Xpnpep1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xpnpep1
Entrez Gene ID	170751
Full Name	X-prolyl aminopeptidase 1
General protein information	Preferred Names X-prolyl aminopeptidase 1 Names xaa-Pro aminopeptidase 1 X-Pro aminopeptidase 1, soluble X-prolyl aminopeptidase (aminopeptidase P) 1, soluble X-prolyl aminopeptidase 1, soluble aminoacylproline aminopeptidase cytoplasmic aminopeptidase P cytosolic aminopeptidase P sAmp soluble aminopeptidase P
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q55
Summary	cytosolic enzyme that catalyzes the release of any N-terminal amino acid that is linked with proline [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_131913.1	NP_571988.1	xaa-Pro aminopeptidase 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	XPNPEP1	NP_065116.3
	XPNPEP1	XP_001085192.2
Gallus gallus (chicken)	XPNPEP1	XP_421751.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001037	XP_560264.4
Pan troglodytes (chimpanzee)	XPNPEP1	XP_508027.3
Rattus norvegicus (Norway rat)	Xpnpep1	NP_571988.1
Caenorhabditis elegans (roundworm)	Y45G5AM.2	NP_504162.2
Bos taurus (cattle)	XPNPEP1	NP_001069070.1
Mus musculus (house mouse)	Xpnpep1	NP_573479.3
Saccharomyces cerevisiae (baker's yeast)	FRA1	NP_013071.1
Eremothecium gossypii	AGOS_AGL032C	NP_986634.1
Arabidopsis thaliana (thale cress)	APP1	NP_195394.4
Oryza sativa (rice)	Os11g0540100	NP_001068038.1
Canis lupus familiaris (dog)	XPNPEP1	XP_864026.2
Danio rerio (zebrafish)	xpnpep1	NP_998145.1
Drosophila melanogaster (fruit fly)	ApepP	NP_001246053.1
Caenorhabditis elegans (roundworm)	app-1	NP_491489.1
Kluyveromyces lactis	KLLA0F18128g	XP_455893.1
Schizosaccharomyces pombe (fission yeast)	SPAC22G7.01c	XP_001713044.1
Magnaporthe oryzae (rice blast fungus)	MGG_00476	XP_003718587.1
Neurospora crassa	NCU00112	XP_957236.1

Gene Ontology
Bibliography

Related articles in PubMed

Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats.
Hye Khan MA, Sharma A, Rarick KR, Roman RJ, Harder DR, Imig JD
PloS one10(12)e0145335(2015)

Lung vascular targeting using antibody to aminopeptidase P: CT-SPECT imaging, biodistribution and pharmacokinetic analysis.
Chrastina A, Valadon P, Massey KA, Schnitzer JE
Journal of vascular research47(6)531-43(2010)

Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit.
Li X, Lou Z, Li X, Zhou W, Ma M, Cao Y, Geng Y, Bartlam M, Zhang XC, Rao Z
The Journal of biological chemistry283(33)22858-66(2008 Aug)

Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors.
Liu G, Nakayama K, Awata S, Tang S, Kitaoka N, Manabe M, Kodama H
Pediatric research62(1)54-9(2007 Jul)

The kallikrein-kinin system: current and future pharmacological targets.
Moreau ME, Garbacki N, Molinaro G, Brown NJ, Marceau F, Adam A
Journal of pharmacological sciences99(1)6-38(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Aminopeptidase P expression is higher in the cerebral arteries of Fawn Hooded Hypertensive rats compared to Brown Norway rats.
Title: Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats.

Aminopeptidase P expressed in endothelial caveolae appears to be readily accessible to circulating antibody rather specifically in lung.
Title: Lung vascular targeting using antibody to aminopeptidase P: CT-SPECT imaging, biodistribution and pharmacokinetic analysis.

Results describe the organ distribution, developmental change and specific inhibitors of prolidases I and II in the rat.
Title: Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors.

aminopeptidase p and podoplanin are expressed in endothelial cells of blood and lymphatic vessels
Title: Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels.

