Ucn2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ucn2
Entrez Gene ID	170896
Full Name	urocortin 2
Synonyms	Ucn3
General protein information	Preferred Names urocortin 2 Names urocortin-2 ucn II urocortin 3 urocortin II
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	member of the corticotropin-releasing hormone (CRH)-related peptides; may play a role in cardiac hypertrophy and fibrosis; promotes cell proliferation of cardiac non-myocytes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133385.2	NP_596876.2	urocortin-2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ucn2	NP_659543.1
Rattus norvegicus (Norway rat)	Ucn2	NP_596876.2
Canis lupus familiaris (dog)	UCN2	XP_005632644.1
Bos taurus (cattle)	UCN2	XP_005223073.1
Homo sapiens (human)	UCN2	NP_149976.1

Gene Ontology
Bibliography

Related articles in PubMed

The effects of neuropeptide urocortin 2 on the spontaneous discharge and glutamatergic neurotransmission of striatum neurons.
Liu C, Liu X, Song F, Li J, Zhang X, Yang J
Neuropeptides5017-21(2015 Apr)

The effects of vasoactive peptide urocortin 2 on hemodynamics in spontaneous hypertensive rat and the role of L-type calcium channel and CRFR2.
Liu C, Liu X, Yang J, Duan Y, Yao H, Li F, Zhang X
Pharmacological reports : PR67(2)394-8(2015 Apr)

Differential stress response in rats subjected to chronic mild stress is accompanied by changes in CRH-family gene expression at the pituitary level.
Kolasa M, Faron-G?recka A, Ku?mider M, Szafran-Pilch K, Solich J, ?urawek D, Gruca P, Papp M, Dziedzicka-Wasylewska M
Peptides6198-106(2014 Nov)

Estrogens downregulate urocortin 2 expression in rat uterus.
Watanabe K, Nemoto T, Akira S, Takeshita T, Shibasaki T
The Journal of endocrinology219(3)269-78(2013 Dec)

Stress-induced changes in gene expression of urocortin 2 and other CRH peptides in rat adrenal medulla: involvement of glucocorticoids.
Tillinger A, Nostramo R, Kvetnansky R, Serova L, Sabban EL
Journal of neurochemistry125(2)185-92(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UCN2 could significantly inhibit the firing rate of 84% of the tested striatal neurons, and its inhibitory effect followed a concentration-dependent manner.
Title: The effects of neuropeptide urocortin 2 on the spontaneous discharge and glutamatergic neurotransmission of striatum neurons.

UCN2 can modulate electrical remodeling of the myocardium and hemodynamics.
Title: The effects of vasoactive peptide urocortin 2 on hemodynamics in spontaneous hypertensive rat and the role of L-type calcium channel and CRFR2.

The differentiated behavioral stress responses were reflected by gene expression changes in the pituitary. Alterations in the mRNA levels of Crh, Ucn2 and Ucn3 in the pituitary might confirm the paracrine and/or autocrine effects of these peptides
Title: Differential stress response in rats subjected to chronic mild stress is accompanied by changes in CRH-family gene expression at the pituitary level.

Data suggest that estrogens down-regulate Ucn2 expression in uterus; at 9 weeks, mRNA expression levels and contents of Ucn2 in uterus are lower in proestrus than in diestrus; plasma Ucn2 levels do not differ between the two estrous cycle phases.
Title: Estrogens downregulate urocortin 2 expression in rat uterus.

the stress-triggered rise in glucocorticoids is involved in the induction of Ucn2 mRNA by immobilization stress which may allow Ucn2 to act in an autocrine/paracrine fashion to modulate adrenomedullary function or as an endocrine hormone
Title: Stress-induced changes in gene expression of urocortin 2 and other CRH peptides in rat adrenal medulla: involvement of glucocorticoids.

The following Ucn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ucn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00644	NM_133385.2 Latest version!	Rattus norvegicus urocortin 2 (Ucn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ucn2 ( NM_133385.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_596876.2 Rattus norvegicus urocortin 2 (Ucn2), mRNA.

