Keap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Keap1
Entrez Gene ID	117519
Full Name	Kelch-like ECH-associated protein 1
Synonyms	Inrf2
General protein information	Preferred Names Kelch-like ECH-associated protein 1 Names kelch-like ECH-associated protein 1 cytosolic inhibitor of Nrf2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q13
Summary	binds nuclear transcription factor Nrf2 and retains it in the cytoplasm thus inhibiting it from functioning in the nucleus [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006242591.3	XP_006242653.1	kelch-like ECH-associated protein 1 isoform X1
NM_057152.2	NP_476493.2	kelch-like ECH-associated protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	KEAP1	NP_987096.1
Canis lupus familiaris (dog)	KEAP1	XP_005632954.1
Mus musculus (house mouse)	Keap1	NP_001103777.1
Rattus norvegicus (Norway rat)	Keap1	NP_476493.2
Drosophila melanogaster (fruit fly)	Keap1	NP_732202.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003645	XP_562507.4
Bos taurus (cattle)	KEAP1	NP_001094612.1
Pan troglodytes (chimpanzee)	KEAP1	XP_003316158.1
Danio rerio (zebrafish)	keap1b	NP_001106948.1
Xenopus tropicalis (tropical clawed frog)	keap1	NP_001008024.1

Gene Ontology
Bibliography

Related articles in PubMed

Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress.
Zhang JC, Yao W, Dong C, Han M, Shirayama Y, Hashimoto K
European archives of psychiatry and clinical neuroscience(2017 Nov)

Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway.
Pan PK, Qiao LY, Wen XN
Cellular and molecular biology (Noisy-le-Grand, France)62(14)11-17(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PGAM5 controls cardiomyocyte apoptosis induced by MIRI through regulating Keap1-mediated Bcl-xL degradation, which may supply a novel molecular target for acute myocardial infarction (AMI) therapy.
Title: Mitochondrial phosphatase PGAM5 regulates Keap1-mediated Bcl-xL degradation and controls cardiomyocyte apoptosis driven by myocardial ischemia/reperfusion injury.

Data show that safranal inhibited the expression of kelch-like ECH-associated protein 1 (Keap1) and promoted the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in rotenone-induced dopaminergic neurons.
Title: Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway.

this paper shows that that epigallocatechin gallate potentially abrogates fluoride-induced oxidative lung injury by activation of the Nrf2/Keap1 pathway
Title: Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: An in-vivo and in-silico study.

these results indicate that defect mitochondrial biogenesis in RVLM neurons entailing redox-sensitive and IL-1beta-dependent suppression of TFAM because of the increase in the formation of Keap1/Nrf2 complex, reductions in nuclear translocation of the activated Nrf2 and its binding to the Tfam gene promoter may underlie hypertension developed under the LPS-induced systemic inflammation
Title: Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation.

Our data suggest that polyphenols may induce cellular defense genes by derepressing Nrf2 inhibition by Keap1.
Title: Nrf2 transcriptional derepression from Keap1 by dietary polyphenols.

The following Keap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Keap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12236	NM_057152.2 Latest version!	Rattus norvegicus Kelch-like ECH-associated protein 1 (Keap1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$370.30 $529.00
ORa30875	XM_006242591.3 Latest version!	Rattus norvegicus Kelch-like ECH-associated protein 1 (Keap1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Keap1 ( NM_057152.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476493.2 Rattus norvegicus Kelch-like ECH-associated protein 1 (Keap1), mRNA.