The following Xpnpep1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xpnpep1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42460	NM_131913.1 Latest version!	Rattus norvegicus X-prolyl aminopeptidase 1 (Xpnpep1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$363.30 $519.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xpnpep1 ( NM_131913.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_571988.1 Rattus norvegicus X-prolyl aminopeptidase 1 (Xpnpep1), mRNA.

Price & Availability↑

CloneID	ORa42460
Clone ID Related Accession (Same CDS sequence)	NM_131913.1
Accession Version	NM_131913.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1872bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	xaa-Pro aminopeptidase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF038591.1. ##Evidence-Data-START## CDS exon combination :: AF038591.1, BC061758.1 [ECO:0000331] ##Evidence-Data-END##

ATGGCTCCGA AGGTGACCTC AGAGCTTCTG CGGCAGCTGC GACAAGCTAT GAGGAACTCG 
GAGTGCGTGG CAGAACCCAT CCAGGCCTAC ATCATCCCAT CGGGAGACGC CCACCAGAGT 
GAGTACATTG CACCCTGTGA CTGTCGGAGG GCGTTCGTCT CCGGCTTCGA TGGCTCTGCA 
GGCACAGCTA TCATCACGGA GGAGCATGCG GCCATGTGGA CGGATGGGCG CTACTTTCTC 
CAAGCTGCCA AGCAGATGGA CAACAACTGG ACCCTCATGA AGATGGGTCT GAAGGACACA 
CCGACTCAGG AGGACTGGCT GGTGAGTGTG CTTCCGGAAG GATCCAGGGT TGGTGTGGAC 
CCTCTCATCA TTCCCACAGA TTACTGGAAG AAGATGGCCA AGGTACTTCG AAGTGCTGGT 
CACCACCTCG TGCCTGTGAA GGAGAACCTT GTGGATAAGA TCTGGACAGA CCGGCCAGAG 
CGCCCTTGCA AGCCCCTCCT CACACTGGGT CTGGATTATA CAGGCATCTC GTGGAAGGAG 
AAGGTTGCAG ACCTTCGGTT GAAAATGGCG GAGAGGAGCA TCGTGTGGTT TGTGGTCACT 
GCCCTAGACG AGATTGCATG GCTGTTCAAT CTCCGAGGGT CAGATGTGGA GCACAACCCG 
GTGTTTTTCT CCTACGCAAT CATAGGACTA GAGAGGATCA TGCTCTTCAT CGACGGGGAC 
CGCATTGATG CGCCTGGTGT GAAACAGCAC CTGCTCCTTG ACTTGGGCCT GGAGGCAGAA 
TATAAAATCC AGGTGCTGCC TTACAAGTCC ATCCTGAGTG AACTCAAGAC CCTGTGTGCT 
