Pabpn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pabpn1
Entrez Gene ID	116697
Full Name	poly(A) binding protein, nuclear 1
General protein information	Preferred Names poly(A) binding protein, nuclear 1 Names polyadenylate-binding protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p13
Summary	mouse homolog may be involved in specific spermatogenetic cell differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001135008.1	NP_001128480.1	polyadenylate-binding protein 2

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Pabp2	NP_724648.1
Caenorhabditis elegans (roundworm)	pabp-2	NP_492504.1
Oryza sativa (rice)	Os06g0219600	NP_001057163.1
Homo sapiens (human)	PABPN1	NP_004634.1
Arabidopsis thaliana (thale cress)	AT5G65260	NP_201329.1
Arabidopsis thaliana (thale cress)	AT5G10350	NP_196597.1
Pan troglodytes (chimpanzee)	PABPN1	XP_001162168.1
Canis lupus familiaris (dog)	PABPN1	NP_001123909.2
Rattus norvegicus (Norway rat)	Pabpn1	NP_001128480.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005117	XP_313998.3
Oryza sativa (rice)	Os02g0757900	NP_001048174.1
Bos taurus (cattle)	PABPN1	NP_776994.1
Mus musculus (house mouse)	Pabpn1	NP_062275.1

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
Matsubara S, Shimizu T, Komori T, Mori-Yoshimura M, Minami N, Hayashi YK
Neuromuscular disorders : NMD26(7)436-40(2016 Jul)

Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors.
Gruber AR, Martin G, Keller W, Zavolan M
Wiley interdisciplinary reviews. RNA5(2)183-96(2014 Mar-Apr)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1.
Su YL, Wang SC, Chiang PY, Lin NY, Shen YF, Chang GD, Chang CJ
PloS one7(7)e41313(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pabpn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pabpn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03847	NM_001135008.1 Latest version!	Rattus norvegicus poly(A) binding protein, nuclear 1 (Pabpn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pabpn1 ( NM_001135008.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001128480.1 Rattus norvegicus poly(A) binding protein, nuclear 1 (Pabpn1), mRNA.

Price & Availability↑

CloneID	ORa03847
Clone ID Related Accession (Same CDS sequence)	NM_001135008.1
Accession Version	NM_001135008.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Rattus norvegicus(Norway rat)
Product	polyadenylate-binding protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC115371.6. On Sep 16, 2008 this sequence version replaced XM_214172.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CK479333.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG 
CCGGGGCGGC GGCGCCATCT TGTGCCCGGG GCCGGTGGGG AGGCCGGGGA GGGGGACCCG 
GGGGGCGCAG GGGACTACGG GAACGGCCTG GAGTCTGAGG AGCTGGAGCC TGGGGAGCTG 
CTGCCAGAGC CCGAGCCCGA AGAGGAGCCG CCCCGGCCCC GCGCCCCTCC GGGAGCTCCG 
GGTCCTGGGC CCGGCTCGGG AGCCCCCGGC AGCCAGGAGG AGGAGGAAGA GCCGGGACTG 
GTTGAGACCG ACCCCGGGGA CGGCGCCATT GAGGACCCGG AGCTAGAAGC GATCAAAGCT 
CGAGTCAGGG AGATGGAGGA AGAGGCTGAG AAGCTAAAGG AGCTACAAAA CGAGGTAGAG 
AAACAGATGA ATATGAGTCC ACCCCCAGGC AATGCTGGCC CAGTGATCAT GTCTCTTGAG 
GAGAAGATGG AGGCTGATGC CCGTTCCATC TACGTTGGCA ATGTGGACTA TGGTGCGACA 
GCAGAAGAGC TGGAGGCCCA TTTTCACGGC TGCGGTTCAG TCAACCGGGT GACTATACTC 
TGTGACAAAT TTAGTGGCCA TCCCAAAGGG TTTGCATATA TAGAGTTCTC AGACAAAGAG 
TCAGTGAGGA CGTCCCTGGC CTTAGATGAG TCCCTGTTTA GAGGAAGACA AATCAAGGTG 
ATTCCCAAGC GAACCAACAG ACCAGGCATC AGCACAACAG ACCGGGGCTT CCCGCGTGCC 
CGATACCGCG CCCGGACTAC CAATTACAAC AGCTCCAGAT CTCGATTCTA CAGTGGTTTT 
AACAGCAGGC CCCGGGGTCG AATCTACAGG GGCCGGGCTA GAGCGACATC ATGGTATTCC 
CCTTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128480.1
CDS	14..922
Translation	MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGDPGGAGDYGNGLESEELEPGELLPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVETDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSLEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRIYRGRARATSWYSPY

Target ORF information:

RefSeq Version	NM_001135008.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus poly(A) binding protein, nuclear 1 (Pabpn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135008.1

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG 
CCGGGGCGGC GGCGCCATCT TGTGCCCGGG GCCGGTGGGG AGGCCGGGGA GGGGGACCCG 
GGGGGCGCAG GGGACTACGG GAACGGCCTG GAGTCTGAGG AGCTGGAGCC TGGGGAGCTG 
CTGCCAGAGC CCGAGCCCGA AGAGGAGCCG CCCCGGCCCC GCGCCCCTCC GGGAGCTCCG 
GGTCCTGGGC CCGGCTCGGG AGCCCCCGGC AGCCAGGAGG AGGAGGAAGA GCCGGGACTG 
GTTGAGACCG ACCCCGGGGA CGGCGCCATT GAGGACCCGG AGCTAGAAGC GATCAAAGCT 
CGAGTCAGGG AGATGGAGGA AGAGGCTGAG AAGCTAAAGG AGCTACAAAA CGAGGTAGAG 
AAACAGATGA ATATGAGTCC ACCCCCAGGC AATGCTGGCC CAGTGATCAT GTCTCTTGAG 
GAGAAGATGG AGGCTGATGC CCGTTCCATC TACGTTGGCA ATGTGGACTA TGGTGCGACA 
GCAGAAGAGC TGGAGGCCCA TTTTCACGGC TGCGGTTCAG TCAACCGGGT GACTATACTC 
TGTGACAAAT TTAGTGGCCA TCCCAAAGGG TTTGCATATA TAGAGTTCTC AGACAAAGAG 
TCAGTGAGGA CGTCCCTGGC CTTAGATGAG TCCCTGTTTA GAGGAAGACA AATCAAGGTG 
ATTCCCAAGC GAACCAACAG ACCAGGCATC AGCACAACAG ACCGGGGCTT CCCGCGTGCC 
CGATACCGCG CCCGGACTAC CAATTACAAC AGCTCCAGAT CTCGATTCTA CAGTGGTTTT 
AACAGCAGGC CCCGGGGTCG AATCTACAGG GGCCGGGCTA GAGCGACATC ATGGTATTCC 
CCTTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
Neuromuscular disorders : NMD26(7)436-40(2016 Jul)
Matsubara S,Shimizu T,Komori T,Mori-Yoshimura M,Minami N,Hayashi YK

Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors.
Wiley interdisciplinary reviews. RNA5(2)183-96(2014 Mar-Apr)
Gruber AR,Martin G,Keller W,Zavolan M

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1.
PloS one7(7)e41313(2012)
Su YL,Wang SC,Chiang PY,Lin NY,Shen YF,Chang GD,Chang CJ