Price & Availability↑

CloneID	ORa12236
Clone ID Related Accession (Same CDS sequence)	NM_057152.2
Accession Version	NM_057152.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Rattus norvegicus(Norway rat)
Product	kelch-like ECH-associated protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07069442.1 and AABR07069441.1. On Dec 21, 2012 this sequence version replaced NM_057152.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ212383.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCCCG AACCCAAGCC TAGCGGGGCT CCCCGCAGCA GCCAGTTCCT GCCCCTGTGG 
TCAAAGTGCC CGGAGGGGGC AGGGGACGCG GTGATGTATG CATCCACGGA GTGCAAGGCG 
GAGGTGACGC CCTCGCAGGA TGGTAACCGA ACCTTCAGTT ACACACTAGA GGATCACACC 
AAGCAGGCTT TTGGCATCAT GAACGAGCTT CGGCTGAGCC AGCAGCTCTG TGACGTGACC 
CTGCAGGTCA AATATGAGGA CATCCCAGCT GCCCAATTCA TGGCCCACAA AGTGGTGCTG 
GCCTCCTCCA GCCCAGTCTT TAAAGCTATG TTCACCAACG GGCTTCGGGA GCAGGGCATG 
GAGGTGGTGT CCATTGAAGG CATCCACCCC AAGGTCATGG AGAGGCTAAT TGAGTTCGCC 
TACACGGCCT CCATCTCCGT GGGCGAGAAG TGTGTGCTGC ATGTGATGAA CGGGGCAGTC 
ATGTACCAGA TTGACAGCGT GGTCCGAGCC TGCAGCGACT TCCTCGTGCA GCAGCTGGAC 
CCCAGCAACG CCATCGGCAT CGCCAACTTC GCCGAGCAGA TCGGCTGCAC GGAACTGCAC 
CAGCGTGCTC GGGAGTATAT CTACATGCAC TTCGGGGAGG AGGAGTTCTT CAACCTGTCA 
CACTGCCAGC TGGCCACGCT CATCAGCCGC GATGATCTGA ACGTGCGCTG CGAGTCCGAG 
GTGTTCCATG CGTGCATCGA CTGGGTCAAA TACGACTGCC CGCAGCGGCG CTTCTACGTG 
CAGGCACTGC TACGGGCCGT GCGCTGCCAC GCTCTCACGC CACGCTTCCT GCAGACACAG 
CTGCAAAAGT GCGAGATCCT GCAGGCCGAC GCGCGCTGCA AGGACTACCT GGTGCAGATC 
TTCCAGGAGC TCACGCTGCA CAAGCCCACA CAAGCGGTGC CCTGCCGGGC GCCCAAAGTG 
GGCCGCCTCA TCTACACTGC GGGCGGTTAC TTCCGACAGT CGCTCAGCTA CCTGGAGGCC 
TACAACCCGA GCAATGGCTC CTGGCTGCGC CTGGCAGACC TACAGGTGCC CCGCAGTGGG 
CTGGCGGGCT GCGTGGTGGG CGGGCTGCTG TATGCTGTGG GCGGCCGCAA CAACTCGCCG 
GACGGCAACA CTGATTCCAG CGCCCTGGAC TGCTACAACC CCATGACCAA CCAGTGGTCG 
CCCTGTGCCT CTATGAGCGT GCCGCGCAAC CGCATCGGGG TGGGGGTCAT AGATGGCCAC 
ATCTACGCAG TCGGGGGTTC CCACGGCTGC ATCCACCACA GCAGCGTGGA GAGATATGAG 
CCAGATCGAG ACGAGTGGCA CCTAGTCGCG CCAATGTTGA CGCGGAGGAT CGGCGTGGGC 
GTGGCAGTGC TCAACCGCTT GCTGTATGCA GTGGGGGGCT TTGATGGGAC TAACCGGCTT 
AACTCGGCAG AATGTTACTA CCCGGAGAGG AATGAGTGGC GGATGATTAC ACCAATGAAT 
ACCATCCGGA GCGGGGCCGG GGTCTGTGTG CTGCACAGCT GCATCTATGC CGCAGGAGGC 
TACGATGGGC AGGACCAGCT GAACAGCGTG GAACGCTACG ACGTGGAGAC AGAGACCTGG 
ACTTTCGTAG CCTCCATGAA GCATCGCCGG AGCGCGCTGG GGATTGCTGT GCACCAGGGC 
AGGATCTACG TCCTCGGAGG CTACGATGGC CACACTTTTC TGGACAGTGT GGAATGCTAT 
GACCCAGACA CTGATACCTG GAGTGAAGTG ACCCGCTTGA CATCTGGCCG CAGTGGGGTG 
GGTGTTGCTG TCACCATGGA ACCCTGTCGG AAGCAAATTG ATCAACAAAA CTGTACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476493.2
CDS	324..2186
Translation	MQPEPKPSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHSCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTMEPCRKQIDQQNCTC

Target ORF information:

RefSeq Version	NM_057152.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Kelch-like ECH-associated protein 1 (Keap1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057152.2

ORF Insert Sequence:

ATGCAGCCCG AACCCAAGCC TAGCGGGGCT CCCCGCAGCA GCCAGTTCCT GCCCCTGTGG 
TCAAAGTGCC CGGAGGGGGC AGGGGACGCG GTGATGTATG CATCCACGGA GTGCAAGGCG 
GAGGTGACGC CCTCGCAGGA TGGTAACCGA ACCTTCAGTT ACACACTAGA GGATCACACC 
AAGCAGGCTT TTGGCATCAT GAACGAGCTT CGGCTGAGCC AGCAGCTCTG TGACGTGACC 
CTGCAGGTCA AATATGAGGA CATCCCAGCT GCCCAATTCA TGGCCCACAA AGTGGTGCTG 
GCCTCCTCCA GCCCAGTCTT TAAAGCTATG TTCACCAACG GGCTTCGGGA GCAGGGCATG 
GAGGTGGTGT CCATTGAAGG CATCCACCCC AAGGTCATGG AGAGGCTAAT TGAGTTCGCC 
TACACGGCCT CCATCTCCGT GGGCGAGAAG TGTGTGCTGC ATGTGATGAA CGGGGCAGTC 
ATGTACCAGA TTGACAGCGT GGTCCGAGCC TGCAGCGACT TCCTCGTGCA GCAGCTGGAC 
CCCAGCAACG CCATCGGCAT CGCCAACTTC GCCGAGCAGA TCGGCTGCAC GGAACTGCAC 
CAGCGTGCTC GGGAGTATAT CTACATGCAC TTCGGGGAGG AGGAGTTCTT CAACCTGTCA 
CACTGCCAGC TGGCCACGCT CATCAGCCGC GATGATCTGA ACGTGCGCTG CGAGTCCGAG 
GTGTTCCATG CGTGCATCGA CTGGGTCAAA TACGACTGCC CGCAGCGGCG CTTCTACGTG 
CAGGCACTGC TACGGGCCGT GCGCTGCCAC GCTCTCACGC CACGCTTCCT GCAGACACAG 
CTGCAAAAGT GCGAGATCCT GCAGGCCGAC GCGCGCTGCA AGGACTACCT GGTGCAGATC 
TTCCAGGAGC TCACGCTGCA CAAGCCCACA CAAGCGGTGC CCTGCCGGGC GCCCAAAGTG 
GGCCGCCTCA TCTACACTGC GGGCGGTTAC TTCCGACAGT CGCTCAGCTA CCTGGAGGCC 
TACAACCCGA GCAATGGCTC CTGGCTGCGC CTGGCAGACC TACAGGTGCC CCGCAGTGGG 
CTGGCGGGCT GCGTGGTGGG CGGGCTGCTG TATGCTGTGG GCGGCCGCAA CAACTCGCCG 
GACGGCAACA CTGATTCCAG CGCCCTGGAC TGCTACAACC CCATGACCAA CCAGTGGTCG 
CCCTGTGCCT CTATGAGCGT GCCGCGCAAC CGCATCGGGG TGGGGGTCAT AGATGGCCAC 
ATCTACGCAG TCGGGGGTTC CCACGGCTGC ATCCACCACA GCAGCGTGGA GAGATATGAG 
CCAGATCGAG ACGAGTGGCA CCTAGTCGCG CCAATGTTGA CGCGGAGGAT CGGCGTGGGC 
GTGGCAGTGC TCAACCGCTT GCTGTATGCA GTGGGGGGCT TTGATGGGAC TAACCGGCTT 
AACTCGGCAG AATGTTACTA CCCGGAGAGG AATGAGTGGC GGATGATTAC ACCAATGAAT 
ACCATCCGGA GCGGGGCCGG GGTCTGTGTG CTGCACAGCT GCATCTATGC CGCAGGAGGC 
TACGATGGGC AGGACCAGCT GAACAGCGTG GAACGCTACG ACGTGGAGAC AGAGACCTGG 
ACTTTCGTAG CCTCCATGAA GCATCGCCGG AGCGCGCTGG GGATTGCTGT GCACCAGGGC 
AGGATCTACG TCCTCGGAGG CTACGATGGC CACACTTTTC TGGACAGTGT GGAATGCTAT 
GACCCAGACA CTGATACCTG GAGTGAAGTG ACCCGCTTGA CATCTGGCCG CAGTGGGGTG 
GGTGTTGCTG TCACCATGGA ACCCTGTCGG AAGCAAATTG ATCAACAAAA CTGTACCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Keap1 ( XM_006242591.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006242653.1 Rattus norvegicus Kelch-like ECH-associated protein 1 (Keap1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa30875
Clone ID Related Accession (Same CDS sequence)	XM_006242591.3