GACCTGTCCC CGAGGGAGAA GGTGTGGGTC AGTGACAAAG CCAGCTATGC TGTGAGCGAG 
GCCATCCCCA AGGATCATCG GTGCTGTATG CCTTATACGC CCATCTGCAT TGCCAAAGCC 
GTGAAGAACT CCGCCGAGTC AGCAGGCATG AGGCGGGCTC ATATTAAAGA TGCCGTTGCC 
CTCTGCGAGC TCTTCAACTG GCTGGAGCAA GAGGTCCCCA AAGGTGGCGT AACGGAGATC 
TCTGCAGCTG ACAAGGCTGA GGAATTTCGA AGACAACAGG CTGACTTTGT GGACCTGAGC 
TTCCCAACGA TTTCCAGCAC GGGACCCAAC GGCGCCATCA TTCACTACGC GCCGATCCCT 
GAGACGAATA GGACCCTGTC CCTGGATGAG GTGTATCTCA TTGACTCCGG TGCTCAGTAC 
AAGGATGGAA CTACAGACGT TACCCGGACC ATGCACTTCG GGACCCCTAC TGCCTATGAG 
AAGGAGTGTT TCACGTATGT ACTGAAAGGC CACATTGCTG TGAGCGCGGC TGTTTTCCCA 
ACGGGAACCA AAGGCCACCT TCTAGACTCC TTTGCCCGGT CAGCCCTGTG GGATTCCGGC 
CTGGATTACC TGCACGGAAC AGGACACGGC GTCGGGTCTT TCCTGAATGT TCACGAGGGC 
CCTTGTGGCA TCAGTTATAA AACGTTCTCT GACGAGCCCT TGGAAGCCGG CATGATCGTC 
ACTGATGAGC CAGGGTATTA TGAAGATGGG GCGTTTGGGA TCCGCATCGA GAACGTTGTT 
TTGGTGGTCC CTGCGAAGAC CAAGTATAAT TTCAATAACC GAGGAAGCCT GACCTTTGAA 
CCTCTAACTT TGGTTCCCAT CCAGACCAAA ATGATAGATG TGGATGCTCT TACAGATAAA 
GAGTGTGACT GGCTCAACAG CTACCACCAG ACCTGCAGGG ATGTGATTGG GAAGGAGCTG 
CAGACTCAAG GCCGCCAGGA AGCTCTCGAG TGGCTCCTCA GAGAGACAGA GCCCATCTCC 
AGGCAGCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571988.1
CDS	45..1916
Translation	MAPKVTSELLRQLRQAMRNSECVAEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAIITEEHAAMWTDGRYFLQAAKQMDNNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAGHHLVPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKEKVADLRLKMAERSIVWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLERIMLFIDGDRIDAPGVKQHLLLDLGLEAEYKIQVLPYKSILSELKTLCADLSPREKVWVSDKASYAVSEAIPKDHRCCMPYTPICIAKAVKNSAESAGMRRAHIKDAVALCELFNWLEQEVPKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPIPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDALTDKECDWLNSYHQTCRDVIGKELQTQGRQEALEWLLRETEPISRQH

