial cells in vitro and in patients with diabetic nephropathy.

The following Nsa2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nsa2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01380	NM_134415.2 Latest version!	Rattus norvegicus NSA2 ribosome biogenesis factor (Nsa2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nsa2 ( NM_134415.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_599242.2 Rattus norvegicus NSA2 ribosome biogenesis factor (Nsa2), mRNA.

Price & Availability↑

CloneID	ORa01380
Clone ID Related Accession (Same CDS sequence)	NM_134415.2
Accession Version	NM_134415.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	ribosome biogenesis protein NSA2 homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR473148.1, BC098657.1, BP486932.1 and BP485557.1. On Mar 10, 2007 this sequence version replaced NM_134415.1. ##Evidence-Data-START## Transcript exon combination :: FQ226635.1, FQ214845.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906350, SAMN01906352 [ECO:0000348] ##Evidence-Data-END##

ATGCCACAAA ATGAATATAT TGAATTGCAC CGCAAACGAT ATGGATATCG TTTGGATTAC 
CATGAGAAAA AGAGAAAGAA AGAAGGTCGG GAGGCCCATG AACGTTCAAA GAAAGCAAAA 
AAAATGATCG GCCTGAAGGC TAAGCTCTAC CATAAACAGC GCCATGCCGA GAAAATACAA 
ATGAAAAAGA CCATTAAGAT GCATGAGAAG AGAAACACCA AGCAGAAGGA TGACGAGAAG 
ACTCCACAGG GAGCAGTCCC TGCCTACCTG CTAGACAGAG AGGGGCAGTC AAGAGCAAAA 
GTACTTTCCA ACATGATTAA GCAGAAGCGG AAAGAAAAGG CGGGAAAATG GGAGGTCCCT 
CTACCCAAAG TTCGTGCCCA AGGAGAAACA GAAGTATTGA AAGTTATTCG AACAGGAAAA 
AGAAAAAAGA AGGCATGGAA GAGAATGGTT ACAAAAGTCT GCTTTGTTGG TGATGGTTTT 
ACAAGAAAAC CACCTAAATA TGAAAGGTTC ATTAGGCCAA TGGGTCTACG TTTCAAAAAA 
GCCCATGTCA CACACCCTGA GCTGAAAGCT ACCTTTTGCC TGCCTATACT CGGTGTGAAA 
AAGAACCCCT CCTCCCCGTT ATATACAACC CTGGGTGTGA TCACCAAAGG GACAGTCATT 
GAAGTGAATG TAAGCGAGCT GGGCCTTGTG ACACAAGGAG GCAAGGTCAT TTGGGGAAAG 
TATGCTCAAG TTACCAACAA TCCTGAAAAT GATGGGTGCA TAAATGCAGT CTTGCTGGTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599242.2
CDS	99..881
Translation	MPQNEYIELHRKRYGYRLDYHEKKRKKEGREAHERSKKAKKMIGLKAKLYHKQRHAEKIQMKKTIKMHEKRNTKQKDDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVPLPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKKAHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGKYAQVTNNPENDGCINAVLLV

Target ORF information:

RefSeq Version	NM_134415.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NSA2 ribosome biogenesis factor (Nsa2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134415.2

ORF Insert Sequence:

ATGCCACAAA ATGAATATAT TGAATTGCAC CGCAAACGAT ATGGATATCG TTTGGATTAC 
CATGAGAAAA AGAGAAAGAA AGAAGGTCGG GAGGCCCATG AACGTTCAAA GAAAGCAAAA 
AAAATGATCG GCCTGAAGGC TAAGCTCTAC CATAAACAGC GCCATGCCGA GAAAATACAA 
ATGAAAAAGA CCATTAAGAT GCATGAGAAG AGAAACACCA AGCAGAAGGA TGACGAGAAG 
ACTCCACAGG GAGCAGTCCC TGCCTACCTG CTAGACAGAG AGGGGCAGTC AAGAGCAAAA 
GTACTTTCCA ACATGATTAA GCAGAAGCGG AAAGAAAAGG CGGGAAAATG GGAGGTCCCT 
CTACCCAAAG TTCGTGCCCA AGGAGAAACA GAAGTATTGA AAGTTATTCG AACAGGAAAA 
AGAAAAAAGA AGGCATGGAA GAGAATGGTT ACAAAAGTCT GCTTTGTTGG TGATGGTTTT 
ACAAGAAAAC CACCTAAATA TGAAAGGTTC ATTAGGCCAA TGGGTCTACG TTTCAAAAAA 
GCCCATGTCA CACACCCTGA GCTGAAAGCT ACCTTTTGCC TGCCTATACT CGGTGTGAAA 
AAGAACCCCT CCTCCCCGTT ATATACAACC CTGGGTGTGA TCACCAAAGG GACAGTCATT 
GAAGTGAATG TAAGCGAGCT GGGCCTTGTG ACACAAGGAG GCAAGGTCAT TTGGGGAAAG 
TATGCTCAAG TTACCAACAA TCCTGAAAAT GATGGGTGCA TAAATGCAGT CTTGCTGGTT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Elevated levels of renal and circulating Nop-7-associated 2 (NSA2) in rat and mouse models of diabetes, in mesangial cells in vitro and in patients with diabetic nephropathy.
Diabetologia55(3)825-34(2012 Mar)
Shahni R,Gnudi L,King A,Jones P,Malik AN

mRNA expression patterns in different stages of asbestos-induced carcinogenesis in rats.
Carcinogenesis21(5)1023-9(2000 May)
Sandhu H,Dehnen W,Roller M,Abel J,Unfried K