Price & Availability↑

CloneID	ORa00644
Clone ID Related Accession (Same CDS sequence)	NM_133385.2
Accession Version	NM_133385.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Rattus norvegicus(Norway rat)
Product	urocortin-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EF078966.1, AABR07073448.1 and AI454706.1. On Jul 24, 2009 this sequence version replaced NM_133385.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF078966.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN02642877 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGACCA GGTGGGCACT GGTGGTGTTT ATGGTCCTGA TGTTGGATAG GGTCCCAGGA 
ACCCCTATCC CCACCTTCCA GCTCCTCCCT CAGAACTATC CGGAGACAAC TCCCAGCTCT 
GTGTCCTCAG AGAGCCCCTC AGATACCACC ACTGGGCCCT CAGCTTCCTG GAGCAACTCT 
AAAGCCAGCC CTTACCTGGA CACCCGTGTC ATACTCTCCC TGGATGTCCC CATTGGCCTC 
CTGCGGATCT TACTGGAACA GGCTCGGAAC AAGGCTGCCA GGAATCAGGC TGCTACTAAT 
GCCCAAATAC TAGCCCGTGT TGGCCGCCGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_596876.2
CDS	23..355
Translation	MMTRWALVVFMVLMLDRVPGTPIPTFQLLPQNYPETTPSSVSSESPSDTTTGPSASWSNSKASPYLDTRVILSLDVPIGLLRILLEQARNKAARNQAATNAQILARVGRR

Target ORF information:

RefSeq Version	NM_133385.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus urocortin 2 (Ucn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133385.2

ORF Insert Sequence:

ATGATGACCA GGTGGGCACT GGTGGTGTTT ATGGTCCTGA TGTTGGATAG GGTCCCAGGA 
ACCCCTATCC CCACCTTCCA GCTCCTCCCT CAGAACTATC CGGAGACAAC TCCCAGCTCT 
GTGTCCTCAG AGAGCCCCTC AGATACCACC ACTGGGCCCT CAGCTTCCTG GAGCAACTCT 
AAAGCCAGCC CTTACCTGGA CACCCGTGTC ATACTCTCCC TGGATGTCCC CATTGGCCTC 
CTGCGGATCT TACTGGAACA GGCTCGGAAC AAGGCTGCCA GGAATCAGGC TGCTACTAAT 
GCCCAAATAC TAGCCCGTGT TGGCCGCCGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The effects of neuropeptide urocortin 2 on the spontaneous discharge and glutamatergic neurotransmission of striatum neurons.
Neuropeptides5017-21(2015 Apr)
Liu C,Liu X,Song F,Li J,Zhang X,Yang J

The effects of vasoactive peptide urocortin 2 on hemodynamics in spontaneous hypertensive rat and the role of L-type calcium channel and CRFR2.
Pharmacological reports : PR67(2)394-8(2015 Apr)
Liu C,Liu X,Yang J,Duan Y,Yao H,Li F,Zhang X

Differential stress response in rats subjected to chronic mild stress is accompanied by changes in CRH-family gene expression at the pituitary level.
Peptides6198-106(2014 Nov)
Kolasa M,Faron-G?recka A,Ku?mider M,Szafran-Pilch K,Solich J,?urawek D,Gruca P,Papp M,Dziedzicka-Wasylewska M

Estrogens downregulate urocortin 2 expression in rat uterus.
The Journal of endocrinology219(3)269-78(2013 Dec)
Watanabe K,Nemoto T,Akira S,Takeshita T,Shibasaki T

Stress-induced changes in gene expression of urocortin 2 and other CRH peptides in rat adrenal medulla: involvement of glucocorticoids.
Journal of neurochemistry125(2)185-92(2013 Apr)
Tillinger A,Nostramo R,Kvetnansky R,Serova L,Sabban EL