Accession Version	XM_006242591.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	kelch-like ECH-associated protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242591.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCCCG AACCCAAGCC TAGCGGGGCT CCCCGCAGCA GCCAGTTCCT GCCCCTGTGG 
TCAAAGTGCC CGGAGGGGGC AGGGGACGCG GTGATGTATG CATCCACGGA GTGCAAGGCG 
GAGGTGACGC CCTCGCAGGA TGGTAACCGA ACCTTCAGTT ACACACTAGA GGATCACACC 
AAGCAGGCTT TTGGCATCAT GAACGAGCTT CGGCTGAGCC AGCAGCTCTG TGACGTGACC 
CTGCAGGTCA AATATGAGGA CATCCCAGCT GCCCAATTCA TGGCCCACAA AGTGGTGCTG 
GCCTCCTCCA GCCCAGTCTT TAAAGCTATG TTCACCAACG GGCTTCGGGA GCAGGGCATG 
GAGGTGGTGT CCATTGAAGG CATCCACCCC AAGGTCATGG AGAGGCTAAT TGAGTTCGCC 
TACACGGCCT CCATCTCCGT GGGCGAGAAG TGTGTGCTGC ATGTGATGAA CGGGGCAGTC 
ATGTACCAGA TTGACAGCGT GGTCCGAGCC TGCAGCGACT TCCTCGTGCA GCAGCTGGAC 
CCCAGCAACG CCATCGGCAT CGCCAACTTC GCCGAGCAGA TCGGCTGCAC GGAACTGCAC 
CAGCGTGCTC GGGAGTATAT CTACATGCAC TTCGGGGAGG TGGCCAAGCA GGAGGAGTTC 
TTCAACCTGT CACACTGCCA GCTGGCCACG CTCATCAGCC GCGATGATCT GAACGTGCGC 
TGCGAGTCCG AGGTGTTCCA TGCGTGCATC GACTGGGTCA AATACGACTG CCCGCAGCGG 
CGCTTCTACG TGCAGGCACT GCTACGGGCC GTGCGCTGCC ACGCTCTCAC GCCACGCTTC 
CTGCAGACAC AGCTGCAAAA GTGCGAGATC CTGCAGGCCG ACGCGCGCTG CAAGGACTAC 
CTGGTGCAGA TCTTCCAGGA GCTCACGCTG CACAAGCCCA CACAAGCGGT GCCCTGCCGG 
GCGCCCAAAG TGGGCCGCCT CATCTACACT GCGGGCGGTT ACTTCCGACA GTCGCTCAGC 
TACCTGGAGG CCTACAACCC GAGCAATGGC TCCTGGCTGC GCCTGGCAGA CCTACAGGTG 
CCCCGCAGTG GGCTGGCGGG CTGCGTGGTG GGCGGGCTGC TGTATGCTGT GGGCGGCCGC 
AACAACTCGC CGGACGGCAA CACTGATTCC AGCGCCCTGG ACTGCTACAA CCCCATGACC 
AACCAGTGGT CGCCCTGTGC CTCTATGAGC GTGCCGCGCA ACCGCATCGG GGTGGGGGTC 
ATAGATGGCC ACATCTACGC AGTCGGGGGT TCCCACGGCT GCATCCACCA CAGCAGCGTG 
GAGAGATATG AGCCAGATCG AGACGAGTGG CACCTAGTCG CGCCAATGTT GACGCGGAGG 
ATCGGCGTGG GCGTGGCAGT GCTCAACCGC TTGCTGTATG CAGTGGGGGG CTTTGATGGG 
ACTAACCGGC TTAACTCGGC AGAATGTTAC TACCCGGAGA GGAATGAGTG GCGGATGATT 
ACACCAATGA ATACCATCCG GAGCGGGGCC GGGGTCTGTG TGCTGCACAG CTGCATCTAT 
GCCGCAGGAG GCTACGATGG GCAGGACCAG CTGAACAGCG TGGAACGCTA CGACGTGGAG 
ACAGAGACCT GGACTTTCGT AGCCTCCATG AAGCATCGCC GGAGCGCGCT GGGGATTGCT 
GTGCACCAGG GCAGGATCTA CGTCCTCGGA GGCTACGATG GCCACACTTT TCTGGACAGT 
GTGGAATGCT ATGACCCAGA CACTGATACC TGGAGTGAAG TGACCCGCTT GACATCTGGC 
CGCAGTGGGG TGGGTGTTGC TGTCACCATG GAACCCTGTC GGAAGCAAAT TGATCAACAA 
AACTGTACCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006242653.1
CDS	413..2287
Translation	MQPEPKPSGAPRSSQFLPLWSKCPEGAGDAVMYASTECKAEVTPSQDGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHSCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTMEPCRKQIDQQNCTC

Target ORF information:

RefSeq Version	XM_006242591.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Kelch-like ECH-associated protein 1 (Keap1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006242591.3

ORF Insert Sequence:

ATGCAGCCCG AACCCAAGCC TAGCGGGGCT CCCCGCAGCA GCCAGTTCCT GCCCCTGTGG 
TCAAAGTGCC CGGAGGGGGC AGGGGACGCG GTGATGTATG CATCCACGGA GTGCAAGGCG 
GAGGTGACGC CCTCGCAGGA TGGTAACCGA ACCTTCAGTT ACACACTAGA GGATCACACC 
AAGCAGGCTT TTGGCATCAT GAACGAGCTT CGGCTGAGCC AGCAGCTCTG TGACGTGACC 
CTGCAGGTCA AATATGAGGA CATCCCAGCT GCCCAATTCA TGGCCCACAA AGTGGTGCTG 
GCCTCCTCCA GCCCAGTCTT TAAAGCTATG TTCACCAACG GGCTTCGGGA GCAGGGCATG 
GAGGTGGTGT CCATTGAAGG CATCCACCCC AAGGTCATGG AGAGGCTAAT TGAGTTCGCC 
TACACGGCCT CCATCTCCGT GGGCGAGAAG TGTGTGCTGC ATGTGATGAA CGGGGCAGTC 
ATGTACCAGA TTGACAGCGT GGTCCGAGCC TGCAGCGACT TCCTCGTGCA GCAGCTGGAC 
CCCAGCAACG CCATCGGCAT CGCCAACTTC GCCGAGCAGA TCGGCTGCAC GGAACTGCAC 
CAGCGTGCTC GGGAGTATAT CTACATGCAC TTCGGGGAGG TGGCCAAGCA GGAGGAGTTC 
TTCAACCTGT CACACTGCCA GCTGGCCACG CTCATCAGCC GCGATGATCT GAACGTGCGC 
TGCGAGTCCG AGGTGTTCCA TGCGTGCATC GACTGGGTCA AATACGACTG CCCGCAGCGG 
CGCTTCTACG TGCAGGCACT GCTACGGGCC GTGCGCTGCC ACGCTCTCAC GCCACGCTTC 
CTGCAGACAC AGCTGCAAAA GTGCGAGATC CTGCAGGCCG ACGCGCGCTG CAAGGACTAC 
CTGGTGCAGA TCTTCCAGGA GCTCACGCTG CACAAGCCCA CACAAGCGGT GCCCTGCCGG 
GCGCCCAAAG TGGGCCGCCT CATCTACACT GCGGGCGGTT ACTTCCGACA GTCGCTCAGC 
TACCTGGAGG CCTACAACCC GAGCAATGGC TCCTGGCTGC GCCTGGCAGA CCTACAGGTG 
CCCCGCAGTG GGCTGGCGGG CTGCGTGGTG GGCGGGCTGC TGTATGCTGT GGGCGGCCGC 
AACAACTCGC CGGACGGCAA CACTGATTCC AGCGCCCTGG ACTGCTACAA CCCCATGACC 
AACCAGTGGT CGCCCTGTGC CTCTATGAGC GTGCCGCGCA ACCGCATCGG GGTGGGGGTC 
ATAGATGGCC ACATCTACGC AGTCGGGGGT TCCCACGGCT GCATCCACCA CAGCAGCGTG 
GAGAGATATG AGCCAGATCG AGACGAGTGG CACCTAGTCG CGCCAATGTT GACGCGGAGG 
ATCGGCGTGG GCGTGGCAGT GCTCAACCGC TTGCTGTATG CAGTGGGGGG CTTTGATGGG 
ACTAACCGGC TTAACTCGGC AGAATGTTAC TACCCGGAGA GGAATGAGTG GCGGATGATT 
ACACCAATGA ATACCATCCG GAGCGGGGCC GGGGTCTGTG TGCTGCACAG CTGCATCTAT 
GCCGCAGGAG GCTACGATGG GCAGGACCAG CTGAACAGCG TGGAACGCTA CGACGTGGAG 
ACAGAGACCT GGACTTTCGT AGCCTCCATG AAGCATCGCC GGAGCGCGCT GGGGATTGCT 
GTGCACCAGG GCAGGATCTA CGTCCTCGGA GGCTACGATG GCCACACTTT TCTGGACAGT 
GTGGAATGCT ATGACCCAGA CACTGATACC TGGAGTGAAG TGACCCGCTT GACATCTGGC 
CGCAGTGGGG TGGGTGTTGC TGTCACCATG GAACCCTGTC GGAAGCAAAT TGATCAACAA 
AACTGTACCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress.
European archives of psychiatry and clinical neuroscience(2017 Nov)
Zhang JC,Yao W,Dong C,Han M,Shirayama Y,Hashimoto K

Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway.
Cellular and molecular biology (Noisy-le-Grand, France)62(14)11-17(2016 Dec)
Pan PK,Qiao LY,Wen XN

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Keap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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