Target ORF information:

RefSeq Version	NM_131913.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus X-prolyl aminopeptidase 1 (Xpnpep1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131913.1

ORF Insert Sequence:

ATGGCTCCGA AGGTGACCTC AGAGCTTCTG CGGCAGCTGC GACAAGCTAT GAGGAACTCG 
GAGTGCGTGG CAGAACCCAT CCAGGCCTAC ATCATCCCAT CGGGAGACGC CCACCAGAGT 
GAGTACATTG CACCCTGTGA CTGTCGGAGG GCGTTCGTCT CCGGCTTCGA TGGCTCTGCA 
GGCACAGCTA TCATCACGGA GGAGCATGCG GCCATGTGGA CGGATGGGCG CTACTTTCTC 
CAAGCTGCCA AGCAGATGGA CAACAACTGG ACCCTCATGA AGATGGGTCT GAAGGACACA 
CCGACTCAGG AGGACTGGCT GGTGAGTGTG CTTCCGGAAG GATCCAGGGT TGGTGTGGAC 
CCTCTCATCA TTCCCACAGA TTACTGGAAG AAGATGGCCA AGGTACTTCG AAGTGCTGGT 
CACCACCTCG TGCCTGTGAA GGAGAACCTT GTGGATAAGA TCTGGACAGA CCGGCCAGAG 
CGCCCTTGCA AGCCCCTCCT CACACTGGGT CTGGATTATA CAGGCATCTC GTGGAAGGAG 
AAGGTTGCAG ACCTTCGGTT GAAAATGGCG GAGAGGAGCA TCGTGTGGTT TGTGGTCACT 
GCCCTAGACG AGATTGCATG GCTGTTCAAT CTCCGAGGGT CAGATGTGGA GCACAACCCG 
GTGTTTTTCT CCTACGCAAT CATAGGACTA GAGAGGATCA TGCTCTTCAT CGACGGGGAC 
CGCATTGATG CGCCTGGTGT GAAACAGCAC CTGCTCCTTG ACTTGGGCCT GGAGGCAGAA 
TATAAAATCC AGGTGCTGCC TTACAAGTCC ATCCTGAGTG AACTCAAGAC CCTGTGTGCT 
GACCTGTCCC CGAGGGAGAA GGTGTGGGTC AGTGACAAAG CCAGCTATGC TGTGAGCGAG 
GCCATCCCCA AGGATCATCG GTGCTGTATG CCTTATACGC CCATCTGCAT TGCCAAAGCC 
GTGAAGAACT CCGCCGAGTC AGCAGGCATG AGGCGGGCTC ATATTAAAGA TGCCGTTGCC 
CTCTGCGAGC TCTTCAACTG GCTGGAGCAA GAGGTCCCCA AAGGTGGCGT AACGGAGATC 
TCTGCAGCTG ACAAGGCTGA GGAATTTCGA AGACAACAGG CTGACTTTGT GGACCTGAGC 
TTCCCAACGA TTTCCAGCAC GGGACCCAAC GGCGCCATCA TTCACTACGC GCCGATCCCT 
GAGACGAATA GGACCCTGTC CCTGGATGAG GTGTATCTCA TTGACTCCGG TGCTCAGTAC 
AAGGATGGAA CTACAGACGT TACCCGGACC ATGCACTTCG GGACCCCTAC TGCCTATGAG 
AAGGAGTGTT TCACGTATGT ACTGAAAGGC CACATTGCTG TGAGCGCGGC TGTTTTCCCA 
ACGGGAACCA AAGGCCACCT TCTAGACTCC TTTGCCCGGT CAGCCCTGTG GGATTCCGGC 
CTGGATTACC TGCACGGAAC AGGACACGGC GTCGGGTCTT TCCTGAATGT TCACGAGGGC 
CCTTGTGGCA TCAGTTATAA AACGTTCTCT GACGAGCCCT TGGAAGCCGG CATGATCGTC 
ACTGATGAGC CAGGGTATTA TGAAGATGGG GCGTTTGGGA TCCGCATCGA GAACGTTGTT 
TTGGTGGTCC CTGCGAAGAC CAAGTATAAT TTCAATAACC GAGGAAGCCT GACCTTTGAA 
CCTCTAACTT TGGTTCCCAT CCAGACCAAA ATGATAGATG TGGATGCTCT TACAGATAAA 
GAGTGTGACT GGCTCAACAG CTACCACCAG ACCTGCAGGG ATGTGATTGG GAAGGAGCTG 
CAGACTCAAG GCCGCCAGGA AGCTCTCGAG TGGCTCCTCA GAGAGACAGA GCCCATCTCC 
AGGCAGCATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats.
PloS one10(12)e0145335(2015)
Hye Khan MA,Sharma A,Rarick KR,Roman RJ,Harder DR,Imig JD

Lung vascular targeting using antibody to aminopeptidase P: CT-SPECT imaging, biodistribution and pharmacokinetic analysis.
Journal of vascular research47(6)531-43(2010)
Chrastina A,Valadon P,Massey KA,Schnitzer JE

Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit.
The Journal of biological chemistry283(33)22858-66(2008 Aug)
Li X,Lou Z,Li X,Zhou W,Ma M,Cao Y,Geng Y,Bartlam M,Zhang XC,Rao Z

Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors.
Pediatric research62(1)54-9(2007 Jul)
Liu G,Nakayama K,Awata S,Tang S,Kitaoka N,Manabe M,Kodama H

The kallikrein-kinin system: current and future pharmacological targets.
Journal of pharmacological sciences99(1)6-38(2005 Sep)
Moreau ME,Garbacki N,Molinaro G,Brown NJ,Marceau F,Adam A

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Xpnpep1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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